DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ncam2 and DIP-alpha

DIOPT Version :9

Sequence 1:	NP_001106679.1	Gene:	Ncam2 / 17968	MGIID:	97282	Length:	837	Species:	Mus musculus
Sequence 2:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster

Alignment Length:	338	Identity:	81/338 - (23%)
Similarity:	128/338 - (37%)	Gaps:	65/338 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse   117 FREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWL---------YHNEEVTTIPDNRFAVLANN--N 170
            |.|.:|......|.||...|.|.......|.||         .|...:|..|....:.|..|  |
  Fly    44 FVESISNVSVAVGRDATFTCHVRHLGGYRVGWLKADTKAIQAIHENVITHNPRVTVSHLDQNTWN 108

Mouse   171 LQILNINKSDEGIYRCEGRVE-ARGEIDFRDIIVIVNVPPAIMMPQKSFNATAERGEEMTLTCKA 234
            |.|..:::.|.|.|.|:...: .:.:|.|.|::    :||..:....|.:.....|..:.|||:|
  Fly   109 LHIKAVSEEDRGGYMCQLNTDPMKSQIGFLDVV----IPPDFISEDTSSDVIVPEGSSVRLTCRA 169

Mouse   235 SGSPDPTISWFRNGKLIEENEKYILK---GSNT--------ELTVRNIINKDGGSYVCKATNKAG 288
            .|.|:|.::|.|     |:..:.:||   |:.|        .|.:..|...:.|||:|.|:|...
  Fly   170 RGYPEPIVTWRR-----EDGNEIVLKDNVGTKTLAPSFRGEVLKLSKISRNEMGSYLCIASNGVP 229

Mouse   289 ED-QKQAFLQVFVQPHILQLKNETTSE--NGHVTLVCEAEGEPVPEITWKRAIDGVMFSEG---- 346
            .. .|:..|.:...| ::|:.|:....  ...|.:.|..|..|.....|.:....::.:.|
  Fly   230 PSVSKRISLSIHFHP-VIQVPNQLVGAPLGTDVQIECHVEASPKSINYWIKDTGEMIVTSGKYHV 293

Mouse   347 DKSPDGRIEVKGQHGRSSLHIRDVKLSDSGRYDCEAASRIGGHQRSMHLDIEYAPKFVSNQTMYY 411
            .:|.....|.|     .|:.:|..:..|.|.|.|.|.:.:|....|:.|               |
  Fly   294 QESSQSMYETK-----MSMIVRKFQKDDVGSYRCIAKNSLGEVDSSIRL---------------Y 338

Mouse   412 SWEG-----NPIN 419
            ...|     ||:|
  Fly   339 EIPGPNRNKNPLN 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncam2	NP_001106679.1	Ig1_NCAM-2	21..112	CDD:143274
		I-set	22..111	CDD:254352
		I-set	117..193	CDD:254352	23/87 (26%)
		IGc2	128..189	CDD:197706	20/71 (28%)
		Ig	208..301	CDD:299845	28/104 (27%)
		I-set	215..298	CDD:254352	26/94 (28%)
		Ig	300..397	CDD:299845	22/102 (22%)
		IG_like	308..395	CDD:214653	19/92 (21%)
		IG_like	413..491	CDD:214653	4/12 (33%)
		IGc2	414..482	CDD:197706	4/11 (36%)
		FN3	496..588	CDD:238020
		fn3	594..678	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..810
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	21/79 (27%)
		Ig	51..131	CDD:299845	20/79 (25%)
		I-set	144..240	CDD:254352	27/100 (27%)
		IGc2	159..228	CDD:197706	23/73 (32%)
		Ig	244..337	CDD:299845	21/98 (21%)
		I-set	244..337	CDD:254352	21/98 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000