DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo5a and Mhc

DIOPT Version :9

Sequence 1:XP_006510890.1 Gene:Myo5a / 17918 MGIID:105976 Length:1880 Species:Mus musculus
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:2090 Identity:559/2090 - (26%)
Similarity:928/2090 - (44%) Gaps:445/2090 - (21%)


- Green bases have known domain annotations that are detailed below.


Mouse     4 SELYTKFARVWIPDPEEVWKSAELLKDYK--PGDKVLLLHLEEGKDLEYRLDPKTGELPHLRNPD 66
            |:.|......||||.:|.:    ||.:.|  .|| ::.:.|:.|   |.| |.|:.::..: ||.
  Fly    29 SKPYDSKKSCWIPDEKEGY----LLGEIKATKGD-IVSVGLQGG---EVR-DIKSEKVEKV-NPP 83

Mouse    67 ILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSGQN 131
            ......|:..::.|:.|.||||||.|:. :||||||.|:..||||||::.|:|.......|.|:.
  Fly    84 KFEKIEDMADMTVLNTPCVLHNLRQRYY-AKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKR 147

Mouse   132 MGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGS-------ASE 189
            ..::.|||||:::.||..|..:..|||::::||||||||.:.|..:.|||||..|       .|:
  Fly   148 RNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSK 212

Mouse   190 ANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAE 254
            .::|::|:.:||::|:.|||||.||||||||||:|.|.|....::.||::.||||||:||:.|..
  Fly   213 GSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQS 277

Mouse   255 EERNYHIFYQLCASAKLPEFK--MLRLGNADSFHYTKQGGSPMIEGVDDAKEMAHTRQACTLLGI 317
            .||:||||||: .|..:|..|  .|...|...:|...| |...:..:|||:|.:.|.||..:||.
  Fly   278 LERSYHIFYQI-MSGSVPGVKDICLLTDNIYDYHIVSQ-GKVTVASIDDAEEFSLTDQAFDILGF 340

Mouse   318 SESYQMGIFRILAGILHLGNVGFASRDSDSCTIPPKHEPLTIFCDLMGVDYEEMCHWLCHRKLAT 382
            ::..:..::||.|.::|:|.:.|..|..:........|.......|.|.|..|:...|...::..
  Fly   341 TKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKV 405

Mouse   383 ATETYIKPISKLQATNARDALAKHIYAKLFNWIVDHVNQALHSAVKQHSFIGVLDIYGFETFEIN 447
            ..|...:..:..|.||:..||.|.::.:||.|:|...|:.|.:..|:..|||||||.|||.||.|
  Fly   406 GNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYN 470

Mouse   448 SFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDF-YDNQPCINLIESKLGILDLLDE 511
            .|||.|||:.||||||.||.|:|.||||||.:|.|.|..||| .|...||:|||..:|||.:|:|
  Fly   471 GFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEE 535

Mouse   512 ECKMPKGTDDTWAQKLYNTHLNKCALFEKPRMSNKA-----FIIKHFADKVEYQCEGFLEKNKDT 571
            |...||.||.|:::||.||||.|.|.|:||:.....     |.|.|:|..|.|...|:||||||.
  Fly   536 ESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDP 600

Mouse   572 VFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRVPVKPTKGRPGQTAK--EHKK- 633
            :.:..:...|.|:.|:|.|:|.|        .|..||               .|:.||  ..|| 
  Fly   601 LNDTVVDQFKKSQNKLLIEIFAD--------HAGQSG---------------GGEQAKGGRGKKG 642

Mouse   634 ----TVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISA 694
                ||...::..|:.||.||.:|.||:||||.||:.|.|...|....:.||...||||.|||..
  Fly   643 GGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICR 707

Mouse   695 AGFPSRWTYQEFFSRYRVLMKQ--KDVLGDRKQTCKNVLEKLI-LDKDKYQFGKTKIFFRAGQVA 756
            .|||:|..|.:|..||:::..:  :.|..|:|.|  .::.|.| |.:|:|:.|.||:|||||.:.
  Fly   708 KGFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKAT--EIIIKFIDLPEDQYRLGNTKVFFRAGVLG 770

Mouse   757 YLEKLRADKLRAACIRIQKTIRGWLLRKRYLCMQRAAITVQRYVRGYQARCYAKFLRRTKAATTI 821
            .:|:.|.::|        ..|..|:               |.:.|||.:|         |....:
  Fly   771 QMEEFRDERL--------GKIMSWM---------------QAWARGYLSR---------KGFKKL 803

Mouse   822 QKYWRMYVVRRRYKIRRAATIVIQSYLRGYLTRNR--YRKILREYKAVIIQKRVRGWLARTHYK- 883
            |:             :|.|..|:|..||.||....  :.|:.::.|.::...|:...:||...| 
  Fly   804 QE-------------QRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKA 855

Mouse   884 --------RTMKAIVYLQCCFRRMMAKRE--LKKLKIEARSVERYKKLHIGMENKIMQLQRKVDE 938
                    ..:|....|:....:::|::.  |..|..|..:::.|::.:.    |:...:..::.
  Fly   856 KKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNA----KLTAQKNDLEN 916

Mouse   939 QNKDYKCLMEKLTNLEGVYN----------SETEKLRNDVERLQL----SEEEAKVATGRVLSLQ 989
            |.:|   :.|:||..|...|          .|...|:.|:|.|:|    :|::......::.:|.
  Fly   917 QLRD---IQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLN 978

Mouse   990 EEIA-------KLRKDL-------EQTRSEKKSIEERAD-------KYKQETDQLVSNLKEENTL 1033
            :|||       ||.|:.       ::|..|.::.|::.:       |.:|..|:|..:|:.|..:
  Fly   979 DEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKV 1043

Mouse  1034 ---LKQEKETL--NHRIVEQA--------KEMTETMERKLVEETKQLELDLNDER---LRYQNLL 1082
               :::.|..:  :.::.::|        ||:.:|::|| .:|...:...|.||:   |::|..:
  Fly  1044 RGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRK-DKELSSITAKLEDEQVVVLKHQRQI 1107

Mouse  1083 NEFSRLEERYDDLKEEMTLMLNV-PKPGHKRTDSTHSSNESEYTFSSEFAETEDIAPRTEE---P 1143
            .|   |:.|.::|:||:...... .|...:|.|...              |.|::..|.||   .
  Fly  1108 KE---LQARIEELEEEVEAERQARAKAEKQRADLAR--------------ELEELGERLEEAGGA 1155

Mouse  1144 IEKKVPLDMSLFLKLQKRVTELEQEKQLMQDELDRKEEQVFRSKAKEEERPQIRGAELEYESLKR 1208
            ...::.|:       :||..||.:.::.:::...:.|..:...:.|..:..    ||:..:..:.
  Fly  1156 TSAQIELN-------KKREAELSKLRRDLEEANIQHESTLANLRKKHNDAV----AEMAEQVDQL 1209

Mouse  1209 QELESENKKLKNE----LNELRKAL----SEKSAPEVTAPGAPAYRVLMEQLTSVSEEL------ 1259
            .:|:::.:|.|||    ||:||..:    :||:|.|..|      :.|...|..|..:|      
  Fly  1210 NKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIA------KQLQHTLNEVQSKLDETNRT 1268

Mouse  1260 ----DVRKEEVLILRSQLVSQKEAIQPKDDK--NTMTDSTILLEDVQKMKDKGEIAQAYIGLKET 1318
                |..|:::.|..|.|:.|.|..:.:..:  ......|..|||.:::.|:....:|.:..|..
  Fly  1269 LNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFR 1333

Mouse  1319 NRSSTMD-------------------YQELNEDGELW-MVYEG--------LKQANRLLESQLQS 1355
            |....:|                   ..:.|.:.::| ..||.        |::|.|.|:::|..
  Fly  1334 NLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAE 1398

Mouse  1356 QKRSHEN----------EAEALRGEIQSLKEENNR--------------------QQQLLAQNLQ 1390
            .:.:.|:          ..:.|..|::.|:.|.:|                    :.:|...:| 
  Fly  1399 AEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDL- 1462

Mouse  1391 LPPEARIEASLQHEITRLTNENLYFEELYADDPKKYQSYR---ISLYKRMIDLMEQLEKQDKTVR 1452
               .|.::|| |.|....:.|....:..|.:..::.::.|   .:|...:.||::|:.:..:.:.
  Fly  1463 ---AAELDAS-QKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIH 1523

Mouse  1453 KLKKQLKVFAKKIGELEVG---------QMEN------ISPGQIIDEPIRPVNIPRKEKDFQGML 1502
            :::|..|....:..||:..         |.||      :...|:..|..|  .|..||::|:...
  Fly  1524 EIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDR--RIQEKEEEFENTR 1586

Mouse  1503 EYKREDEQKLVKNLILELKPRGVAVNLIPGLPAYI--LFMCVRHADYLN-DDQKVRSLLTSTINS 1564
            :..:.....:..:|..|.|.:..|:.:...|.|.|  |.:.:.||:..| :.||........:..
  Fly  1587 KNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKD 1651

Mouse  1565 IKKVLKKRGDDFETVSFWLSNTCRFLHCLKQYSGEEGFMKHNTSRQNEHCLTNFDLAEYRQVLSD 1629
            |:..|::                      :|.:.::...:...|.:..:.|.| :|.|.|.:|..
  Fly  1652 IQTALEE----------------------EQRARDDAREQLGISERRANALQN-ELEESRTLLEQ 1693

Mouse  1630 L---AIQIYQQLVRVLENILQPMIVSGMLEHETIQGVSGVKPTGLRKRTSSIADEGTYTLDSILR 1691
            .   ..|..|:|...               ||.:..||.        :.:||: .....|:|.|:
  Fly  1694 ADRGRRQAEQELADA---------------HEQLNEVSA--------QNASIS-AAKRKLESELQ 1734

Mouse  1692 QLNSFHSVMCQHGMDPELIKQVVKQMFYIVGAITLNNLL------------LRKDMCSWSKGMQI 1744
            .|:|....:.....:.|  ::..|.|   |.|..|.:.|            |||.:....|.:|:
  Fly  1735 TLHSDLDELLNEAKNSE--EKAKKAM---VDAARLADELRAEQDHAQTQEKLRKALEQQIKELQV 1794

Mouse  1745 RYN-------------VSQLEEWLRD----------------KNLMNSGAK-------------- 1766
            |.:             :.:||:.:|:                |||..|..:              
  Fly  1795 RLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKN 1859

Mouse  1767 -ETLEPLI-QAAQLLQVKKKTDDDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSFIRTI 1829
             |.::.|: :..|.::..|:..::||.|.::       .:.|.......:.|.|||..::.....
  Fly  1860 HERMQDLVDKLQQKIKTYKRQIEEAEEIAAL-------NLAKFRKAQQELEEAEERADLAEQAIS 1917

Mouse  1830 QMRLRDRKDS 1839
            :.|.:.|..|
  Fly  1918 KFRAKGRAGS 1927

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo5aXP_006510890.1 COG5022 7..1448 CDD:227355 472/1616 (29%)
MYSc_Myo5 83..751 CDD:276831 284/692 (41%)
Myo5a_CBD 1506..1880 CDD:271262 72/397 (18%)
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 15/45 (33%)
MYSc 81..777 CDD:214580 293/723 (41%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 284/692 (41%)
Myosin_tail_1 842..1897 CDD:279860 220/1162 (19%)
V_Alix_like 1557..1877 CDD:187408 67/373 (18%)
ATP-synt_B <1671..1771 CDD:304375 28/129 (22%)
TMPIT 1739..>1825 CDD:285135 16/90 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

Return to query results.
Submit another query.