Protein Alignment Myo5a and dachs

DIOPT Version :10

• Sequence 1: XP_006510890.1
• Gene: Myo5a / 17918
• MGIID: 105976
• Length: 1880
• Species: Mus musculus
• Sequence 2: NP_001188730.1
• Gene: dachs / 34179
• FlyBaseID: FBgn0262029
• Length: 1426
• Species: Drosophila melanogaster
• Alignment Length: 825
• Identity: 241/825 - (29%)
• Similarity: 365/825 - (44%)
• Gaps: 142/825 - (17%)

Mouse    46 KDLEYRLDPKTGELPHLRNPDILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAI 110
            ||::        :|.||..|              |.|.||:..|:.|| :.:..:|..|.:|::|
  Fly   473 KDMQ--------DLIHLSGP--------------LTEHAVMRTLQARF-NERRYFTNVGPILLSI 514

Mouse   111 NPYEQLPIYGEDIIN--AYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSA 173
            |||       .|:.|  ..:......:.|.:..:.:||.:|.:.....|:||:||.||||||.:|
  Fly   515 NPY-------LDVGNPLTLTSTRAMPLAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANA 572

Mouse   174 KYAMRYFATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGAN 238
            ...:|....::|...|.:..:.:.|:..::.|:|:||||.|..|||.|::||:....     ||.
  Fly   573 MLMLRQLFAIAGGGPETDAFKHLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQVTD-----GAL 632

Mouse   239 MRT----YLLEKSRVVFQAEEERNYHIFYQLCASAKLPEFKMLRLGNADSFHYTKQGGSPM---- 295
            .||    |.|:::||:....:|:||||||||.|.....|.:.|.|          .|.||.
  Fly   633 YRTKIHCYFLDQTRVIRPLPKEKNYHIFYQLLAGLSREERQKLHL----------DGYSPANLRY 687

Mouse   296 ---IEGVDDAKEMAHTRQACTLLGISESYQMGIFRILAGILHLGNVGFASRDSDSCTIPPKHE-P 356
               ..|.::.::.|..:...|.|||.....:.:.|:||.:|.||||.|.  |.....:..|.| .
  Fly   688 LRGDIGQNEQEDAARFQAWKTCLGILGIPFLDVVRVLAAVLLLGNVQFI--DGGGLEVDVKGETE 750

Mouse   357 LTIFCDLMGVDYEEMCHWLCHRKLATATETYIKPISKL-----QATNARDALAKHIYAKLFNWIV 416
            |.....|:||....:     .|.|.|.|......:.|.     .|...||.|||.:|.:....||
  Fly   751 LNSVASLLGVPPAAL-----FRGLTTRTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIV 810

Mouse   417 DHVNQ--------------------------------------------ALHSAVK---QHSFIG 434
            ...|.                                            ||::||:   ...|||
  Fly   811 RRANSLKRLGSTLGTLSSDSNESVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIG 875

Mouse   435 VLDIYGFETFEINS-FEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPW-TLIDFYDNQPCIN 497
            :||::|||....:: .|..|||...|.:|..:|.|:||...|....|.|.. |.:|:.||.|||:
  Fly   876 ILDMFGFEEPSPHAHLEHLCINLCAETMQHFYNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCID 940

Mouse   498 LIES-KLGILDLLDEECKMPKGTDDTWAQKLYNTHLNKCALFEKPRM---SNKAFIIKHFADKVE 558
            ||.| :.|:|.:||.||.: :||.:::..||...|.:...|..||..   ..:.|:|:|||.:||
  Fly   941 LISSLRTGLLSMLDAECSV-RGTAESYVTKLKVQHRSSTRLETKPTAEPHDPRMFLIRHFAGRVE 1004

Mouse   559 YQCEGFLEKNKDTVFEEQIKVL--KSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRVPVKPTK 621
            |....||:.|:|.|.::.:.|.  .:..|.....||..:.||:........|.:    ..:.||.
  Fly  1005 YDTTDFLDTNRDVVPDDLVGVFYKHTCNFGFATHLFGSELKALYAQQQAPRGLS----FRISPTS 1065

Mouse   622 GRPGQTAKEHKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGV 686
            ........|...|:...|...|..|:.||....||:||||:.|..:...:||....|:|:|:..|
  Fly  1066 HSDLLNGDEPVSTLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQV 1130

Mouse   687 LETIRISAAGFPSRWTYQEFFSRYRVL-------MKQKDVLGDRKQTCKNVLEK-LILDKD---K 740
            |||:.:.|:|||.|..:::|.:|||:|       ..:...|.|.:...|..:|: .:||..   .
  Fly  1131 LETVNLMASGFPHRMRFKQFNARYRMLAPFRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLA 1195

Mouse   741 YQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKR 785
            :..||..:|...|...:||.||.:....:...:|.|.|||..||:
  Fly  1196 WAPGKRHVFLSEGIRQHLEHLRTEIRHKSATLMQATWRGWWWRKK 1240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo5a	XP_006510890.1	COG5022	7..1448	CDD:227355	241/825 (29%)
		MYSc_Myo5	83..751	CDD:276831	221/752 (29%)
		Myo5a_CBD	1506..1880	CDD:271262
dachs	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	221/752 (29%)
		IQCD	1219..1250	CDD:467745	7/22 (32%)