Protein Alignment Nfkb1 and dl

DIOPT Version :10

• Sequence 1: NP_032715.2
• Gene: Nfkb1 / 18033
• MGIID: 97312
• Length: 971
• Species: Mus musculus
• Sequence 2: NP_724054.1
• Gene: dl / 35047
• FlyBaseID: FBgn0260632
• Length: 999
• Species: Drosophila melanogaster
• Alignment Length: 1061
• Identity: 257/1061 - (24%)
• Similarity: 380/1061 - (35%)
• Gaps: 351/1061 - (33%)

Mouse    40 PYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNI 104
            ||::|.|||..:..||||.|||.|.|.:||.:|....|:||.::|..|.|.|.|:|..||.....
  Fly    47 PYVKITEQPAGKALRFRYECEGRSAGSIPGVNSTPENKTYPTIEIVGYKGRAVVVVSCVTKDTPY 111

Mouse   105 HLHAHSLVGKH-CEDGVCTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLL 168
            ..|.|:||||. |:.||||:....:.|...|:||||..|.||.:...|:|| .|..:..:..|.
  Fly   112 RPHPHNLVGKEGCKKGVCTLEINSETMRAVFSNLGIQCVKKKDIEAALKAR-EEIRVDPFKTGF- 174

Mouse   169 VHSDLAYLQAEGGGDRQLTDREKEIIRQAAVQQTKEMDLSVVRLMFTAFL-PDSTGSFTRRLEPV 232
                                        :...|...:||:.|||.|..|: .:..|.||..|.||
  Fly   175 ----------------------------SHRFQPSSIDLNSVRLCFQVFMESEQKGRFTSPLPPV 211

Mouse   233 VSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGD 297
            ||:.|:|.||  .|:|.|.|:...:..|.|..:|.|||:||.|:||.:||:||:....|||.|||
  Fly   212 VSEPIFDKKA--MSDLVICRLCSCSATVFGNTQIILLCEKVAKEDISVRFFEEKNGQSVWEAFGD 274

Mouse   298 FSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYP------------- 349
            |..||||:|.||.||||:|..::||:||.||:||||.||..|||..||.|.|
  Fly   275 FQHTDVHKQTAITFKTPRYHTLDITEPAKVFIQLRRPSDGVTSEALPFEYVPMDSGKHTFWNLHR 339

Mouse   350 ---------------EIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPG 399
                           .:..|.|||
  Fly   340 HLKRKPDEDLFQQILRLDAKREVQ----------------------------------------- 363

Mouse   400 PGYGYSNYGFPPYGGITFHPGVTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEG 464
                      ||                    ||.....:.||...:.:....:....:|::...
  Fly   364 ----------PP--------------------TIEVIDLDTPKIDVQREIPSEMEFNHEESQQSE 398

Mouse   465 PSLPM------------------ACTKTEPIALASTMEDKEQDMGFQDNLFLEKALQLARR-HAN 510
            |:|..                  ..|:.:.:.....::..||...||    ||:.:|..:. .|.
  Fly   399 PALEQEQSVQQEQYTQEQSLQQEQYTQEQSLQQEQYLQQLEQQQSFQ----LEEPMQQDQELPAQ 459

Mouse   511 ALFDYAV------TGD--VKMLLAVQRH-------LTAVQDENGDSVLHLAIIHLHAQLVRDLLE 560
            ..||.|:      |.|  .:.:.|...|       |.:.|::..|:::.        :.||:|.:
  Fly   460 QSFDQAIDHLPDHTSDHIPEDMEAADAHAEAEAHRLRSEQEKEIDTIID--------EKVRELEQ 516

Mouse   561 VTSG-------LISDDIIN--MRNDLYQTPLHLAVITKQEDVVEDLLRVGADLSLLDRWGNSVLH 616
            :..|       |.::|.|.  |::...:..:|....|.:.||::..|.:......||....:|..
  Fly   517 LDLGQQLEPRPLTANDKITEWMKSSEIEQQVHEPSPTAEADVLDSALEISKADKTLDELLETVAE 581

Mouse   617 LAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLLLLVAAGAEVNAQEQKSG 681
            |      |.|.:.....|..     :.|          .:.|.|        ||.:        |
  Fly   582 L------DEIYTDFKVQRDT-----YKN----------TIQNEL--------AGLQ--------G 609

Mouse   682 RTALHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENF 746
            |..|.:...:|                |:.||   |.|.||.               .:|:
  Fly   610 RAPLQVEDSFD----------------DAATY---TSLQIAF---------------KNPV---- 636

Mouse   747 EPLYDLDDSWEKAGEDEGVVPGTTPLDMAA---NWQVFDILN-----GKPYEP----------VF 793
              |..:||          ::|.|.|:...|   ..|.:|.:.     .||..|          :.
  Fly   637 --LIPMDD----------IMPPTPPMSQCAPEDAHQHYDPVEVNSQARKPETPMRPVPPVPPAIL 689

Mouse   794 T-----SDDILPQGDMKQL-TEDTRLQ-------------------LCKLLEIPDPDKNWATLAQ 833
            |     .:|.||....|:: .:|:..:                   |.|.|.....:.|:.||.:
  Fly   690 TIQYPPEEDKLPPLPPKRIRKQDSNAENRSIEANTVQTKPSTGESPLNKRLPPAPKNPNFNTLPR 754

Mouse   834 KLGLGILNNAFRLSPAPSK-TLMDNYEVSGGTIKELMEALQQMGYTEAIEVIQAAFRT------- 890
            :...|..:..|  |...|| .|....|.|.....:.......:|:....:.::|:.|:
  Fly   755 QKKPGFFSKLF--SRRKSKPDLAQGQENSSILDSKANSREPSIGHFNMQDPMRASLRSSKSAAPF 817

Mouse   891 ---PATTASSPVTTAQVHCLPLSSSSTRQHIDELRDSDSVCDSGVETSFRKLSFTE-SLTGDSPL 951
               ||...||||...:      ..|...:.:.  |...||  ||...::....... .|.||
  Fly   818 ISNPAPAKSSPVKAKK------PGSKLTKPVG--RSVSSV--SGKRPAYLNADVVHIPLKGD--- 869

Mouse   952 LSLNKMP-----HGYGQEGPI 967
             |:|.:|     .||.|...|
  Fly   870 -SVNSLPQQQRTEGYSQSSTI 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nfkb1	NP_032715.2	RHD-n_NFkB1	40..241	CDD:143651	72/202 (36%)
		IPT_NFkappaB	248..349	CDD:238582	55/100 (55%)
		Nuclear localization signal. /evidence=ECO:0000255	358..363		1/4 (25%)
		GRR. /evidence=ECO:0000250|UniProtKB:P19838	370..392		0/21 (0%)
		Interaction with CFLAR. /evidence=ECO:0000250|UniProtKB:P19838	433..971		119/638 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	439..470		5/48 (10%)
		ANKYR	492..765	CDD:440430	56/297 (19%)
		ANK repeat	538..575	CDD:293786	9/45 (20%)
		ANK repeat	577..608	CDD:293786	5/30 (17%)
		Essential for interaction with HIF1AN. /evidence=ECO:0000250|UniProtKB:P19838	646..680		4/33 (12%)
		ANK repeat	646..677	CDD:293786	4/30 (13%)
		ANK repeat	680..712	CDD:293786	5/31 (16%)
		Death_NFkB1_p105	812..886	CDD:260063	15/93 (16%)
dl	NP_724054.1	RHD-n_Dorsal_Dif	47..220	CDD:143647	72/202 (36%)
		IPT_NFkappaB	225..326	CDD:238582	55/100 (55%)