Protein Alignment Myo9b and ck

DIOPT Version :10

• Sequence 1: XP_006509629.1
• Gene: Myo9b / 17925
• MGIID: 106624
• Length: 2164
• Species: Mus musculus
• Sequence 2: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Alignment Length: 2117
• Identity: 533/2117 - (25%)
• Similarity: 846/2117 - (39%)
• Gaps: 628/2117 - (29%)

Mouse   109 LQERNADGSIQYLPIQ--LLAQPTAACRLVERGLLPRPQADFDDLCNLPELTEANLLQNLKLRFM 171
            :|.|:.||...:|..:  :.|...::.:.||            |:.:|.:|.||.:|:||.:|:.
  Fly    36 IQVRDDDGDEVWLAPERRIKAMHASSVQGVE------------DMISLGDLHEAGILRNLLIRYK 88

Mouse   172 QQKIYTYAGSILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFALADVAYYAMLRKHVNQCIV 236
            :..||||.||||||:||::.||||....:|:|:.:::|:|.||:||:.|.||..|.|...:||||
  Fly    89 ENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIV 153

Mouse   237 ISGESGSGKTQSTNFLIHCLTALSQKGYASGVERTILGAGPVLEAFGNAKTAHNNNSSRFGKFIQ 301
            ||||||:|||:||..::..|.|:|  |..|.:|:.||.|.|:|||||||||..|:|||||||:|.
  Fly   154 ISGESGAGKTESTKLILQYLAAIS--GKHSWIEQQILEANPILEAFGNAKTIRNDNSSRFGKYID 216

Mouse   302 VNYLENGIVRGAVVEKYLLEKSRLVSQEKDERNYHVFYYLLLGVSEEERLEFQLKQPQDYFYLNQ 366
            :::..||::.||.:|:|||||||:|||...||||||||.:|.|:|.:|:....|....||.||..
  Fly   217 IHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAADYKYLTG 281

Mouse   367 HNLNIEDGEDLKHDFERLQQAMEMVGFLPATKKQIFSVLSAILYLGNVTYKKRATGRDEGLEVGP 431
            .|....:|.|...:|..::.||:::.|......:|..:|:|:|:.||:.||.......:..|:..
  Fly   282 GNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPE 346

Mouse   432 PEVLDTLSQLLKVKRETLVEVLTKRKTVTVNDKLILPYSLSEAITARDSMAKSLYSALFDWIVLR 496
            ...::.::.||.:..:.|::.||:|......:.::...|..:::..||:..|.:|..:|..||.:
  Fly   347 HINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRK 411

Mouse   497 INHALLNKKDMEEAVSCLSIGVLDIFGFEDFERNSFEQFCINYANEQLQYYFTQHIFKLEQEEYQ 561
            ||.|:...:    ..|..:||||||||||:|::|||||||||||||.||.:|.|||||||||||.
  Fly   412 INTAIFKPR----GTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYN 472

Mouse   562 GEGISWHNIDYTDNVGCIHLISKKPTGLFYLLDEESNFPHATSHTLLAKFKQQHEDNKYFLGTPV 626
            .|.|:|.:|::.||...:.||:.|...:..|:|||:.||..|..|:|||..:.|..:|.:|....
  Fly   473 HEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKS 537

Mouse   627 -LEPAFIIQHFAGRVKYQIKDFREKNMDYMRPDIVALLRGSDSSYVRQLIGMDPVAVFRWAVLRA 690
             :..:|.:.||||.|.|..:.|.:||.|...||::.|:..|.:.::||:...|
  Fly   538 DINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQD------------ 590

Mouse   691 AIRAMAVLREAGRLRAERAEKAAAGISSPATRSHMEELPRGASTPSEKLYRCTGLDFSFERSEEL 755
                                                 :..||.|
  Fly   591 -------------------------------------IEMGAET--------------------- 597

Mouse   756 DVNAFEDIMAFYESRKARGQSDLHNQIIKSLKGLPWQGEDPRRLLQSLSLFQKPRTSFLKSKGIK 820
                                                                             
  Fly   598 ----------------------------------------------------------------- 597

Mouse   821 QKQIIPKNLLDSKSLRLIISMTLHDRTTKSLLHLHKKKKPPSISAQFQTSLNKLLEALGKAEPFF 885
                                                :|:.|::|.||:.||:.|::.|...:|||
  Fly   598 ------------------------------------RKRTPTLSTQFRKSLDALMKTLSSCQPFF 626

Mouse   886 IRCIRSNAEKKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDFTEQFQVLLP------- 943
            ||||:.|..||.:.||..|..:||||:||:||:||||:||..::.|::|.|:::.|:|
  Fly   627 IRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHR 691

Mouse   944 KDVQPCREAIAALLEKLQVDRQNYQIGKTKVFLKETERQTLQEKLHGEVLRRILQLQSWFRMVLE 1008
            .|.|.....|.|::    :.:.:||:|.||||||:.....|:::....:.|:||.||...|..:.
  Fly   692 TDCQAATSRICAVV----LGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVY 752

Mouse  1009 RKHFVQMKHAALTIQACWRSYRVRR-------------ALERTQA-----------AVYLQAAWR 1049
            |:.|::::.||:|:|..|:.|..|:             ||.|::.           .|.|||..|
  Fly   753 RRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHAR 817

Mouse  1050 GYLQRQAYHHQRHSIIRLQSLCRG----------HLQRRSFSQMVSEKQKAEQ---------ARE 1095
            |||.|:.|.|:..::|::||..|.          .|:.:.|::::..::..||         |||
  Fly   818 GYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQELLHRGNKHARE 882

Mouse  1096 AA----GGKLSEGEPGPVAAGEQL-------------------SEHPVEDPESLGVEAETWMNKS 1137
            .|    ..:|.|.|...:.  |||                   .|.||:|    |...|...:..
  Fly   883 IAEQHYRDRLHELERREIQ--EQLENRRRVEVNMNIINDAARKQEEPVDD----GKLVEAMFDFL 941

Mouse  1138 PDGMSPKKETPSPE--METAAQKTVPAESHEKVSSSREKRESRRQRGLEHVERQNK-------HI 1193
            ||..|   :.|:|.  .||:....:|                       |.:..|:       ||
  Fly   942 PDSSS---DAPTPHGGRETSVFNDLP-----------------------HAQNVNQDDIIAPIHI 980

Mouse  1194 QSCREESSTHREPSRRASLEIGE-------------SFPEGTKGPREDGLEAWTETTAPSSSKQA 1245
            ....|:.|..:.....|:...|.             ..|..|:|.:......|...        .
  Fly   981 SEDEEDLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLPLHTQGDQLAAQALWITI--------L 1037

Mouse  1246 QVVGDPPGSPS--PVQRPTTLALDSRVSPML-----PSSSLEVSPVL---PSSSL-ESPKD-KDK 1298
            :..||.| .|.  .:.|..|.::.|:|:..|     .|...:.:.::   |.:.| :.|:. :.|
  Fly  1038 RFTGDMP-EPKYHTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHK 1101

Mouse  1299 DESSTKAQDKPESPSGSTQIQRYQHPDTERLATAVEIWRGKKLASAVLSQSLDLSEKHRATGAAL 1363
            ..|.|.   |.::..|....:|.|  |.|..|.:.:.|...:..|       :|.:.|...|..:
  Fly  1102 LVSLTL---KRKNKLGEDVRRRLQ--DDEYTADSYQSWLQSRPTS-------NLEKLHFIIGHGI 1154

Mouse  1364 TPTEERRISFS------TSDVSKLSPVK--VQTSAEIDGDFSSKKPSIHKKKS----GDPSAGPD 1416
            ...|.|...:.      |::..|.|..:  :..|..: |.|:..:..::..::    |.|...|.
  Fly  1155 LRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCV-GCFAPSEKFVNYLRAFIREGPPGYAPY 1218

Mouse  1417 AGLSPGSQGDSKSAFKRLFLHKAKDKKPS-LEGVEETESNGGQAAQETPARKTLDVPSSQQHRHT 1480
            .          :...||.|.:..:::.|| ||            .|.|.::|.:.:|.:....:|
  Fly  1219 C----------EERLKRTFNNGTRNQPPSWLE------------LQATKSKKPIMLPITFMDGNT 1261

Mouse  1481 TGEKPLKGKKNRNRKVGQITVSEKWRESVFRKITNANELKFLDEFLLNKVNDLRSQKTPIE-SLF 1544
                                     :..:....|.|.|       |.|:::|..|.|.... ||:
  Fly  1262 -------------------------KTLLADSATTARE-------LCNQLSDKISLKDQFGFSLY 1294

Mouse  1545 IEATERFRSNIKTMYSVPNGKIHVGYKDLM---ENYQIVVSNLAAERGEKDTNLVLNVFQSLLDE 1606
            |...::       :.|:.:|..||  .|.:   |.|       |.|:|.::.|....:|  ...|
  Fly  1295 IALFDK-------VSSLGSGGDHV--MDAISQCEQY-------AKEQGAQERNAPWRLF--FRKE 1341

Mouse  1607 FTRSYNKTDFERAK-----QSKAQKKKRKQERAVQEHNGHVFASYQVNIPQSCEQ---------- 1656
            ....:::...::..     |...:..|..:.|..:|.:..:.|:.|..|..|.:.
  Fly  1342 IFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLP 1406

Mouse  1657 ------CLSYIWLMDKAL-LCSVCKMTCHKKCVHKIQSYCSYTGRRKSELGAEPGHFGVCVDSLT 1714
                  |||.:   |||: ..:...:..:||      ||  |...:.:.|..:.       |.::
  Fly  1407 NFIPDFCLSGV---DKAIERWAALVLQAYKK------SY--YVKDKIAPLKIKE-------DIVS 1453

Mouse  1715 SDKASVPIVLEKLLEHVEMHGLYTEGLYRKSG----------AANRTRELRQALQTDPAAVKLE- 1768
            ..|...|::..:..|           .||.||          |.|.|...   :..|...|.||
  Fly  1454 YAKYKWPLLFSRFYE-----------AYRNSGPNLPKNDVIIAVNWTGVY---VVDDQEQVLLEL 1504

Mouse  1769 DFPIHAITGVLKQWLREL---------------------PEPLMTFAQYGDFLRAVELPEKQEQL 1812
            .||  .||.|..|...::                     .|.:.....|  ||..::...|.
  Fly  1505 SFP--EITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVY--FLDGLKKRSKY--- 1562

Mouse  1813 SAIYAVLDHLPEANHTSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRC------------ 1865
              :.|:.|:...::.||.  |.|....:.:|||   .|.|...:....|:.||
  Fly  1563 --VIALQDYRAPSDGTSF--LSFFKGDLIILED---ESCGESVLNNGWCIGRCDRSQERGDFPAE 1620

Mouse  1866 -----PDNSDPLTSMKDVLKITTCVEMLIKEQMRKYKMKMEEINHLEAAESIAFRRLSLLRQNAP 1925
                 |..|.|   .:|:|.:                ..:||.:|        .||||:....
  Fly  1621 TVYVLPTLSKP---PQDILAL----------------FNIEEAHH--------GRRLSMASNG-- 1656

Mouse  1926 WPLKLGFSSPYEGVRIKSPRTPVVQDLELGALP----------------EEAAGGDEDREKEILM 1974
                 |...|.:     .|.|.:...|:...||                ||......|..|..|:
  Fly  1657 -----GAVEPRD-----RPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRDPIKAPLL 1711

Mouse  1975 ERIQSIKEEKEDITYR----------LPELDPRGSDE 2001
            .::||.:|..|:..:.          ||...||..:|
  Fly  1712 RKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNE 1748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo9b	XP_006509629.1	RA_Myosin-IXb	16..112	CDD:340737	1/2 (50%)
		MYSc_Myo9	160..977	CDD:276836	277/824 (34%)
		IQCD	1008..>1037	CDD:467745	11/41 (27%)
		IQ	1036..1058	CDD:197470	10/32 (31%)
		C1_Myosin-IXb	1636..1693	CDD:410434	16/73 (22%)
		RhoGAP_myosin_IXB	1706..1891	CDD:239872	45/233 (19%)
		SepH	<1932..2073	CDD:468676	20/96 (21%)
		PHA02682	<2029..>2123	CDD:177464
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	277/824 (34%)
		MyTH4	<1138..1245	CDD:214535	23/136 (17%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	26/147 (18%)
		B41	1251..1467	CDD:214604	49/283 (17%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	22/115 (19%)
		SH3	1560..1624	CDD:473055	15/73 (21%)
		MyTH4	1701..1849	CDD:214535	12/48 (25%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020