Protein Alignment vps-41 and lt

DIOPT Version :10

• Sequence 1: NP_001367568.1
• Gene: vps-41 / 180800
• WormBaseID: WBGene00017974
• Length: 901
• Species: Caenorhabditis elegans
• Sequence 2: NP_001036415.2
• Gene: lt / 3355130
• FlyBaseID: FBgn0002566
• Length: 841
• Species: Drosophila melanogaster
• Alignment Length: 917
• Identity: 225/917 - (24%)
• Similarity: 419/917 - (45%)
• Gaps: 136/917 - (14%)

 Worm    19 NSYHDDVTFNTEDDDEPPLEPRFKYERLKGEETLPFMKTA-TFTSIDLHDKFIAIGTATGLIYIL 82
            :|:.|.:  |.||     :||:|||.||..:  |.:|..| ..|...:|.||:..||..|.:.|.
  Fly    11 DSWADSI--NEED-----VEPKFKYHRLAND--LKYMLNADVITCSAVHLKFLIFGTFRGRVCIF 66

 Worm    83 DHHG---YGNFDSVPPLKPHRCAVSKVKFDETGSYVLSCANDSKIVVSGVGNDKLCCTINIQVMP 144
            ||.|   |.|. |......|:.||:.:..|..|.||.:|::|.|:.::|:.:.....:::.....
  Fly    67 DHQGNSVYSNL-SASERHTHQVAVNNIDVDHKGEYVATCSDDGKVNITGLFSSDNNHSLSFGKFI 130

 Worm   145 KSIYFSPDFIRQQSGHC--FIMGERNLVLYEKRMF-QYKASSLYSGSERDGFIHCCSWNENLIAF 206
            |.:...||    ...|.  |::|:..|:|||:.:. :.|...|.|   .:|.:....|:.|.||:
  Fly   131 KVVSLEPD----SKAHIKRFVVGDDKLILYERNLLKKLKPVELCS---VEGSVLSICWHGNFIAW 188

 Worm   207 TNDTGTRVYERGAER-----IITSVQPSHDVDRVRSSRSPPKH-TWMPENNLVIGWADTVTILKI 265
            .:..|.|||:.. ||     |...|.|...::..|.      | .|..::.|:|||.||:.:..|
  Fly   189 ASHIGVRVYDLN-ERCSLGLIKWEVPPQERLENFRC------HLRWSNKHTLLIGWVDTIRVCVI 246

 Worm   266 RDDDGVKKG----EVHHI-----FHVSMFICGISYIPESGIDNMELFLVGLQLEGEDFDDCASVI 321
            |..:.::..    .|:.:     |..:.::||::  |.|.   .:|.::|.:
  Fly   247 RKRNSIEASTGNLPVYIVDPISTFQTTFYVCGLA--PLSA---KQLVVLGFR------------- 293

 Worm   322 STVTTLTALESSACTILKTSVIRP-LGLKEFELQSEDMI----------ESVKLSNHTLPYMIHG 375
                    .|.|:|    ...:|| |.:.|:::.:.:.|          |...:::::|.
  Fly   294 --------KEKSSC----FKALRPVLCVIEYKMNNSEEICTDSLTLRGFEEYTVNDYSLG----- 341

 Worm   376 LGIPYLATYFILTTKHIIMAVPYGPEDGIRWRLKYKLYDEALDMAKHNADLLSKTDLSPKKVGRM 440
             ||.....::|:..|.|::|.....:|.|.|.:|:..::||:::...|..     ::....|.::
  Fly   342 -GIIEENRFYIVAPKDIVVASLIETDDRIEWLIKHSKFEEAMELISANGG-----NVPVLSVAKL 400

 Worm   441 IIEGYLTGKRARAAASRLPLICGECKEEWEWAVNQFEEVKLCTLLAEVLPDGTP-TLDPECYQKV 504
            .|...|..|:...||.....:.|..|..||..|.:|.:.:....::..||.... .|||..|:.|
  Fly   401 YINHLLALKKYDDAAKLCLRMLGNDKVLWEEEVFKFVKCQQLRSVSAYLPTSDECKLDPHVYEMV 465

 Worm   505 LIACLFNNVKQFRKLVQTWSPDLYMTSFIID------RTQWRIQQISKSGNLADVDETERVLMDA 563
            |...|..:|..|..|::.|...||....:|:      |..:..|                 |:::
  Fly   466 LYEFLKFDVCGFLNLIKEWPSHLYDGLAVINAIHDNFRKHYANQ-----------------LLES 513

 Worm   564 LAHLYLYERKYESALKILMSCQDFQIFNVIDKHQLFDLVKDQITELMNINSERALRLLLDNADSV 628
            ||.||.|:..:||||::.:..|:..:|.:|.:::|:|::...|..|:.::.:.|..:|||. ..:
  Fly   514 LALLYSYQGDFESALRMYLKLQNKDVFQLIRRYELYDVISKLIIPLIQLDRDCAFEILLDK-KKI 577

 Worm   629 EPSFVMEKIGRQPKLQLAYLTKLMSRNEGTEFADKAVQLYAEYDQKKLLPFLRKNANYNVNKARK 693
            :...|:.::....:....||..|:.::....|..|.:.|||.:|:.||||||:::.:|::.:|..
  Fly   578 KTEIVVHQLEHNQEYLYWYLDSLLKKDPSNVFQKKLISLYAIFDRNKLLPFLKRSKDYDIQEALV 642

 Worm   694 LCSDKGYIEETIYLLAKSG--NHYDAVKMMVREYRNMEKVIDYCKDQNDPDLWIHLLGVVAEFPA 756
            :|..:.:..|.:|||...|  ...:|:.:::...|::|..|::||:.:|.|||..|:...::.|.
  Fly   643 ICKQENFYPEIVYLLGCMGGVEASEALNIIIHRIRDIEMAIEFCKEHDDSDLWNALINEFSKHPE 707

 Worm   757 HFSQLIIEASNCLDPLLIMDKLPDDSDIPNLSEALDKLLVDYTNHAELQQCCYDSTLNDLNVLTQ 821
            ..::::....:...|.:::.|:....:||||.::|.|:|..|....|:........|||...:..
  Fly   708 IVTKVLDGIVDYFSPAVVVGKIKMGQNIPNLRQSLIKMLRHYNLQGEILSSAQQIQLNDYFEIHS 772

 Worm   822 GLISAADESVSVNIVSRCSLCAQIIINSNQETTKKFSDIKVFKCGHIFHLACSTSEMERRQSIEE 886
            .:::.......|:....||||.:.::.:.   |..:..|:: :|||::|..|...|:.:.
  Fly   773 EIVTTQRRGQQVSYEQLCSLCHRPVLMAG---THLYCIIRL-ECGHVYHKPCIQGELLKN----- 828

 Worm   887 GLCIACS 893
              |..|:
  Fly   829 --CNECN 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vps-41	NP_001367568.1	WD40 repeat	61..98	CDD:293791	14/39 (36%)
		WD40 repeat	103..139	CDD:293791	9/35 (26%)
		WD40 repeat	145..187	CDD:293791	12/44 (27%)
		WD40 repeat	194..228	CDD:293791	12/38 (32%)
		WD40 repeat	235..279	CDD:293791	12/48 (25%)
		CLH	621..755	CDD:128594	38/135 (28%)
		HRD1	<791..>883	CDD:227568	21/91 (23%)
		RING_Ubox	838..893	CDD:473075	13/54 (24%)
lt	NP_001036415.2	WD40 repeat	33..81	CDD:293791	17/50 (34%)
		WD40 repeat	90..123	CDD:293791	8/32 (25%)
		WD40 repeat	130..168	CDD:293791	11/41 (27%)
		CLH	570..707	CDD:128594	38/137 (28%)