DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ncam1 and DIP-epsilon

DIOPT Version :9

Sequence 1:	XP_006510118.1	Gene:	Ncam1 / 17967	MGIID:	97281	Length:	1162	Species:	Mus musculus
Sequence 2:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	360	Identity:	89/360 - (24%)
Similarity:	140/360 - (38%)	Gaps:	52/360 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse    98 VTAEDGTQSEA------TVNVKIFQKLMF----KNAPTPQEFKEGEDAVIVCDVVSSLPPTIIWK 152
            ::.:.|::..|      |:|..|.:...|    :|...|    .|.:..:.|.|.:.....:.|.
  Fly    26 LSTDTGSEGNAGNVGGSTLNNVISEDPEFTDVIENITVP----AGRNVKLACSVKNLGSYKVAWM 86

Mouse   153 HKGRDVILKKDVRFIVLSNN----------------YLQIRGIKKTDEGTYRCE-GRILARGEIN 200
            |..:..||  .|...|::.|                :|.|..:::.|.|.|.|: ..:.|:.:..
  Fly    87 HFEQSAIL--TVHNHVITRNPRISVTHDKHDKHRTWFLHINNVQEEDRGRYMCQINTVTAKTQYG 149

Mouse   201 FKDIQVIVNVPPTVQARQSIVNATANLGQSVTLVCDADGFPEPTMSWTK-DGEPIENEEEDDEKH 264
            |    |.|.|||.:....:..:.....|.:|||.|.|.|.||||:.|.: ||..|. ..:..|.|
  Fly   150 F----VKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIV-INKTLEVH 209

Mouse   265 IFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQ-DASIHLKVFAKPKITYVENQTAMELEEQVTL 328
            ....||.||  ..:.:.....|:|||.|..... ...|.:.|...|.:........:.:...:||
  Fly   210 DLETDSLEL--ERISRLHMGAYLCIASNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITL 272

Mouse   329 TCEASGDPIPSITW-RTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAG 392
            .|....:|.....| |.:.:.|:...|      .|.||:.||   .|:.....||:.::|.:|.|
  Fly   273 ECFIEANPTSLNYWTRENDQMITESSK------YKTETIPGH---PSYKATMRLTITNVQSSDYG 328

Mouse   393 EYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYT 427
            .|.|.|.|..|....::.|.:...|..|.|....|
  Fly   329 NYKCVAKNPRGDMDGNIKLYMSSPPTTQPPPTTTT 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncam1	XP_006510118.1	Ig1_NCAM-1	20..115	CDD:143273	4/22 (18%)
		IG	124..190	CDD:214652	16/81 (20%)
		Ig3_NCAM-1_like	211..308	CDD:143207	30/98 (31%)
		Ig_NCAM-1	307..413	CDD:143277	26/106 (25%)
		Ig_3	417..494	CDD:372822	4/11 (36%)
		FN3	509..606	CDD:238020
		fn3	649..731	CDD:365830
		PHA03247	<905..1140	CDD:223021
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	22/105 (21%)
		Ig	69..139	CDD:143165	15/71 (21%)
		IG_like	165..249	CDD:214653	27/86 (31%)
		IGc2	172..237	CDD:197706	26/67 (39%)
		IG_like	267..348	CDD:214653	24/89 (27%)
		Ig	270..339	CDD:299845	23/77 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910