DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hum-6 and zip

DIOPT Version :9

Sequence 1:	NP_508420.1	Gene:	hum-6 / 180539	WormBaseID:	WBGene00002039	Length:	2098	Species:	Caenorhabditis elegans
Sequence 2:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster

Alignment Length:	2079	Identity:	509/2079 - (24%)
Similarity:	857/2079 - (41%)	Gaps:	408/2079 - (19%)

- Green bases have known domain annotations that are detailed below.

Worm    10 IWIEPGKTEGSIPIGARVIDQDHG-RLKV-IDDLGNEQWLSADRRVRLMHPTSVQGVEDMCQLGD 72
            :|: |.:.:|.:   |..|.::|| .::| :.:.|....:..| .::.|:|.....||||.:|..
  Fly    82 VWV-PHENQGFV---AASIKREHGDEVEVELAETGKRVMILRD-DIQKMNPPKFDKVEDMAELTC 141

Worm    73 FHESAILRNLFIRYREKLIYAYTGSILIAVNPYMDIAIYTADEIRMYKRKRIGELPPHIFAIADN 137
            .:|:::|.|:..||...|||.|:|...:.||||..:.|||...:..||..:..|:|||:|||.|:
  Fly   142 LNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDS 206

Worm   138 AYTNMRREKKNQSVIISGESGAGKTESTKLVLQFLATISG------------------------- 177
            ||.||..::::||::.:|||||||||:||.|:||||.::.
  Fly   207 AYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKY 271

Worm   178 -----------------------------QHSWIEQQVLEANPVLEAFGNAKTIRNDNSSRFGKY 213
                                         |...:|||:|:|||:|||||||||::|||||||||:
  Fly   272 IKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKF 336

Worm   214 IDVHFNESGSIEGAKIEQYLLEKSRIVTQSENERNYHIFYCLLAGLSREEKSELELGTAADYYYL 278
            |.::|:.||.|.||.||.|||||||.:.|:::||.:||||.||||.:.|::.:..|.....|.:|
  Fly   337 IRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDVKSYAFL 401

Worm   279 IQGKTLTAEGRDDAADLAEIRSAMRVLMINEQEIGSIFKLLASLLHIGNIRFRQNTNDNMESVDV 343
            ..| :|...|.||.|:......:|.::.:..::..|||::::::|..|:::|||..|:  :...:
  Fly   402 SNG-SLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNN--DQATL 463

Worm   344 ADPSTLVRIAKLLQLHEQNLLDAITTKSLVTREERVISRLNGQQAVDARDALAKAIYGKLFIHIV 408
            .|.:...:||.||.|...::..|..|..:....:.|......:|...|.:|:|||.|.::|..:|
  Fly   464 PDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLV 528

Worm   409 RRVNDAIYKPSQSRRTSIGILDIFGFENFESNSFEQLCINFANETLQQFFVHHVFKMEQKEYDEE 473
            .|:|.::.:..:...:.|||||:.|||.||.|||||||||:.||.|||.|.|.:|.:||:||..|
  Fly   529 NRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQRE 593

Worm   474 HINWRHIKF-VDNQATVDLIAQRPLNILSLIDEESIFPKGTDKTMLLKLHSTHGRNELYLQPKSE 537
            .|.|:.|.| :|.|.|:||| .:|..|::|:|||..|||.||||.:.||.|.|..:..:::....
  Fly   594 GIEWKFIDFGLDLQPTIDLI-DKPGGIMALLDEECWFPKATDKTFVDKLVSAHSMHPKFMKTDFR 657

Worm   538 LQRAFGVTHFAGNVFYNTRGFLEKNRDSFSADLSVLISSSKMPFLARLFDDIE------------ 590
            ....|.:.|:||.|.|:...:|.||.|..:.::..|:..|:.||:..::.|.|
  Fly   658 GVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDT 722

Worm   591 -YDTSSRKKV--TVGNQFRRSLEQLMSQLTQTHPFFIRCIKPNEMKRALVMDRDLVLRQLRYSGM 652
             :...:||.:  ||.:.::..|.:||..|..|:|.|:|||.||..|||..:|..|||.|||.:|:
  Fly   723 QFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGV 787

Worm   653 METIKIRRSGYPIRHDYYPFVFRYRVLVSSIQGPVNRIDLHDAAKKICH-MILGTNAD---YQLG 713
            :|.|:|.|.|:|.|..:..|..||.:|..::. |...:|    .||.|. ||.....|   |::|
  Fly   788 LEGIRICRQGFPNRIPFQEFRQRYELLTPNVI-PKGFMD----GKKACEKMIQALELDSNLYRVG 847

Worm   714 KTKVFLKDKHDLVLEQEYYRILKDKAIVIQKNVRRWLVRKDFEK-----------QRQAAVTIQT 767
            ::|:|.:......||:|....:.|..:..|...|.:|.|::::|           ||..|..::.
  Fly   848 QSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKL 912

Worm   768 A----WRGFDQRKRYRQIISGFSRL-QAVLRSRQLVSHYQTLRKTIIQFQAVCRGSLVRR----- 822
            .    ||.:.:.|...::.....:| |.....:|:.....||.|...:::...:.:||.:
  Fly   913 RNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAE 977

Worm   823 ----------QVGEKRKR--GEKAPLTEVSSTASVISDSHEELV---GHLFDFLPSDGKDSGNEN 872
                      :..|.|.|  ..|..|.::........:..||.|   |.....|..:.:|...:.
  Fly   978 QLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQL 1042

Worm   873 DSADSSRRGSYSRLHTSPVMPPANIPRVDSYVDEDLSKYQFGKYAATFFQAQATATHVK------ 931
            :..:::|:    :|....|...|.|.:    .:|||        |.|..|.|......|
  Fly  1043 EEEEAARQ----KLQLEKVQLDAKIKK----YEEDL--------ALTDDQNQKLLKEKKLLEERA 1091

Worm   932 KPLKTALLTHTEPSAQLAALTA--WTTI---------------------LRFMGDLADVKPGSTN 973
            ..|...|....|.:..||.|.|  ..||                     .:...::||:|
  Fly  1092 NDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLK----- 1151

Worm   974 GSEVYDKTPVMIKLYATLGKKFSAHDLEEAMLS-SEYGGAKTLKKGMGRKLISMTLKRKGKINGS 1037
             .::.::...:.::.|.|.|:  ..:|.:.:|. .|....|...:...|:|.|...:.:..:...
  Fly  1152 -EQLNERRVQVDEMQAQLAKR--EEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAE 1213

Worm  1038 DTSSISSDSVYSSFNAMLENKPMTSLDKLHYIIG-----------LGILREDLRDEI-------- 1083
            ..:...::.|....:..||......||.|.....           |..|::.|.:|.
  Fly  1214 KAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLA 1278

Worm  1084 -----YCQLCKQLSNNPSKLSAARGWILLSLCVGCFAPSERFIKYLFCFIRERGPAGT-----GY 1138
                 :.|....:::....|..|:  .:|....|...             .|.....|     ..
  Fly  1279 DMRHKHSQELNSINDQLENLRKAK--TVLEKAKGTLE-------------AENADLATELRSVNS 1328

Worm  1139 SKYIEDRLRRTQVNGTRHQPPSYVELQANKSQKPVVLAVTFMDGSVKTLCADSATTAAELCKQLA 1203
            |:...||.|:...:..........|::..:|:             ::..|......|..:..||
  Fly  1329 SRQENDRRRKQAESQIAELQVKLAEIERARSE-------------LQEKCTKLQQEAENITNQL- 1379

Worm  1204 EKVGLTNSFGFSLYIALFDKVSSLGSGTDHVMDAISQCEQYAKEQGRQERNAPWRLFFRKEIFSP 1268
            |:..|              |.|:......::...:::.:|..:|:.||:.....:|   ::|.|.
  Fly  1380 EEAEL--------------KASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKL---RQIESE 1427

Worm  1269 WHD-----PRDDPVSTNLIYQQVIRGIKYGEYRCDKDEELAAICAQQYYIDEGTMDVNKLENNLP 1328
            ...     ..||....|  |::.:..:........|..|..|..|::  ::||...:||
  Fly  1428 KEALQEQLEEDDEAKRN--YERKLAEVTTQMQEIKKKAEEDADLAKE--LEEGKKRLNK------ 1482

Worm  1329 SYLPDFEMSGKEMALEKWTQTIMHQYRK--KFTGRLPSQIEVKENVVSVAKTKWPLLFSRFYEAL 1391
                |.|      |||:..:.::.|..:  |...::.|::|.....:...:||...|..:.....
  Fly  1483 ----DIE------ALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFD 1537

Worm  1392 KFAGPPLPKNEVIIAVNWTGVYVVDDREHVMLEFS------FPEISTAYYGKGKRSTTDTCTVRT 1450
            |........:|.|.....|......::|..:|..|      |.:|...   :.||.|...
  Fly  1538 KILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDL---ENKRKTLQN----- 1594

Worm  1451 VVGDEYTFQSPNADDITNLIVMFLEG--------LKKRSR----YLVAIKSQKGDEKNNFLEFEK 1503
                       ..||:.|     .:|        |:|..|    .|..:|:|..:.:::....|.
  Fly  1595 -----------ELDDLAN-----TQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTED 1643

Worm  1504 GDLLILVN------EFTGNTLLTESVVKGENSRTCLFGLIR-----AENVYVLPTLVKPSKNTLQ 1557
            ..|.:.||      :|..:.|..|.  ..|..|..|...:|     .:......|....||..|:
  Fly  1644 AKLRLEVNMQALRSQFERDLLAKEE--GAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLE 1706

Worm  1558 IFPKDMDLSLDLFNNNKQVTVVDYNAEPYTLENFAEDNFNSQVKRVGSQISLMTLRKKESQIECW 1622
            ...|:::.::::.|..|:    |.......|:...:|......:...::..|..| .||::.:..
  Fly  1707 GDLKEIETTMEMHNKVKE----DALKHAKKLQAQVKDALRDAEEAKAAKEELQAL-SKEAERKVK 1766

Worm  1623 RFSREHIDQPLLKKLNGREDACRGAIEIFAAIMKYMGDEPSKRSRLGTHLTDHIFKLPISMEALR 1687
            ....|.:.  |.:.|...|.|.|.|    ......:.:|.:..:..|:.:.|...:|...:..|.
  Fly  1767 ALEAEVLQ--LTEDLASSERARRAA----ETERDELAEEIANNANKGSLMIDEKRRLEARIATLE 1825

Worm  1688 DELYCQLVKQLTLNPSIM---SEERGWELLWMATGLFAPSAALAKEISHFLKSRPHPIALDCQNR 1749
            :||     ::...|..::   |.:...::..:.|       .||.|.|:..|:......|:.||:
  Fly  1826 EEL-----EEEQSNSEVLLDRSRKAQLQIEQLTT-------ELANEKSNSQKNENGRALLERQNK 1878

Worm  1750 MQKLAKGGSRKYPPHLVEVEAIQH---KTT--QIFHKVFFPDNTDEAIEVDSATRARDFCHKIGY 1809
            ..| ||         |.|:|..|.   |.|  .:..|:   .|.:|.:|.:...|.
  Fly  1879 ELK-AK---------LAEIETAQRTKVKATIATLEAKI---ANLEEQLENEGKERL--------- 1921

Worm  1810 RLGLKSSDGFSLFVKIKDKVLAVPESEFFFDYVRSLSDWVHTNHATQKDATMIPINYQVYFMRK 1873
               |:......:..|||:..:.:.:..               .|..|....|..:|.::..:::
  Fly  1922 ---LQQKANRKMDKKIKELTMNIEDER---------------RHVDQHKEQMDKLNSRIKLLKR 1967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hum-6	NP_508420.1	MYSc	57..731	CDD:214580	275/747 (37%)
		MYSc_Myo7	76..720	CDD:276832	266/717 (37%)
		IQ	757..779	CDD:197470	7/36 (19%)
		MyTH4	929..1168	CDD:214535	45/297 (15%)
		B41	1174..1388	CDD:214604	39/220 (18%)
		FERM_B-lobe	1278..1378	CDD:271216	19/101 (19%)
		FERM_C1_MyoVII	1382..1480	CDD:270019	18/111 (16%)
		SH3	1481..1544	CDD:302595	15/77 (19%)
		MyTH4	1624..1772	CDD:214535	31/150 (21%)
		B41	1779..1993	CDD:214604	13/95 (14%)
		FERM_B-lobe	1890..1985	CDD:271216
		FERM_C2_MyoVII	1989..2087	CDD:270020
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	9/38 (24%)
		Myosin_head	133..854	CDD:278492	272/729 (37%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	266/717 (37%)
		Myosin_tail_1	931..2011	CDD:279860	210/1216 (17%)
		Prefoldin	1431..1515	CDD:298833	21/103 (20%)
		FAM76	<1847..1926	CDD:292665	24/110 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910