DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo7a and didum

DIOPT Version :9

Sequence 1:XP_011239990.1 Gene:Myo7a / 17921 MGIID:104510 Length:2250 Species:Mus musculus
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:1683 Identity:467/1683 - (27%)
Similarity:725/1683 - (43%) Gaps:384/1683 - (22%)


- Green bases have known domain annotations that are detailed below.


Mouse    37 DYVWMDLKSGQEFDVPIGAVVKLC-DSGQIQVV----DDEDNEHWISPQNATHIKPM-HPTSVHG 95
            |.||......:.:....| .:|:| |||:::.|    |..|            :.|: :|..:.|
  Fly    20 DLVWESATLEESYRKGAG-FLKICTDSGKLKEVKLKADGSD------------LPPLRNPAILVG 71

Mouse    96 VEDMIRLGDLNEAGILRNLLIRYRD-HLIYTSCGGRTYTGSILVAVNPYQLLSIYSPEHIRQYTN 159
            ..|:..|..|:|.|:|.||.:|:.: .:|||.|      |.||||:|||..:.:|.|..||.|..
  Fly    72 QNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYC------GIILVAINPYAEMPLYGPSIIRAYRG 130

Mouse   160 KKIGEMPPHIFAIADNCYFNMKRNNRDQCCIISGESGAGKTESTKLILQFLAAISGQHS--WIEQ 222
            ..:|::.|||||:|:..|..::|.|.:...|:|||||||||.|.|..:::.||:.|..|  .:|:
  Fly   131 HAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGSESETQVER 195

Mouse   223 QVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHF-NKRGA--IEGAKIEQYLLEKSRVCRQAPDE 284
            :||.::||:||||||||.||||||||||:..:.| |:.|.  ::||.:..||||||||..||..|
  Fly   196 KVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGE 260

Mouse   285 RNYHVFY--CMLEGMNEEEKKKLGLGQAADYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTD 347
            ||||:||  |.......|    |.|.....:.:|.||.....|...|::::.....||.||.|:.
  Fly   261 RNYHIFYQLCAARSKYPE----LVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSI 321

Mouse   348 TENWEISKLLAAILHMGNLQY-----EARTFENLDACEVLFSP-SLATAASLLEVNPPDLMSCLT 406
            .:..:|.|:||.|||:||:|.     |....|:.|:|::..:. .|...|.||.|:..||...|.
  Fly   322 QQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLL 386

Mouse   407 SRTLITRGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPPLEVKNSRRS---I 468
            .|.:.:..|.|..|.|.|.|...|||..|.||.:||.:||..:|.::        .|..:.   |
  Fly   387 MRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSL--------NNGSKQCSFI 443

Mouse   469 GLLDIFGFENFTVNSFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQEALDM 533
            |:|||:|||.|.||||||.|||:|||.|||.|.:||||||||||..|.|.|..|:|.|||..:|:
  Fly   444 GVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDL 508

Mouse   534 IANRPMNVISLIDEESKFPKGTDATMLHKLNSQHKLNANYVPPKNSHETQFGINHFAGVVYYESQ 598
            |.:| :.|:.|:|||.:.|||:|.:...||..:.....::..|:.. .|.|.|.||:..|.|:..
  Fly   509 IESR-LGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPRFG-TTSFFIKHFSDTVEYDVN 571

Mouse   599 GFLEKNRDTLHGDIIQLVHSSRNKFIKQIFQ--------ADVA-----------------MGAET 638
            |||||||||:..::.|::..|.....||:..        .|.|                 .|.:|
  Fly   572 GFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDT 636

Mouse   639 RKR-------SPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGM 696
            |:|       ..|:.|||:.||..|:.||.|..|.:|||||||:.|....::....::|||..|:
  Fly   637 RRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGV 701

Mouse   697 METIRIRHAGYPIRYSFVEFVERYRVLLPGVKPAYKQGDLRGTCQRMAEAVLGTHDDWQIGKTKI 761
            :||:||..||:|.|:.:.:|..||::|:  .:....:.|::.:|:.:....:...|.::.|.|:|
  Fly   702 LETVRISAAGFPSRWLYPDFYMRYQLLV--YRSKLDKNDMKLSCRNIVMKWIQDEDKYRFGNTQI 764

Mouse   762 FLKDHHDMLLEVERDKAITDRVILLQKVIRGFKDRSNFLRLKSAATLIQRHWRGH---------- 816
            |.:......||..|.......:.::|.|:|.|..|..|||::.....||:|.||:          
  Fly   765 FFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMR 829

Mouse   817 ---------------HCRKNYELIRLGFLRLQALHRSRKLHKQYRLARQ--RIIEFQARCRAYLV 864
                           .||:.|..:|.....:|...|......::...|.  |.::.|...|..|.
  Fly   830 EARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALA 894

Mouse   865 RKAFRHRLWAVITVQAYARGMIARRLHRRLRVEYQRRLEAERMRLAEEEK--------------- 914
            |:|::.|...:|..||..|..:|||..:|::.|.:.....|...:..|.|               
  Fly   895 RRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENKIISMQQRIDELNRDN 959

Mouse   915 ------------LRKEMSAKKAKE------------------------EAERKHQERLAQLARED 943
                        |:.::..||..|                        ||||..:.:|.:.....
  Fly   960 SNLKHKTSEISVLKMKLELKKTLEAEFKNVKAACQDKDKLIEALNKQLEAERDEKMQLLEENGHA 1024

Mouse   944 AERELKEKEEARRKKELL-----EQMEKARHEPINHSDMVDKMFGFLGTSGSLPGQEGQAPSGFE 1003
            .|..:.:|:..|::.|.|     |.::.|::..:|..:..|:|...:...              |
  Fly  1025 QEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNR--------------E 1075

Mouse  1004 DLERGRREMVEEDVDAALPLPDED---EEDLSEYKFAKFA----------------ATYFQGTTT 1049
            ..|..:|.:.:::|     :.:|:   :|:||......|:                ..|.....|
  Fly  1076 LNEAYQRAIKDKEV-----IENENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNT 1135

Mouse  1050 HSYTRRP--LKQPLLYHDDEGDQLAALAVWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYET 1112
            ....|.|  |.:...|:|.     .:|.|              |..:.:.:..:|..|:.:.|..
  Fly  1136 LDINRPPDLLSKNYSYNDS-----TSLVV--------------KLRSILEEEKQKHKVLQEQYIK 1181

Mouse  1113 LGKKTYKRE----LQALQGEGETQLPE-GQKKTSVRHKL-VHLTLKKKSKLTEEVTKRLNDGEST 1171
            |..:....|    :..|:.|.|....| .|.:||::|.: ::....:.:.|.|||.:|   .|..
  Fly  1182 LSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRR---REEC 1243

Mouse  1172 VQGNSMLEDRPTS----NLEKLHFIIGNGILRPALRDEIYCQ--ISKQL---------THNPSKS 1221
            :|..::|..:..|    ..|.|. :.||.:  ..|.:..:.|  |::||         .|| || 
  Fly  1244 IQLKAVLLQQSQSMRSLEPESLQ-MRGNDV--NELMEAFHSQKLINRQLESELKAITEEHN-SK- 1303

Mouse  1222 SYARGWILVSLCVG--------------CFAPSEKFV-----------KYLRNFIH--------- 1252
                   ||.:...              .|...::|.           :|||..:.         
  Fly  1304 -------LVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLV 1361

Mouse  1253 -----------------GGPPGYAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPIM-LPVTF 1299
                             ||...:.  .||.:.|...|||.....:.:..|.:::.:.:| ...:.
  Fly  1362 QEELKLANAKLKAYRQDGGQLEHK--IEEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSD 1424

Mouse  1300 MDGTTKTLLTDSATTARELCNALADKISLKDRFGFSLY-IALFDKVSSLGSGSDHVMDAISQCEQ 1363
            :|...:.||  ||.|.|.:...|.         ||..| |.:..:.:.|.:..|.|.:.:|:   
  Fly  1425 LDKILQRLL--SALTPRTVVGLLP---------GFPAYLIFMCIRYTDLTNADDDVRELLSK--- 1475

Mouse  1364 YAKEQGAQERNAPWRLFFRKEVFTPWHNPSEDNV--------ATNLI--YQQVVRGVKFGEYRCE 1418
                         :.:..:|...||  :|.|:.|        ..||:  |..|...|||.     
  Fly  1476 -------------FVIQIKKMHRTP--HPIENRVIWLVNSITLLNLMKQYGDVDEYVKFN----- 1520

Mouse  1419 KEDDLAELASQQYFVDYG----SEMILERLLSLVPTYIP------DREITP--LKNLE 1464
                 .|..:||...::.    ..:||:.:::|....|.      |.:|.|  |.|.|
  Fly  1521 -----TEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDE 1573

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo7aXP_011239990.1 MYSc_Myo7 108..764 CDD:276832 274/704 (39%)
IQ 801..822 CDD:197470 8/45 (18%)
PTZ00121 <838..>1010 CDD:173412 41/229 (18%)
MAP7 <892..970 CDD:368554 21/133 (16%)
MyTH4 1052..1288 CDD:214535 59/309 (19%)
FERM1_F1_Myosin-VII 1292..1390 CDD:340612 20/99 (20%)
B41 1294..1509 CDD:214604 43/195 (22%)
FERM_C1_MyoVII 1503..1639 CDD:270019
SH3_MYO7A 1640..1704 CDD:212814
MyTH4 1782..1931 CDD:214535
FERM2_F1_Myosin-VII 1936..2033 CDD:340613
B41 1938..2150 CDD:214604
FERM_C2_MyoVII 2146..2241 CDD:270020
didumNP_724569.1 MYSc 65..778 CDD:214580 282/734 (38%)
MYSc_Myo5 84..767 CDD:276831 274/704 (39%)
IQ 900..922 CDD:197470 8/21 (38%)
GBP_C <971..1086 CDD:303769 22/128 (17%)
coiled coil 1049..1068 CDD:293879 3/18 (17%)
coiled coil 1077..1086 CDD:293879 2/8 (25%)
JAKMIP_CC3 <1190..1299 CDD:292653 27/114 (24%)
Myo5_CBD 1424..1792 CDD:271254 42/189 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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