Protein Alignment hum-6 and Mhc

DIOPT Version :10

• Sequence 1: NP_508420.1
• Gene: hum-6 / 180539
• WormBaseID: WBGene00002039
• Length: 2098
• Species: Caenorhabditis elegans
• Sequence 2: NP_523587.4
• Gene: Mhc / 35007
• FlyBaseID: FBgn0264695
• Length: 1962
• Species: Drosophila melanogaster
• Alignment Length: 1928
• Identity: 508/1928 - (26%)
• Similarity: 794/1928 - (41%)
• Gaps: 438/1928 - (22%)

 Worm    11 WIEPGKTEGSIPIGARVIDQDHGRLKVIDDLGNEQWLSADRRVRLM---HPTSVQGVEDMCQLGD 72
            || |.:.||.: :|.  |....|.:..:...|.|   :.|.:..|:   :|...:..|||..|..
  Fly    39 WI-PDEKEGYL-LGE--IKATKGDIVSVGLQGGE---TRDLKKDLLQQVNPPKYEKAEDMSNLTY 96

 Worm    73 FHESAILRNLFIRYREKLIYAYTGSILIAVNPYMDIAIYTADEIRMYKRKRIGELPPHIFAIADN 137
            .:::::|.||..||..||||.|:|...:|:|||....:||....:||:.||..|:|||||||:|.
  Fly    97 LNDASVLHNLRQRYYNKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDG 161

 Worm   138 AYTNMRREKKNQSVIISGESGAGKTESTKLVLQFLATISGQHSW---------IEQQVLEANPVL 193
            ||.:|.....|||::|:|||||||||:||.|:.:.||:......         :|.||::.||||
  Fly   162 AYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVL 226

 Worm   194 EAFGNAKTIRNDNSSRFGKYIDVHFNESGSIEGAKIEQYLLEKSRIVTQSENERNYHIFYCLLAG 258
            ||||||||:||||||||||:|.:||..:|.:.||.||.|||||:|:::|...||:|||||.:::|
  Fly   227 EAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSG 291

 Worm   259 LSREEKSE-LELGTAADYYYLIQGKTLTAEGRDDAADLAEIRSAMRVLMINEQEIGSIFKLLASL 322
            .....|.. |......||:.:.||| :|....|||.:.:....|..:|...:||...::::.|::
  Fly   292 SVPGVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAV 355

 Worm   323 LHIGNIRFRQNTNDNMESVDVADPSTLVRIAKLLQLHEQNLLDAITTKSLVTREERVISRLNGQQ 387
            :|:|.::|:|...:.....|..:...  |::||.......|...:....:....|.|....|.||
  Fly   356 MHMGGMKFKQRGREEQAEQDGEEEGG--RVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQ 418

 Worm   388 AVDARDALAKAIYGKLFIHIVRRVNDAIYKPSQSRRTSIGILDIFGFENFESNSFEQLCINFANE 452
            ..::..||.|.::.:||..:|::.|:.: ...|.|:..||:|||.|||.||.|.||||||||.||
  Fly   419 VTNSIGALCKGVFDRLFKWLVKKCNETL-DTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNE 482

 Worm   453 TLQQFFVHHVFKMEQKEYDEEHINWRHIKF-VDNQATVDLIAQRPLNILSLIDEESIFPKGTDKT 516
            .|||||.||:|.:||:||..|.|.|..|.| :|.|..:||| ::|:.|||:::|||:|||.||:|
  Fly   483 KLQQFFNHHMFVLEQEEYQREGIEWTFIDFGMDLQLCIDLI-EKPMGILSILEEESMFPKATDQT 546

 Worm   517 MLLKLHSTH-GRNELYLQPKSEL--QRA--FGVTHFAGNVFYNTRGFLEKNRDSFSADLSVLISS 576
            ...||.:|| |::..:.:||...  |:|  |.:.|:||.|.||..|:||||:|..:..:......
  Fly   547 FSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKK 611

 Worm   577 SKMPFLARLFDDI-------EYDTSSRKK-----VTVGNQFRRSLEQLMSQLTQTHPFFIRCIKP 629
            |:...|..:|.|.       |.....|.|     .||.:.::..|..||:.|..|.|.|:|||.|
  Fly   612 SQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIP 676

 Worm   630 NEMKRALVMDRDLVLRQLRYSGMMETIKIRRSGYPIRHDYYPFVFRYRVLVSS-IQGPVNRIDLH 693
            ||||:..|:|..||:.||..:|::|.|:|.|.|:|.|..|..|..||:::... :||    ::..
  Fly   677 NEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLLQG----VEKD 737

 Worm   694 DAAKKICHMILGTNAD-YQLGKTKVFLKDKHDLVLEQEYYRILKDKAIV--IQKNVRRWLVRKDF 755
            ..|.:|....:....| |:||.||||.  :..::.:.|.:|..:...|:  :|...|.:|.||.|
  Fly   738 KKATEIIIKFIDLPEDQYRLGNTKVFF--RAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGF 800

 Worm   756 EKQRQAAVTIQTAWRGFDQRKRYRQIISGFSRLQAVLRSRQLVSHYQTLRKTIIQFQAVCRGSLV 820
            :|.::..|.::...|..   ::|.|           ||:......:|.: |.::....: ...:.
  Fly   801 KKLQEQRVALKVVQRNL---RKYLQ-----------LRTWPWYKLWQKV-KPLLNVSRI-EDEIA 849

 Worm   821 RRQVGEKRKRGEKAPLTEV---------------SSTASVISDSHEELVGHLFDFLPSDGKDSGN 870
            |.:  ||.|:.|:....||               ..||.:.|.|.|:  |.|.|:...:.|.:..
  Fly   850 RLE--EKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEK--GALQDYQERNAKLTAQ 910

 Worm   871 ENDSADSSRRGSYSRL------HTSPVMPPANIPRVDSYVDEDLSKYQFGKYAATFFQAQATATH 929
            :|| .::..|....||      ............:..|.:.:|:...:.....|.  |.:||..|
  Fly   911 KND-LENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAE--QDKATKDH 972

 Worm   930 VKKPLKTALLTHTEPSAQLAALTAWTTILRFMGDLADVK--PGSTN---GSEVY---DK----TP 982
            ..:.|...:....|                .:..|...|  .|.||   |.|:.   ||    ..
  Fly   973 QIRNLNDEIAHQDE----------------LINKLNKEKKMQGETNQKTGEELQAAEDKINHLNK 1021

 Worm   983 VMIKLYATLG--------KKFSAHDLEEAMLSSEYGGAKTLKKGM-----GRKLISMTLKRKGKI 1034
            |..||..||.        :|....|:|::....| |..|..::.:     .:|.:..|::||
  Fly  1022 VKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVE-GDLKLTQEAVADLERNKKELEQTIQRK--- 1082

 Worm  1035 NGSDTSSISSDSVYSSFNAMLENKPMTSLDKLHYIIGLGILREDLRDEIYCQLCKQLSNNPSKLS 1099
                      |...||..|.||::.:..|.....|..|....|:|.:|:..:...:......:..
  Fly  1083 ----------DKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRAD 1137

 Worm  1100 AARGWILLSLCVGCFAPSERFIKYLFCFIRERG----PAGTGYSKYIE-DRLRRTQVNGTRHQPP 1159
            .||.                        :.|.|    .||...|..|| ::.|..:::..|.
  Fly  1138 LARE------------------------LEELGERLEEAGGATSAQIELNKKREAELSKLRR--- 1175

 Worm  1160 SYVELQANKSQKPVVLAVTFMDGSVKTLCADSATTAAELCKQL------AEKVGLTNSFGFSLYI 1218
               :|:....|....||      :::....|:....||...||      |||.  .|.:
  Fly  1176 ---DLEEANIQHESTLA------NLRKKHNDAVAEMAEQVDQLNKLKAKAEKE--KNEY------ 1223

 Worm  1219 ALFDKVSSLGSGTDHVMDAISQCEQYAKEQGRQERNAPWRLFFRKEIFSPWHDPRDDPVSTNLIY 1283
              :.:::.|.:|.||:.:..:..|:.||:                                   .
  Fly  1224 --YGQLNDLRAGVDHITNEKAAQEKIAKQ-----------------------------------L 1251

 Worm  1284 QQVIRGIKYGEYRCDKDEELAAICAQQYYIDEGTMDVNKLENNLPSYLPDFEMSGKEMALEKWTQ 1348
            |..:..:                   |..:||....:|           ||:.|.|::::|
  Fly  1252 QHTLNEV-------------------QSKLDETNRTLN-----------DFDASKKKLSIE---- 1282

 Worm  1349 TIMHQYRKKFTGRLPSQIEVKENVVS-VAKTKWPLLFSRFYEALKFAGPPLPKNEVIIAVNWTGV 1412
                      ...|..|:|..|:.|| ::|.|..|. ::..:..:.|..
  Fly  1283 ----------NSDLLRQLEEAESQVSQLSKIKISLT-TQLEDTKRLADE---------------- 1320

 Worm  1413 YVVDDREHVMLEFSFPEISTAYYGKGKRSTTDTCTVRTVVGDEYTFQSPNADDITNLIVMFLEGL 1477
               :.||...|           .||.:....|...:|..|.:|   ....||....|.....|..
  Fly  1321 ---ESRERATL-----------LGKFRNLEHDLDNLREQVEEE---AEGKADLQRQLSKANAEAQ 1368

 Worm  1478 KKRSRYLVAIKSQKGDEKNNFLEFEKGDLLILVNEFTGNTLLTESVVKGENSRTCLFGLIRAENV 1542
            ..||:|     ...|..::..||..|..|...:.|       .|..::..|.: |: ||
  Fly  1369 VWRSKY-----ESDGVARSEELEEAKRKLQARLAE-------AEETIESLNQK-CI-GL------ 1413

 Worm  1543 YVLPTLVKPSKNTLQIFPKDMDLSLDLFNNNKQVTVVDYNAEPYTLENFAEDNFNSQVKRVGS-- 1605
                   :.:|..|....:|:.|.:|..|               .:.|.||....:..|.:|.
  Fly  1414 -------EKTKQRLSTEVEDLQLEVDRAN---------------AIANAAEKKQKAFDKIIGEWK 1456

 Worm  1606 -QISLMTLRKKESQIECWRFSREHIDQPLLKKLNGREDACRGAIEIFAAIMKYMGDEPS---KRS 1666
             ::..:......||.||..:|.|      |.:|.|..:..:..:|......|.:.||..   .:.
  Fly  1457 LKVDDLAAELDASQKECRNYSTE------LFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQI 1515

 Worm  1667 RLGTHLTDHIFKLPISMEALRDELYCQLVK---------------QLTLNP-------SIMSEER 1709
            ..|......|.|....:||.:|||...|.:               ||.|:.       .|..:|.
  Fly  1516 GEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQEKEE 1580

 Worm  1710 GWE---------LLWMATGLFAPSAALAKEISHFLKSRPH------PIALDCQNRMQKLAKGGSR 1759
            .:|         |..|...|.|.:...|:.:.  :|.:..      .||||..|:....|:...:
  Fly  1581 EFENTRKNHQRALDSMQASLEAEAKGKAEALR--MKKKLEADINELEIALDHANKANAEAQKNIK 1643

 Worm  1760 KYPPHLVEVEAIQHKTTQIFHKVFFPDNTDEAIEVDSATRARD 1802
            :|...|.:::.                    |:|.:.  ||||
  Fly  1644 RYQQQLKDIQT--------------------ALEEEQ--RARD 1664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hum-6	NP_508420.1	MYSc_Myo7	76..720	CDD:276832	270/673 (40%)
		CBD_MYO6-like	738..>808	CDD:409646	16/71 (23%)
		IQ	757..779	CDD:197470	3/21 (14%)
		MyTH4	929..1168	CDD:214535	51/268 (19%)
		FERM1_F1_Myosin-VII	1172..1270	CDD:340612	18/103 (17%)
		B41	1174..1388	CDD:214604	37/220 (17%)
		FERM_C1_MyoVII	1382..1480	CDD:270019	15/97 (15%)
		SH3	1481..1544	CDD:473055	13/62 (21%)
		MyTH4	1624..1772	CDD:214535	38/187 (20%)
		FERM2_F1_Myosin-VII	1777..1875	CDD:340613	6/26 (23%)
		B41	1779..1993	CDD:214604	6/24 (25%)
		FERM_C2_MyoVII	1989..2087	CDD:270020
Mhc	NP_523587.4	Myosin_N	33..75	CDD:460670	11/42 (26%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	270/675 (40%)
		Myosin_tail_1	842..1922	CDD:460256	203/1092 (19%)