DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo7a and ck

DIOPT Version :9

Sequence 1:	XP_011239990.1	Gene:	Myo7a / 17921	MGIID:	104510	Length:	2250	Species:	Mus musculus
Sequence 2:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster

Alignment Length:	2236	Identity:	1368/2236 - (61%)
Similarity:	1704/2236 - (76%)	Gaps:	97/2236 - (4%)

- Green bases have known domain annotations that are detailed below.

Mouse    35 KGDYVWMDLKSGQEFDVPIGAVVKLCDSGQIQVVDDEDNEHWISPQNATHIKPMHPTSVHGVEDM 99
            :|||:|::..||:||||.|||.|...:..:|||.||:.:|.|::|:.  .||.||.:||.|||||
  Fly     6 RGDYIWIEPASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPER--RIKAMHASSVQGVEDM 68

Mouse   100 IRLGDLNEAGILRNLLIRYRDHLIYTSCGGRTYTGSILVAVNPYQLLSIYSPEHIRQYTNKKIGE 164
            |.||||:||||||||||||:::|||      ||||||||||||||:|.||:.:.|:.|..:||||
  Fly    69 ISLGDLHEAGILRNLLIRYKENLIY------TYTGSILVAVNPYQILPIYTGDQIKLYKERKIGE 127

Mouse   165 MPPHIFAIADNCYFNMKRNNRDQCCIISGESGAGKTESTKLILQFLAAISGQHSWIEQQVLEATP 229
            :|||||||.||.|.:|||..:|||.:||||||||||||||||||:||||||:|||||||:|||.|
  Fly   128 LPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSWIEQQILEANP 192

Mouse   230 ILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQAPDERNYHVFYCML 294
            |||||||||||||||||||||||||||:..|.|||||||||||||||:..|...|||||||||:|
  Fly   193 ILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCIL 257

Mouse   295 EGMNEEEKKKLGLGQAADYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEISKLLAA 359
            .|::.:||.:|.||.||||.||..||.||||||.|:.|:::||||||||:|:|.|.|||.|||||
  Fly   258 AGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAA 322

Mouse   360 ILHMGNLQYEARTFENLDACEVLFSPSLATAASLLEVNPPDLMSCLTSRTLITRGETVSTPLSRE 424
            :||.||::|:|...:||||.|:....::...|.||.:....|:..||.|||...||||.:.|||:
  Fly   323 LLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRD 387

Mouse   425 QALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPPLEVKNSRRSIGLLDIFGFENFTVNSFEQLCI 489
            |::|||||||||||||:||.||.|||.||:||.    ..||.:||:|||||||||..|||||.||
  Fly   388 QSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPR----GTSRNAIGVLDIFGFENFDQNSFEQFCI 448

Mouse   490 NFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQEALDMIANRPMNVISLIDEESKFPKG 554
            |:|||:||||||:|:||||||||:.|:|:|.||||.|||:|||:||.:.:|:::|||||::||||
  Fly   449 NYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMALIDEEARFPKG 513

Mouse   555 TDATMLHKLNSQHKLNANYVPPKNSHETQFGINHFAGVVYYESQGFLEKNRDTLHGDIIQLVHSS 619
            ||.|||.||:..|..:.||:.||:...|.||:|||||||:|:::|||:|||||...|::.||..|
  Fly   514 TDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQS 578

Mouse   620 RNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNEFKKPMLFDR 684
            .|||::|||..|:.||||||||:||||:||::||:.||:||.:|||||:|||||||.||||:|||
  Fly   579 TNKFLRQIFAQDIEMGAETRKRTPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDR 643

Mouse   685 HLCVRQLRYSGMMETIRIRHAGYPIRYSFVEFVERYRVLLPGVKPAYKQGDLRGTCQRMAEAVLG 749
            .||.|||||||||||||||.||||||:.|.|||||||.|:|||.||::. |.:....|:...|||
  Fly   644 GLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIPGVPPAHRT-DCQAATSRICAVVLG 707

Mouse   750 THDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKDRSNFLRLKSAATLIQRHWR 814
             ..|:|:|.||:||||.||:.||.|||:.:|.::::||:.|||:..|..||||::||..:||.|:
  Fly   708 -KSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRLRAAAITVQRFWK 771

Mouse   815 GHHCRKNYELIRLGFLRLQALHRSRKLHKQYRLARQRIIEFQARCRAYLVRKAFRHRLWAVITVQ 879
            |:..||.|..:|:|::|||||.|||.|..::|..|..|:..||..|.||||:.:.|::||||.:|
  Fly   772 GYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAHARGYLVRREYGHKMWAVIKIQ 836

Mouse   880 AYARGMIARRLHRRLRVEYQRRLEAERMRLAEEEKLRKEMSAKKAKEEAERKHQERLAQLAREDA 944
            ::.|.|||.|.:|:||:|:::..|..::|..||::| .....|.|:|.||:.:::||.:|.|
  Fly   837 SHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQEL-LHRGNKHAREIAEQHYRDRLHELER--- 897

Mouse   945 ERELKEKEEARRKKE----LLEQMEKARHEPINHSDMVDKMFGFLGTSGS---LPGQEGQAPSGF 1002
             ||::|:.|.||:.|    ::....:.:.||::...:|:.||.||..|.|   .| ..|:..|.|
  Fly   898 -REIQEQLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTP-HGGRETSVF 960

Mouse  1003 EDLERGRREMVEEDVDAALPLPDEDEEDLSEYKFAKFAATYFQGTTTHSYTRRPLKQPLLYHDDE 1067
            .||... :.:.::|:.|.:.: .||||||||:||.|||||||||...|.|.::.||.|||....:
  Fly   961 NDLPHA-QNVNQDDIIAPIHI-SEDEEDLSEFKFQKFAATYFQGNVNHQYAKKALKHPLLPLHTQ 1023

Mouse  1068 GDQLAALAVWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYETLGKKTYK-RELQALQGEGET 1131
            ||||||.|:|||||||.||:|||||||  .|..:...||:|:..|||:...: :|.|      |.
  Fly  1024 GDQLAAQALWITILRFTGDMPEPKYHT--MDRMDTTSVMSKVTATLGRNFIRSKEFQ------EA 1080

Mouse  1132 QL----PEG---QKKTSVRHKLVHLTLKKKSKLTEEVTKRLNDGESTVQG-NSMLEDRPTSNLEK 1188
            ||    |:.   ||..|:|||||.||||:|:||.|:|.:||.|.|.|... .|.|:.||||||||
  Fly  1081 QLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSWLQSRPTSNLEK 1145

Mouse  1189 LHFIIGNGILRPALRDEIYCQISKQLTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHG 1253
            ||||||:||||..|||||||||.||||:||.|||:||||||:||||||||||||||.|||.||..
  Fly  1146 LHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIRE 1210

Mouse  1254 GPPGYAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAREL 1318
            |||||||||||||:|||.||||.||||||||||||||||||||:|||||.|||||.|||||||||
  Fly  1211 GPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSATTAREL 1275

Mouse  1319 CNALADKISLKDRFGFSLYIALFDKVSSLGSGSDHVMDAISQCEQYAKEQGAQERNAPWRLFFRK 1383
            ||.|:|||||||:|||||||||||||||||||.||||||||||||||||||||||||||||||||
  Fly  1276 CNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRK 1340

Mouse  1384 EVFTPWHNPSEDNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFVDYGSEMILERLLSLV 1448
            |:|.|||.|:.|.|||||||||||||||||||||:||:|||.:|:||||::|.::|.:|||.:|:
  Fly  1341 EIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLL 1405

Mouse  1449 PTYIPDREITPL-KNLEKWAQLAIAAHKKGIYAQRRTDSQKVKEDVVNYARFKWPLLFSRFYEAY 1512
            |.:|||..::.: |.:|:||.|.:.|:||..|.:.:....|:|||:|:||::|||||||||||||
  Fly  1406 PNFIPDFCLSGVDKAIERWAALVLQAYKKSYYVKDKIAPLKIKEDIVSYAKYKWPLLFSRFYEAY 1470

Mouse  1513 KFSGPPLPKSDVIVAVNWTGVYFVDEQEQVLLELSFPEIMAVSSSRECRVLLSLGCSDLGCATCQ 1577
            :.|||.|||:|||:||||||||.||:|||||||||||||.||||.:.
  Fly  1471 RNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFPEITAVSSQKT------------------ 1517

Mouse  1578 SGRAGLTPAGPCSPCWSCRGTKMMAPSFTLATIKGDEYTFTSSNAEDIRDLVVTFLEGLRKRSKY 1642
                                .|:...:|:|:|::|:|:||.|.||||||||||.||:||:|||||
  Fly  1518 --------------------NKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKY 1562

Mouse  1643 VVALQDNPNPAGEESGFLSFAKGDLIIL-DHDTGEQVMNSGWANGINERTKQRGDFPTDCVYVMP 1706
            |:||||...|: :.:.||||.||||||| |...||.|:|:||..|..:|:::|||||.:.|||:|
  Fly  1563 VIALQDYRAPS-DGTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLP 1626

Mouse  1707 TVTLPPREIVALVTMTPDQRQDVVRLLQLRT----AEPEVRAKPYTLEEFSYDYFRPPPKHTLSR 1767
            |::.||::|:||..:   :.....|.|.:.:    .||  |.:|:||.|::.|:||.|||.|:|:
  Fly  1627 TLSKPPQDILALFNI---EEAHHGRRLSMASNGGAVEP--RDRPHTLMEYALDHFRLPPKRTMSK 1686

Mouse  1768 VMVSKARGKDRLWSHTREPLKQALLKKILGSEELSQEACMAFVAVLKYMGDYPSKRMRSVNELTD 1832
            .:...::..:.||.::|:|:|..||:|:...||.::|||.||.|:||||||.||||.|..||:||
  Fly  1687 TLTLSSKRSEELWRYSRDPIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITD 1751

Mouse  1833 QIFEWALKAEPLKDEAYVQILKQLTDNHIRYSEERGWELLWLCTGLFPPSNILLPHVQRFLQSRK 1897
            .||:..||.|.|:||.|.|::||||||..|.||||||||:||.||||..|..||..:..||::|:
  Fly  1752 HIFDGPLKHEILRDEIYCQLMKQLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLRTRR 1816

Mouse  1898 HCPLAIDCLQRLQKALRNGSRKYPPHLVEVEAIQHKTTQIFHKVYFPDDTDEAFEVESSTKAKDF 1962
            | |::.|.:.||||.:|:|.||||||.|||||||||||||||||||||||||||||:|||:||||
  Fly  1817 H-PISQDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFEVDSSTRAKDF 1880

Mouse  1963 CQNIASRLLLKSSEGFSLFVKIADKVISVPENDFFFDFVRHLTDWIKKARPIKDGIVPSLTYQVF 2027
            |.||:.||.|::|||||||||||||||||||.||||||||||||||||||||:||..|..|||||
  Fly  1881 CNNISQRLSLRTSEGFSLFVKIADKVISVPEGDFFFDFVRHLTDWIKKARPIRDGANPQFTYQVF 1945

Mouse  2028 FMKKLWTTTVPGKDPMADSIFHYYQELPKYLRGYHKCTREEVLQLGALIYRVKFEEDKSYFPSIP 2092
            |||||||.||||||..||.||||:|||||.|||||||:|||..:|.||::||:|.|:|....:||
  Fly  1946 FMKKLWTNTVPGKDRNADLIFHYHQELPKLLRGYHKCSREEAAKLAALVFRVRFGENKQELQAIP 2010

Mouse  2093 KLLRELVPQDLIRQVSPDDWKRSIVAYFNKHAGKSKEEAKLAFLKLIFKWPTFGSAFFEVKQTTE 2157
            ::||||:|.|:::..|..:|||||||.:|:..|.:.|:||:||||::::||||||||||||||||
  Fly  2011 QMLRELIPSDIMKIQSTSEWKRSIVASYNQDGGMTSEDAKVAFLKIVYRWPTFGSAFFEVKQTTE 2075

Mouse  2158 PNFPEILLIAINKYGVSLIDPRTKDILTTHPFTKISNWSSGNTYFHITIGNLVRGSKLLCETSLG 2222
            ||:||:|||||||:|||||.|.|||||.|||||:||||||||||||:||||||||||||||||||
  Fly  2076 PNYPEMLLIAINKHGVSLIHPVTKDILVTHPFTRISNWSSGNTYFHMTIGNLVRGSKLLCETSLG 2140

Mouse  2223 YKMDDLLTSYISQMLTAMSKQRNSRS 2248
            ||||||||||||.|||.|:|.|..|:
  Fly  2141 YKMDDLLTSYISLMLTNMNKNRTIRA 2166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo7a	XP_011239990.1	MYSc_Myo7	108..764	CDD:276832	428/655 (65%)
		IQ	801..822	CDD:197470	10/20 (50%)
		PTZ00121	<838..>1010	CDD:173412	64/178 (36%)
		MAP7	<892..970	CDD:368554	25/81 (31%)
		MyTH4	1052..1288	CDD:214535	157/244 (64%)
		FERM1_F1_Myosin-VII	1292..1390	CDD:340612	88/97 (91%)
		B41	1294..1509	CDD:214604	155/215 (72%)
		FERM_C1_MyoVII	1503..1639	CDD:270019	69/135 (51%)
		SH3_MYO7A	1640..1704	CDD:212814	35/64 (55%)
		MyTH4	1782..1931	CDD:214535	86/148 (58%)
		FERM2_F1_Myosin-VII	1936..2033	CDD:340613	82/96 (85%)
		B41	1938..2150	CDD:214604	150/211 (71%)
		FERM_C2_MyoVII	2146..2241	CDD:270020	84/94 (89%)
ck	NP_001285949.1	MYSc	64..733	CDD:214580	447/680 (66%)
		MYSc_Myo7	77..721	CDD:276832	428/655 (65%)
		MyTH4	<1138..1245	CDD:214535	91/106 (86%)
		B41	1251..1467	CDD:214604	155/215 (72%)
		FERM_B-lobe	1355..1439	CDD:271216	49/83 (59%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	69/135 (51%)
		SH3	1560..1624	CDD:302595	35/64 (55%)
		MyTH4	1701..1849	CDD:214535	86/148 (58%)
		B41	1856..2068	CDD:214604	150/211 (71%)
		FERM_M	1966..2068	CDD:278785	58/101 (57%)
		FERM_C2_MyoVII	2064..2159	CDD:270020	84/94 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838151
Domainoid	1	1.000	889	1.000	Domainoid score	I52
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H219
Inparanoid	1	1.050	2607	1.000	Inparanoid score	I27
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52371
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001409
OrthoInspector	1	1.000	-	-		oto93622
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2580
SonicParanoid	1	1.000	-	-		X1286
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790