DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kin-29 and par-1

DIOPT Version :9

Sequence 1:	NP_508493.1	Gene:	kin-29 / 180574	WormBaseID:	WBGene00002210	Length:	822	Species:	Caenorhabditis elegans
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	883	Identity:	238/883 - (26%)
Similarity:	390/883 - (44%)	Gaps:	144/883 - (16%)

- Green bases have known domain annotations that are detailed below.

Worm     2 AAPRR-RMGLEKIGLYDVGRAIGKGNFATVRIARHKIAKTKVAIKSIDVSALDRENLIKLEREVK 65
            :||.| |...|.||.|.:.:.|||||||.|::|:|.....:||||.||.:.|:..:|.||.|||:
  Fly   238 SAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVR 302

Worm    66 IVKVIDHPHIVKSYEIMRVDNMLYIVSEYCSSGELYETLIEKGRVAENVARKWFSETASAVAYLH 130
            |:|::|||:|||.::::..:..||::.||.|.||:::.|:..||:.|..||..|.:..|||.|.|
  Fly   303 IMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCH 367

Worm   131 SQGIVHRDLKAENILLGKNSNIKIIDFGFSNFQTGDQLLNTWCGSPPYAAPELLLGNSYDGMKAD 195
            .:.|:||||||||:||....||||.||||||..|....|:|:|||||||||||..|..|||.:.|
  Fly   368 QKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVD 432

Worm   196 IWSMGVLLYILVAGGFPFPSDSVNKLKRSVLSGLVKIPYWVSVECADFIRKMLVLNPGKRYTIQN 260
            :||:||:||.||:|..||...::.:|:..||.|..:||:::|.:|.:.:||.|||||.||.:::.
  Fly   433 VWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLET 497

Worm   261 VLQHRWMHIRDDVQKNQAAQLLEAIPSSSIEIRQQSTKLNPTIMMFMQQHGKWSEEQIIDAVLGR 325
            ::..:||::  ..::::....:|  |.:.:   ....::...:.|...:    ||   |:|.|.:
  Fly   498 IMGDKWMNM--GFEEDELKPYIE--PKADL---ADPKRIEALVAMGYNR----SE---IEASLSQ 548

Worm   326 DFESPIFATYELLADKVKKGTLEG--TGEEFPRR---GSRGSILSGKANVDEQPLTPT------- 378
            .....:||||.||..|......:|  :|.....|   |:.....:|.|:|.    :||
  Fly   549 VRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQ----SPTHRGVHRS 609

Worm   379 ISAHQLAQLNLSSPDCDSDDSSNSDLCDDSPMSSMGPMNHERQFGTPHGLDIIGNRFENRRHTLC 443
            |||........:|......:::.:.......:.::.|.|:....|:......:|:.|: |::|:.
  Fly   610 ISASSTKPSRRASSGVGPTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGSNFK-RQNTID 673

Worm   444 A------SEQLLSPNMMGQFPPPNLLLNNFSMNPPLGFPPMPEGQAAEFPLPSLHPAFATIPIAD 502
            :      :.:|.:.|.........:|.   :.:..|..|..|. .|.::     .|......::.
  Fly   674 SATIKENTARLAAQNQRPASATQKMLT---TADTTLNSPAKPR-TATKY-----DPTNGNRTVSG 729

Worm   503 LSKMLPVPKS---ERRASAGET-LLPTNFDLTQHLANLPAPPIS--FP-TVEEEGKSYLSKYGGK 560
            .|.::|...:   |:.:|..:| ::|...:|...|....|...|  || .|......:..:...:
  Fly   730 TSGIIPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSGQTRAR 794

Worm   561 RNTVHCLGNQLGGGIQNPIP-----------RYQRTPY---TKAPPAERRSSWASPSLSAQQQNH 611
            .||........|....:..|           |:.:.|.   ..|.|...|.:|:..:.|....:.
  Fly   795 NNTALEYSGTSGASGDSSHPGRMSFFSKLSSRFSKRPTIADEAAKPRVLRFTWSMKTTSPLMPDQ 859

Worm   612 LEKLFKQALQTNN-------------------------------DMTRL------HKEFKGLSHG 639
            :.:..::.|..||                               .:.||      .|...|.|.|
  Fly   860 IMQKIREVLDQNNCDYEQRERFVLWCVHGDPNTDSLVQWEIEVCKLPRLSLNGVRFKRISGTSIG 924

Worm   640 CAQSQITNEGSSLACPQISITDEYNRQHNIAPSAS-SFDPVSIFQKNAQEVVFGQRPATAIGFSS 703
                 ..|..|.:|.......::.|.:.|.|.:|| ..||.     :.......:||      |:
  Fly   925 -----FKNIASRIAFDLKLXLNQTNNEGNAAATASRPTDPT-----DTMTTTNCRRP------SN 973

Worm   704 TSFSGMSTPEQTTRSIDD------RVRSIVCTLPFTEVIDELKASLNILKI-----PFSESHEMV 757
            .|.|.:|......||:..      |.:|.:.    |...::.|.|.::|..     |||....|.
  Fly   974 DSTSRLSELSLLCRSLTSQQGSQRRKKSRLS----TGGSEDQKKSNSLLSAFQMYSPFSSKENMQ 1034

Worm   758 YEPQVTEMRRLSLPSGVEIGVAVLPPEHKAHVEFAIIN 795
            ...:|.::..:....|..:.|.:.       .:|:.||
  Fly  1035 SSEEVEDLHVIDTQPGHSVDVPLF-------ADFSPIN 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kin-29	NP_508493.1	PKc_like	16..267	CDD:304357	119/250 (48%)
kin-29	NP_508493.1	S_TKc	16..267	CDD:214567	119/250 (48%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	119/251 (47%)
		S_TKc	253..504	CDD:214567	119/250 (48%)
		UBA_MARK_Par1	525..563	CDD:270522	12/44 (27%)
		MARK1-3_C	839..936	CDD:213381	16/101 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910