DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Naip1 and Bruce

DIOPT Version :9

Sequence 1:NP_032696.2 Gene:Naip1 / 17940 MGIID:1298223 Length:1403 Species:Mus musculus
Sequence 2:NP_001262460.1 Gene:Bruce / 41260 FlyBaseID:FBgn0266717 Length:4976 Species:Drosophila melanogaster


Alignment Length:1739 Identity:318/1739 - (18%)
Similarity:522/1739 - (30%) Gaps:671/1739 - (38%)


- Green bases have known domain annotations that are detailed below.


Mouse    57 MRSEAKRLKTFETYDTF-RSWT-PQEMAAAGFYHTGVKLG---VQCFCCSLILFGNSLRKLPIER 116
            |.|||.|.:|||.:... ..|. |.:||.|||||.....|   ..||.||:.|........|...
  Fly   245 MHSEAVRRQTFEKWPHMDYKWALPDQMAQAGFYHQPSSSGEDRAMCFTCSVCLVCWEKTDEPWSE 309

Mouse   117 HKKLRPECEFLQGKDVGNIGKYDIRVKSPEKMLRG----------------------GKARYHEE 159
            |::..|.|.|::|:...|:........:|.....|                      |:......
  Fly   310 HERHSPLCPFVKGEYTQNVPLSITYATNPALPAPGLGFDIISNSDYANVLCTSCSQTGELSVWSI 374

Mouse   160 EARL-----------------ESFEDWPFYAHGTSPRVL-------------SAAGFVFTGKRDT 194
            |..|                 ||||    :|..|:..||             |||.:..:|..:.
  Fly   375 ERHLKLMHTFHVPTLLNYIFEESFE----WARVTAICVLPNARARTKVNYVYSAANYGGSGSSNG 435

Mouse   195 VQCFS-----CGGSLGNWEEGDDPWKEHAKWFPKCEFLQS-------------KKSSEEIA---- 237
            ..|.|     .||..|:         .:|:.......|::             ::||.|:|    
  Fly   436 AGCNSGLNAVSGGKFGS---------VNAQHITSTSTLRAGVVGSKIVLGVSVRQSSGELALRMV 491

Mouse   238 --------------QYIQGYEGFVHVTGEHFVNSWVRRELPM--VSAYCNDSVF-ANEELRMDTF 285
                          ..:....|.|...|...:.|    ..||  |||..|.:|. .|.|.:.|..
  Fly   492 VLNIVEVDRNSESSTSVSNDSGSVSSGGGQLMKS----SSPMVNVSAENNATVTQVNLESKDDDN 552

Mouse   286 KDW-PHE---SPVAVDALVRAGLFYTGKKGIVQCFSCGGCM---EKCTEGDDPIQEHNKFFP--- 340
            |.. |:|   .....:..|.|.:.|....|:.|.......:   :.||...  |.:||...|   
  Fly   553 KAMTPYEKFADGFDSNGFVSALMTYNKNNGVSQNTDDASALYDFDLCTLSQ--ILDHNLEEPLSL 615

Mouse   341 -------------------------------------------------------NCVFLQTPKS 350
                                                                   |.:......|
  Fly   616 MVGSSNTVNVSNIGMGNEINKLVVDVEISHQNNNNNNNNNNEASSLGGNSSNNNNNIMINGGTNS 680

Mouse   351 SAEVIPALQS-HC------------ALPEAMETTSESNHDD------------------------ 378
            |.:.:.|::. .|            ||..|....:..||.|                        
  Fly   681 SIDKMTAIEEIDCVVESWTSVKRMNALDGASSGVNGVNHMDQEVIEIAEILPTTPKCNQLLVKLL 745

Mouse   379 ----PAAVHSTVV--GLGRSEAQWFQEARSLSEQLRDN-----------------------YTKA 414
                |.|..|.::  .:.:.|.:..:|.|:......||                       ||.|
  Fly   746 RTKAPEAEGSKIIMATVAKEEEEEDEEQRTDESMETDNNAEGNVAAQLLVFDYDDTEISNDYTLA 810

Mouse   415 -TFRHMNLP-EVC----SSLGTDH------LIGCDVSIISKHISQPVQGALTIPEVFSNLSSVMC 467
             ||.....| ::|    .:...:|      .:.|....:..:.....||.:.|.|...:..||:.
  Fly   811 MTFSRAKFPKQLCILPHFNSSPEHKDAGSICVVCADGTVEIYSLADFQGTMVIEEEGEHFESVVY 875

Mouse   468 VEGETGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSITPDQGLANIICAQLLGAGGCISE 532
            ...         |.|:.      ||.  .:..|:|| |||....|.|                  
  Fly   876 CRN---------LDRLC------CCS--RQGGLLFY-SLSDGENDSG------------------ 904

Mouse   533 VCLSSIIQQLQHQVLFLLDDYSGLASLPQALHTLITK--NYLSRTCLLIAVHTNRVRGIRSYLDT 595
                       .::|.:.||.|  .:|.||....:|.  ..|:||.||   ....:......:|.
  Fly   905 -----------DELLEMDDDCS--TTLTQAADVSVTDGGRQLARTDLL---GKTLLANESICMDA 953

Mouse   596 SLEIKEFPLSNTVYILKKFFSHNIKRLLEFMVYFGQNEDLQGIH--KTPLFVAAVCTD---WFEN 655
            ..|....|.|::.                          .||.|  .:|...:|..|:   ....
  Fly   954 GSEAAAIPNSSSA--------------------------AQGAHVQTSPSASSAPSTNANLLAYK 992

Mouse   656 PSDQPFQDMALFKSYMQY---LSLKHKGAAKPLQATVSSC----GQLALTGLFSSCFEFNSDDLA 713
            .:|...:|:.:|.:..|:   |::        ..|.|.||    ||:...       ...|.::.
  Fly   993 TADLTLEDLKVFYALTQFDDKLTV--------YSAEVPSCWNDIGQVQNQ-------RKQSQNMR 1042

Mouse   714 EAGVDEDEELTTCLMSKFTAQRLRPVYRFLGPLFQEFLAAMRLTELLSSDRQEDQDLGLYYLRQI 778
            ..|.:.|...|..|.:..|.             :.|.:..:.|.:.:|...   .||.....:|.
  Fly  1043 HGGDERDFTRTWRLHNDATT-------------WDEHIIELNLAQPVSLGH---IDLKFTVYQQC 1091

Mouse   779 NSP----LKALTTYNNFLKYVFSHPSSKAGPTVVS---HLLHLVDETELLENTYKNEDYVNHPPG 836
            ::|    :..|...||...|....|.|...|.|:.   .|.::.:|..:|...|    .:.|   
  Fly  1092 SNPAAIQVTLLKQNNNGFGYRMKGPHSSYKPNVIDDNIDLSYIANENPVLSEEY----LLAH--- 1149

Mouse   837 TSRIMKGLKEL-------------WLLSPEYYSSFVSEHLLRIALNFAYESNTVAECSPFILQFL 888
            .:.::.|..||             .|.||:.:.:.....||.|        .||::.|.      
  Fly  1150 NAEVLAGPIELSSCIDLCDQGGTATLTSPKLFKTRTRNFLLHI--------KTVSDPSK------ 1200

Mouse   889 RGRTLALKVLNLQYFRDHPESLLLVKSLEVSINGNKVPK-----------VVDYSVME------- 935
            .|:...         ||.|........:|..:..|||.:           ||..:|:|       
  Fly  1201 DGQNKT---------RDSPTRHKRPHHVEGFVERNKVSRNPFNVAANIISVVKTAVLEVFPAAKN 1256

Mouse   936 ---KSFETLQPPTID--------------QDYASA--------FEQMKEHE--KNLSENEETIKS 973
               |..:..:|.|.|              |..::|        .||:...|  ..|.|...::::
  Fly  1257 ACVKIIQVNKPKTQDNEKVFVAKIIKNKTQSQSAAVAPSVGRRLEQLPSREGCDWLHEISISVRA 1321

Mouse   974 IKNIFPLQPPKISSGYWKLSPKPCKIPRLEVGVTNMGPADQALLQVLMEVFS--ASQSIEFRLS- 1035
            :|:     ..:||:|..:      :|..||..|         ||..|:.:.|  ||.|:...|| 
  Fly  1322 VKS-----HSRISNGRMQ------RIAMLESNV---------LLVQLLRIASDPASSSLAKNLSL 1366

Mouse  1036 DSSGFLESIR------PALELSKASVTKCSMSRLE---------LSRAEQE-------------- 1071
            |...::..||      |..|..|..:.|.:.:.::         :|.||:.              
  Fly  1367 DILNWICFIRLNRFRSPKSERLKDQINKQTAANIQDLLAQQFECISLAEKHIEQLLRNCVIYSER 1431

Mouse  1072 ----------LLLT-----LPA-LQ-------SLEVSETNQLPD----------QLFHNL----- 1098
                      ::||     ||| :|       |.:.:..|..|:          :.:..|     
  Fly  1432 STAHKCVKLLIMLTEGATNLPAEVQDHTTLDYSFKAAIANTFPELPRAQCGSVVRWYMMLTCATS 1496

Mouse  1099 ----HKFLG------LKELCVRLD-----------------GKPDVLSVLPGEFPNLLHMEKLSI 1136
                |..:.      |||:...:|                 |.|....:...:|||:        
  Fly  1497 TAESHNSISEQAISLLKEIAAEIDKRWDPHCALLCTRFGLYGYPFEPEIFDFDFPNV-------- 1553

Mouse  1137 RTSMESDLSKLVKLIQNSPNLHVFHLKCDFLSNCDSLMAVLASCKKLREIEFSGRCFEAMPFVNI 1201
              |.:...|.:..:|::||.:               |.......|:|..|:  |..|...|:: |
  Fly  1554 --SRQGPGSSVANVIRSSPTI---------------LPVTGLDIKRLSSID--GVDFRTFPYL-I 1598

Mouse  1202 LPNFISLK---ILNLISQQFPDKETSEKFAQALGSLRNLEELLVPTGDGIHQVAKLIVRQCLQLP 1263
            ....||.:   :|.::...|...:|||     ...:.|::.:...||      |.:|:...:.:|
  Fly  1599 RGKSISNQLRGLLEVVQLHFNCVQTSE-----ATRIDNIDSVGGNTG------ANVIIEDVMMMP 1652

Mouse  1264 CLRVLAFH--------YILDNDSVIEIARVATSGGFQKLEKLDL------------------SMN 1302
             .:|:|..        .:.|.:.::|..:|..:   :|.||:|.                  |:.
  Fly  1653 -KQVVAKEKGEEMLNDLVNDVECLVEEMKVDEN---EKQEKVDYDAFGLVNGFKDKTLSSLNSVK 1713

Mouse  1303 HKITEEGYRNFFQALDNLPNLQNLNICRHIPECIQVQATTVKALGQCVS 1351
            ..:.||..:.....:|      .|.|.:.:|:...:::...|.:.:.:|
  Fly  1714 QTLKEEVKKEKADIMD------KLTIAKFLPKLSLLESYMQKKINEHIS 1756

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Naip1NP_032696.2 BIR 61..129 CDD:237989 25/72 (35%)
BIR 1 63..128 24/69 (35%)
BIR 159..229 CDD:197595 21/104 (20%)
BIR 2 162..228 19/100 (19%)
BIR 279..346 CDD:237989 17/131 (13%)
BIR 3 281..346 16/129 (12%)
NACHT 464..617 CDD:283404 31/154 (20%)
AAA 465..600 CDD:214640 28/136 (21%)
AMN1 1072..>1191 CDD:187754 29/173 (17%)
leucine-rich repeat 1132..1156 CDD:275381 4/23 (17%)
leucine-rich repeat 1157..1182 CDD:275381 1/24 (4%)
leucine-rich repeat 1183..1236 CDD:275381 13/55 (24%)
leucine-rich repeat 1237..1261 CDD:275381 4/23 (17%)
leucine-rich repeat 1262..1293 CDD:275381 6/38 (16%)
leucine-rich repeat 1294..1322 CDD:275381 7/45 (16%)
leucine-rich repeat 1323..1355 CDD:275381 5/29 (17%)
BruceNP_001262460.1 BIR 251..321 CDD:279047 24/69 (35%)
DUF3643 3539..3664 CDD:289152
UQ_con 4636..4790 CDD:278603
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.