Protein Alignment Naip5 and Diap2

DIOPT Version :9

• Sequence 1: NP_035000.2
• Gene: Naip5 / 17951
• MGIID: 1298220
• Length: 1403
• Species: Mus musculus
• Sequence 2: NP_477127.1
• Gene: Diap2 / 36748
• FlyBaseID: FBgn0015247
• Length: 498
• Species: Drosophila melanogaster
• Alignment Length: 456
• Identity: 116/456 - (25%)
• Similarity: 186/456 - (40%)
• Gaps: 88/456 - (19%)

Mouse    57 MRSEAKRLKTFETYDTFRSWTPQEMAAAGFYHTGVRLGVQCFCCSLIL----FGNSLRKLPIERH 117
            |..|:.||.||..:......:.:::.|.||:.||..|..:|..|.:.:    :|:.:    .|||
  Fly     6 MELESVRLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQV----AERH 66

Mouse   118 KKLRPECEF-LQGKDVGNIGKYDIRVKRPEKMLRGGKARYHEEEA-----------RLESFEDWP 170
            ::..|.|.. |.....||       |.|.::....|.:.....|:           ||.:|:|||
  Fly    67 RRSSPICSMVLAPNHCGN-------VPRSQESDNEGNSVVDSPESCSCPDLLLEANRLVTFKDWP 124

Mouse   171 FYAHGTSPRVLSAAGFVFTGKRDTVQCFSCGGSLGNWEEGDDPWKEHAKWFPKCEFLQSKKSSEE 235
              ....:|:.|:.|||.:..:.|.|:|..|.|.:..||:.|:.::||.::||:|..:|.....|
  Fly   125 --NPNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAFEEHKRFFPQCPRVQMGPLIE- 186

Mouse   236 IAQYIQSYEGFVHVTGEHFVKSWVR-RELPMVSAY-CNDSVFANEELRMDMFKDWPQESPVGVEA 298
                        ..||::..:..:: ..||:...| |.|:       |:..|.|||..:.....|
  Fly   187 ------------FATGKNLDELGIQPTTLPLRPKYACVDA-------RLRTFTDWPISNIQPASA 232

Mouse   299 LVRAGFFYTGKKDIVRCFSCGGCLEKWAEGDDPMEDHIKFFPECVFLQTLKSSA---EVI----- 355
            |.:||.:|....|.||||.|...|..|.:.|:|..:|.|:.|:|.|:...|..|   ||:
  Fly   233 LAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPWFEHAKWSPKCQFVLLAKGPAYVSEVLATTAA 297

Mouse   356 -----------PTLQSQYALPEATETTRESNHGDAAAVHSTVVDLGRSEAQWFQEARSLSEQLRD 409
                       ||||:...:.||......:...|...|.:.:.....|....|.   :|.|.|.|
  Fly   298 NASSQPATAPAPTLQADVLMDEAPAKEALALGIDGGVVRNAIQRKLLSSGCAFS---TLDELLHD 359

Mouse   410 NY----TKATFRHMNLPEVCSSLGTDHLLSCDVSIISKHISQPVQEALTIP------EVFSNLNS 464
            .:    ..|.......||..:..    :..|..: .||..|.|:..|.:||      |..:|::.
  Fly   360 IFDDAGAGAALEVREPPEPSAPF----IEPCQAT-TSKAASVPIPVADSIPAKPQAAEAVANISK 419

Mouse   465 V 465
            :
  Fly   420 I 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Naip5	NP_035000.2	BIR 1	60..127		19/71 (27%)
		BIR	61..129	CDD:237989	19/72 (26%)
		BIR 2	159..227		25/78 (32%)
		BIR	162..228	CDD:366227	24/65 (37%)
		BIR 3	278..345		24/66 (36%)
		BIR	279..346	CDD:237989	25/66 (38%)
		NACHT	464..618	CDD:368582	0/2 (0%)
		NOD2_WH	688..743	CDD:375327
		NLRC4_HD	767..873	CDD:375406
		leucine-rich repeat	1055..1078	CDD:275380
		AMN1	1072..1271	CDD:187754
		leucine-rich repeat	1079..1100	CDD:275380
		leucine-rich repeat	1104..1130	CDD:275380
		leucine-rich repeat	1132..1156	CDD:275381
		leucine-rich repeat	1157..1182	CDD:275381
		leucine-rich repeat	1183..1207	CDD:275381
		leucine-rich repeat	1208..1236	CDD:275381
		leucine-rich repeat	1265..1293	CDD:275381
		leucine-rich repeat	1294..1322	CDD:275381
Diap2	NP_477127.1	BIR	12..78	CDD:237989	18/69 (26%)
		BIR	112..181	CDD:197595	24/70 (34%)
		BIR	213..281	CDD:237989	26/74 (35%)
		UBA_IAPs	320..363	CDD:270506	9/45 (20%)
		zf-C3HC4_3	447..492	CDD:290631

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830703
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.700