DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ncam1 and DIP-zeta

DIOPT Version :9

Sequence 1:	XP_006510118.1	Gene:	Ncam1 / 17967	MGIID:	97281	Length:	1162	Species:	Mus musculus
Sequence 2:	NP_723441.2	Gene:	DIP-zeta / 34231	FlyBaseID:	FBgn0051708	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	423	Identity:	100/423 - (23%)
Similarity:	161/423 - (38%)	Gaps:	90/423 - (21%)

- Green bases have known domain annotations that are detailed below.

Mouse   122 NAPTPQ--------EFKE---------GEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVL 169
            |.||..        ||.|         |.:..:.|.|.:.....:.|.|..:..||  .|...|:
  Fly   100 NVPTSNLNIVVEEPEFTEYIENVTVPAGRNVKLGCSVKNLGSYKVAWMHFEQSAIL--TVHNHVI 162

Mouse   170 SNN----------------YLQIRGIKKTDEGTYRCE-GRILARGEINFKDIQVIVNVPPTVQAR 217
            :.|                ||.|..:.:.|.|.|.|: ..:.|:.:..:.::.|..|:..::.:.
  Fly   163 TRNPRISVTHDKHDRHRTWYLHINNVHEEDRGRYMCQINTVTAKTQFGYLNVVVPPNIDDSLSSS 227

Mouse   218 QSIVNATANLGQSVTLVCDADGFPEPTMSWTKDGEPIENEE-EDDEKHIFSD-DSSELTIRNVDK 280
            ..||...||    ::|.|.|.|.|.|.:.|.:|    :|.. ..::.||.:: :...|.|..:.:
  Fly   228 DVIVREGAN----ISLRCRASGSPRPIIKWKRD----DNSRIAINKNHIVNEWEGDTLEITRISR 284

Mouse   281 NDEAEYVCIAENKAGEQDASIHLKVFAK-PKITYVENQTAMELEE-QVTLTCEASGDPIPSITWR 343
            .|...|:|||.|.. ....|..:||... |.:..:.:|.....|. .||:.|.....| .|:.:
  Fly   285 LDMGAYLCIASNGV-PPTVSKRIKVSVDFPPMLLIPHQLVGAPEGFNVTIECFTEAHP-TSLNY- 346

Mouse   344 TSTRNISSEEKASWTRPE----------KQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTA 398
                         |||.|          |.|...|....::|.:   ||:.::...|.|.|.|.|
  Fly   347 -------------WTRGEGPIIHDSHKYKVEATVGLPAYKTHMK---LTIINVSSGDDGIYKCVA 395

Mouse   399 SNTIGQDSQSMYLEVQYAPKLQGPVAVYT----WEGNQVNITCEVFAY--PSATIS-WFRDGQLL 456
            .|..|:....:.|.|.|.|..... .:|:    |..|.:|   ..:||  |.:|.| :.:|....
  Fly   396 KNPRGETDGIIRLYVSYPPTTASS-GIYSTDTHWGENGIN---NNYAYGGPDSTRSIYAQDKNTR 456

Mouse   457 PSSNYSNIKIYNTPSASYLEVTPDSENDFGNYN 489
            ..||.:.|.:  :...|:|:.|.:.....||.|
  Fly   457 YQSNLNEIGL--SEQKSFLDKTQNPLLANGNAN 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncam1	XP_006510118.1	Ig1_NCAM-1	20..115	CDD:143273
		IG	124..190	CDD:214652	21/98 (21%)
		Ig3_NCAM-1_like	211..308	CDD:143207	26/98 (27%)
		Ig_NCAM-1	307..413	CDD:143277	26/117 (22%)
		Ig_3	417..494	CDD:372822	20/80 (25%)
		FN3	509..606	CDD:238020
		fn3	649..731	CDD:365830
		PHA03247	<905..1140	CDD:223021
DIP-zeta	NP_723441.2	IG_like	120..216	CDD:214653	18/97 (19%)
		Ig	130..200	CDD:143165	16/71 (23%)
		I-set	226..310	CDD:254352	26/92 (28%)
		IGc2	233..298	CDD:197706	21/72 (29%)
		Ig	313..410	CDD:299845	26/114 (23%)
		IG_like	325..410	CDD:214653	24/102 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910