Protein Alignment Nedd9 and p130CAS

DIOPT Version :10

• Sequence 1: XP_036013794.1
• Gene: Nedd9 / 18003
• MGIID: 97302
• Length: 834
• Species: Mus musculus
• Sequence 2: NP_001097456.2
• Gene: p130CAS / 38021
• FlyBaseID: FBgn0035101
• Length: 831
• Species: Drosophila melanogaster
• Alignment Length: 904
• Identity: 234/904 - (25%)
• Similarity: 379/904 - (41%)
• Gaps: 244/904 - (26%)

Mouse     7 LMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLL----IGP 67
            |.|:|:|||..:.::||.|:|||||||:||:|.|.:|||||||..|||:.||||:::|    .|.
  Fly    80 LYAKAIYDNYADTSDELPFKKGDILTVLEQDTEGFQGWWLCSLRNRQGLCPGNRLRVLNSYDSGC 144

Mouse    68 VQETPGHEQPTPGPMHQTFGQQKLYQVPNSQAASRDTIYQVPPSYQNQGIYQVPTGHGTPEQDVY 132
            ...:|. ..|.|                 |.|||..|:   ..|..:..||:    :|:    |.
  Fly   145 FSPSPA-SSPVP-----------------SLAASTATL---DSSICSAEIYE----NGS----VI 180

Mouse   133 QVPPSVQRNIGGTNGPLLSK---------------KVITPVRTGHGYVYEYPSRYQKDVYDVPPS 182
            ....|...|.||.:..|.|:               |||||.|.|..|:|.|           .|.
  Fly   181 SAVSSSNSNSGGASSGLGSESVSRVSRRSWHASPTKVITPQRHGDVYIYNY-----------SPG 234

Mouse   183 HSTQGVYDIPPSSVKGPVFSVPVGEIKPQGVYDIPPTQGVYAIPPSACRDEAGLREKEYDFPPPM 247
            .:|.......||:.:..::|       .|.:|.      .:|:..|..::.:|...:.||.|
  Fly   235 SATGSGARAAPSTPQQQIYS-------NQSIYQ------NFAMMSSPRQNASGSEFETYDIP--- 283

Mouse   248 KQDGKPDTRPEGVYDIP-------PTSTKTAGKDLHIKFPCDAPGGVEPMARRHQSFSLHHAPSQ 305
                ||.|.....||.|       ..||.|:...|..:|.                 :|....:.
  Fly   284 ----KPATPVPLNYDSPRSGLPKASNSTTTSSSSLGTRFE-----------------TLKSVAAS 327

Mouse   306 LGQSGDTQSDAYDVPRGVQFLEVPTETSEKANPEERDGVYDVPLHNPADAKGSRDVVDGINRLSF 370
            :.:      ::|||||                          ||     ..||..:...:::::.
  Fly   328 IAE------ESYDVPR--------------------------PL-----ILGSNQLQQQMSQMTP 355

Mouse   371 SSTGS---TRSNMSTSSTSSKESSLSASPSQD--------------------------------- 399
            ||:.|   |..::|.|.:||..|||:..|..|
  Fly   356 SSSASSLLTSDSLSLSFSSSNRSSLANMPDYDIPRRNPLPVRRQQSGLTYDFPLPPLQEQVPRVL 420

Mouse   400 ---------KRLRLDPDTAIEKLYRLQQTLEMGVCSLMSLVTTDWRCYGYMERHINEIRTAVDKV 455
                     |.|.|:..:|:|.|.:||......:..|:|.|..:||....:|..|.:::.|..::
  Fly   421 CTPSTVTTTKELPLELSSALETLAKLQLQTTAAINRLLSFVVPNWRTRAQLEPAIMDLKLAALRL 485

Mouse   456 ELFLREYLHFAKGALANASCLPELVLHNKMKRELQRVEDSHQILSQTSHDLN-ECSWSLNILAIN 519
            ...|.:...|.:|||.||:...:..|..|::..::.:.|:::::..:|..|: :.:||::.||.:
  Fly   486 RTTLHDLAEFGEGALGNATRSEDRNLALKLRPLVRALRDANKLIHDSSESLDAQGAWSIDQLARS 550

Mouse   520 KPQNKC---DDLDRFVMVAKTVPDDAKQLTTTISTYAETLFRADPANSHLKNGPNSIMNSSEYTH 581
            ..::.|   |.||:.::.|:|:.:|.:..|:.|...|..||:......|  ||
  Fly   551 DEKHGCRPPDALDQLMVCAQTLTEDVRSTTSFIQGNASLLFKRQLTVGH--NG------------ 601

Mouse   582 PGSQMQPLHPGDYKAQVHSKPLPPSLSKDQPPDCGSSDGSERS--WMDDYDYVHLQGKEEFERQQ 644
             ||                             ..|..:||..|  |::|||||..:.|:...|:.
  Fly   602 -GS-----------------------------GTGVLEGSRGSAEWLEDYDYVAFESKDAAARKN 636

Mouse   645 KELLEKENIMKQSKAQLEHHQLSQFQLLEQEITKPVENDISKWKPSQSLPTT---NNSVGAQDRQ 706
            :.|  :|.|....|.|.:    :..:..|..........|.....:::.|||   :..:..:|::
  Fly   637 EAL--REAIPADLKTQFD----TVIRTAESSAMGAGSGSIPTTPTARTTPTTPCKSPEMTDKDKK 695

Mouse   707 LLCFYYDQCETHFISLLNAIDALFSCVSSAQPPRIFVAHSKFVILSAHKLVFIGDTLTRQVAAQD 771
            |:.:|..|..||..:|:.|||:....|...|||:.|:|:.|||::|||.||.|||.:.|.::.:.
  Fly   696 LVRYYAQQISTHMGNLMQAIDSFLETVEKNQPPKFFIAYGKFVVVSAHNLVTIGDNVYRNISKEA 760

Mouse   772 IRNKVRNSSNQLCEQLKTIVMATKMAALHYPSTTALQEMVHQVTDLSRNAQLFKRSLLE 830
            :|.|:...:|.|.:.|||.|:.:|.||.|:||.:|:||||..|..::..|:..|..:|:
  Fly   761 LREKILRCTNALSDALKTCVLKSKKAAAHFPSGSAVQEMVDSVVHINNLARDLKSVMLQ 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd9	XP_036013794.1	SH3_NEDD9	8..64	CDD:212935	33/55 (60%)
		Serine_rich_NEDD9	401..561	CDD:211404	43/163 (26%)
		CAS_C	619..828	CDD:463437	71/213 (33%)
p130CAS	NP_001097456.2	SH3_CAS	81..136	CDD:212778	33/54 (61%)
		Serine_rich_CAS	434..596	CDD:211403	42/161 (26%)
		CAS_C	611..817	CDD:463437	70/211 (33%)