DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ncam1 and DIP-theta

DIOPT Version :9

Sequence 1:	XP_006510118.1	Gene:	Ncam1 / 17967	MGIID:	97281	Length:	1162	Species:	Mus musculus
Sequence 2:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster

Alignment Length:	368	Identity:	85/368 - (23%)
Similarity:	152/368 - (41%)	Gaps:	55/368 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse   119 MFKNAPTPQEFKEGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNY---------- 173
            :.:|...|    ...:||:.|.|.:.....|.|.......||  .::..|::.|:
  Fly   135 LLQNVTVP----VSREAVLQCVVDNLQTYKIAWLRVDTQTIL--TIQNHVITKNHRMSITHAEKR 193

Mouse   174 ---LQIRGIKKTDEGTYRCE-GRILARGEINFKDIQVIVNVPPTVQARQSIVNATANLGQSVTLV 234
               |:||.:|::|:|.|.|: .....:.::.:.|    |.|||.:....:..:.....|.:|||.
  Fly   194 AWILRIRDVKESDKGWYMCQINTDPMKSQVGYLD----VVVPPDILDYPTSTDMVIREGSNVTLK 254

Mouse   235 CDADGFPEPTMSWTKDGE---PIENEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENKAGE 296
            |.|.|.|.||::|.::|.   |:.|..|     ..:.:.|.|||..|::.:...|:|||.|....
  Fly   255 CAATGSPTPTITWRREGGELIPLPNGAE-----AVAYNGSFLTIAKVNRLNMGAYLCIASNGIPP 314

Mouse   297 QDASIHLKVFAKPKITYVENQ-TAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRP 360
            ..:...:.:...|.:.:::|| ....|.:.:||.|::...|.....|..:...|...|:..   |
  Fly   315 TVSKRVMLIVHFPPMIWIQNQLVGAALTQNITLECQSEAYPKSINYWMKNDTIIVPGERFV---P 376

Mouse   361 EKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAV 425
            |..|:  |:.:      ...||:..:...|.|.|.|.|.|::|....:  :::.:.|:
  Fly   377 ETFES--GYKI------TMRLTIYEVDIQDFGAYRCVAKNSLGDTDGA--IKLYHIPQ------- 424

Mouse   426 YTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYN 468
             |.....:..|..:...|...:.:.:: |...||..||...||
  Fly   425 -TTTMTTMAPTVSINTVPVVLVKYNKE-QRYGSSQNSNTNPYN 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncam1	XP_006510118.1	Ig1_NCAM-1	20..115	CDD:143273
		IG	124..190	CDD:214652	18/78 (23%)
		Ig3_NCAM-1_like	211..308	CDD:143207	27/99 (27%)
		Ig_NCAM-1	307..413	CDD:143277	24/106 (23%)
		Ig_3	417..494	CDD:372822	11/52 (21%)
		FN3	509..606	CDD:238020
		fn3	649..731	CDD:365830
		PHA03247	<905..1140	CDD:223021
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	22/102 (22%)
		IG_like	137..230	CDD:214653	22/102 (22%)
		IG_like	240..324	CDD:214653	25/88 (28%)
		IGc2	247..310	CDD:197706	24/67 (36%)
		Ig	327..419	CDD:299845	24/104 (23%)
		IG_like	343..420	CDD:214653	20/89 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910