DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kin-30 and btl

DIOPT Version :9

Sequence 1:	NP_506771.3	Gene:	kin-30 / 180032	WormBaseID:	WBGene00002211	Length:	458	Species:	Caenorhabditis elegans
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	421	Identity:	129/421 - (30%)
Similarity:	196/421 - (46%)	Gaps:	72/421 - (17%)

- Green bases have known domain annotations that are detailed below.

Worm    35 ALFIYGVLSIIFVTICFLRRIYRSSATK-------NGNRRYLVQNTYVKAQLDTNSSSS----LP 88
            |||:.|...|.|:    |||:.|....|       ...::.::   |.....:.:..||    :|
  Fly   612 ALFLLGSAFITFM----LRRLRREKLLKLRIETVHQWTKKVII---YRPGGEEGSGCSSGDLQMP 669

Worm    89 VDKEIIETISINEETPII-------TDYQPLNERAEY-LPYNPAFEIHSEHLDVFEKQFGQGNFG 145
            |       |.|.::...:       ||  |.....|| .|.:..:||..:.|.: ....|:|.||
  Fly   670 V-------IRIEKQRTTVSTTGTGGTD--PAQGFNEYEFPLDSNWEIPRQQLSL-GSILGEGAFG 724

Worm   146 KVNKALLKLINQKTGEVVRMDVAVKK-PADSTDKSQDKLILDEIKLMCAIGKHPNVLAIVGAITK 209
            :|..|..:.: .::.::....||||. ..:.||.....|: .|:::|..||||.|::.::|..:
  Fly   725 RVVMAEAEGL-PRSPQLAETIVAVKMVKEEHTDTDMASLV-REMEVMKMIGKHINIINLLGCCS- 786

Worm   210 QEKVIGREHNLVVTEFVEGGDLRSVLKYTPYTFHDELTSTDRTGGQMVNSD---IFDE------- 264
                             :||.|..:::|.|:....:....:|.|.....||   ..|:
  Fly   787 -----------------QGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQ 834

Worm   265 -LSTSDLYSFAYQIANGMEYLAAKPCVHRDLALRNVFVKRNKMIRIGDFGLARHHSKKSYYRMQC 328
             |...:|..||:|||.||||||::.|:|||||.|||.|....:::|.||||||......|||.
  Fly   835 HLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRK-- 897

Worm   329 NPDTPLPIFWLAPECFNESKFTEMTDVWSYGVCLFELFSLGESPYKKLHNSPSYDVVHYLKKGYR 393
            |.:..|||.|:|||...|.|:...:|||||||.|:|:.:.|:.||.  |...:.::..||..|.|
  Fly   898 NTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYP--HILSAEELYSYLITGQR 960

Worm   394 LSAPRYCNAEIYEFMLYCWNIDATLRPKFTE 424
            :..|..|:..||..|..||:.::..||.|.|
  Fly   961 MEKPAKCSLNIYVVMRQCWHFESCARPTFAE 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kin-30	NP_506771.3	TyrKc	134..428	CDD:197581	102/303 (34%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652
		Ig	258..340	CDD:143165
		I-set	394..479	CDD:254352
		IGc2	408..469	CDD:197706
		IG_like	492..583	CDD:214653
		Ig	507..583	CDD:299845
		PKc_like	700..1000	CDD:304357	106/317 (33%)
		TyrKc	712..996	CDD:197581	103/305 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810