DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myom2 and hbs

DIOPT Version :9

Sequence 1:	XP_006508790.1	Gene:	Myom2 / 17930	MGIID:	1328358	Length:	1486	Species:	Mus musculus
Sequence 2:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	1343	Identity:	241/1343 - (17%)
Similarity:	436/1343 - (32%)	Gaps:	426/1343 - (31%)

- Green bases have known domain annotations that are detailed below.

Mouse    10 SAKTEWSKSVGTLKMSLVAVPFYQKRHKHFD--QSYRNIQTRYLLDQYALKKQATTQSSS----Q 68
            :.|.:|:|....|..|.| :|.:.:.....|  |:..|:|.          |.||.:..:    |
  Fly    66 AGKVQWTKDGFALGFSAV-IPGFPRYSVLVDAKQNAYNLQI----------KNATLEDDAEYQCQ 119

Mouse    69 RSLTERSSSKRASSQSSAGAMTCRLCAKRVSASEEEEVENENRYRSQAASYGEAKRQRFLSELAQ 133
            ......:.:.||:::.|..|....:..:..:.:...|||.    |.....:..|:.....:|:..
  Fly   120 VGPAAGNPAIRANAKLSIVAAPSSIVIEGYARNARVEVEE----RQNLTLHCIAENANPAAEIVW 180

Mouse   134 LEENVHLARS---QARDKLDKYF-------MEQTVEDNLAWERHSFEDR-MSRAPEILVRL---- 183
            .:..|.::.:   .......|.|       ::...||:  ::..|.|.| .:..|::.:|.
  Fly   181 FQGEVPVSTAPIVTVNQTAPKRFTTSSTLHLQPRAEDD--YKEFSCEARHKALPPDVPMRAQVQL 243

Mouse   184 ---------------RSHTIWERMSVRL-CFTVQGFPTPVVQWYKDGSLICQAGEPGKYRIESRY 232
                           :..|:.....|:: |.:..|.|...:.||::|..|     ....|...|.
  Fly   244 SVLYPPGAPFFEGYSQGETLHRGQEVQIACRSRGGNPPAQLTWYRNGVAI-----SSPQRTSGRL 303

Mouse   233 GVHTLEINRANFEDTATYSAVATNSHGQVSTNAAVVVRRYRGEEEPFHSVGLPIGLPLSSVIPYT 297
            .           |:...::|.|.::...:...|..::            ...|:...|:..:.|.
  Fly   304 S-----------ENVYKFTAAAEDNGANLVCEAKNLL------------ATTPLRAELNLTVLYA 345

Mouse   298 HFDVQFLEKFGVTFRREGETVTLKCTLLVTPDLKRVQPRAEWYRDDVLLKES--KWTKMFFGEGQ 360
            ..|| :|.  |....:.|::|.|.|  :..|  ...|.|..|..:...|..|  |.|....| |.
  Fly   346 PKDV-YLS--GANQAKVGDSVQLSC--VTAP--SNPQARISWSINGRPLDNSTYKTTSSSDG-GW 402

Mouse   361 ASLSFSHLNKDDEGLYTLRI-------VSRGGVSDHSAFMFVRDADPLVTG-------APGAPMD 411
            .|.|...|..|.:....:.:       :::..|..|:..:....:.||:||       ..|:.:.
  Fly   403 VSSSNISLTIDSQSRTFIAVCHALNTELTQNVVGSHTVNVLYPPSPPLLTGYNDGDILISGSILK 467

Mouse   412 LQCHDANRDYVIVTWKPPNTTTESPVIGYFIDKCEVGTNNWVQCND----APVKICKYPVTGLFE 472
            |||..|..:       ||.|.                  .|.: ||    ||.|:....:|.
  Fly   468 LQCSSAGGN-------PPPTL------------------QWYK-NDKIINAPSKLVDSKITS--- 503

Mouse   473 GRSYVFRVRAVNNAGISRPSRISDAVAALD-PVDLRRLQAIHLEGEKEIVIYQDDLEGDVQIPGP 536
              .....|.|.:|..|.: .::.:  ||:| |:...:...:|.                     |
  Fly   504 --ELSLLVNASDNNAIYK-CKVQN--AAIDIPLFATKTLGVHF---------------------P 542

Mouse   537 PTNVQASEVSRNYV----------VLSWDPPSPRG--KDPL----MYFIEKSAVGSGSWQRVNAQ 585
            |..|:.|.|.:|.|          ..|.:||:...  ||.:    :....:..:..||...:...
  Fly   543 PETVKISVVPKNLVPGIRAKLICDSSSSNPPAKISWWKDGIPVEGLNLANRPGLWGGSVSTLEMY 607

Mouse   586 TAVRSPRYAVFDLAEGKSYVFR----VLSANKHG------LSDPSEITPPIQAQDMIVVPSAPGR 640
            ..:..      || :|..|..:    ||..:.|.      |..|...||  |:...:.|..||..
  Fly   608 VNITQ------DL-DGIVYTCQSHNEVLQRSVHETISLDILYPPKFETP--QSTTFVGVEGAPFH 663

Mouse   641 V--LASRNTKTSVVVQWDRPKHEEDLLGYYVDCCVAGTNMWEPCNHKPIGYNRFVVHG------- 696
            |  |||.|... :...|.:     |.|               |.:...:...|.:..|
  Fly   664 VELLASGNPMV-ITYTWTK-----DGL---------------PISSNSLSGQRLISDGPRLNISR 707

Mouse   697 LTTGEQYIFRVKAVNAVGTSENSQESEVIKVQAALT-VPSHPYGITLLNCDGHSMTLGWKVPKFS 760
            |:..:..::..:|:|:.||:       ::::|.|:. .|:    ||.:: :|.|..        :
  Fly   708 LSRNDAGVYICEALNSQGTA-------LLEIQVAVEYAPT----ITAVS-EGRSFV--------A 752

Mouse   761 GGSAIIGYYLDKR--EVHHKNW---------HEVNSSPVKERILTVEGLTEGSLYEFKI------ 808
            |..|::..::..|  |..|..|         ..::|......:|.:..:....:..|..
  Fly   753 GEPAVLACHIQARPLEAAHVRWSRDGYDLATRTISSFENGTALLQIASVERSDIGNFTCIVDNQR 817

Mouse   809 ---AATNLAGIGQPSDPSEH----------------FKCEAWTDPEPGPAY-----DLTF----- 844
               ||.|:..:.|.:...:|                ..|.:...|:|...:     ||..
  Fly   818 GAPAAQNVLLVVQTAPEIDHSPGFTRYAARLGVRAQLICRSLASPQPSFIWRRHGKDLKMQRRNK 882

Mouse   845 -------------------------------CEVR------------------------------ 848
                                           |.||
  Fly   883 FKSVERQVDALNFESALLIENTSPDDYGQYECVVRNSLGQASTTLEFSKPSRPDAPLQLRVGNVS 947

Mouse   849 DTSLVILWKAPVYSGSSPVSGYF-VDFKEEDSGEWKTTSEAATPNRYLKVCDLQQGKTYVFRIRA 912
            ||.:.:.| .|.:.|.  :..|| :..|:....::|.. :|...::.:.:..|:.|.||.|.:.|
  Fly   948 DTGVDLNW-TPGFDGG--MQTYFRLRLKQHGEDKYKYV-DAKPGHQNISLDGLKPGATYYFSVMA 1008

Mouse   913 VNASGPGK-PSDTSEPVLVEARPGTKEISAGVDEEGNI-YLGFDCQEMT----DASQFTWCKAYE 971
            .|.:|..| ..|....:...::|.:.|.:. .||..|: .:|.....|.    :|:...|.
  Fly  1009 ANEAGGSKFMPDIKLTLSKGSQPHSAEYTE-KDELPNVMIIGITSAAMVLLVLNAALVAWF---- 1068

Mouse   972 EIADEERFEVHTEGDHSKLYFKNPDKEDLGTYSVSVSDTD----GVSSSFVLDEEELERLMAL-- 1030
            .|..:.:.:...|..:..:|.|: |.:.:....::....|    ..:|:::::..::.:..|.
  Fly  1069 VIRRQNKSQSEAEPSNDDVYSKD-DSQSVYKLPITALQADVQKKAAASTYLVENVDIIQSTAYPP 1132

Mouse  1031 ---SNEIKNPTIPLKSELAYEIFDKGQVRFWLQAEHLSPDASFRFIINDREVSDSDTHRIKCDRS 1092
               .:.:..|..||                      .:||.: |.:.|.:..|..::       :
  Fly  1133 KYQESSMCTPPYPL----------------------CNPDFT-RTLPNPKRHSQRNS-------A 1167

Mouse  1093 TGMIE-MVM----DRFTIENEGTYTVQIQDGKAKNQSSLVLIG 1130
            ||||| |.|    |...|.| |.|.     ......||||:.|
  Fly  1168 TGMIEGMQMRSKDDHMLISN-GLYI-----PSPSPASSLVIKG 1204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myom2	XP_006508790.1	I-set	177..269	CDD:369462	17/111 (15%)
		Ig	313..395	CDD:386229	20/90 (22%)
		FN3	406..498	CDD:238020	19/95 (20%)
		FN3	534..626	CDD:238020	25/117 (21%)
		FN3	635..725	CDD:238020	18/98 (18%)
		FN3	734..824	CDD:238020	18/109 (17%)
		FN3	836..926	CDD:238020	26/162 (16%)
		IG	<963..1018	CDD:214652	8/58 (14%)
		Ig_M-protein_C	1367..1458	CDD:143299
hbs	NP_001286439.1	Ig	44..122	CDD:299845	15/66 (23%)
		IG_like	45..137	CDD:214653	17/81 (21%)
		Ig	153..231	CDD:299845	14/83 (17%)
		IG_like	258..342	CDD:214653	17/111 (15%)
		Ig	266..327	CDD:299845	14/76 (18%)
		IG_like	357..>414	CDD:214653	17/61 (28%)
		Ig	360..427	CDD:299845	18/71 (25%)
		Ig	<468..526	CDD:299845	18/91 (20%)
		I-set	547..633	CDD:254352	17/92 (18%)
		Ig	556..631	CDD:299845	14/81 (17%)
		I-set	644..735	CDD:254352	24/120 (20%)
		IGc2	668..725	CDD:197706	12/77 (16%)
		IG_like	751..829	CDD:214653	12/85 (14%)
		IGc2	753..815	CDD:197706	9/61 (15%)
		Ig	852..928	CDD:143165	8/75 (11%)
		FN3	935..1017	CDD:238020	18/85 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000