Protein Alignment DPYSL3 and CG6106

DIOPT Version :10

• Sequence 1: NP_001184223.1
• Gene: DPYSL3 / 1809
• HGNCID: 3015
• Length: 684
• Species: Homo sapiens
• Sequence 2: NP_573287.1
• Gene: CG6106 / 32816
• FlyBaseID: FBgn0030914
• Length: 486
• Species: Drosophila melanogaster
• Alignment Length: 527
• Identity: 131/527 - (24%)
• Similarity: 210/527 - (39%)
• Gaps: 110/527 - (20%)

Human   126 DKSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEAN---------GKMVI- 180
            |.|...||.||.||:           .:|:|:::   |..|..|.|...|         |.:|:
  Fly    14 DGSQNALIHGGIIVD-----------TEGIIRRV---LRSPQEVNTYLYNTESESVYDFGDLVLM 64

Human   181 PGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAYEKWR-EWADGK 244
            ||.||.:.|...|  |....:.|...||||.|||.|.|||........:::.|:.|.: ..|.||
  Fly    65 PGLIDPNVHINEP--GRKDWEGFATATKAAAAGGFTTIIDRPTNAQPPTVSVAHLKAKTSTARGK 127

Human   245 SCCDYALHVDITHWNDSVKQEVQNL--IKDKGVNSFMVYM------AYKDLYQVSNTELYEIFTC 301
                  ::||:..|...|......|  :...||......:      ..::...|:.::|.|..:.
  Fly   128 ------IYVDVGFWGGLVPGNGDQLAALLGAGVMGLQCTLCDPAAPVSQEFPAVNESQLEEALSQ 186

Human   302 L------GELGAIAQVHAE---NGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAITIA 357
            |      ||  ||..||||   ..:|...|:... |.|.     .:::||.::|..|......:|
  Fly   187 LDKDQAEGE--AIVAVHAELPLTTEIHPDEEAPR-EYGT-----FLVTRPPQMEISATQLLCRLA 243

Human   358 SQ--TNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDG-THYWSKNWAKAA------ 413
            ::  ..| :::....|..:..|:.:.|::|         .:|.:|. .||    .|.||
  Fly   244 NRHPRRC-IHILNCSSGESLPLVEECRRQG---------GNLTVDTCPHY----LALAAEDVPDC 294

Human   414 --AFVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAI----GKDNFTAIPEGTNGV 472
              .|.|.||:...........:|...|.:::.||.|...:...:|:    |:.||.....|.|.:
  Fly   295 GTEFKTWPPIRERRNQEQLWQALRPGGAIRMIGSDHSPATPGARALTCGRGRGNFLKAWPGINSL 359

Human   473 EERMSVIWDKAVATGKMDENQFVA----VTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKI 533
            :..:||:| .|.|..:...|..:|    :.....|.:..|...||||:.|.|:|..:|.|:....
  Fly   360 QLSLSVVW-TAAANRRGSANLTIADIHRLMCQEPANLCGLSASKGRIAEGYDADFCVWSPEEEFT 423

Human   534 VSAKNHQSAAEYNIFEGMELRGAPLVVICQGKIMLEDGNLHVTQ---GAGRFIPCSPFSDYVYKR 595
            |..:...:|.:...:.|.:|||.....:.:|        |||.|   |.|:     |....:.:|
  Fly   424 VGPELLYTATKATPYAGQKLRGVVHATVVRG--------LHVYQQFEGFGQ-----PLGKVLLRR 475

Human   596 IKARRKM 602
              :.||:
  Fly   476 --SSRKL 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DPYSL3	NP_001184223.1	D-hydantoinase	131..585	CDD:273937	125/503 (25%)
CG6106	NP_573287.1	L-HYD_ALN	2..473	CDD:238640	128/516 (25%)