DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ncam2 and DIP-iota

DIOPT Version :9

Sequence 1:	NP_001106679.1	Gene:	Ncam2 / 17968	MGIID:	97282	Length:	837	Species:	Mus musculus
Sequence 2:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster

Alignment Length:	341	Identity:	87/341 - (25%)
Similarity:	142/341 - (41%)	Gaps:	63/341 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse   219 NATAERGEEMTLTCKASGSPDPTISWFR---------NGKLIEENEKYILKGSNTE-----LTVR 269
            |:|...|.:..|||.........::|.|         ...:|.:|.:..:  |:||     |.:|
  Fly    39 NSTVPVGRDALLTCVVHDLVSFKVAWLRVDTQTILSIQNHVITKNHRISI--SHTEHRIWQLKIR 101

Mouse   270 NIINKDGGSYVCKATNKAGEDQKQAFLQVFVQPHIL--QLKNETTSENG-HVTLVCEAEGEPVPE 331
            ::...|.|.|:|:......:.| ..:|.|.|.|.|:  |...:.....| :|||.|.|.|.|:|.
  Fly   102 DVQESDRGWYMCQINTDPMKSQ-MGYLDVVVPPDIVDYQTSQDVVRSTGQNVTLTCSATGVPMPT 165

Mouse   332 ITWKR--AIDGVMFSEGDKSPDGRIEVKGQHGRSSLHIRDVKLSDSGRYDCEAASRIGGH-QRSM 393
            |||:|  |...::..:||:..   ..|:||    :|.:..|:.|..|.|.|.|::.:... .:.:
  Fly   166 ITWRREEATPILISDDGDREV---FSVEGQ----NLTLWQVQRSHMGAYLCIASNGVPPTVSKRV 223

Mouse   394 HLDIEYAPKFVSNQTMYYSWEGNPINISCDVTANPPASIH-WRREKLLLPAKNTTHLKTHSVGR- 456
            .|.:.:||...:.....|...|..:.:.| :|.:.|||:: |.|:..||...:...:....|.|
  Fly   224 MLVVNFAPTIWTRYDTIYVGLGQKLTLEC-ITESQPASVNFWLRDSQLLQGGSYESVSVDHVFRI 287

Mouse   457 KMILEIAPTSDNDFGRYNCTATNRIGTRFQEYILELADVPSSPHGVKIIELSQTTAKIS-FNKPE 520
            .|.:.:.|.:..|||.|.|.|.|.:|                          ||...|: .:|.:
  Fly   288 VMRITLRPITKRDFGEYICRAKNAMG--------------------------QTDRIITVHHKAK 326

Mouse   521 SHGGVPIHHYQVDVKE 536
            .||.   |.:|...:|
  Fly   327 KHGQ---HSHQTSSRE 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncam2	NP_001106679.1	Ig1_NCAM-2	21..112	CDD:143274
		I-set	22..111	CDD:254352
		I-set	117..193	CDD:254352
		IGc2	128..189	CDD:197706
		Ig	208..301	CDD:299845	22/95 (23%)
		I-set	215..298	CDD:254352	21/92 (23%)
		Ig	300..397	CDD:299845	31/102 (30%)
		IG_like	308..395	CDD:214653	26/90 (29%)
		IG_like	413..491	CDD:214653	22/79 (28%)
		IGc2	414..482	CDD:197706	21/69 (30%)
		FN3	496..588	CDD:238020	9/42 (21%)
		fn3	594..678	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..810
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	20/88 (23%)
		Ig	39..122	CDD:299845	19/84 (23%)
		Ig	132..213	CDD:299845	29/87 (33%)
		IG_like	141..227	CDD:214653	27/92 (29%)
		IG_like	239..322	CDD:214653	26/109 (24%)
		IGc2	245..313	CDD:197706	21/68 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900