DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo5a and d

DIOPT Version :9

Sequence 1:	XP_006510890.1	Gene:	Myo5a / 17918	MGIID:	105976	Length:	1880	Species:	Mus musculus
Sequence 2:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	825	Identity:	241/825 - (29%)
Similarity:	365/825 - (44%)	Gaps:	142/825 - (17%)

- Green bases have known domain annotations that are detailed below.

Mouse    46 KDLEYRLDPKTGELPHLRNPDILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAI 110
            ||::        :|.||..|              |.|.||:..|:.|| :.:..:|..|.:|::|
  Fly   473 KDMQ--------DLIHLSGP--------------LTEHAVMRTLQARF-NERRYFTNVGPILLSI 514

Mouse   111 NPYEQLPIYGEDIIN--AYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSA 173
            |||       .|:.|  ..:......:.|.:..:.:||.:|.:.....|:||:||.||||||.:|
  Fly   515 NPY-------LDVGNPLTLTSTRAMPLAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANA 572

Mouse   174 KYAMRYFATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGAN 238
            ...:|....::|...|.:..:.:.|:..::.|:|:||||.|..|||.|::||:....     ||.
  Fly   573 MLMLRQLFAIAGGGPETDAFKHLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQVTD-----GAL 632

Mouse   239 MRT----YLLEKSRVVFQAEEERNYHIFYQLCASAKLPEFKMLRLGNADSFHYTKQGGSPM---- 295
            .||    |.|:::||:....:|:||||||||.|.....|.:.|.|          .|.||.
  Fly   633 YRTKIHCYFLDQTRVIRPLPKEKNYHIFYQLLAGLSREERQKLHL----------DGYSPANLRY 687

Mouse   296 ---IEGVDDAKEMAHTRQACTLLGISESYQMGIFRILAGILHLGNVGFASRDSDSCTIPPKHE-P 356
               ..|.::.::.|..:...|.|||.....:.:.|:||.:|.||||.|.  |.....:..|.| .
  Fly   688 LRGDIGQNEQEDAARFQAWKTCLGILGIPFLDVVRVLAAVLLLGNVQFI--DGGGLEVDVKGETE 750

Mouse   357 LTIFCDLMGVDYEEMCHWLCHRKLATATETYIKPISKL-----QATNARDALAKHIYAKLFNWIV 416
            |.....|:||....:     .|.|.|.|......:.|.     .|...||.|||.:|.:....||
  Fly   751 LNSVASLLGVPPAAL-----FRGLTTRTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIV 810

Mouse   417 DHVNQ--------------------------------------------ALHSAVK---QHSFIG 434
            ...|.                                            ||::||:   ...|||
  Fly   811 RRANSLKRLGSTLGTLSSDSNESVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIG 875

Mouse   435 VLDIYGFETFEINS-FEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPW-TLIDFYDNQPCIN 497
            :||::|||....:: .|..|||...|.:|..:|.|:||...|....|.|.. |.:|:.||.|||:
  Fly   876 ILDMFGFEEPSPHAHLEHLCINLCAETMQHFYNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCID 940

Mouse   498 LIES-KLGILDLLDEECKMPKGTDDTWAQKLYNTHLNKCALFEKPRM---SNKAFIIKHFADKVE 558
            ||.| :.|:|.:||.||.: :||.:::..||...|.:...|..||..   ..:.|:|:|||.:||
  Fly   941 LISSLRTGLLSMLDAECSV-RGTAESYVTKLKVQHRSSTRLETKPTAEPHDPRMFLIRHFAGRVE 1004

Mouse   559 YQCEGFLEKNKDTVFEEQIKVL--KSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRVPVKPTK 621
            |....||:.|:|.|.::.:.|.  .:..|.....||..:.||:........|.:    ..:.||.
  Fly  1005 YDTTDFLDTNRDVVPDDLVGVFYKHTCNFGFATHLFGSELKALYAQQQAPRGLS----FRISPTS 1065

Mouse   622 GRPGQTAKEHKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGV 686
            ........|...|:...|...|..|:.||....||:||||:.|..:...:||....|:|:|:..|
  Fly  1066 HSDLLNGDEPVSTLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQV 1130

Mouse   687 LETIRISAAGFPSRWTYQEFFSRYRVL-------MKQKDVLGDRKQTCKNVLEK-LILDKD---K 740
            |||:.:.|:|||.|..:::|.:|||:|       ..:...|.|.:...|..:|: .:||..   .
  Fly  1131 LETVNLMASGFPHRMRFKQFNARYRMLAPFRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLA 1195

Mouse   741 YQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKR 785
            :..||..:|...|...:||.||.:....:...:|.|.|||..||:
  Fly  1196 WAPGKRHVFLSEGIRQHLEHLRTEIRHKSATLMQATWRGWWWRKK 1240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo5a	XP_006510890.1	COG5022	7..1448	CDD:227355	241/825 (29%)
		MYSc_Myo5	83..751	CDD:276831	221/752 (29%)
		Myo5a_CBD	1506..1880	CDD:271262
d	NP_001188730.1	MYSc	476..1217	CDD:214580	230/797 (29%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	221/752 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820