DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo5a and zip

DIOPT Version :9

Sequence 1:XP_006510890.1 Gene:Myo5a / 17918 MGIID:105976 Length:1880 Species:Mus musculus
Sequence 2:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster


Alignment Length:2022 Identity:553/2022 - (27%)
Similarity:913/2022 - (45%) Gaps:440/2022 - (21%)


- Green bases have known domain annotations that are detailed below.


Mouse     7 YTKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGK-------DLEYRLDPKTGELPHLRN 64
            :|:...||:|...:.:.:|.:.:::  ||:|.:...|.||       |::....||..::     
  Fly    76 WTQKRLVWVPHENQGFVAASIKREH--GDEVEVELAETGKRVMILRDDIQKMNPPKFDKV----- 133

Mouse    65 PDILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSG 129
                   .|:..|:.|:|.:||||::.|:. |.|||||.|:..|.:|||::||||.|.|:..|.|
  Fly   134 -------EDMAELTCLNEASVLHNIKDRYY-SGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKG 190

Mouse   130 QNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGS-------- 186
            ....::.||:||:.:.||:.|..|..:|||:.:||||||||.:.|..:::.|.|:.|        
  Fly   191 IKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAV 255

Mouse   187 --------------------------------------------ASEANVEEKVLASNPIMESIG 207
                                                        ..|..:|:::|.:|||:|:.|
  Fly   256 PHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFG 320

Mouse   208 NAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAKLP 272
            ||||.:|||||||||:|.|.||....|.|||:.||||||||.:.||::||.:||||||.|.|...
  Fly   321 NAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPE 385

Mouse   273 EFKMLRLGNADSFHYTKQGGSPMIEGVDDAKEMAHTRQACTLLGISESYQMGIFRILAGILHLGN 337
            :.:...|.:..|:.:...|..| :.||||..|...|.::..::|::......||||::.:|..|:
  Fly   386 QREKFILDDVKSYAFLSNGSLP-VPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGS 449

Mouse   338 VGF-ASRDSDSCTIPPKHEPLTIFCDLMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARD 401
            :.| ..|::|..|:|.......| ..|:|:...:|.......::....:...|..:|.|...|.:
  Fly   450 MKFRQERNNDQATLPDNTVAQKI-AHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVE 513

Mouse   402 ALAKHIYAKLFNWIVDHVNQALHSAVKQ-HSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQF 465
            |:||..|.::|.|:|:.:|::|....:| .||||:||:.|||.||:|||||.||||.||||||.|
  Fly   514 AIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLF 578

Mouse   466 NMHVFKLEQEEYMKEQIPWTLIDF-YDNQPCINLIESKLGILDLLDEECKMPKGTDDTWAQKLYN 529
            |..:|.||||||.:|.|.|..||| .|.||.|:||:...||:.||||||..||.||.|:..||.:
  Fly   579 NHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVS 643

Mouse   530 THLNKCALFEKPRMSNKA-FIIKHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQ 593
            .| :....|.|......| |.|.|:|.:|:|....:|.||.|.:.|..:.:|:.|:...:..:::
  Fly   644 AH-SMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWK 707

Mouse   594 DDE---KAISPTSATSSGRTPLTRVPVKPTKGRPGQTAKEHKKTVGHQFRNSLHLLMETLNATTP 655
            |.|   .|....:.|..|                .:|.|...:||.|.::..|..||:||..|.|
  Fly   708 DAEIVGMAQQALTDTQFG----------------ARTRKGMFRTVSHLYKEQLAKLMDTLRNTNP 756

Mouse   656 HYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVL 720
            ::||||.||..|.....|....:.|||..||||.|||...|||:|..:|||..||.:|.......
  Fly   757 NFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPK 821

Mouse   721 G--DRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLR 783
            |  |.|:.|:.:::.|.||.:.|:.|::|||||||.:|:||:.|..|:....:..|...||:|.|
  Fly   822 GFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLAR 886

Mouse   784 KRYLCMQRAAITVQRYVRGYQARCYAKFLRRTKAATTIQKYWRMYV-VRRRYKIRRAATIVIQ-- 845
            :.|    :..:.....:|..|..|.|....|.      .::||:|. |:...::.:....::|  
  Fly   887 RNY----QKRLQQLNAIRIIQRNCAAYLKLRN------WQWWRLYTKVKPLLEVTKQEEKLVQKE 941

Mouse   846 ---SYLR---GYLTRNRYRKILREYKAVIIQKRVRGWLARTHYKRTMKAIVYLQCCFRRMMAKRE 904
               ..:|   ..|.:|. ::..|:|:..:::|        |.....::|.:.|  |     |:.|
  Fly   942 DELKQVREKLDTLAKNT-QEYERKYQQALVEK--------TTLAEQLQAEIEL--C-----AEAE 990

Mouse   905 LKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLMEKLTNLEGVYNSETEKLRNDVE 969
            ..:.::.||..|        :|:.:.:|:.:::|:.       |::..|.|    |.:||..:::
  Fly   991 ESRSRLMARKQE--------LEDMMQELETRIEEEE-------ERVLALGG----EKKKLELNIQ 1036

Mouse   970 RL--QLSEEEA---KVATGRVLSLQEEIAKLRKDL-------EQTRSEKKSIEERADKYKQ---- 1018
            .|  ||.||||   |:...:| .|..:|.|..:||       ::...|||.:||||:...|    
  Fly  1037 DLEEQLEEEEAARQKLQLEKV-QLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAE 1100

Mouse  1019 --ETDQLVSNLKEENTLLKQEKETLNHRIVEQAKEMTETMERKLVEETKQLELDLNDERLRYQNL 1081
              |..:.::.||.::.....|.|...|:..:|.:| ::..:||:..|...|:..||:.|::...:
  Fly  1101 EEEKAKHLAKLKAKHEATISELEERLHKDQQQRQE-SDRSKRKIETEVADLKEQLNERRVQVDEM 1164

Mouse  1082 LNEFSRLEERYDDLKEEMT-LMLNVPKPGHKRTDSTHSSNESEYTFSSEFAE-TEDI-APRTEEP 1143
            ..:.::.|       ||:| .:|.:.:....:..:..:..|.|    |:.|| .||: |.:....
  Fly  1165 QAQLAKRE-------EELTQTLLRIDEESATKATAQKAQRELE----SQLAEIQEDLEAEKAARA 1218

Mouse  1144 IEKKVPLDMSLFLKLQKRVTELEQEKQLMQDELD-----------RKEEQVFRSKAKEEERPQIR 1197
            ..:||..|:|         .|||..|..:.|.||           |::|.....|:.|||.....
  Fly  1219 KAEKVRRDLS---------EELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHE 1274

Mouse  1198 GAELEYESLKRQELESENKKLKNELNELRKA--LSEKSAPEVTAPGAPAYRVLMEQLTSVSE--- 1257
            |...:......|||.|.|.:|:|    ||||  :.||:...:.|..|.    |..:|.||:.   
  Fly  1275 GVLADMRHKHSQELNSINDQLEN----LRKAKTVLEKAKGTLEAENAD----LATELRSVNSSRQ 1331

Mouse  1258 --------------ELDVRKEEVLILRSQLVSQKEAIQPKDDKNTMTDSTILLEDVQKMKDKGEI 1308
                          ||.|:..|:...||:|  |::..:.:.:...:|:.   ||:.: :|....:
  Fly  1332 ENDRRRKQAESQIAELQVKLAEIERARSEL--QEKCTKLQQEAENITNQ---LEEAE-LKASAAV 1390

Mouse  1309 AQAYIGLKETNRSSTMDYQELNEDGELWMVYEGLKQANRLLESQ------LQSQKRSHENEAEAL 1367
            ..|          |.|:.|              |.:|.:|||.:      |.|:.|..|:|.|||
  Fly  1391 KSA----------SNMESQ--------------LTEAQQLLEEETRQKLGLSSKLRQIESEKEAL 1431

Mouse  1368 RGEIQSLKEENNRQQQLLA----QNLQLPPEARIEASLQHEITRLTNENLYFEELYADDPKKYQS 1428
            :.:::...|.....::.||    |..::..:|..:|.|..|:               ::.||..:
  Fly  1432 QEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKEL---------------EEGKKRLN 1481

Mouse  1429 YRISLYKRMI-DLMEQLEKQDKTVRKLKKQLKVFAKKIGELEVGQMENISPGQIIDEPIRPVNIP 1492
            ..|...:|.: :|:.|.::.||:.:|::.:|:   ....|||.             :..:.:.:.
  Fly  1482 KDIEALERQVKELIAQNDRLDKSKKKIQSELE---DATIELEA-------------QRTKVLELE 1530

Mouse  1493 RKEKDFQGML-EYKREDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQKVRS 1556
            :|:|:|..:| |.|...||...:....|.:.|.....::         ...|..|...|  |:..
  Fly  1531 KKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVL---------SVSRELDEAFD--KIED 1584

Mouse  1557 LLTSTINSIKKVLKKRGDDFETVSFWLSNTCRFLHCLKQYSGEEGFMKHNTSRQNEHCL------ 1615
            |     .:.:|.|:...||       |:||                  ..|:.:|.|.|      
  Fly  1585 L-----ENKRKTLQNELDD-------LANT------------------QGTADKNVHELEKAKRA 1619

Mouse  1616 ----------TNFDLAEYRQVLSD--LAIQIYQQLVRVLENILQPMIVSGMLEHETIQGVSGV-- 1666
                      .|.:|.:..|:..|  |.:::..|.:|            ...|.:.:....|.  
  Fly  1620 LESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALR------------SQFERDLLAKEEGAEE 1672

Mouse  1667 KPTGLRKRTSSIADEGTYTLDSILRQLNSFHSVMCQHGMDPELIKQVVKQMFYIVGAITLNNLLL 1731
            |..||.|:...:..|    ||...:|..:  :|..:..::.:| |::...|       .::| .:
  Fly  1673 KRRGLVKQLRDLETE----LDEERKQRTA--AVASKKKLEGDL-KEIETTM-------EMHN-KV 1722

Mouse  1732 RKDMCSWSKGMQIRYNVSQLEEWLRDKNLMNSGAKETLEPL-------IQA--AQLLQV------ 1781
            ::|....:|.:|     :|:::.|||.....: |||.|:.|       ::|  |::||:      
  Fly  1723 KEDALKHAKKLQ-----AQVKDALRDAEEAKA-AKEELQALSKEAERKVKALEAEVLQLTEDLAS 1781

Mouse  1782 --------KKKTDDDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSFIRTIQMRLRDRKD 1838
                    :.:.|:.||.|.:  ||...:.::.           |:|...:.|.|::..|.:.:.
  Fly  1782 SERARRAAETERDELAEEIAN--NANKGSLMID-----------EKRRLEARIATLEEELEEEQS 1833

Mouse  1839 SPQLLMD 1845
            :.::|:|
  Fly  1834 NSEVLLD 1840

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo5aXP_006510890.1 COG5022 7..1448 CDD:227355 469/1579 (30%)
MYSc_Myo5 83..751 CDD:276831 272/728 (37%)
Myo5a_CBD 1506..1880 CDD:271262 71/383 (19%)
zipNP_523860.2 Myosin_N 80..117 CDD:280832 10/38 (26%)
Myosin_head 133..854 CDD:278492 276/752 (37%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 272/728 (37%)
Myosin_tail_1 931..2011 CDD:279860 239/1123 (21%)
Prefoldin 1431..1515 CDD:298833 19/101 (19%)
FAM76 <1847..1926 CDD:292665
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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