DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myom1 and robo2

DIOPT Version :9

Sequence 1:	NP_034997.2	Gene:	Myom1 / 17929	MGIID:	1341430	Length:	1667	Species:	Mus musculus
Sequence 2:	NP_001259868.1	Gene:	robo2 / 44522	FlyBaseID:	FBgn0002543	Length:	1519	Species:	Drosophila melanogaster

Alignment Length:	1060	Identity:	226/1060 - (21%)
Similarity:	367/1060 - (34%)	Gaps:	364/1060 - (34%)

- Green bases have known domain annotations that are detailed below.

Mouse    55 RQESEAFSQASATSYQQQASQTYSLGAS------------------SSSRHSQGSEVSRKTASAY 101
            |:||:      |.:|..:|...:.:..|                  :::|.:|| ||:
  Fly   156 RRESD------AGTYWCEAKNEFGVARSRNATLQVAFLRDEFRLEPANTRVAQG-EVA------- 206

Mouse   102 DYGYSHGLTDSSLLLEDYSSKLSPQTKRAKRSLLSGEETGSLPGNYLVPIYSGRQVHISGIRDSE 166
                         |:|..:.:.||:.:.:.|   ...:|.:|.||..:.|..|..:.|...|.|:
  Fly   207 -------------LMECGAPRGSPEPQISWR---KNGQTLNLVGNKRIRIVDGGNLAIQEARQSD 255

Mouse   167 EERIKEAAAYIAQKTLLASEEA-------------IAASKQSTASKQSATS-------------- 204
            :.|.:     ...|.::.:.|:             |...:..||...|:..
  Fly   256 DGRYQ-----CVVKNVVGTRESATAFLKVHVRPFLIRGPQNQTAVVGSSVVFQCRIGGDPLPDVL 315

Mouse   205 -KRTTS----TLQREETFEKKSRNIAIREKAEELSLKKTLE---ETQTYHGKLNEDHLL--HA-P 258
             :||.|    .|:|....|.:|.      |.::::|:...|   |.....|.:....:|  || |
  Fly   316 WRRTASGGNMPLRRVHVLEDRSL------KLDDVTLEDMGEYTCEADNAVGGITATGILTVHAPP 374

Mouse   259 EFIIKPRSHTVWEKENVKLHCSVAGWPEPRLTWYKNQVPINVHAN-----PG-----KYIIESRY 313
            :|:|:|::..|...:.|...|...|.|.|.|.|       :|..|     ||     ..:..:..
  Fly   375 KFVIRPKNQLVEIGDEVLFECQANGHPRPTLYW-------SVEGNSSLLLPGYRDGRMEVTLTPE 432

Mouse   314 GMHTLEISKCDFEDTAQ-YRASAMNVQGELSAYASVVVKRYKGELDESLLRGG---VSMPL-SFA 373
            |...|.|::...||:.: ...:|:|..|.:|: .:||....:.||...::..|   .::|: |..
  Fly   433 GRSVLSIARFAREDSGKVVTCNALNAVGSVSS-RTVVSVDTQFELPPPIIEQGPVNQTLPVKSIV 496

Mouse   374 VTPYGYASKFEIHFDDKFDVSFGREGETMSLGCRVVITPEIKHFQPEVQWYRNGAPVSPSKWVQP 438
            |.|                             ||.:.||     .|:|.||.:|.|:.    ||.
  Fly   497 VLP-----------------------------CRTLGTP-----VPQVSWYLDGIPID----VQE 523

Mouse   439 HWS---GDRATLTFSHLNK-EDEGLYTIRVRMGEYYEQYSAYV-----------FVRDADAEIEG 488
            |..   .|...||.|.|.: |||||||...........:|.|:           |.|  ..|:..
  Fly   524 HERRNLSDAGALTISDLQRHEDEGLYTCVASNRNGKSSWSGYLRLDTPTNPNIKFFR--APELST 586

Mouse   489 APAAPLDVVSLDANKDYIIISWKQPAVDGGSPILGYFID---KCEVGTDTWSQCNDTPVKFARFP 550
            .|..|.....::..::.:.:||.:....|||.::||.|:   |.|  ||.|.... |.|:...|.
  Fly   587 YPGPPGKPQMVEKGENSVTLSWTRSNKVGGSSLVGYVIEMFGKNE--TDGWVAVG-TRVQNTTFT 648

Mouse   551 VTGLIEGRSYIFRVRAVNKTGIGLPSRVSEPVAALDPAEKARLKSHPSAPWTGQIIVTEEEPTEG 615
            .|||:.|.:|.|.:||.|..|:.|||.:|||:..
  Fly   649 QTGLLPGVNYFFLIRAENSHGLSLPSPMSEPITV------------------------------- 682

Mouse   616 VIPGPPTDLSVTEATRSYVVLSWKPPGQRGHEGIMYFVEKCDVGAENWQRVNTELPVKSPRFALF 680
                                            |..||              |:.|.:...|.:|.
  Fly   683 --------------------------------GTRYF--------------NSGLDLSEARASLL 701

Mouse   681 DLVEGKSYRFRVRCSNSAGVGEPSETTEVTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWEESRDA 745
            .                               ||.:::..|  .::.|    ||:.::| :..:.
  Fly   702 S-------------------------------GDVVELSNA--SVVDS----TSMKLTW-QIING 728

Mouse   746 KELVGYYIEA-----SVVGSGKWEPCNNNPVKGSRFTCHGLTTAQSYIFRVRA-VNAAGLSEYSQ 804
            |.:.|:|:.|     .:|.:......|.||:.||..|....:.:.|.:...:. :.|||    .:
  Fly   729 KYVEGFYVYARQLPNPIVNNPAPVTSNTNPLLGSTSTSASASASASALISTKPNIAAAG----KR 789

Mouse   805 DSEAIEVKAAIGGGVSPDVWPQLSDTPGGLTDSRGGMNGASPPTSQKDALLGSNPNKPSPPSSPS 869
            |.|                           |:..||  ||..|.:.|..:|           :..
  Fly   790 DGE---------------------------TNQSGG--GAPTPLNTKYRML-----------TIL 814

Mouse   870 SRGQKEVSTVSESVQEPLSS---PPQEAAPEEEQSQSEPPKKKKDPVAVPS-APYDITCLESFRD 930
            :.|.....|::..||..|..   .|...:.|.:.|.|...:..:|   ||| |||.:..|.....
  Fly   815 NGGGASSCTITGLVQYTLYEFFIVPFYKSVEGKPSNSRIARTLED---VPSEAPYGMEALLLNSS 876

Mouse   931 SMVLGWKQPDTTGGAEITGYYVNYREVVGEVPGKWREANI--KAVSDAA---YKISNLKENTLYQ 990
            ::.|.||.|:.   .:..|..:||..:|..:......:.|  ....|||   ..::||.|..:|.
  Fly   877 AVFLKWKAPEL---KDRHGVLLNYHVIVRGIDTAHNFSRILTNVTIDAASPTLVLANLTEGVMYT 938

Mouse   991 FQVSAMNIAGLG---APSTV 1007
            ..|:|.|.||:|   .|:|:
  Fly   939 VGVAAGNNAGVGPYCVPATL 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myom1	NP_034997.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	192..217		8/43 (19%)
		IG_like	264..350	CDD:214653	23/96 (24%)
		Ig	397..464	CDD:386229	25/70 (36%)
		FN3	490..580	CDD:238020	31/92 (34%)
		FN3	618..711	CDD:238020	7/92 (8%)
		FN3	719..809	CDD:238020	22/95 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..915		18/99 (18%)
		FN3	916..1010	CDD:238020	30/101 (30%)
		FN3	1021..1110	CDD:238020
		Ig	1137..1203	CDD:386229
		Ig	1356..1425	CDD:386229
		Ig	1554..1645	CDD:386229
robo2	NP_001259868.1	Ig1_Robo	90..185	CDD:143317	7/34 (21%)
		I-set	91..184	CDD:254352	7/33 (21%)
		I-set	190..279	CDD:254352	22/117 (19%)
		Ig2_Robo	193..279	CDD:143201	22/114 (19%)
		I-set	283..370	CDD:254352	17/92 (18%)
		Ig	300..370	CDD:299845	13/75 (17%)
		Ig	388..>457	CDD:299845	17/75 (23%)
		I-set	479..561	CDD:254352	30/119 (25%)
		Ig	496..561	CDD:143165	27/102 (26%)
		FN3	588..681	CDD:238020	34/95 (36%)
		FN3	<817..856	CDD:238020	9/38 (24%)
		fn3	864..952	CDD:278470	26/90 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8219
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950