DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vps-41 and lt

DIOPT Version :9

Sequence 1:	NP_001367568.1	Gene:	vps-41 / 180800	WormBaseID:	WBGene00017974	Length:	901	Species:	Caenorhabditis elegans
Sequence 2:	NP_001036415.2	Gene:	lt / 3355130	FlyBaseID:	FBgn0002566	Length:	841	Species:	Drosophila melanogaster

Alignment Length:	917	Identity:	225/917 - (24%)
Similarity:	419/917 - (45%)	Gaps:	136/917 - (14%)

- Green bases have known domain annotations that are detailed below.

Worm    19 NSYHDDVTFNTEDDDEPPLEPRFKYERLKGEETLPFMKTA-TFTSIDLHDKFIAIGTATGLIYIL 82
            :|:.|.:  |.||     :||:|||.||..:  |.:|..| ..|...:|.||:..||..|.:.|.
  Fly    11 DSWADSI--NEED-----VEPKFKYHRLAND--LKYMLNADVITCSAVHLKFLIFGTFRGRVCIF 66

Worm    83 DHHG---YGNFDSVPPLKPHRCAVSKVKFDETGSYVLSCANDSKIVVSGVGNDKLCCTINIQVMP 144
            ||.|   |.|. |......|:.||:.:..|..|.||.:|::|.|:.::|:.:.....:::.....
  Fly    67 DHQGNSVYSNL-SASERHTHQVAVNNIDVDHKGEYVATCSDDGKVNITGLFSSDNNHSLSFGKFI 130

Worm   145 KSIYFSPDFIRQQSGHC--FIMGERNLVLYEKRMF-QYKASSLYSGSERDGFIHCCSWNENLIAF 206
            |.:...||    ...|.  |::|:..|:|||:.:. :.|...|.|   .:|.:....|:.|.||:
  Fly   131 KVVSLEPD----SKAHIKRFVVGDDKLILYERNLLKKLKPVELCS---VEGSVLSICWHGNFIAW 188

Worm   207 TNDTGTRVYERGAER-----IITSVQPSHDVDRVRSSRSPPKH-TWMPENNLVIGWADTVTILKI 265
            .:..|.|||:.. ||     |...|.|...::..|.      | .|..::.|:|||.||:.:..|
  Fly   189 ASHIGVRVYDLN-ERCSLGLIKWEVPPQERLENFRC------HLRWSNKHTLLIGWVDTIRVCVI 246

Worm   266 RDDDGVKKG----EVHHI-----FHVSMFICGISYIPESGIDNMELFLVGLQLEGEDFDDCASVI 321
            |..:.::..    .|:.:     |..:.::||::  |.|.   .:|.::|.:
  Fly   247 RKRNSIEASTGNLPVYIVDPISTFQTTFYVCGLA--PLSA---KQLVVLGFR------------- 293

Worm   322 STVTTLTALESSACTILKTSVIRP-LGLKEFELQSEDMI----------ESVKLSNHTLPYMIHG 375
                    .|.|:|    ...:|| |.:.|:::.:.:.|          |...:::::|.
  Fly   294 --------KEKSSC----FKALRPVLCVIEYKMNNSEEICTDSLTLRGFEEYTVNDYSLG----- 341

Worm   376 LGIPYLATYFILTTKHIIMAVPYGPEDGIRWRLKYKLYDEALDMAKHNADLLSKTDLSPKKVGRM 440
             ||.....::|:..|.|::|.....:|.|.|.:|:..::||:::...|..     ::....|.::
  Fly   342 -GIIEENRFYIVAPKDIVVASLIETDDRIEWLIKHSKFEEAMELISANGG-----NVPVLSVAKL 400

Worm   441 IIEGYLTGKRARAAASRLPLICGECKEEWEWAVNQFEEVKLCTLLAEVLPDGTP-TLDPECYQKV 504
            .|...|..|:...||.....:.|..|..||..|.:|.:.:....::..||.... .|||..|:.|
  Fly   401 YINHLLALKKYDDAAKLCLRMLGNDKVLWEEEVFKFVKCQQLRSVSAYLPTSDECKLDPHVYEMV 465

Worm   505 LIACLFNNVKQFRKLVQTWSPDLYMTSFIID------RTQWRIQQISKSGNLADVDETERVLMDA 563
            |...|..:|..|..|::.|...||....:|:      |..:..|                 |:::
  Fly   466 LYEFLKFDVCGFLNLIKEWPSHLYDGLAVINAIHDNFRKHYANQ-----------------LLES 513

Worm   564 LAHLYLYERKYESALKILMSCQDFQIFNVIDKHQLFDLVKDQITELMNINSERALRLLLDNADSV 628
            ||.||.|:..:||||::.:..|:..:|.:|.:::|:|::...|..|:.::.:.|..:|||. ..:
  Fly   514 LALLYSYQGDFESALRMYLKLQNKDVFQLIRRYELYDVISKLIIPLIQLDRDCAFEILLDK-KKI 577

Worm   629 EPSFVMEKIGRQPKLQLAYLTKLMSRNEGTEFADKAVQLYAEYDQKKLLPFLRKNANYNVNKARK 693
            :...|:.::....:....||..|:.::....|..|.:.|||.:|:.||||||:::.:|::.:|..
  Fly   578 KTEIVVHQLEHNQEYLYWYLDSLLKKDPSNVFQKKLISLYAIFDRNKLLPFLKRSKDYDIQEALV 642

Worm   694 LCSDKGYIEETIYLLAKSG--NHYDAVKMMVREYRNMEKVIDYCKDQNDPDLWIHLLGVVAEFPA 756
            :|..:.:..|.:|||...|  ...:|:.:::...|::|..|::||:.:|.|||..|:...::.|.
  Fly   643 ICKQENFYPEIVYLLGCMGGVEASEALNIIIHRIRDIEMAIEFCKEHDDSDLWNALINEFSKHPE 707

Worm   757 HFSQLIIEASNCLDPLLIMDKLPDDSDIPNLSEALDKLLVDYTNHAELQQCCYDSTLNDLNVLTQ 821
            ..::::....:...|.:::.|:....:||||.::|.|:|..|....|:........|||...:..
  Fly   708 IVTKVLDGIVDYFSPAVVVGKIKMGQNIPNLRQSLIKMLRHYNLQGEILSSAQQIQLNDYFEIHS 772

Worm   822 GLISAADESVSVNIVSRCSLCAQIIINSNQETTKKFSDIKVFKCGHIFHLACSTSEMERRQSIEE 886
            .:::.......|:....||||.:.::.:.   |..:..|:: :|||::|..|...|:.:.
  Fly   773 EIVTTQRRGQQVSYEQLCSLCHRPVLMAG---THLYCIIRL-ECGHVYHKPCIQGELLKN----- 828

Worm   887 GLCIACS 893
              |..|:
  Fly   829 --CNECN 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vps-41	NP_001367568.1	WD40	<38..>294	CDD:225201	77/277 (28%)
		WD40 repeat	61..98	CDD:293791	14/39 (36%)
		WD40 repeat	103..139	CDD:293791	9/35 (26%)
		WD40 repeat	145..187	CDD:293791	12/44 (27%)
		WD40 repeat	194..228	CDD:293791	12/38 (32%)
		WD40 repeat	235..279	CDD:293791	12/48 (25%)
		CLH	621..755	CDD:128594	38/135 (28%)
		HRD1	<791..>883	CDD:227568	21/91 (23%)
		RING_Ubox	838..893	CDD:418438	13/54 (24%)
lt	NP_001036415.2	WD40 repeat	33..81	CDD:293791	17/50 (34%)
		WD40	<42..204	CDD:295369	49/170 (29%)
		WD40 repeat	90..123	CDD:293791	8/32 (25%)
		WD40 repeat	130..168	CDD:293791	11/41 (27%)
		CLH	570..707	CDD:128594	38/137 (28%)
		Clathrin	580..708	CDD:279031	36/127 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167407
Domainoid	1	1.000	162	1.000	Domainoid score	I2435
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	273	1.000	Inparanoid score	I1804
Isobase	1	0.950	-	0.919607	Normalized mean entropy	S2845
OMA	1	1.010	-	-		QHG54432
OrthoDB	1	1.010	-	-		D103854at33208
OrthoFinder	1	1.000	-	-		FOG0004492
OrthoInspector	1	1.000	-	-		oto17606
orthoMCL	1	0.900	-	-		OOG6_103391
Panther	1	1.100	-	-	LDO	PTHR12616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1654
SonicParanoid	1	1.000	-	-		X3779
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.890