DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nedd4 and Nedd4

DIOPT Version :9

Sequence 1:NP_001344927.1 Gene:Nedd4 / 17999 MGIID:97297 Length:1207 Species:Mus musculus
Sequence 2:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster


Alignment Length:890 Identity:416/890 - (46%)
Similarity:506/890 - (56%) Gaps:191/890 - (21%)


- Green bases have known domain annotations that are detailed below.


Mouse   477 TRDDFLGQVDVPLYPLPTENPRM---ERPYTFKDFVLHPR---SHKSRVKGYLRLKMTYL----- 530
            |||||||.|::.|..||||....   |:.||     |.||   ..|||:||.||:...::     
  Fly   150 TRDDFLGMVELTLVNLPTEQEGRTIGEQSYT-----LRPRRSVGAKSRIKGTLRIYHAFIRETRE 209

Mouse   531 ---PKNGSEDENADQAEELEPGWVVLDQPDAATHLPHP-PE--PSPLPPGWEERQDVLGRTYYVN 589
               |.:|:.|...:..|....|        ..:..||| |.  ...||.|||||||..|||||||
  Fly   210 QSEPSSGNSDGEWEHVEATNAG--------ETSAQPHPFPTGGHDALPAGWEERQDANGRTYYVN 266

Mouse   590 HESRRTQWKRP---------SPDDDLTD---------------------------EDNDDMQ--- 615
            |.:|.|||.||         |.||.|..                           |||::..   
  Fly   267 HTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAGLA 331

Mouse   616 ---------------------LQAQRAFTTRRQISED---------------------------- 631
                                 :.||.|...|.:..:|                            
  Fly   332 YTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATS 396

Mouse   632 ------------------VDGPDNRESPEN------WEIVREDENTEYSGQAVQSPPSGH----- 667
                              :..|..|.:..|      |:..|..:..:...|..|......     
  Fly   397 LQNDLRPVREAPGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRI 461

Mouse   668 -IDV---------------QTHLAEEFNTRLAVCGNPA-TSQPVTSSNHSSRGGSLQTCIFEEQP 715
             :||               |.|.....:|......||: .|.|.|..|..           |:..
  Fly   462 LLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSE-----------EDNA 515

Mouse   716 TLPVLLPTSSG----LPPGWEEKQDDRGRSYYVDHNSKTTTWSKPTMQDDPR----SKIPAHLRG 772
            .:|.:...:.|    |||.|..:....||::::||.|:.|||.      |||    |.:|...|.
  Fly   516 AVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWI------DPRNGRASPMPNQTRR 574

Mouse   773 KTDSNDLGPLPPGWEERTHTDGRVFFINHNIKKTQWEDPRLQNVAITGPAVPYSRDYKRKYEFFR 837
            ..|  ||||||.|||||.|||||||:|:||.:.||||||||.|..|.|.|||||||||:|||:|:
  Fly   575 VED--DLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYEYFK 637

Mouse   838 RKLKKQTDIPNKFEMKLRRANILEDSYRRIMGVKRADLLKARLWIEFDGEKGLDYGGVAREWFFL 902
            ..::|.|::|||||:::||.:|||||||.|..|.:.||||.:||:||:||.||||||:|||||:|
  Fly   638 SHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYL 702

Mouse   903 ISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPF 967
            :||||||||||||||||.||||||||..||||||:||||||||||:||||||||||||.||||||
  Fly   703 LSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPF 767

Mouse   968 YKMMLQKLITLHDMESVDSEYYSSLRWILENDPTELDLRFIIDEELFGQTHQHELKTGGSEIVVT 1032
            |||||||.|.|.||||||:|||:||.||.||||..|:|.|.:||::|||..|||||.||:.|.||
  Fly   768 YKMMLQKPIDLKDMESVDTEYYNSLMWIKENDPRILELTFCLDEDVFGQKSQHELKPGGANIDVT 832

Mouse  1033 NKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWRE 1097
            |:||.|||.|||:||||.|:::||::|.:||..:||.:|||||||:||||||||:.::||.||||
  Fly   833 NENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRE 897

Mouse  1098 HTKYKNGYSMNHQVIHWFWKAVWMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQW 1162
            :|.||..|.|||.:|.|||:||....:|.|.|||||||||||||||||.|||||||||.||:|:|
  Fly   898 NTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKW 962

Mouse  1163 GTPDKLPRAHTCFNRLDLPPYESFDELWDKLQMAIENTQGFDGVD 1207
            |||:..||||||||||||||||.:.:|.|||..|||.:|||.|||
  Fly   963 GTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGFAGVD 1007

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nedd4NP_001344927.1 C2 <477..530 CDD:326325 26/58 (45%)
WW 574..602 CDD:238122 21/36 (58%)
WW 727..756 CDD:306827 12/28 (43%)
WW 781..813 CDD:197736 24/31 (77%)
HECTc 874..1203 CDD:214523 238/328 (73%)
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999 26/67 (39%)
WW 248..277 CDD:278809 21/37 (57%)
WW 531..560 CDD:278809 17/28 (61%)
WW 581..613 CDD:197736 27/31 (87%)
HECTc 650..1003 CDD:238033 155/231 (67%)
HECTc 674..1003 CDD:214523 137/207 (66%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 465 1.000 Domainoid score I469
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 880 1.000 Inparanoid score I404
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49869
OrthoDB 1 1.010 - - D142537at33208
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 1 1.000 - - otm43672
orthoMCL 1 0.900 - - OOG6_100256
Panther 1 1.100 - - LDO PTHR11254
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2273
SonicParanoid 1 1.000 - - X1682
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.870

Return to query results.
Submit another query.