Protein Alignment kin-29 and par-1

DIOPT Version :10

• Sequence 1: NP_508493.1
• Gene: kin-29 / 180574
• WormBaseID: WBGene00002210
• Length: 822
• Species: Caenorhabditis elegans
• Sequence 2: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Alignment Length: 883
• Identity: 238/883 - (26%)
• Similarity: 390/883 - (44%)
• Gaps: 144/883 - (16%)

 Worm     2 AAPRR-RMGLEKIGLYDVGRAIGKGNFATVRIARHKIAKTKVAIKSIDVSALDRENLIKLEREVK 65
            :||.| |...|.||.|.:.:.|||||||.|::|:|.....:||||.||.:.|:..:|.||.|||:
  Fly   238 SAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVR 302

 Worm    66 IVKVIDHPHIVKSYEIMRVDNMLYIVSEYCSSGELYETLIEKGRVAENVARKWFSETASAVAYLH 130
            |:|::|||:|||.::::..:..||::.||.|.||:::.|:..||:.|..||..|.:..|||.|.|
  Fly   303 IMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCH 367

 Worm   131 SQGIVHRDLKAENILLGKNSNIKIIDFGFSNFQTGDQLLNTWCGSPPYAAPELLLGNSYDGMKAD 195
            .:.|:||||||||:||....||||.||||||..|....|:|:|||||||||||..|..|||.:.|
  Fly   368 QKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVD 432

 Worm   196 IWSMGVLLYILVAGGFPFPSDSVNKLKRSVLSGLVKIPYWVSVECADFIRKMLVLNPGKRYTIQN 260
            :||:||:||.||:|..||...::.:|:..||.|..:||:::|.:|.:.:||.|||||.||.:::.
  Fly   433 VWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLET 497

 Worm   261 VLQHRWMHIRDDVQKNQAAQLLEAIPSSSIEIRQQSTKLNPTIMMFMQQHGKWSEEQIIDAVLGR 325
            ::..:||::  ..::::....:|  |.:.:   ....::...:.|...:    ||   |:|.|.:
  Fly   498 IMGDKWMNM--GFEEDELKPYIE--PKADL---ADPKRIEALVAMGYNR----SE---IEASLSQ 548

 Worm   326 DFESPIFATYELLADKVKKGTLEG--TGEEFPRR---GSRGSILSGKANVDEQPLTPT------- 378
            .....:||||.||..|......:|  :|.....|   |:.....:|.|:|.    :||
  Fly   549 VRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQ----SPTHRGVHRS 609

 Worm   379 ISAHQLAQLNLSSPDCDSDDSSNSDLCDDSPMSSMGPMNHERQFGTPHGLDIIGNRFENRRHTLC 443
            |||........:|......:::.:.......:.::.|.|:....|:......:|:.|: |::|:.
  Fly   610 ISASSTKPSRRASSGVGPTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGSNFK-RQNTID 673

 Worm   444 A------SEQLLSPNMMGQFPPPNLLLNNFSMNPPLGFPPMPEGQAAEFPLPSLHPAFATIPIAD 502
            :      :.:|.:.|.........:|.   :.:..|..|..|. .|.::     .|......::.
  Fly   674 SATIKENTARLAAQNQRPASATQKMLT---TADTTLNSPAKPR-TATKY-----DPTNGNRTVSG 729

 Worm   503 LSKMLPVPKS---ERRASAGET-LLPTNFDLTQHLANLPAPPIS--FP-TVEEEGKSYLSKYGGK 560
            .|.::|...:   |:.:|..:| ::|...:|...|....|...|  || .|......:..:...:
  Fly   730 TSGIIPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSGQTRAR 794

 Worm   561 RNTVHCLGNQLGGGIQNPIP-----------RYQRTPY---TKAPPAERRSSWASPSLSAQQQNH 611
            .||........|....:..|           |:.:.|.   ..|.|...|.:|:..:.|....:.
  Fly   795 NNTALEYSGTSGASGDSSHPGRMSFFSKLSSRFSKRPTIADEAAKPRVLRFTWSMKTTSPLMPDQ 859

 Worm   612 LEKLFKQALQTNN-------------------------------DMTRL------HKEFKGLSHG 639
            :.:..::.|..||                               .:.||      .|...|.|.|
  Fly   860 IMQKIREVLDQNNCDYEQRERFVLWCVHGDPNTDSLVQWEIEVCKLPRLSLNGVRFKRISGTSIG 924

 Worm   640 CAQSQITNEGSSLACPQISITDEYNRQHNIAPSAS-SFDPVSIFQKNAQEVVFGQRPATAIGFSS 703
                 ..|..|.:|..... .::.|.:.|.|.:|| ..||.     :.......:||      |:
  Fly   925 -----FKNIASRIAFDLKLXLNQTNNEGNAAATASRPTDPT-----DTMTTTNCRRP------SN 973

 Worm   704 TSFSGMSTPEQTTRSIDD------RVRSIVCTLPFTEVIDELKASLNILKI-----PFSESHEMV 757
            .|.|.:|......||:..      |.:|.:.    |...::.|.|.::|..     |||....|.
  Fly   974 DSTSRLSELSLLCRSLTSQQGSQRRKKSRLS----TGGSEDQKKSNSLLSAFQMYSPFSSKENMQ 1034

 Worm   758 YEPQVTEMRRLSLPSGVEIGVAVLPPEHKAHVEFAIIN 795
            ...:|.::..:....|..:.|.:.       .:|:.||
  Fly  1035 SSEEVEDLHVIDTQPGHSVDVPLF-------ADFSPIN 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kin-29	NP_508493.1	Protein Kinases, catalytic domain	16..267	CDD:473864	119/250 (48%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	119/251 (47%)
		UBA_MARK_Par1	525..563	CDD:270522	12/44 (27%)
		MARK1-3_C	839..936	CDD:213381	16/101 (16%)