DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nfkbia and cact

DIOPT Version :9

Sequence 1:NP_035037.2 Gene:Nfkbia / 18035 MGIID:104741 Length:314 Species:Mus musculus
Sequence 2:NP_001260496.1 Gene:cact / 34969 FlyBaseID:FBgn0000250 Length:500 Species:Drosophila melanogaster


Alignment Length:278 Identity:97/278 - (34%)
Similarity:141/278 - (50%) Gaps:43/278 - (15%)


- Green bases have known domain annotations that are detailed below.


Mouse    66 WKQ--QLTEDGDSFLHLAIIHEEKPLTMEVIGQVKGDLAFLNFQNNLQQTPLHLAVITNQPGIAE 128
            |:|  |..:|||:.||||.|.....:...:| ::......||.||::.|||||||.:|.||.|..
  Fly   220 WEQFYQQNDDGDTPLHLACISGSVDVVAALI-RMAPHPCLLNIQNDVAQTPLHLAALTAQPNIMR 283

Mouse   129 ALLKAGCDPELRDFRGNTPLHLAC---EQGCL-------------------------ASVAVLTQ 165
            .||.||.:|.:||..|||.|||:|   |:.|:                         .:|:.|:.
  Fly   284 ILLLAGAEPTVRDRHGNTALHLSCIAGEKQCVRALTEKFGATEIHEAHRQYGHRSNDKAVSSLSY 348

Mouse   166 TCTPQHLHSVLQATNYNGHTCLHLASIHGYLAIVEHLVTLGADVNAQEPCNGRTALHLAVDLQNP 230
            .|.|    :.|:..||:|..|:|||:..|::.|:..||:.|||:||:|..:|||.||:|::..|.
  Fly   349 ACLP----ADLEIRNYDGERCVHLAAEAGHIDILRILVSHGADINAREGKSGRTPLHIAIEGCNE 409

Mouse   231 DLVSLLL-KC-GADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTES 293
            ||.:.|| :| ..::...||.|.:.||.......:|:|..|.:...|.  :.|...|.:|.|.|.
  Fly   410 DLANFLLDECEKLNLETATYAGLTAYQFACIMNKSRMQNILEKRGAET--VTPPDSDYDSSDIED 472

Mouse   294 EFTEDELPYDDCVFGGQR 311
              .:|...||.  ||..|
  Fly   473 --LDDTKMYDR--FGDPR 486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NfkbiaNP_035037.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40
Ank_2 <26..>151 CDD:330894 39/86 (45%)
Destruction motif 30..36
Nuclear export signal. /evidence=ECO:0000250 45..54
ANK repeat 73..108 CDD:293786 11/34 (32%)
ANK 1 73..103 9/29 (31%)
ANK 105..237 CDD:238125 61/159 (38%)
ANK repeat 110..141 CDD:293786 16/30 (53%)
ANK 2 110..139 16/28 (57%)
Nuclear import signal. /evidence=ECO:0000250 110..120 7/9 (78%)
ANK repeat 143..180 CDD:293786 14/64 (22%)
ANK 3 143..172 13/56 (23%)
ANK repeat 182..213 CDD:293786 14/30 (47%)
ANK 4 182..211 12/28 (43%)
ANK repeat 216..246 CDD:293786 12/31 (39%)
ANK 5 216..245 12/30 (40%)
cactNP_001260496.1 ANK <225..286 CDD:238125 25/61 (41%)
ANK repeat 229..263 CDD:293786 11/34 (32%)
Ank_4 230..286 CDD:290365 23/56 (41%)
ANK 260..416 CDD:238125 61/159 (38%)
ANK repeat 265..296 CDD:293786 16/30 (53%)
Ank_2 270..391 CDD:289560 44/124 (35%)
ANK repeat 298..324 CDD:293786 9/25 (36%)
ANK repeat 361..393 CDD:293786 14/31 (45%)
Ank_5 381..438 CDD:290568 25/56 (45%)
ANK repeat 395..425 CDD:293786 12/29 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167846747
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BM8A
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H7863
Inparanoid 1 1.050 133 1.000 Inparanoid score I4587
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1341288at2759
OrthoFinder 1 1.000 - - FOG0002150
OrthoInspector 1 1.000 - - otm43754
orthoMCL 1 0.900 - - OOG6_108699
Panther 1 1.100 - - LDO PTHR46680
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4493
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1211.830

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