Protein Alignment Myo1b and ck

DIOPT Version :9

• Sequence 1: XP_006495827.1
• Gene: Myo1b / 17912
• MGIID: 107752
• Length: 1138
• Species: Mus musculus
• Sequence 2: NP_001285949.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Alignment Length: 1069
• Identity: 346/1069 - (32%)
• Similarity: 556/1069 - (52%)
• Gaps: 139/1069 - (13%)

Mouse     6 VKSSLLDNMIGVGDMVLLEPLNEETFIDNLKKRFDHNEIYTYIGSVVISVNPYRSLPIYSPEKVE 70
            :|:....::.||.||:.|..|:|...:.||..|:..|.||||.||::::||||:.||||:.::::
  Fly    54 IKAMHASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIK 118

Mouse    71 DYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEV 135
            .|:.|...||.|||||:.|.||..::...:||||:|:|||||||||::||::.|:||:.||.:.:
  Fly   119 LYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKHSWI 183

Mouse   136 NQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPR 200
            .|   |:|::||:|||||||||:|||||||||||:||.|...|...|..|..|||||||:|.|..
  Fly   184 EQ---QILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNH 245

Mouse   201 GERNFHVFYQLLSG--ASEELLYKLKLERDFSRYNYLS-LDSAKVNGVDDAANFRTVRNAMQIVG 262
            .|||:||||.:|:|  |.|:....|.:..|   |.||: .:|....|.||||.|..:|:||:::.
  Fly   246 SERNYHVFYCILAGLSADEKSRLDLGMAAD---YKYLTGGNSITCEGRDDAAEFSDIRSAMKVLL 307

Mouse   263 FLDHEAEAVLEVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTSIDQVVLERAFSFR 327
            |.|.|...:::::||:|..|||::| .:.|:.||.::|.:...::.:..|..:....|..|.:.|
  Fly   308 FSDQEIWEIIKLLAALLHCGNIKYK-ATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRR 371

Mouse   328 TVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFE 392
            |:.|..|.|.:||:..|:...|||..|.:|.|:|..:|.:||.:|.......:..:|||||:|||
  Fly   372 TLFAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFE 436

Mouse   393 IFENADNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNG 457
            .|:  .||||||.|||.||.|||.|::...|.|||||..|.|.|.||::.:|....|||......
  Fly   437 NFD--QNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLN 499

Mouse   458 ILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTTLPHSCFRIQHYAGKVL 522
            |:|::|||...| ..||:|.|.||::...:|::          :|...:..::.|.:.|:||.|.
  Fly   500 IMALIDEEARFP-KGTDQTMLAKLHKTHGSHKN----------YLKPKSDINTSFGLNHFAGVVF 553

Mouse   523 YQVEGFVDKNNDLLYRDLSQAMWKAGHSLIKSLFPE----GNPAKVNLKRPPTAGSQFKASVATL 583
            |...||:|||.|....||...:.::.:..::.:|.:    |...:   ||.||..:||:.|:..|
  Fly   554 YDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIFAQDIEMGAETR---KRTPTLSTQFRKSLDAL 615

Mouse   584 MRNLQTKNPNYIRCIKPNDKKAAHIFNESLVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYK 648
            |:.|.:..|.:|||||||:.|...:|:..|.|.|:||.|::|.:|:|||||..|..:...:|||:
  Fly   616 MKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYR 680

Mouse   649 MLCKQTWPHWKGPARSGVEVLFNELEIPVEEHSFGRSKIFIRNPRTLFQLEDLRKQRLEDLATLI 713
            .|.....|..:...::....:. .:.:...::..|.:|:|:::...|| ||..|.:.|.....::
  Fly   681 FLIPGVPPAHRTDCQAATSRIC-AVVLGKSDYQLGHTKVFLKDAHDLF-LEQERDRVLTRKILIL 743

Mouse   714 QKIYRGWKCRTHFLLMKRSQVVIAAWYRRYAQQKRYQQIKSSALVIQSYIRGWKARKILRELKHQ 778
            |:..|||..|..||.::.:.:.:..:::.|||:|||:.::...:.:|:.||.       |.|.|:
  Fly   744 QRSIRGWVYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRS-------RVLSHR 801

Mouse   779 -KRCKEAATTIAAYWHGTQARRELRRLKDEARNKHAIAVIWAYWLGSKARRELKRLKEEARRKHA 842
             :..:.....:.|:..|...|||.         .|.:      |...|.:..::|:  .|.|::.
  Fly   802 FRHLRGHIVGLQAHARGYLVRREY---------GHKM------WAVIKIQSHVRRM--IAMRRYR 849

Mouse   843 VAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYLLEMKNKMPSLSPIDKNWPSRPYL 907
                       |:|.|:::|...        ..|:::.::.||...||
  Fly   850 -----------KLRLEHKQFAEV--------LQLRKLEEQELLHRGNK----------------- 878

Mouse   908 FLDSTH-KELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLE 971
                 | :|:..       :.|||:..:.::...:|:||                    ....:|
  Fly   879 -----HAREIAE-------QHYRDRLHELERREIQEQLE--------------------NRRRVE 911

Mouse   972 INKNPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDV 1036
            :|.|    .:.||..::   .|.|:     :||....:|....::...|....|..::.| ..|:
  Fly   912 VNMN----IINDAARKQ---EEPVD-----DGKLVEAMFDFLPDSSSDAPTPHGGRETSV-FNDL 963

Mouse  1037 TKVSMSSQNDGFFAVHLKEGSEAASKGDF 1065
            ......:|:|....:|:.|..|..|:..|
  Fly   964 PHAQNVNQDDIIAPIHISEDEEDLSEFKF 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo1b	XP_006495827.1	MYSc_Myo1	29..690	CDD:276829	264/667 (40%)
		IQ	751..773	CDD:197470	3/21 (14%)
		Myosin_TH1	943..1120	CDD:368706	23/123 (19%)
ck	NP_001285949.1	MYSc	64..733	CDD:214580	275/693 (40%)
		MYSc_Myo7	77..721	CDD:276832	264/667 (40%)
		MyTH4	<1138..1245	CDD:214535
		B41	1251..1467	CDD:214604
		FERM_B-lobe	1355..1439	CDD:271216
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910