Protein Alignment DPYSL3 and CRMP

DIOPT Version :10

• Sequence 1: NP_001184223.1
• Gene: DPYSL3 / 1809
• HGNCID: 3015
• Length: 684
• Species: Homo sapiens
• Sequence 2: NP_730954.2
• Gene: CRMP / 40675
• FlyBaseID: FBgn0023023
• Length: 594
• Species: Drosophila melanogaster
• Alignment Length: 614
• Identity: 292/614 - (47%)
• Similarity: 388/614 - (63%)
• Gaps: 53/614 - (8%)

Human    95 SREPAPASPAPAGVEIRSATGKEVLQNLGPKDKSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQI 159
            |..|.|....|  :.::||      ||        |:.||.|.|||.|:||.||:|:|||:||.:
  Fly     2 STSPKPVKKVP--IHLQSA------QN--------RVYIKNGEIVNHDKSFKADVYIEDGIIKFV 50

Human   160 G--DNLIVPGGVKTIEANGKMVIPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHV 222
            |  ..:.:||||:||:|:|.|:||||||.|||.|:|:.|...||||:.|||||:|||||||||.|
  Fly    51 GPSSEITIPGGVRTIDASGLMIIPGGIDPHTHMQLPFGGAVAVDDFYHGTKAAVAGGTTMIIDFV 115

Human   223 VPEPESSLTEAYEKWREWADGKSCCDYALHVDITHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDL 287
            :|....|:.|||:|||.|||.|.||||.|||.||.|:.||.:|:..|.|:.|||||..:||||.|
  Fly   116 LPNKHESMIEAYDKWRSWADPKVCCDYGLHVGITWWSKSVSEEIGILCKELGVNSFKTFMAYKGL 180

Human   288 YQVSNTELYEIFTCLGELGAIAQVHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFR 352
            ||:::::|.::|..:..|..:|.||||||||||:...|:|..||.|||||.||||||:|||||.|
  Fly   181 YQLNDSDLLDVFERIRHLNGVAMVHAENGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHR 245

Human   353 AITIASQTNCPLYVTKVMSKSAADLISQARK--KGNVVFGEPITASLGIDGTHYWSKNWAKAAAF 415
            |..:|.|.:|||||..||||||...:::||.  :|..:.||.:.|:||.|.|......:...||.
  Fly   246 ACVLAHQADCPLYVVHVMSKSAGIELARARHRYRGRYIMGETLAAALGTDATCCQHLGFDAEAAH 310

Human   416 VTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIW 480
            |.||||.||.|||:::..|||:.||||:||.:|||:...||:||.:||.||.|.||||:|||::|
  Fly   311 VLSPPLRPDKTTPEFLMKLLANDDLQLTGSDNCTFNKEHKALGKGDFTKIPNGVNGVEDRMSLVW 375

Human   481 DKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKIVSAKNHQSAAEY 545
            :|.|..|.:|..:||||||||||||||:||:||||:||||:|:|||:|:|.:.:|...|..|.::
  Fly   376 EKGVHAGLLDPCRFVAVTSTNAAKIFNIYPQKGRIAVGSDADIVIWNPNATRTISKDTHHHACDF 440

Human   546 NIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYKRIKAR----------- 599
            ||||||.:.|....|:.:|:|..|.||:.|.:|.|||||......:||..|:.:
  Fly   441 NIFEGMTVHGVCEFVLVRGRICAERGNVRVAEGFGRFIPTPVRPPFVYDIIEGKVQSQPEEQHEE 505

Human   600 -------RKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSARGSPTRPNPPV-------RNLHQS 650
                   ::.|:|.      ...||.:..:....|..|..|.|| ....|.|       |:|.:|
  Fly   506 KQNGSMAKRFAELD------IQIPVQEPISAMLAGNLAMPAEGS-LCSTPSVRGRVDGKRDLQES 563

Human   651 GFSLSGTQVDEGVRSASKRIVAPPGGRSN 679
            .||:|......|||:..| :..||||:|:
  Fly   564 SFSISEELDRSGVRACIK-VKNPPGGKSS 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DPYSL3	NP_001184223.1	D-hydantoinase	131..585	CDD:273937	253/457 (55%)
CRMP	NP_730954.2	D-HYD	22..475	CDD:238639	249/452 (55%)