DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DOCK3 and spg

DIOPT Version :10

Sequence 1:XP_005264971.1 Gene:DOCK3 / 1795 HGNCID:2989 Length:2071 Species:Homo sapiens
Sequence 2:NP_733258.4 Gene:spg / 43404 FlyBaseID:FBgn0264324 Length:2187 Species:Drosophila melanogaster


Alignment Length:2203 Identity:818/2203 - (37%)
Similarity:1200/2203 - (54%) Gaps:299/2203 - (13%)


- Green bases have known domain annotations that are detailed below.


Human     1 MWTPTEEEKYGVVICSFRGSVPQGLVLEIGETVQILEKCEGWYRGVSTKKPNVKGIFPANYIHLK 65
            ||.|: ..||||.|.::.|.|..||.|::|::|.|:|:|:.||||...:|....|:||..|||:|
  Fly     1 MWIPS-NNKYGVAIHNWHGDVRFGLALDVGDSVDIVEECKHWYRGSCPRKSRAVGLFPKTYIHIK 64

Human    66 KAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRRQLL 130
            .            :...|.:|.|.|..|:||:.:||:|||..:...|..||.||..:::.||:||
  Fly    65 D------------LSKIDPVVAECTQVLREWSEIWKRLYVDREAYKFQTLRKVMFSILESRRELL 117

Human   131 SGHLTQDQVREVKRHITVRLDWGNEHLGLDLVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQST 195
            |..:||||..|::..:..::||||..||||||||:....||...|.:..||.:|:||..:.:.|:
  Fly   118 SATMTQDQTLELQMVVVSKIDWGNRKLGLDLVPREGPLAVDPHGIGIVKLYNVHVSSADNAKASS 182

Human   196 SQVDTMRPRHGETCRMPVPHHFFLSLKSFTYNTIGEDTDVFFSLYDMREGKQISERFLVRLNKNG 260
            |: .|:|.:   |.|..:.||.:..::.|.:...|:|.:|:|.|||....:.:||||||:::|:|
  Fly   183 SR-GTLRRK---TQRKILTHHLYFCMRDFGHRIGGDDAEVYFFLYDGSHMRPLSERFLVKISKDG 243

Human   261 GPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRMLLNDSKK----------GPPHLHYRR 315
            .....|::...|.:||||.:.|:..:|::||.|:|:|:::.:||.|          ||.   :||
  Fly   244 FSNYIERLHSNCTVFTDLGAADLNEELHLVAVVMRVGKIIQSDSIKKIEKSGTLGHGPT---FRR 305

Human   316 PYGCAVLSILDVL---QSLTEVKEEKDFVLKVYTCNNESEWSQIHENIIRKSSAKYS---APSAS 374
            |:|..|||:.|:.   .||.:..:|:::..|::.| .|.::..:.|.||:|||.|||   |...:
  Fly   306 PFGVGVLSLGDIAHFDSSLEQSSDEREYNFKLFQC-EEKDFHLLPELIIKKSSGKYSPIQASQGT 369

Human   375 HGLIISLQLLRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPGDIRNDLYLTLEKGDFERGGKS 439
            .|:::||:||.|.:.|.|:|.||:| :|..||||:||||||||||:||||:|.||:|:||||||:
  Fly   370 QGIVVSLKLLHGGLGQARQEQPMLF-QGSTITRKMGFPDVIMPGDVRNDLFLNLERGEFERGGKN 433

Human   440 VQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSH 504
            ..|||.||:.||...|.:|.||:...||..::..|.|.:|||.|:|.|.|:::|.:|||:|..:|
  Fly   434 TGKNILVTVVVLDVAGNVLTDCLWGASGMESQPQYRSMILYHQNAPSWNEMLRLSVPIDKFSTAH 498

Human   505 LRFEFRHCSTKDKGEKKLFGFAFSTLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLPC-- 567
            :|||||||||:||.|.|||.|:|:.||...|.||.|.:||||||||::.:.. ..|.||.|.|  
  Fly   499 VRFEFRHCSTRDKTEPKLFAFSFARLMDTGGATLGDGLHELYVYKCEDPAKL-QVANYLRLQCRP 562

Human   568 ----CKEDYNGCPNIPSSLIFQRSTKESFFISTQLSSTKLTQNVDLLALLKWKAFPDRIMDVLGR 628
                .|.|..||        |.||:||.|.:.:.|.|||||||.|||:||:|:.:|:.|.|.|..
  Fly   563 RDAQAKMDCGGC--------FSRSSKEVFVLRSLLCSTKLTQNADLLSLLQWRTYPETIQDSLTG 619

Human   629 LRHVSGEEIVKFLQDILDTLFVIL---DDNTEKYGLLVFQSLVFIINLLRDIKYFHFRPVMDTYI 690
            :..::.||:||||||:||.||.:.   :.|:.::..|||..||.|.:||:..|:.||||||:.||
  Fly   620 VLRLNDEELVKFLQDVLDALFAMFSNEEGNSTQHSGLVFHVLVSIFSLLQSNKFQHFRPVMNEYI 684

Human   691 QKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQSRILYSRATCGMEEEQ 755
            :.|||.||.||.||..::.......:....|..|:...:|||:||.::|||.|::|||.|..|:.
  Fly   685 ENHFAAALVYKGLITSVEHMAVFMTKAEHPDPFQKCFGSLEYIFKLLIQSRKLFARATGGQYEDS 749

Human   756 FRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMP 820
            |:..:..||.::..:|::.|  .:.::.||.|||||...:.::|.......|:....|..|.::|
  Fly   750 FKRDLHSLFTALNGMLAVPS--YDVIIPTQEALLNSTGVVLEQLKDTLPAPELGMLARNMLDAIP 812

Human   821 --STVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKELLICSGILGSI 883
              :.:.:.|:    ||.::...|...||...:||.::|.|...|:.:||.::.||.:|:.||..|
  Fly   813 RGAPIRLIQA----KLHAVKDLVSGELFHEDDSRTVVLSVACKHLRMHLSRRDELRLCAEILSEI 873

Human   884 FSIV----------KTSSLEADVMEEVEMMVESLLDVLLQTLLTIMSKSHAQEAVRGQRCPQCTA 938
            .|.:          .|::|:.|    ::.:.:::|.:|::|:..||..|:|              
  Fly   874 LSQLYDLQKEQREKVTNTLQHD----LDSLCKNILGILIRTISIIMEGSNA-------------- 920

Human   939 EITGEYVSCLLSLLRQMCDTHFQHLLDNFQ-SKD--ELKEFLLKIFCVFRNLMKMS--VFPRDWM 998
             :..:.|||||.||:.:.:||::...|... :||  :|||||.|...|:..|:...  |||.||:
  Fly   921 -VLPQLVSCLLGLLQLLDETHYKRYWDELSPNKDPRDLKEFLSKSLLVYEELLTQDWHVFPNDWL 984

Human   999 VMRLLTSNIIVTTVQYLSSALHKNFTETD-FDFKVWNSYFSLAVLFINQPSLQLEIITSAKRKKI 1062
            ||:|..::::..:::..:..|...|.... ||.::|.|||||||.|:.|||||||.....||.||
  Fly   985 VMKLAANDVLRMSLEEFAKPLVYRFLGPQAFDSQLWWSYFSLAVAFLTQPSLQLEQYREPKRLKI 1049

Human  1063 LDKYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQR 1127
            |..:|||||:|.:::.|||..|||.|:||||.|:||||.|||||:|.:|...:.:|:|||..||.
  Fly  1050 LHSHGDMRVLMGFQILSMWSQLGEQKLHFIPSMVGPFLEVTLVPEPALRKATLSVFYDMMQCEQA 1114

Human  1128 KNGNFKQVEAELIDKLDSMVSEGKGDESYRELFSLLTQLFGPYPSLLEKVEQE--TWRETGISFV 1190
            ..|:|:.||:|||||||.::||.|||:.||||||.:         |||||:.|  .|:|.||:|:
  Fly  1115 ARGSFRLVESELIDKLDLLISENKGDDEYRELFSTI---------LLEKVQVENPNWKEAGIAFI 1170

Human  1191 TSVTRLMERLLDYRDCMKGEETENKKIGCTVNLMNFYKSEINKEEMYIRYIHKLCDMHLQAENYT 1255
            .|||||:|||||||..|:|||..:|::.|||||:||||:|||::|||:|||:||.::||||||||
  Fly  1171 ASVTRLLERLLDYRSVMQGEENRDKRMTCTVNLLNFYKNEINRKEMYLRYIYKLHNLHLQAENYT 1235

Human  1256 EAAFTLLLYCELLQWEDRPLREFLHYPS--QTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELA 1318
            ||.|||.||..:|.| ||..:.|..:.:  |.||||||.|..:|:.||:|||.||.|||||:|||
  Fly  1236 EAGFTLKLYASMLSW-DRETQSFAPFDNSGQPEWQRKERLYHEILKYFDKGKCWEKGIPLCKELA 1299

Human  1319 CQYES-LYDYQSLSWIRKMEASYYDNIMEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYER 1382
            ..||: .:||..||.|...||.::.||:.|.|.|||:|||||||...|.|:|||::|.||.:|||
  Fly  1300 HLYETRRFDYNKLSEILIQEAKFFQNILTQLRPEPEYFRVGFYGMGLPLFVRNKQFVYRGLEYER 1364

Human  1383 LEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPDYVDVLQ--MDRVPDRVKSF 1445
            :.||.||:.:|||.|..:.:.:.||:|||....||:||..|.|:.| ...|:  |..||:::..|
  Fly  1365 IGAFTQRLQTEFPSAQILGNNSPPDNAILNAPDQYIQISNVRPVGD-AQALKTAMVPVPEKIARF 1428

Human  1446 YRVNNVRKFRYDRPFHKGPKDKENEFKSLWIERTTLTLTHSLPGISRWFEVERRELVEVSPLENA 1510
            |.||:|.:|.||||.:||..||:|||||||||||.|.:...||||.||:||:::.:.|::|:|.|
  Fly  1429 YEVNDVTRFIYDRPMYKGTVDKDNEFKSLWIERTILEIASPLPGILRWYEVKQKTMQELTPVEYA 1493

Human  1511 IQVVENKNQELRSLISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQEAFFDKDYINKHP-- 1573
            .:::.|..:||..||.||: :....|||..||.|.|.|||.|.|||::||||||.:.:: |.|  
  Fly  1494 CEIISNAGKELSELIVQYK-RDPKRNINPFSMRLQGTIDANVMGGISKYQEAFFSEQFL-KSPQG 1556

Human  1574 -GDAEKITQLKELMQEQVHVLGVGLAVHEKFVHPEMRPLHKKLIDQFQMMRASLYHEFPGLDKLS 1637
             |....:.:||.|:.||:.:|...|.:|.:.....::|||.:|:::|..::.||           
  Fly  1557 AGQQANVQRLKVLILEQIQILEQALELHGQLAPSGVQPLHNRLLERFSQLKQSL----------- 1610

Human  1638 PACSGTSTPRGNVLASHS------PMSPESIKMTHRHSPMNLMGTGRHSSSSLSSHASSEAGNMV 1696
               ||    .|.:...||      |:.|  :....|.:|..       :||||:::|.|   |.|
  Fly  1611 ---SG----MGRLKRQHSESIVNTPLPP--LPTEQRVAPAT-------ASSSLNANAHS---NYV 1656

Human  1697 --------MLGDGSMGDAPEDLYHHM---QLAYP-----------NPRYQGSVTNVSVLSSSQAS 1739
                    ..||......|...|..:   .|:.|           .||.|..:.|.|:.|.....
  Fly  1657 YDLDEIYTRPGDTVRPVDPLSSYQTLSKESLSIPLEDTAAPPVPNRPRSQNFIGNGSMDSPEVPP 1721

Human  1740 PSSSSLSSTHSAPSQMITSAPSSARGSPSLPDKY--------RHAREMMLLLPTYR------DRP 1790
            ....:|:|.::.|.......|.....:|.:.:.:        ||:::.......|.      |.|
  Fly  1722 KRQPTLNSPNAPPLPPRGITPDKRASNPLIFNDFGSGDAVGRRHSQQQQQHGQKYSVVDISYDDP 1786

Human  1791 SSAMYPAAILENGQPPNFQRALFQQVVGACKPCSDPN---------------------------- 1827
            .:...|.::     |||||    ....|....|..||                            
  Fly  1787 EADQQPHSL-----PPNFQ----DGSGGHLSVCFAPNDFRDSGISTTSSRELNHMNLNNLSEDSS 1842

Human  1828 ----LSVAEKAVPAAPSSWSLDSGAQEAQPFLSAHMGR---------ILAPPVPPRSLLHGHYSL 1879
                ::|..:......|:.|||..|..:..........         :..||:||:||......:
  Fly  1843 SISTITVQHREHCRISSNGSLDYNAAASMNITQRESSTSSFDVEDFPVPPPPIPPKSLAVSSNGV 1907

Human  1880 HF--DAFHHPLGDTPPALPARTLRKSPLHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSESN- 1941
            :|  |..|.|                  ||...:.|:..:.:...|...|.::...:......: 
  Fly  1908 NFSLDEAHSP------------------HPSTQANTTQLNHIQNPNQNHSTNSHHHLQQQQNGDG 1954

Human  1942 FGHSSEAPPRTDTMDSMPSQAWNADEDLEPPYLPVHYSLSESAVLDSIKAQP----------CRS 1996
            .|:|:...|....  .:|:        |.||...|...:..||:..|..:..          ||.
  Fly  1955 DGYSTLQHPMNGL--GLPT--------LPPPPSAVESPMPASAIASSTSSHQHDGGTFXVTICRC 2009

Human  1997 HSAPGCVIPQDPMDPPALPPKPYHPRLPALEHDEGV--LLREETERPRGLHRKAPLPP 2052
            |            .||..|.:|:.|.......|...  ...|.||.....|...|.||
  Fly  2010 H------------HPPDQPHQPHKPSSSTSTSDSTATDTASESTESSSSTHSMTPPPP 2055

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DOCK3XP_005264971.1 SH3_DOCK3_B 10..65 CDD:212981 25/54 (46%)
DOCK_N 73..412 CDD:465040 131/354 (37%)
C2_Dock-B 420..609 CDD:176077 96/194 (49%)
DHR2_DOCK3 1235..1626 CDD:212577 191/398 (48%)
PHA03247 <1752..2052 CDD:223021 64/369 (17%)
spgNP_733258.4 SH3_DOCK_AB 9..64 CDD:212805 25/54 (46%)
DOCK_N 67..406 CDD:465040 131/347 (38%)
C2_Dock-B 414..600 CDD:176077 96/194 (49%)
DHR2_DOCK 1215..1610 CDD:471388 191/398 (48%)

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