Protein Alignment Myo7b and ck

DIOPT Version :9

• Sequence 1: NP_115770.2
• Gene: Myo7b / 17922
• MGIID: 107709
• Length: 2113
• Species: Mus musculus
• Sequence 2: NP_001285949.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Alignment Length: 2216
• Identity: 1027/2216 - (46%)
• Similarity: 1437/2216 - (64%)
• Gaps: 159/2216 - (7%)

Mouse     1 MSVFRLGDHVWLDPPSSSKTGVAIGGIVKETKLGKTLIEDDEGKEHWVHAEDLSTLRPMHPNSAQ 65
            |.:...||::|::|.|..:..||||..|...:..:..:.||:|.|.|:..|  ..::.||.:|.|
  Fly     1 MVIVTRGDYIWIEPASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPE--RRIKAMHASSVQ 63

Mouse    66 GVDDMIRLGDLNEAGVVHNLLIRYQQHKIYTYTGSILVAVNPFQMLPLYTLEQVQIYYSRHMGEL 130
            ||:|||.||||:|||::.||||||:::.||||||||||||||:|:||:||.:|:::|..|.:|||
  Fly    64 GVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGEL 128

Mouse   131 PPHIFAIANSCYFNMKKNKRDQCCIISGESGAGKTETTKLILQFLATVSGQHSWIEQQVLEANPI 195
            |||||||.::.|.:||:.::|||.:|||||||||||:||||||:||.:||:|||||||:||||||
  Fly   129 PPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSWIEQQILEANPI 193

Mouse   196 LEAFGNAKTIRNDNSSRFGKYIDIHFNSSGVIEGASIEHFLLEKSRVCRQAPEERNYHIFYCMLM 260
            ||||||||||||||||||||||||||:::||||||.||.:||||||:..|...|||||:|||:|.
  Fly   194 LEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILA 258

Mouse   261 GMSPEEKQMLSLGMPSEYHYLTMGSCTSSEGLSDAKDYAHVRSAMKILQFSDSENWDISKLLAAI 325
            |:|.:||..|.|||.::|.|||.|:..:.||..||.:::.:|||||:|.|||.|.|:|.|||||:
  Fly   259 GLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAAL 323

Mouse   326 LHLGNVGFMAAVFENLDSSDVMETPAFPLAMKLLEVQHQALRDCLIKHTIPVLGEFVSRPVNIAQ 390
            ||.||:.:.|.|.:|||::::.|.........||.:..|.|.|.|.:.|:...||.|...::..|
  Fly   324 LHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQ 388

Mouse   391 ATDRRDAFVKGIYGRLFQWIVKKINAAIFTPQAQDPQNVRRAIGLLDIFGFENFQNNSFEQLCIN 455
            :.|.|||||||||||:|..||:|||.|||.|:...    |.|||:|||||||||..|||||.|||
  Fly   389 SVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTS----RNAIGVLDIFGFENFDQNSFEQFCIN 449

Mouse   456 FANEHLQQFFVKHVFTMEQEEYLSENITWNYIHYTDNQPILDMLALKPMSIISLLDEESRFPQGT 520
            :|||:||||||:|:|.:|||||..|.|.|.:|.:.|||..||::|:|.::|::|:|||:|||:||
  Fly   450 YANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKGT 514

Mouse   521 DVTMLQKLNSIHANNKSFLSPRSIHDTRFGIAHFAGDVYYQAEGFLEKNRDVLSTDILILIHSSK 585
            |.|||.||:..|.::|::|.|:|..:|.||:.||||.|:|...|||:||||..|.|:|.|:..|.
  Fly   515 DQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQST 579

Mouse   586 NKFLKEIFNVDSSQTKLGHGTICQVKAGSQLFKSSDSIKRPVTLASQFKQSLDQLMRILTNCQPY 650
            ||||::||..|             ::.|      :::.||..||::||::|||.||:.|::|||:
  Fly   580 NKFLRQIFAQD-------------IEMG------AETRKRTPTLSTQFRKSLDALMKTLSSCQPF 625

Mouse   651 FVRCIKPNEYKKPLLFDRELCIQQLRYSGMMETVHIRKSGFPIRYTFDEFSQRFRVLLPS---PE 712
            |:|||||||.|||::|||.||.:||||||||||:.||::|:|||:.|.||.:|:|.|:|.   ..
  Fly   626 FIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAH 690

Mouse   713 RMQFQNKPRQMTLHIADLCLGTDKDWKVGKTKIFLKDHQDTVLEIRRSQALDGAAIRIQRVLRGH 777
            |...|    ..|..|..:.|| ..|:::|.||:||||..|..||..|.:.|....:.:||.:||.
  Fly   691 RTDCQ----AATSRICAVVLG-KSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGW 750

Mouse   778 KYRKEFLRQRRAAVTLQAGWRGYSQRKNFKLILVGFERLQAIARSHLLMRQFQAMRQRIVQLQAR 842
            .||:.|||.|.||:|:|..|:||:|||.::.:.||:.||||:.||.:|..:|:.:|..||.|||.
  Fly   751 VYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAH 815

Mouse   843 CRGYLVRQQVQAKRRAVVIIQAHARGMVVRKSY-------------WQQKSTGPQVILAKEPK-- 892
            .||||||::...|..||:.||:|.|.|:..:.|             .|.:....|.:|.:..|
  Fly   816 ARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQELLHRGNKHA 880

Mouse   893 AQVA-------VHERKRKSIY------------------------DTVTDTAMVEKVFGFLPAMI 926
            .::|       :||.:|:.|.                        :.|.|..:||.:|.|||.
  Fly   881 REIAEQHYRDRLHELERREIQEQLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPD-- 943

Mouse   927 GGQEGPAP------TRFEDLEVKTQKLHEVDLDTVPMMAMPEEEVDSLAEYTFPKFAVTYFQKSA 985
            ...:.|.|      :.|.||. ..|.:::.|:  :..:.:.|:|.| |:|:.|.|||.||||.:.
  Fly   944 SSSDAPTPHGGRETSVFNDLP-HAQNVNQDDI--IAPIHISEDEED-LSEFKFQKFAATYFQGNV 1004

Mouse   986 SHTHIQKPLRYPLLYHENDTDHSAALDVWIIILRFMGDLPEPVVYGRNSLTGSSVMRQIHDKLGK 1050
            :|.:.:|.|::|||......|..||..:||.||||.||:|||..:..:.:..:|||.::...||:
  Fly  1005 NHQYAKKALKHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGR 1069

Mouse  1051 DSVTQHNRSSQVASQLNFGEEAFKFDGP------------------------------------- 1078
            :.:  .::..|.|..:....:||....|
  Fly  1070 NFI--RSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQ 1132

Mouse  1079 --ISDRPMSNLEKVHFIVGYAIMRPGLRDEIYCQICKQLSENYKTSSRARGWILLSLCLGCFPPS 1141
              :..||.|||||:|||:|:.|:|..|||||||||||||:.|...||.||||||||||:|||.||
  Fly  1133 SWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPS 1197

Mouse  1142 ERFMKYLLNFISQGPPSYGPFCAERLQRTFANGVRAEPPTWLELQAVKSKKHIPIQVILATGRSL 1206
            |:|:.||..||.:|||.|.|:|.|||:|||.||.|.:||:||||||.||||.|.:.:....|.:.
  Fly  1198 EKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTK 1262

Mouse  1207 TISVDSASTSREICQHVAQKQGLRDNLGFSLQVAVYDKFWSLGSGCDHLMDAVAQCEQLARERGE 1271
            |:..|||:|:||:|..::.|..|:|..||||.:|::||..|||||.||:|||::||||.|:|:|.
  Fly  1263 TLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGA 1327

Mouse  1272 SQRQAPWRIYFRKEFFTPWHDSQEDPVSTELIYHQVLRGVWSGEYNFEKEEELVELLARHCYVQL 1336
            .:|.||||::||||.|.|||:...|.|:|.|||.||:|||..|||..:|||:|..:.|:..:::.
  Fly  1328 QERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEY 1392

Mouse  1337 GATVKSNAVQELLPSCVPSKLYR--TKSPEKWASLVTAAHAKAQYTQSKATPLAVREQTVEAARL 1399
            ...:....:..|||:.:|.....  .|:.|:||:||..|:.|:.|.:.|..||.::|..|..|:.
  Fly  1393 STDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKY 1457

Mouse  1400 LWPLLFSRLFEVTTLSGPRLPKTQLVLAINWKGMYFLDQKERTLLGLSFAEVMGLVANRDAPGGK 1464
            .|||||||.:|....|||.|||..:::|:||.|:|.:|.:|:.||.|||.|:..:.:.:.    .
  Fly  1458 KWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFPEITAVSSQKT----N 1518

Mouse  1465 KLLLATLQ------EEYEFVSPSSVAIAEMVALFLGGLKERSVFAMALQDRRA-TDDITLLPFKK 1522
            |:...|..      ||:.|.||::..|.::|..||.|||:||.:.:||||.|| :|..:.|.|.|
  Fly  1519 KVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAPSDGTSFLSFFK 1583

Mouse  1523 GDLLILTKK---QGLLASENWALGQNDRTGKTGLVPTACLYTIPSVTKPSTQLLSLLAMSPE--- 1581
            |||:||..:   :.:| :..|.:|:.||:.:.|..|...:|.:|:::||...:|:|..:...
  Fly  1584 GDLIILEDESCGESVL-NNGWCIGRCDRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHG 1647

Mouse  1582 KRKLAAQEVRALEPPLEDQLTESPYTLEEFSYQFFRAPEKETISRAAMPMARSRGHLWAYSPEPL 1646
            :|...|....|:||      .:.|:||.|::...||.|.|.|:|:.....::....||.||.:|:
  Fly  1648 RRLSMASNGGAVEP------RDRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRDPI 1706

Mouse  1647 RQPLLKSVHDKAKLRDAACQIFLAILKYTGDYPSRQSWHSLELTDQMFSLALQDPALQDELYCQI 1711
            :.|||:.:..|.:..:.||..|.|||||.||.||::.....|:||.:|...|:...|:||:|||:
  Fly  1707 KAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRDEIYCQL 1771

Mouse  1712 LKQLTHNSIRFSEERAWQLLWLCTGLFPPGKTLLPHAQKFIDSRKKKPLALDCSRRLHRVLRVGP 1776
            :||||.|..|.||||.|:|:||.||||...:.||.....|:.:| :.|::.|...||.:.:|.|.
  Fly  1772 MKQLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLRTR-RHPISQDSMHRLQKTIRHGQ 1835

Mouse  1777 RKQPPHDVEVKAAEQNVSKLHHEVYLPNDTSKSMEVGSSSRVRDLCEGIGTRLQLASWDGCSLFI 1841
            ||.|||.|||:|.:...:::.|:||.|:||.::.||.||:|.:|.|..|..||.|.:.:|.|||:
  Fly  1836 RKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQRLSLRTSEGFSLFV 1900

Mouse  1842 KITDKVISLKEGDFFFDSLRQVSDWVKKNRPQKEGASVTLPYQVFFMRKLWLNVTPGKDVNADTI 1906
            ||.|||||:.|||||||.:|.::||:||.||.::||:....||||||:|||.|..||||.|||.|
  Fly  1901 KIADKVISVPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVFFMKKLWTNTVPGKDRNADLI 1965

Mouse  1907 LHYHQELPKYLRGFHKCSREDAIHLGGLICKIQFGSDSSQLASVSKVLKELVPQNLTRLMSSEEW 1971
            .||||||||.|||:||||||:|..|..|:.:::||.:..:|.::.::|:||:|.::.::.|:.||
  Fly  1966 FHYHQELPKLLRGYHKCSREEAAKLAALVFRVRFGENKQELQAIPQMLRELIPSDIMKIQSTSEW 2030

Mouse  1972 KKSLLLECDKNKRKTVAEAKVEFLKYMYRWPTFGSAFFEVKQTSEPSYPDILLIAINRHGLLLIH 2036
            |:|::...:::...|..:|||.|||.:||||||||||||||||:||:||::||||||:||:.|||
  Fly  2031 KRSIVASYNQDGGMTSEDAKVAFLKIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSLIH 2095

Mouse  2037 PKTKELLNTYPFTKISSWSSGNTYFHMALGSLGQGSRLLCETSLGYKMDDLLTSYVQQLLNTVNK 2101
            |.||::|.|:|||:||:||||||||||.:|:|.:||:||||||||||||||||||:..:|..:||
  Fly  2096 PVTKDILVTHPFTRISNWSSGNTYFHMTIGNLVRGSKLLCETSLGYKMDDLLTSYISLMLTNMNK 2160

Mouse  2102 QRGFRA 2107
            .|..||
  Fly  2161 NRTIRA 2166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo7b	NP_115770.2	MYSc	60..759	CDD:214580	389/701 (55%)
		MYSc_Myo7	79..748	CDD:276832	370/671 (55%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	637..659		14/21 (67%)
		IQ	785..807	CDD:197470	12/21 (57%)
		Mediates interaction with ANKS4B. /evidence=ECO:0000269|PubMed:26812017	962..1578		279/666 (42%)
		MyTH4	989..1189	CDD:214535	102/238 (43%)
		B41	1196..1409	CDD:214604	94/214 (44%)
		FERM_B-lobe	1299..1400	CDD:271216	36/102 (35%)
		FERM_C1_MyoVII	1403..1499	CDD:270019	39/101 (39%)
		Mediates interaction with CDHR2, CDHR5 and USH1C. /evidence=ECO:0000250|UniProtKB:Q6PIF6	1497..2113		295/618 (48%)
		SH3	1500..1560	CDD:302595	23/63 (37%)
		MyTH4	1641..1788	CDD:214535	66/146 (45%)
		B41	1797..2009	CDD:214604	110/211 (52%)
		FERM_M	1907..2009	CDD:278785	48/101 (48%)
		FERM_C2_MyoVII	2005..2100	CDD:270020	68/94 (72%)
ck	NP_001285949.1	MYSc	64..733	CDD:214580	386/696 (55%)
		MYSc_Myo7	77..721	CDD:276832	370/671 (55%)
		MyTH4	<1138..1245	CDD:214535	73/106 (69%)
		B41	1251..1467	CDD:214604	94/215 (44%)
		FERM_B-lobe	1355..1439	CDD:271216	30/83 (36%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	39/101 (39%)
		SH3	1560..1624	CDD:302595	23/64 (36%)
		MyTH4	1701..1849	CDD:214535	67/148 (45%)
		B41	1856..2068	CDD:214604	110/211 (52%)
		FERM_M	1966..2068	CDD:278785	48/101 (48%)
		FERM_C2_MyoVII	2064..2159	CDD:270020	68/94 (72%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5568
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1958
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D21221at33208
OrthoFinder	1	1.000	-	-		FOG0001409
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1286
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.730