DRSC/TRiP Functional Genomics Resources

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Protein Alignment DOK1 and Dok

DIOPT Version :10

Sequence 1:NP_001372.1 Gene:DOK1 / 1796 HGNCID:2990 Length:481 Species:Homo sapiens
Sequence 2:NP_572391.1 Gene:Dok / 31667 FlyBaseID:FBgn0029944 Length:622 Species:Drosophila melanogaster


Alignment Length:475 Identity:114/475 - (24%)
Similarity:178/475 - (37%) Gaps:133/475 - (28%)


- Green bases have known domain annotations that are detailed below.


Human     5 VMEGPLFLQSQ------RFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRLDCK 63
            |:.|.|.:.:|      |...|:....:.:|:.||.||:||||..:.|...:.           |
  Fly     7 VLAGYLNVPTQTGFSLNRISKKKACSRYCLLFKASRHGIARLEMCESKEDRNP-----------K 60

Human    64 VIRLAECVSVAPVTVETPPEPGATAFRL-DTAQRSHLLAADAPSSAA---WVQTLCRNAFPKGSW 124
            :..|..||.   :|.|.|||      || ...:|...|.....|...   |:..|         .
  Fly    61 IFTLENCVK---ITQEPPPE------RLIHIVKRQATLTLSTSSEEELKDWITAL---------Q 107

Human   125 TLAPTDNPPK--LSALEMLENSLYSPTWEGSQFWVTVQRTEAAERCGLH-GSYVLRVEAERLTLL 186
            |:|..|..|.  :.|:|. :|.||..:::| .|.:|:..:||:.||.:. .:|:|::....|.|.
  Fly   108 TVAFCDTSPSGGIGAIEE-DNDLYCSSFDG-LFIITLIPSEASIRCCIEPKTYMLQMTPTELQLK 170

Human   187 T--VGAQSQILEPLLSWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVETAI 249
            :  :||      .:..|||..:|:||.....|:|||||:|.:|.|.||.......::|:.:..  
  Fly   171 SEDLGA------TIAMWPYRFIRKYGYRDGKFTFEAGRKCTTGEGVFTLDHTNPQEVFRCMSA-- 227

Human   250 HRQKAQGK--AGQGHDVLRADSHEGEVAEG-----KLPSPPGPQ--------ELLDSPPALYAEP 299
             :.|:..|  :|.....|....::...|.|     :.|.||.|.        |:..:...:    
  Fly   228 -KMKSMKKLISGDSLSTLECGENQFSAAAGMEPGSRSPLPPSPSSNPHGGEFEINSTQSCI---- 287

Human   300 LDSLRIAPCPSQDSL----------------------------YSDPLDSTS-AQAGEGVQRKKP 335
              ||| ....|.|||                            .|.|.:|.| :.:.:.:..|.|
  Fly   288 --SLR-GFISSNDSLNNFSAGGGGASGATATGGGVLGSTGGITLSVPANSNSNSSSSKHIPNKPP 349

Human   336 -----LYWDLYEH----------------AQQQLLKAKLTDPKEDPIYDEPEGLAPVPPQGLYDL 379
                 .:.|.|.:                |...:..:.:..|.|......||..|.:||    ||
  Fly   350 RKSPTTHCDKYRNIVKYEPVAITTISSPSANSDVNSSVILKPLEGESISLPETAADLPP----DL 410

Human   380 PREPKDAWWCQARVKEEGYE 399
            |...:.|  .:|...|..||
  Fly   411 PLRNESA--SKAPPPERDYE 428

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DOK1NP_001372.1 PH-like 6..119 CDD:473070 31/122 (25%)
PTB_DOK1_DOK2_DOK3 151..253 CDD:269914 31/104 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 270..293 7/35 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 307..329 8/50 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 404..481
DokNP_572391.1 PH 6..107 CDD:459697 32/128 (25%)
IRS 138..233 CDD:460473 31/103 (30%)
Blue background indicates that the domain is not in the aligned region.

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