DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment unc-2 and para

DIOPT Version :9

Sequence 1:NP_001355464.1 Gene:unc-2 / 180570 WormBaseID:WBGene00006742 Length:2171 Species:Caenorhabditis elegans
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2152 Identity:510/2152 - (23%)
Similarity:827/2152 - (38%) Gaps:636/2152 - (29%)


- Green bases have known domain annotations that are detailed below.


 Worm   211 TFVRKTTLSSNAPVKEKGPSSLFIFAED---------NIIRRNAKAIIEWGPFEYFILLTIIGNC 266
            |||          |..|| ..:|.|:..         |.|||.|..|:....|..||:.||:.||
  Fly   114 TFV----------VVSKG-KDIFRFSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNC 167

 Worm   267 VVLSMEQHLPKNDKKALSEWLERTEPYFMGIFCLECVLKVIAFGFALHKGSYLRSGWNIMDFIVV 331
            :::.|          ..:..:|.||..|.||:..|..:||:|.||.|...:|||..||.:||:|:
  Fly   168 ILMIM----------PTTPTVESTEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVI 222

 Worm   332 VSGVVTMLPFSPATQTANQPVDSVDLRTLRAVRVLRPLKLVSGIPSLQVVLKSILCAMAPLLQIG 396
            ....|||            .:|..:|..||..||||.||.|:.:|.|:.::.:::.::..|..:.
  Fly   223 ALAYVTM------------GIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVI 275

 Worm   397 LLVLFAIIIFAIIGLEFYSGAFHSACYNE---RGEIENVSERPMPCTNKTS------------PM 446
            :|.:|::.:||::||:.|.|.....|..:   .|...|:::......|:.|            |:
  Fly   276 ILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPL 340

 Worm   447 -----GVYNCDVKGTTCLQKW-IGPNYGITSFDNIGFAMITVFQCITMEGWTTVMYYTNDSLGST 505
                 |...|| ....|||.: ..||||.||||:.|:|.::.|:.:|.:.|..:......:.| .
  Fly   341 CGNISGAGQCD-DDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG-P 403

 Worm   506 YNWAYFIPLIVLGSFFMLNLVLGVLSGEF------AKERERVE----NRREFLKLRRQQQIEREL 560
            ::..:||.:|.||||:::||:|.:::..:      |:|.|..|    ...|.....:..::|...
  Fly   404 WHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERA 468

 Worm   561 NGYLEW---ILTAEEVILKED--------------------------------RTTEEEKAAIME 590
            |...:.   ...|||..|..:                                |:.|.|..::..
  Fly   469 NAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSV 533

 Worm   591 ARRRAANKKLKQASKQQSTETEE------------------------------------------ 613
            .:|:.|.....||:|.:...|..                                          
  Fly   534 IQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLS 598

 Worm   614 ---------DFEEDED---EMEEE----------------------------YVDEGG------- 631
                     .:.:|.:   .|.||                            |...|.       
  Fly   599 TYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAV 663

 Worm   632 ------TVEDEFAERKKRG-----------------------------CCHSVGK-------FIK 654
                  |.|.:...|..|.                             |....||       ||:
  Fly   664 MGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIE 728

 Worm   655 QLRIQIRIMVK-----------------------TQIFY-------------------------- 670
            .::.|..:.:|                       ..::|                          
  Fly   729 PVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGID 793

 Worm   671 ----WS-----------------------VITL-VFLNTCCVASEHYGQPQWFTDFLKYAEFVFL 707
                |.                       .||| :.:||..:|.:|:...:.....||...:.|.
  Fly   794 VFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFT 858

 Worm   708 GIFVVEMLLKLFAMGSRTYFASKFNRFDCVVIVGSAAEVIWAEVYG--GSFGISVMRALRLLRIF 770
            ..|.:|..:||.||..:.||...:|.||.:::..|..|:      |  |..|:||:|:.||||:|
  Fly   859 ATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLEL------GLEGVQGLSVLRSFRLLRVF 917

 Worm   771 KLTSYWVSLRNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFGGRFN-----FPTMH-PYTH 829
            ||...|.:|..|:..:..:|.::.:|.|:|.:.|.|||::||||||..::     ||... |..:
  Fly   918 KLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWN 982

 Worm   830 FDTFPVALITVFQILTGEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLVLFGNYTLLNVFLAIAV 894
            |..|..:.:.||::|.|| |.|.|:      ..:|.|......:|:..|:.||..:||:|||:.:
  Fly   983 FTDFMHSFMIVFRVLCGE-WIESMW------DCMYVGDVSCIPFFLATVVIGNLVVLNLFLALLL 1040

 Worm   895 DNLANAQELTAAEEADEKANEIEE----------------------------------------- 918
            .|..::.  .:|..||...|:|.|                                         
  Fly  1041 SNFGSSS--LSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTN 1103

 Worm   919 -------------------------------------------ESEELDEQYQEGDHCTI----- 935
                                                       |..:|:....:|...||     
  Fly  1104 QISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMK 1168

 Worm   936 ------------------------------------------DMEGKTAGDMCAVARAMD-DLDE 957
                                                      .|||:...|.......:| :|||
  Fly  1169 NNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDE 1233

 Worm   958 ECEEEESPFGG---------------PKPMVP--YSSMFFL---SPTNPF-------RVLIHSIV 995
            |.|.||.|..|               |....|  |...|.:   ...:||       |:....::
  Fly  1234 EGECEEGPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLI 1298

 Worm   996 CTKYFEMMVMTVICLSSVSLAAEDPVDEENP-RNKVLQYMDYCFTGVFACEMLLKLIDQGILLHP 1059
            ..||||..|:|:|.:||::||.||....:.| ...:|.|||..||.:|..|||:|.:..|..:  
  Fly  1299 ENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKV-- 1361

 Worm  1060 GSYCRDFWNILDGIVVTCALFAFGFAGTEGSAGKNLNTIKSLRVLRVLRPLKTIKRIPKLKAVFD 1124
              |..:.|..||.::|..:|..| .|...|:.|  :...|::|.||.||||:.:.|:..::.|.:
  Fly  1362 --YFTNAWCWLDFVIVMVSLINF-VASLVGAGG--IQAFKTMRTLRALRPLRAMSRMQGMRVVVN 1421

 Worm  1125 CVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFFFCTDKN-RKFA-------NTCHGQFFVYD 1181
            .:|.::.::||:|:|..:|..|||::.||||.||:|.|.|.| .|.:       |.|..:.:.:.
  Fly  1422 ALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENYTWV 1486

 Worm  1182 NQNDPPRVEQREWRLRPFNYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVA 1246
            |.              ..|:|:..||.|.||.|.|.:||..|..:::|:...|:.|.....:.:.
  Fly  1487 NS--------------AMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMY 1537

 Worm  1247 LFYVMFFIVFPFFFVNIFVALIIITFQEQ-----GEAELSEGDLDKNQKQCIDF--------ALN 1298
            |::|.|.|...||.:|:|:.:||..|.||     |..|:.   :.::||:..:.        .|.
  Fly  1538 LYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMF---MTEDQKKYYNAMKKMGSKKPLK 1599

 Worm  1299 ARPRSLFMPEDKNSTKYRIWRLVTSPPFEYFIMTMICCNTLILMMKYYNNPLFYEEILRLFNTAL 1363
            |.||..:.|:      ..::.:||...|:..||..|..|...:.:..|:....|..:|...|...
  Fly  1600 AIPRPRWRPQ------AIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIF 1658

 Worm  1364 TAVFTVESILKILAFGVR-NYFRDGWNRFDFVTVVGSITDALVTE-FGGHFVSLGFLRLFRAA-- 1424
            ..:|:.|.:|||  |.:| :||.:.||.||.|.|:.||...:::: ...:|||...||:.|.|  
  Fly  1659 VVIFSSECLLKI--FALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKV 1721

 Worm  1425 -RLIRLLQQGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFGNIWLNAATEINRHNN 1488
             |::||::....||.||:....|..||..:|||:.::.||:||.||..|.::  ...:.||...|
  Fly  1722 GRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV--KEKSGINDVYN 1784

 Worm  1489 FQSFFNAVILLFRCATGEGWQDIMMAAVQGKDCARAGSAEINFEKGQ--TCGS-NVSYAYFTSFV 1550
            |::|..::||||:.:|..||..::.|.:..:.|....:     :||.  .||| .|...:..|::
  Fly  1785 FKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDN-----DKGYPGNCGSATVGITFLLSYL 1844

 Worm  1551 FLSSFLMLNLFVAVIMDNFDYLTRD-SSILGPHHLDEFIRVWADYDPAATGRIHYSEMYEMLRIM 1614
            .:|..:::|:::|||::|:...|.| ...|.....|.:..:|..:||..|..|.|.::.|.|.::
  Fly  1845 VISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVL 1909

 Worm  1615 APPVGFGKKCPYRLAYKHLIRMNMPVAEDGTVHFTTTLFALIRESLSIKMRPVEEMDEADEELRL 1679
            .||:...|...|:     :|.|::|:.....::....|.||.::..:.|..|:||..|..|    
  Fly  1910 EPPLQIHKPNKYK-----IISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEETGEIGE---- 1965

 Worm  1680 TLKKIWPLKAKKNMVDLVVPPNHELCFQKLTVGKIYAGLLILENYRARKSGTEVGG-------QG 1737
                   :.|:.: .:...|.:..|..|:    :.|...||...:|..|:..|.||       .|
  Fly  1966 -------IAARPD-TEGYEPVSSTLWRQR----EEYCARLIQHAWRKHKARGEGGGSFEPDTDHG 2018

 Worm  1738 LFG-------------------GGLRSLVAAAKAAESQHSSHTPQPPEETTPIIPQHAQQFSAAP 1783
            ..|                   ||..|:...|:.|.....|:...|.|:..      |...:||.
  Fly  2019 DGGDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADADESNVNSPGEDAA------AAAAAAAA 2077

 Worm  1784 TMSAQGSLQQMQGTSSGGGQRPYSLFNSFVDTIKSGKQDGDVTDVQYQSVDQQHEKMNSTGRRLS 1848
            ..:|..:.....|..|.|.|           |....:.||.||...::.|  .|.:..|...|.:
  Fly  2078 AAAAGTTTAGSPGAGSAGRQ-----------TAVLVESDGFVTKNGHKVV--IHSRSPSITSRTA 2129

 Worm  1849 DMFSKIR 1855
            |:.::.|
  Fly  2130 DVXARPR 2136

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
unc-2NP_001355464.1 Ion_trans 254..536 CDD:366146 90/308 (29%)
Ion_trans 667..904 CDD:366146 80/298 (27%)
Ion_trans 998..1279 CDD:366146 98/294 (33%)
Ion_trans 1323..1577 CDD:366146 82/262 (31%)
GPHH 1586..1639 CDD:374878 14/52 (27%)
Ca_chan_IQ 1650..1726 CDD:370105 16/75 (21%)
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 85/294 (29%)
Na_trans_cytopl 515..648 CDD:288761 13/132 (10%)
Ion_trans 835..1028 CDD:278921 65/205 (32%)
Na_trans_assoc 1054..1296 CDD:284034 30/241 (12%)
Ion_trans 1318..1571 CDD:278921 88/273 (32%)
Na_channel_gate 1561..1613 CDD:240441 12/60 (20%)
Ion_trans 1636..1871 CDD:278921 77/243 (32%)
GPHH 1880..1930 CDD:293510 15/54 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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