Protein Alignment Nedd4 and Nedd4

DIOPT Version :10

• Sequence 1: NP_001344927.1
• Gene: Nedd4 / 17999
• MGIID: 97297
• Length: 1207
• Species: Mus musculus
• Sequence 2: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Alignment Length: 890
• Identity: 416/890 - (46%)
• Similarity: 506/890 - (56%)
• Gaps: 191/890 - (21%)

Mouse   477 TRDDFLGQVDVPLYPLPTENPRM---ERPYTFKDFVLHPR---SHKSRVKGYLRLKMTYL----- 530
            |||||||.|::.|..||||....   |:.||     |.||   ..|||:||.||:...::
  Fly   150 TRDDFLGMVELTLVNLPTEQEGRTIGEQSYT-----LRPRRSVGAKSRIKGTLRIYHAFIRETRE 209

Mouse   531 ---PKNGSEDENADQAEELEPGWVVLDQPDAATHLPHP-PE--PSPLPPGWEERQDVLGRTYYVN 589
               |.:|:.|...:..|....|        ..:..||| |.  ...||.|||||||..|||||||
  Fly   210 QSEPSSGNSDGEWEHVEATNAG--------ETSAQPHPFPTGGHDALPAGWEERQDANGRTYYVN 266

Mouse   590 HESRRTQWKRP---------SPDDDLTD---------------------------EDNDDMQ--- 615
            |.:|.|||.||         |.||.|..                           |||::..
  Fly   267 HTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAGLA 331

Mouse   616 ---------------------LQAQRAFTTRRQISED---------------------------- 631
                                 :.||.|...|.:..:|
  Fly   332 YTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATS 396

Mouse   632 ------------------VDGPDNRESPEN------WEIVREDENTEYSGQAVQSPPSGH----- 667
                              :..|..|.:..|      |:..|..:..:...|..|......
  Fly   397 LQNDLRPVREAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRI 461

Mouse   668 -IDV---------------QTHLAEEFNTRLAVCGNPA-TSQPVTSSNHSSRGGSLQTCIFEEQP 715
             :||               |.|.....:|......||: .|.|.|..|..           |:..
  Fly   462 LLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSE-----------EDNA 515

Mouse   716 TLPVLLPTSSG----LPPGWEEKQDDRGRSYYVDHNSKTTTWSKPTMQDDPR----SKIPAHLRG 772
            .:|.:...:.|    |||.|..:....||::::||.|:.|||.      |||    |.:|...|.
  Fly   516 AVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWI------DPRNGRASPMPNQTRR 574

Mouse   773 KTDSNDLGPLPPGWEERTHTDGRVFFINHNIKKTQWEDPRLQNVAITGPAVPYSRDYKRKYEFFR 837
            ..|  ||||||.|||||.|||||||:|:||.:.||||||||.|..|.|.|||||||||:|||:|:
  Fly   575 VED--DLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYEYFK 637

Mouse   838 RKLKKQTDIPNKFEMKLRRANILEDSYRRIMGVKRADLLKARLWIEFDGEKGLDYGGVAREWFFL 902
            ..::|.|::|||||:::||.:|||||||.|..|.:.||||.:||:||:||.||||||:|||||:|
  Fly   638 SHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYL 702

Mouse   903 ISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPF 967
            :||||||||||||||||.||||||||..||||||:||||||||||:||||||||||||.||||||
  Fly   703 LSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPF 767

Mouse   968 YKMMLQKLITLHDMESVDSEYYSSLRWILENDPTELDLRFIIDEELFGQTHQHELKTGGSEIVVT 1032
            |||||||.|.|.||||||:|||:||.||.||||..|:|.|.:||::|||..|||||.||:.|.||
  Fly   768 YKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRILELTFCLDEDVFGQKSQHELKPGGANIDVT 832

Mouse  1033 NKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 1097
            |:||.|||.|||:||||.|:::||::|.:||..:||.:|||||||:||||||||:.::||.||||
  Fly   833 NENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRE 897

Mouse  1098 HTKYKNGYSMNHQVIHWFWKAVWMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQW 1162
            :|.||..|.|||.:|.|||:||....:|.|.|||||||||||||||||.|||||||||.||:|:|
  Fly   898 NTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKW 962

Mouse  1163 GTPDKLPRAHTCFNRLDLPPYESFDELWDKLQMAIENTQGFDGVD 1207
            |||:..||||||||||||||||.:.:|.|||..|||.:|||.|||
  Fly   963 GTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGFAGVD 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nedd4	NP_001344927.1	C2	<477..530	CDD:472691	26/58 (45%)
		WW	574..602	CDD:238122	21/36 (58%)
		WW	727..756	CDD:459800	12/28 (43%)
		WW	781..813	CDD:197736	24/31 (77%)
		HECTc	874..1203	CDD:214523	238/328 (73%)
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	26/67 (39%)
		WW	248..277	CDD:459800	21/37 (57%)
		HUL4	<523..1003	CDD:227354	256/358 (72%)