DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nek1 and Nek2

DIOPT Version :9

Sequence 1:	NP_001280566.1	Gene:	Nek1 / 18004	MGIID:	97303	Length:	1275	Species:	Mus musculus
Sequence 2:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster

Alignment Length:	777	Identity:	197/777 - (25%)
Similarity:	293/777 - (37%)	Gaps:	209/777 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MEKYVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANMKHPNIVQ 65
            ::.|..|..:|.||||....|:....|..:..|.:|...:.:.:......|::||..::||||||
  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80

Mouse    66 YKESF--EENGSLYIVMDYCEGGDL---FKRINAQKGALFQEDQILDWFVQICLALKHVHDR--- 122
            |....  .|..|:||||:.|.||||   .:|..:|: ..|:|..|.....|:|.||:..|::
  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQR-QRFEEPYIWRVLFQLCRALQVCHNKIPN 144

Mouse   123 -KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDI 186
             .|||||||..||||...|..:|||||:||:|......|.:.:|||:|:|||:.:.:.|:.|||:
  Fly   145 GTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDV 209

Mouse   187 WALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNS 251
            ||:||::||:|.|:..|.......|..||..|.|..:...||.||:.:::.:...:...||.:..
  Fly   210 WAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEV 274

Mouse   252 ILEKGFIAKRIE----KFLSPQLI--AEEFCLKTLSKFGPQPLP-GKRPASGQGVSSFVPAQKIT 309
            |:....:.:.|.    ||  |.|:  .|:|          ..|| |.|....:......|....|
  Fly   275 IIRHPLVVRNISELDGKF--PILVDSGEDF----------YTLPSGARLFEDEEEDGVHPELSST 327

Mouse   310 KPAAKYGVPLTYKKYGDKKL-----------LEKKPPPKHKQAHQIPVKKMNSGEERKKMS---E 360
            ....:|..   .:.||.::|           .|.....|.|   ..|.||:...:.....|   |
  Fly   328 MFTEQYSF---NEGYGQRRLSVTGVFTPDLRSELFYSAKRK---IFPAKKLQLSDPSLYESIRRE 386

Mouse   361 EAAKKRRLEFIEKEKKQKDQIRFLKAEQMKRQE----------------------KQRLERINRA 403
            |.|::|::|..|:.:::|||      ||.||.:                      |.||..| ||
  Fly   387 ERAEERQVELAEERRRKKDQ------EQQKRDQELLKEAPSSPRALTQNIFDEVLKTRLHAI-RA 444

Mouse   404 REQGWRNVLRAGGSGEVKASF-----------------------FGIGGAVSPSPCSPRGQYEHY 445
            :|...:..|....:.|.:...                       ......::| |..||...:.:
  Fly   445 QESLLQQKLEELQTREQELQLAEQRVQTLERQMQEKLLQQEKHTCSCRQPIAP-PIPPRKPAKSH 508

Mouse   446 HAIFD---------------------------QMQRLRAEDNEARWKGGIYG-RWLPERGVPPGV 482
            |   |                           .:..||....::..|...|| ..:|...|.|.|
  Fly   509 H---DDTYCTIELNETSPTVAKLNLATLPAPKSLNTLRKVTFKSPQKFVTYGIENMPPPAVKPAV 570

Mouse   483 RP---GFPSEASGHYHSPDAG-----------------------AIRKTLKRLKAVSKQASTNRQ 521
            .|   |.|.:.|  ..|.|:|                       |..|:|..:..|::.|:|..|
  Fly   571 NPPPTGVPMQMS--VSSNDSGDSQASSTRRKSILSLFGLSRGSKATSKSLPSVNQVAQAAATRVQ 633

Mouse   522 KGHLAV---------------------ERANQVEEFLQRKREAMQNKARAEGHVGLLQNLASLYG 565
            :..|||                     |:..|..|.|     |..|.|..|          :..|
  Fly   634 RPPLAVKPPITQEQPAEVPPVANLWTKEQKKQAFELL-----AAMNAAERE----------ASGG 683

Mouse   566 GRPSSSRGGKPRNNEEEVYLARLRQIRLQNFNERQQIKAKLRGENKEADGTKGQEATEETDM 627
            |...|..||           ||.:.:| |:..||.....:.|........|..|:.|....|
  Fly   684 GVVGSGPGG-----------ARRQHLR-QSVRERNSTLQRNRMRRSLVVATGHQKLTTRDQM 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek1	NP_001280566.1	STKc_Nek1	3..258	CDD:270858	95/263 (36%)
Nek1	NP_001280566.1	S_TKc	4..258	CDD:214567	95/262 (36%)
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	95/263 (36%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	95/262 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920