DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sax-3 and zormin

DIOPT Version :9

Sequence 1:	NP_001024990.1	Gene:	sax-3 / 180637	WormBaseID:	WBGene00004729	Length:	1273	Species:	Caenorhabditis elegans
Sequence 2:	NP_001261317.1	Gene:	zormin / 2769001	FlyBaseID:	FBgn0052311	Length:	3664	Species:	Drosophila melanogaster

Alignment Length:	1382	Identity:	279/1382 - (20%)
Similarity:	427/1382 - (30%)	Gaps:	442/1382 - (31%)

- Green bases have known domain annotations that are detailed below.

Worm    30 APVIIEHPIDVVVSR-GSPATLNC--GAKPSTAKITWYKDGQPVITNKEQVNSHRIVLDTGSLFL 91
            |..:...|:...||| |......|  ...|..| :.|:|||..:.||.:    ::...|.|...|
  Fly  1388 ASPLFTRPLKDAVSREGDRFVFECEVTGTPEPA-VEWFKDGISIQTNSD----YKTTFDKGICRL 1447

Worm    92 LKVNSGKNGKDSDAGAYYCVASNEHG--------EVKSNEGSLKLAMLREDFRVRPRTV------ 142
            :...:..    :|:..:.|.|||..|        .|:.|...::|        |.||.:
  Fly  1448 VIEETFA----ADSARFSCRASNLVGTCDTNATLSVRENAAEVQL--------VPPRILRFLQSG 1500

Worm   143 QALGGEMAVLECSPPRGFPEPVVSWRKDDKELRIQDMPRYTL---HSDGNLIIDPVDRSDSGTYQ 204
            :|..|......| ...|.|.|.|.|.|:||  .|.|.|.|.:   :.:..|..:.|...|...|.
  Fly  1501 KATEGSSFQFAC-VVAGVPLPTVQWFKNDK--CIDDSPDYVISYNNGEATLKFEEVFLEDDAVYT 1562

Worm   205 CVANNMVG------ERVSNPARLSVFEKPKFEQEPKDMTVDVGAAVLFDCRVTGDPQPQITWKRK 263
            |.|:|..|      ..:..|  |...|.|.|:....:....||..:..:..|.|.|:|::.|...
  Fly  1563 CSASNPAGIEHCSASLIVEP--LEPTELPSFKVPLSNAMARVGQKIKLEAIVGGIPRPEVYWLHN 1625

Worm   264 NEPMPVTRAYIAKDNRGLRIERVQPSDEGEYVCYARNPAGTLEASAHLRVQAPPSFQT------- 321
            .:|.....:........|.|.:..|:|.|.||..|:|.||....|.::.|:.....:|
  Fly  1626 GKPFQPRDSKYEYGRVTLIIPQAYPNDAGSYVLSAKNLAGEAYTSCNVIVKGRLPNETSDSEMAS 1690

Worm   322 -----KPA------DQSVPAGGTATFECTLVGQPSPAYFW-------SKEGQQDLLFPSYVSADG 368
                 |||      |.|:..|.....:|.:||||.|...|       .:.....|||.
  Fly  1691 DIEPIKPAVHLPLKDVSIFEGKPVRLDCVIVGQPEPEVIWYHNERPVKESADVQLLFQ------- 1748

Worm   369 RTKVSPTGTLTIEEVRQVDEGAYVCAGMNSAGSSLSKAALKVT----------TKAVTGNTPAKP 423
                ....:|.|:||.|.|.|.|....:||||.:.|...||||          .:|...:.|...
  Fly  1749 ----GDRCSLIIQEVYQEDAGHYKVVAINSAGEASSSCELKVTPLNQAEPATRAQAERQSLPKDS 1809

Worm   424 PPTIEHGHQNQTLMVGSSAILPCQASGKPTPGISWLRDGLPIDITDSRISQHSTGSLHIADL--- 485
            .|..|....:.....|...:|..||||.......|......:.: |.||:..|...|.:..|
  Fly  1810 QPKFERLLSDVLADEGEQVVLEVQASGDQPLTAQWFLTNKELQL-DQRITTQSDSELGVFKLILN 1873

Worm   486 --KKPDTGVYTCIAKNEDGESTWSASLTVEDHTSNAQFVRMPDPSNFPSSPTQPIIVNVTDTEVE 548
              ...|.||||....|..|::...:.|.|:  :.||       |.|..||.:...|       :|
  Fly  1874 NVSGDDKGVYTVKVTNPAGDAKCFSHLIVK--SVNA-------PENRRSSQSSVEI-------IE 1922

Worm   549 LHWNAPSTSGAGPITGYIIQYYSPDLGQTWFNIPDYVASTEYRIKGL-----------KPSHSYM 602
            .| ..|...          :.:|...|:.     |.|...|..:||.           :|.|.:.
  Fly  1923 RH-QCPEFK----------ELFSDKQGEI-----DEVIKFECIVKGKPTPKVHWFFNDQPVHGHN 1971

Worm   603 FVIRAENEKGIGTPSVSSALVTTSKPAAQVALSDKNKMDMAIAEKRLTSEQLIKLE---EVKTIN 664
            |::....|:.:                              :..::||.:.:.|:.   |.:...
  Fly  1972 FLVSTSGERQV------------------------------LTIQKLTHDAVGKISCVAENEAGK 2006

Worm   665 STAVRLFWKKRKLEELIDGYYIKWRGPPRTNDNQYVNVTSPSTENYVVSNLMPFTNYEFFVIPYH 729
            :|.|...             .|:..|.|.::|.|.|:....:..:.|......||...      .
  Fly  2007 ATCVAFL-------------NIRGSGLPASSDVQTVSQEHNTESSRVTIKKQTFTTTS------T 2052

Worm   730 SGVHSIHG-APSNSMDVLTAEAPPSLP------PEDVRI----------RMLNLTTLRISWKAPK 777
            |.|:|..| ||...:...:|....||.      ||.|..          .|.:.|..:.|:...:
  Fly  2053 SQVNSYEGNAPQTEVHHSSAHIDQSLKQLGQQRPEIVESHHYQELHKSKEMSSPTVQQKSFSFIQ 2117

Worm   778 ADGINGILKGFQIVIVGQAPNNNR-----NITTN------ERAASVTLFHLVTGM-TYKIRVAAR 830
            :.|.|    |...|.:..:|...|     ..||.      ::.|.|::..:..|. :.:|:|  .
  Fly  2118 SSGAN----GQSAVAIPDSPTRLRREIAPRFTTPLSGKIVDQGADVSMEAIYDGFPSPEIKV--E 2176

Worm   831 SNGG---------------------------------------VGVSHGTSEVIMNQ----DTLE 852
            .|||                                       ||.|..|:::::.:    ....
  Fly  2177 KNGGQLFEDAHTRISNKCNRVTIELKQVGVGDAGRYAVTASNTVGQSTSTADLVVKKTIFPPVFG 2241

Worm   853 KHLAAQQEN-------ESFLYGL-------------INKSHVPVIVIVA------ILIIFVVIII 891
            :.|.||...       |..:.||             :..:.:....::|      ::|.......
  Fly  2242 RRLQAQVSKKGEKLTMEVEVTGLPEPTVTWLKDDKPLKDAGISEHRLLAQGNSYRLIIEKAQTTD 2306

Worm   892 AYCYWRNSRNSDGKDRSF-------------------IKINDGSVHMASNNLWDVAQNPNQNPMY 937
            :..|...:.|:.|:.:|.                   |....|.|..||.              :
  Fly  2307 SGKYMVRATNAGGEAKSIADCAILEPSPERLQEVVKTIVYETGPVAPASE--------------F 2357

Worm   938 NTAGRMTMNNRNGQALYSLTPNAQDFFNNCDDYSG-------TMHRPGS------EHHYHY---A 986
            .|..:..:.|...|..|.   |:|....:.:|..|       |.||..:      ||..:|   .
  Fly  2358 KTEVQKQIQNSENQQSYQ---NSQTEVTSANDLHGLSESKVITEHRCTTEATMRLEHKSNYLDLP 2419

Worm   987 QLTGGPGNAMSTFYGNQYHDDPSPYATTTLVLSNQQPAWLNDKMLRAPAMPTNPVPPEPPARYAD 1051
            :||..|....:        :|.....|.|..:|..||......:.......|..|||..|.:...
  Fly  2420 ELTTRPKTPTT--------NDTITITTNTATVSMDQPDLTQPTITNTTTTNTTKVPPPVPPKPCT 2476

Worm  1052 HTAGRRSRSSRASDGRGTLNGGLHHRTSGSQRSDSPPHTDVS--YVQLHSSDGTGSS-------- 1106
            ....                      |:..|:...||.|..|  |.|......|.||
  Fly  2477 PVVA----------------------TTFGQQQQQPPQTLTSTRYEQSEHKSTTSSSSFDYFKKI 2519

Worm  1107 -KERTGER-------------RTPPNKTL------MDFIP------------------------- 1126
             :|...:|             |.|..::|      ::.||
  Fly  2520 DEETIIQRPNPLTFKPLDTVVRQPQAQSLAEELRSLNLIPGDAPEFCYSPKTERSEPKIPLITEK 2584

Worm  1127 ------PPPSNPPPPGG 1137
                  ..|..|||.||
  Fly  2585 IKILSEVQPKEPPPQGG 2601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sax-3	NP_001024990.1	Ig	30..129	CDD:299845	26/109 (24%)
		I-set	31..121	CDD:254352	24/100 (24%)
		I-set	135..223	CDD:254352	28/102 (27%)
		Ig2_Robo	137..223	CDD:143201	28/100 (28%)
		I-set	227..313	CDD:254352	22/85 (26%)
		Ig	244..313	CDD:299845	18/68 (26%)
		I-set	317..410	CDD:254352	31/117 (26%)
		Ig	331..411	CDD:299845	26/86 (30%)
		Ig	424..512	CDD:299845	23/92 (25%)
		I-set	432..512	CDD:254352	21/84 (25%)
		FN3	531..624	CDD:238020	17/103 (17%)
		FN3	659..747	CDD:238020	18/88 (20%)
		FN3	755..836	CDD:214495	22/147 (15%)
zormin	NP_001261317.1	SPEC	126..332	CDD:238103
		SPEC	<504..641	CDD:295325
		COG1340	960..1298	CDD:224259
		RILP-like	<1190..1315	CDD:304877
		MAP7	1233..1365	CDD:283355
		I-set	1390..1479	CDD:254352	23/97 (24%)
		IGc2	1403..1469	CDD:197706	18/74 (24%)
		I-set	1491..1580	CDD:254352	25/91 (27%)
		IGc2	1504..1570	CDD:197706	21/68 (31%)
		I-set	1589..1675	CDD:254352	22/85 (26%)
		Ig	1605..1675	CDD:299845	18/69 (26%)
		I-set	1702..1786	CDD:254352	27/94 (29%)
		Ig	1713..1786	CDD:299845	24/83 (29%)
		I-set	1811..1902	CDD:254352	23/91 (25%)
		Ig	1828..1892	CDD:143165	18/64 (28%)
		I-set	1927..2015	CDD:254352	18/145 (12%)
		IGc2	1940..2005	CDD:197706	13/99 (13%)
		I-set	2142..2231	CDD:254352	14/90 (16%)
		Ig	2158..2231	CDD:299845	11/74 (15%)
		I-set	2238..2325	CDD:254352	12/86 (14%)
		Ig	2254..2324	CDD:299845	8/69 (12%)
		I-set	3566..3655	CDD:254352
		Ig	3583..3650	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910