Protein Alignment Nedd9 and p130CAS

DIOPT Version :9

• Sequence 1: XP_036013794.1
• Gene: Nedd9 / 18003
• MGIID: 97302
• Length: 834
• Species: Mus musculus
• Sequence 2: NP_001097456.2
• Gene: p130CAS / 38021
• FlyBaseID: FBgn0035101
• Length: 831
• Species: Drosophila melanogaster
• Alignment Length: 904
• Identity: 234/904 - (25%)
• Similarity: 379/904 - (41%)
• Gaps: 244/904 - (26%)

Mouse     7 LMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLL----IGP 67
            |.|:|:|||..:.::||.|:|||||||:||:|.|.:|||||||..|||:.||||:::|    .|.
  Fly    80 LYAKAIYDNYADTSDELPFKKGDILTVLEQDTEGFQGWWLCSLRNRQGLCPGNRLRVLNSYDSGC 144

Mouse    68 VQETPGHEQPTPGPMHQTFGQQKLYQVPNSQAASRDTIYQVPPSYQNQGIYQVPTGHGTPEQDVY 132
            ...:|. ..|.|                 |.|||..|:   ..|..:..||:    :|:    |.
  Fly   145 FSPSPA-SSPVP-----------------SLAASTATL---DSSICSAEIYE----NGS----VI 180

Mouse   133 QVPPSVQRNIGGTNGPLLSK---------------KVITPVRTGHGYVYEYPSRYQKDVYDVPPS 182
            ....|...|.||.:..|.|:               |||||.|.|..|:|.|           .|.
  Fly   181 SAVSSSNSNSGGASSGLGSESVSRVSRRSWHASPTKVITPQRHGDVYIYNY-----------SPG 234

Mouse   183 HSTQGVYDIPPSSVKGPVFSVPVGEIKPQGVYDIPPTQGVYAIPPSACRDEAGLREKEYDFPPPM 247
            .:|.......||:.:..::|       .|.:|.      .:|:..|..::.:|...:.||.|
  Fly   235 SATGSGARAAPSTPQQQIYS-------NQSIYQ------NFAMMSSPRQNASGSEFETYDIP--- 283

Mouse   248 KQDGKPDTRPEGVYDIP-------PTSTKTAGKDLHIKFPCDAPGGVEPMARRHQSFSLHHAPSQ 305
                ||.|.....||.|       ..||.|:...|..:|.                 :|....:.
  Fly   284 ----KPATPVPLNYDSPRSGLPKASNSTTTSSSSLGTRFE-----------------TLKSVAAS 327

Mouse   306 LGQSGDTQSDAYDVPRGVQFLEVPTETSEKANPEERDGVYDVPLHNPADAKGSRDVVDGINRLSF 370
            :.:      ::|||||                          ||     ..||..:...:::::.
  Fly   328 IAE------ESYDVPR--------------------------PL-----ILGSNQLQQQMSQMTP 355

Mouse   371 SSTGS---TRSNMSTSSTSSKESSLSASPSQD--------------------------------- 399
            ||:.|   |..::|.|.:||..|||:..|..|
  Fly   356 SSSASSLLTSDSLSLSFSSSNRSSLANMPDYDIPRRNPLPVRRQQSGLTYDFPLPPLQEQVPRVL 420

Mouse   400 ---------KRLRLDPDTAIEKLYRLQQTLEMGVCSLMSLVTTDWRCYGYMERHINEIRTAVDKV 455
                     |.|.|:..:|:|.|.:||......:..|:|.|..:||....:|..|.:::.|..::
  Fly   421 CTPSTVTTTKELPLELSSALETLAKLQLQTTAAINRLLSFVVPNWRTRAQLEPAIMDLKLAALRL 485

Mouse   456 ELFLREYLHFAKGALANASCLPELVLHNKMKRELQRVEDSHQILSQTSHDLN-ECSWSLNILAIN 519
            ...|.:...|.:|||.||:...:..|..|::..::.:.|:::::..:|..|: :.:||::.||.:
  Fly   486 RTTLHDLAEFGEGALGNATRSEDRNLALKLRPLVRALRDANKLIHDSSESLDAQGAWSIDQLARS 550

Mouse   520 KPQNKC---DDLDRFVMVAKTVPDDAKQLTTTISTYAETLFRADPANSHLKNGPNSIMNSSEYTH 581
            ..::.|   |.||:.::.|:|:.:|.:..|:.|...|..||:......|  ||
  Fly   551 DEKHGCRPPDALDQLMVCAQTLTEDVRSTTSFIQGNASLLFKRQLTVGH--NG------------ 601

Mouse   582 PGSQMQPLHPGDYKAQVHSKPLPPSLSKDQPPDCGSSDGSERS--WMDDYDYVHLQGKEEFERQQ 644
             ||                             ..|..:||..|  |::|||||..:.|:...|:.
  Fly   602 -GS-----------------------------GTGVLEGSRGSAEWLEDYDYVAFESKDAAARKN 636

Mouse   645 KELLEKENIMKQSKAQLEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTT---NNSVGAQDRQ 706
            :.|  :|.|....|.|.:    :..:..|..........|.....:::.|||   :..:..:|::
  Fly   637 EAL--REAIPADLKTQFD----TVIRTAESSAMGAGSGSIPTTPTARTTPTTPCKSPEMTDKDKK 695

Mouse   707 LLCFYYDQCETHFISLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVAAQD 771
            |:.:|..|..||..:|:.|||:....|...|||:.|:|:.|||::|||.||.|||.:.|.::.:.
  Fly   696 LVRYYAQQISTHMGNLMQAIDSFLETVEKNQPPKFFIAYGKFVVVSAHNLVTIGDNVYRNISKEA 760

Mouse   772 IRNKVRNSSNQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLE 830
            :|.|:...:|.|.:.|||.|:.:|.||.|:||.:|:||||..|..::..|:..|..:|:
  Fly   761 LREKILRCTNALSDALKTCVLKSKKAAAHFPSGSAVQEMVDSVVHINNLARDLKSVMLQ 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd9	XP_036013794.1	SH3_NEDD9	8..64	CDD:212935	33/55 (60%)
		Serine_rich_NEDD9	401..561	CDD:211404	43/163 (26%)
		DUF3513	621..828	CDD:403297	70/211 (33%)
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	33/54 (61%)
		Serine_rich_CAS	434..596	CDD:211403	42/161 (26%)
		DUF3513	612..817	CDD:288849	69/210 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833971
Domainoid	1	1.000	121	1.000	Domainoid score	I5686
eggNOG	1	0.900	-	-		E1_28I76
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	250	1.000	Inparanoid score	I3209
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46840
OrthoDB	1	1.010	-	-		D1086228at2759
OrthoFinder	1	1.000	-	-		FOG0004232
OrthoInspector	1	1.000	-	-		otm43833
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10654
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4915
SonicParanoid	1	1.000	-	-		X2975
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.900