DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sel-12 and Psn

DIOPT Version :9

Sequence 1:	NP_508175.1	Gene:	sel-12 / 180441	WormBaseID:	WBGene00004769	Length:	444	Species:	Caenorhabditis elegans
Sequence 2:	NP_001262111.1	Gene:	Psn / 40260	FlyBaseID:	FBgn0284421	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	496	Identity:	238/496 - (47%)
Similarity:	309/496 - (62%)	Gaps:	88/496 - (17%)

- Green bases have known domain annotations that are detailed below.

Worm     2 PSTRRQQEGGGADAETHTVYGTNLITNRNSQEDENVVEEAELKYGASHVIHLFVPVSLCMALVVF 66
            ||  |...|||......|          |..|     ||..|||||.|||.|||||||||.:||.
  Fly    73 PS--RLTGGGGGSGGPPT----------NEME-----EEQGLKYGAQHVIKLFVPVSLCMLVVVA 120

Worm    67 TMNTITFYSQNNGRHLLYTPFVRETDSIVEKGLMSLGNALVMLCVVVLMTVLLIVFYKYKFYKLI 131
            |:|:|:||:..: .:||||||..::.....|...:|.|:|:::.|||:||.||||.||.:.|::|
  Fly   121 TINSISFYNSTD-VYLLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRII 184

Worm   132 HGWLIVSSFLLLFLFTTIYVQEVLKSFDVS---PSALLVLFGLGNYGVLGMMCIHWKGPLRLQQF 193
            |||||:|||:|||:||.:|::|:|:::::.   |:|||:::   |:||:|||.|||:|||||||.
  Fly   185 HGWLILSSFMLLFIFTYLYLEELLRAYNIPMDYPTALLIMW---NFGVVGMMSIHWQGPLRLQQG 246

Worm   194 YLITMSALMALVFIKYLPEWTVWFVLFVISVWDLVAVLTPKGPLRYLVETAQERNEPIFPALIYS 258
            |||.::|||||||||||||||.|.||..||:|||:|||:|:||||.||||||||||.||||||||
  Fly   247 YLIFVAALMALVFIKYLPEWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYS 311

Worm   259 SGVIYPYVLVTAVENTTDPRE--------PTSSDSNTST-------AFPGEASCSSETPKRPKVK 308
            |.|:|      |:.||..|::        |:||:|.|:|       |.|..|:.|.:......
  Fly   312 STVVY------ALVNTVTPQQSQATASSSPSSSNSTTTTRATQNSLASPEAAAASGQRTGNSH-- 368

Worm   309 RIPQKVQIESNTTAST------TQNSGVRVERELAA------------------ERPTVQDANFH 349
              |::.|.:..:..:|      |..|.:|...|.|.                  |..:.|..|..
  Fly   369 --PRQNQRDDGSVLATEGMPLVTFKSNLRGNAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQ 431

Worm   350 RHEE---------------EERGVKLGLGDFIFYSVLLGKASSYFDWNTTIACYVAILIGLCFTL 399
            |..|               ||||:|||||||||||||:||||||.||.|||||:||||||||.||
  Fly   432 RSNEYRTVTAPDQNHPDGQEERGIKLGLGDFIFYSVLVGKASSYGDWTTTIACFVAILIGLCLTL 496

Worm   400 VLLAVFKRALPALPISIFSGLIFYFCTRWIITPFVTQVSQK 440
            :|||::::|||||||||..||||.|.|..::.||:..:|.|
  Fly   497 LLLAIWRKALPALPISITFGLIFCFATSAVVKPFMEDLSAK 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sel-12	NP_508175.1	Presenilin	44..434	CDD:279427	223/446 (50%)
Psn	NP_001262111.1	Presenilin	98..531	CDD:279427	223/446 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161245
Domainoid	1	1.000	389	1.000	Domainoid score	I408
eggNOG	1	0.900	-	-		E1_KOG2736
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1111
Isobase	1	0.950	-	0	Normalized mean entropy	S3257
OMA	1	1.010	-	-		QHG54370
OrthoDB	1	1.010	-	-		D357270at33208
OrthoFinder	1	1.000	-	-		FOG0002393
OrthoInspector	1	1.000	-	-		oto18091
orthoMCL	1	0.900	-	-		OOG6_101989
Panther	1	1.100	-	-	LDO	PTHR10202
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2736
SonicParanoid	1	1.000	-	-		X1815
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.750