DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo15 and ck

DIOPT Version :9

Sequence 1:NP_034992.2 Gene:Myo15 / 17910 MGIID:1261811 Length:3511 Species:Mus musculus
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2587 Identity:660/2587 - (25%)
Similarity:1033/2587 - (39%) Gaps:750/2587 - (28%)


- Green bases have known domain annotations that are detailed below.


Mouse  1195 PSMRSREQHRE--DGVEDMTQLEDLQETTVLANLKTRFERNLIYTYIGSILVSVNPYRMFAIYGP 1257
            |..|.:..|..  .|||||..|.||.|..:|.||..|::.||||||.|||||:||||::..||..
  Fly    50 PERRIKAMHASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTG 114

Mouse  1258 EQVQQYSGRALGENPPHLFAIANLAFAKMLDAKQNQCVIISGESGSGKTEATKLILRCLAAMNQR 1322
            :|::.|..|.:||.|||:|||.:.|:|.|...:|:||::||||||:||||:|||||:.|||::.:
  Fly   115 DQIKLYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGK 179

Mouse  1323 RDVMQQIKILEATPLLEAFGNAKTVRNDNSSRFGKFVEI-FLEGGVICGAITSQYLLEKSRIVFQ 1386
            ...::| :||||.|:|||||||||:||||||||||:::| |...|||.||...||||||||||.|
  Fly   180 HSWIEQ-QILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQ 243

Mouse  1387 AKNERNYHIFYELLAGLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVLGF 1451
            ..:|||||:||.:||||.|..:....|..|..|.||..|.:....|:.||.:|..:.:||:||.|
  Fly   244 NHSERNYHVFYCILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLF 308

Mouse  1452 TSEDQDSIFRILASILHLGNVYFEKHETDAQEVASVVSAREIQAVAELLQVSPEGLQKAITFKVT 1516
            :.::...|.::||::||.||:.::....|..:...:.....::.||.||.:..:.|..|:|.:..
  Fly   309 SDQEIWEIIKLLAALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTL 373

Mouse  1517 ETIREKIFTPLTVESAVDARDAIAKVLYALLFGWLITRVNALVSPKQDTL--SIAILDIYGFEDL 1579
            ....|.:.:.|:.:.:||.|||..|.:|..:|..::.::|..:...:.|.  :|.:|||:|||:.
  Fly   374 FAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENF 438

Mouse  1580 SFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQMDWREIAFADNQPCINLISLKPYGILRI 1644
            ..|||||.||||||||||..|.:.:|:.|||||..|.::|:.|.|.|||..::||::|...|:.:
  Fly   439 DQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEFVDNQDALDLIAIKQLNIMAL 503

Mouse  1645 LDDQCCFPQATDHTFLQKCHYHHGANPLYSKPKMPL-PEFTIKHYAGKVTYQVHKFLDKNHDQVR 1708
            :|::..||:.||.|.|.|.|..||::..|.|||..: ..|.:.|:||.|.|....|||||.|...
  Fly   504 IDEEARFPKGTDQTMLAKLHKTHGSHKNYLKPKSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFS 568

Mouse  1709 QDVLDLFVHSRTRVVAHLFSSHAAQTAPPRLGKSSSITRLYKAHTVAAKFQQSLLDLVEKMERCN 1773
            .|:|.|...|..:.:..:|:......|..|          .:..|::.:|::||..|::.:..|.
  Fly   569 PDLLHLVSQSTNKFLRQIFAQDIEMGAETR----------KRTPTLSTQFRKSLDALMKTLSSCQ 623

Mouse  1774 PLFVRCLKPNHKKEPGLFEPDVMMAQLRYSGVLETVRIRKEGFPVRLPFQVFIDRYRCLVALKLN 1838
            |.|:||:|||..|:|.:|:..:...||||||::||:|||:.|:|:|..|:.|::|||.|:.   .
  Fly   624 PFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP---G 685

Mouse  1839 V-PADGDMCVSLLSRLCTVT--PDMYRVGISKLFLKEHLHQLLESMRERVQNRAALTLQRYLRGF 1900
            | ||....|.:..||:|.|.  ...|::|.:|:|||:.....||..|:||..|..|.|||.:||:
  Fly   686 VPPAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGW 750

Mouse  1901 FIQR----------------------------------------------HFRSLRRKIILLQSR 1919
            ..:|                                              .||.||..|:.||:.
  Fly   751 VYRRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQAH 815

Mouse  1920 ARGFLARQRYQQMRQSLLKFRSLVHTYVNRRRYLKLRAEQRRRAQEAWLR---EQE--------- 1972
            |||:|.|:.|.....:::|.:|.|...:..|||.|||.|.::.|:...||   |||         
  Fly   816 ARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRYRKLRLEHKQFAEVLQLRKLEEQELLHRGNKHA 880

Mouse  1973 -------------ELSKREV---------VPV---------RHLEVPAEVAGLLQA--------A 1998
                         ||.:||:         |.|         |..|.|.:...|::|        :
  Fly   881 REIAEQHYRDRLHELERREIQEQLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSS 945

Mouse  1999 AGLKLSSGPRVAVV--RAPRLQ--AEPCVTLPL-------DINNYPMAKFIRCHFK-EPSFGMLT 2051
            :......|.|...|  ..|..|  .:..:..|:       |::.:...||...:|: ..:.....
  Fly   946 SDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAK 1010

Mouse  2052 VPLKMPLTRLPVEHHAEAISVFKL---ILRFMGD---PHLHGTQEM------------------- 2091
            ..||.||  ||:....:.::...|   ||||.||   |..|....|                   
  Fly  1011 KALKHPL--LPLHTQGDQLAAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIR 1073

Mouse  2092 --------ILG------------------------------------------------------ 2094
                    ::|                                                      
  Fly  1074 SKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSWLQSR 1138

Mouse  2095 --------NYIVHQGLVEPALRDEILAQLANQVWRNPNAYNSKRGWLLLAACLSGFAPSPHLDKF 2151
                    ::|:..|::...|||||..|:..|:..||...:..|||:||:.|:..||||.....:
  Fly  1139 PTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNY 1203

Mouse  2152 LLKFVSDYGQNGFQAVCQHRLLQAMGSGAARTFPPTQLEWTAIQEKASMALDVSCFNGDQFSCPV 2216
            |..|:.: |..|:...|:.||.:...:| .|..||:.||..|.:.|..:.|.::..:|:..:...
  Fly  1204 LRAFIRE-GPPGYAPYCEERLKRTFNNG-TRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLA 1266

Mouse  2217 HTWSTGEAVAGDILKHRGLADGWRGWTVAMKNGVQWAELAGHDYVLDLVSDLELLRDFPRQKSYF 2281
            .:.:|...:...:.....|.|.: |:::.:.             :.|.||.|             
  Fly  1267 DSATTARELCNQLSDKISLKDQF-GFSLYIA-------------LFDKVSSL------------- 1304

Mouse  2282 IVGAEGPLAGRGDTRGVFGNCWDSDEDTPTRPQPQDHVAKMPDLDGYCSH--KEDGTNGETEAQR 2344
              |:.|                             |||.   |....|..  ||.|........|
  Fly  1305 --GSGG-----------------------------DHVM---DAISQCEQYAKEQGAQERNAPWR 1335

Mouse  2345 WTSNRQAVDSIGESTVPPRELDGYLDSLFDPVLACGDADLEKPTAIAYRMKGGGQPGGGGGSTSE 2409
            ....::......|.|             .|.|          .|.:.|:....|...|......|
  Fly  1336 LFFRKEIFAPWHEPT-------------HDQV----------ATNLIYQQVVRGVKFGEYRCDKE 1377

Mouse  2410 DTSRRPPEPKLKPIPGLDASTLALQQAFIHRQAVLLAREMTLQALALQQQPLSATSRPQLPERPL 2474
            :                |.:.:|.||.||.     .:.:|:::.|.                 .|
  Fly  1378 E----------------DLAMIAAQQYFIE-----YSTDMSMERLF-----------------TL 1404

Mouse  2475 APEARPKTVVGTGPPAKPVLVRPTPQSWAPGSVAKAPKIPSKPVAVPILAQDWTAPESISASPEL 2539
            .|...|                    .:....|.||             .:.|.|          
  Fly  1405 LPNFIP--------------------DFCLSGVDKA-------------IERWAA---------- 1426

Mouse  2540 VRYSTLNSEHFPQPTQQIRSIIKQYKQPPWAGHPEARRTDGGKVFRRPPDPHEEALMILKGQKTQ 2604
                               .:::.||:.                                     
  Fly  1427 -------------------LVLQAYKKS------------------------------------- 1435

Mouse  2605 LAVVPGTQVSREAVAMVKPVTSAPRPCMGPTPVQPSRSLEPPEDPVQTQLHRLVNPNFYGYQDIP 2669
                                                                             
  Fly  1436 ----------------------------------------------------------------- 1435

Mouse  2670 WRIFLRKEVFYPKDNYSHPVQLDLLFRQILHDTFSEACLRISEDERLQMKALFAQNQLDTQRPLV 2734
                     :|.||..                    |.|:|.||                     
  Fly  1436 ---------YYVKDKI--------------------APLKIKED--------------------- 1450

Mouse  2735 TESVKRAAISMARDSWEIYFSRLFPAMGSVGTGVQ----ILAVSHTGIKLLQMVKGSKEASRRLR 2795
                   .:|.|:..|.:.|||.:.|..:.|..:.    |:||:.||:    .|...:|     :
  Fly  1451 -------IVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGV----YVVDDQE-----Q 1499

Mouse  2796 VLCAYSFADILFVTMPSQNML---EFNLS---NEKLILFSARAQQVKTLVDTFILELKKDSDYVV 2854
            ||...||.:|..|:....|.:   .|:||   .|:....|..|:.::.||..|:..|||.|.||:
  Fly  1500 VLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVI 1564

Mouse  2855 AVRNFL--SEDPELLSFHKGDIIHLQSLEPTRVGYSAGCVVRKKLVYLEELRRRGPDFGWRFGAV 2917
            |::::.  |:....|||.|||:|.|:.       .|.|..|...              ||..|..
  Fly  1565 ALQDYRAPSDGTSFLSFFKGDLIILED-------ESCGESVLNN--------------GWCIGRC 1608

Mouse  2918 --HGRVGRFPSELVQ--PAAA---PDFLQL--PAEPGRGRAAAVAAAVASAAAAQEVGRRREGPP 2973
              ....|.||:|.|.  |..:   .|.|.|  ..|...||..::|:               .|..
  Fly  1609 DRSQERGDFPAETVYVLPTLSKPPQDILALFNIEEAHHGRRLSMAS---------------NGGA 1658

Mouse  2974 VRARSADSGEDSIALPPSTMLEFAQKYFR-DPRRRPRDGLKLKSKEDRESKTLEDVLCFTKVPIQ 3037
            |..|..          |.|::|:|..:|| .|:|.....|.|.||..      |::..:::.||:
  Fly  1659 VEPRDR----------PHTLMEYALDHFRLPPKRTMSKTLTLSSKRS------EELWRYSRDPIK 1707

Mouse  3038 ESLIE--LSDSNLNKMAVDMFVAVMRFMGDAPLK----GQSELD-VLCTLLKLCGDHEVMRDECY 3095
            ..|:.  .|.....:.|...|.|::::|||.|.|    |....| :....||    ||::|||.|
  Fly  1708 APLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLK----HEILRDEIY 1768

Mouse  3096 CQIVKQITDNSSPKQDSCQRGWRLLYIMAAYYSCSEVFYPYLIRFLQHVSWTPGLPFQGIAKACE 3160
            ||::||:|||.:...:  :|||.|:::....::||:.....|:.||:    |...|   |::...
  Fly  1769 CQLMKQLTDNRNRMSE--ERGWELMWLATGLFACSQGLLKELLLFLR----TRRHP---ISQDSM 1824

Mouse  3161 QNLQKTLRFGGRLEFPSNMELRAMLAGRSSKRQLF---LLPGGLERHLKIKTCTVALDVIEGLCT 3222
            ..||||:|.|.|...|..:|:.|:   :....|:|   ..|...:...::.:.|.|.|....:..
  Fly  1825 HRLQKTIRHGQRKYPPHQVEVEAI---QHKTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCNNISQ 1886

Mouse  3223 EMALTRPEAF----------------DEYVIFVVTNRGQHVCPLSCRAYILDVASEMEQVDGG-- 3269
            .::|...|.|                |.:..||              .::.|...:...:..|  
  Fly  1887 RLSLRTSEGFSLFVKIADKVISVPEGDFFFDFV--------------RHLTDWIKKARPIRDGAN 1937

Mouse  3270 ----YTLWFRRVLWDQ--PLKFENELYVTMHYNQVLPDYLKGLFSSVPARQPTEQQLQQVSKLAS 3328
                |.::|.:.||..  |.|..|...: .||:|.||..|:|....         ..::.:|||:
  Fly  1938 PQFTYQVFFMKKLWTNTVPGKDRNADLI-FHYHQELPKLLRGYHKC---------SREEAAKLAA 1992

Mouse  3329 LQHRAKDHFYLPSVREVQ-------EYIPAQLYHTTAGDTWLNLVSQHRQQTQALSPHQARAQFL 3386
            |..|.:   :..:.:|:|       |.||:.:....:...|...:.....|...::...|:..||
  Fly  1993 LVFRVR---FGENKQELQAIPQMLRELIPSDIMKIQSTSEWKRSIVASYNQDGGMTSEDAKVAFL 2054

Mouse  3387 GLLSAFPLFGSSFFFIQSCSNVLVPAPCILAVNHNGLNFLSTKTHELIVKIPLKEIQSTWTQQPT 3451
            .::..:|.|||:||.::..:....|...::|:|.:|::.:...|.:::|..|...| |.|     
  Fly  2055 KIVYRWPTFGSAFFEVKQTTEPNYPEMLLIAINKHGVSLIHPVTKDILVTHPFTRI-SNW----- 2113

Mouse  3452 ANSSYPYVEISLGDVAAQRTMQLQLEQGLELCRVVAVHVESMLSAREERLTL 3503
             :|...|..:::|::.....:..:...|.::..::..::..||:...:..|:
  Fly  2114 -SSGNTYFHMTIGNLVRGSKLLCETSLGYKMDDLLTSYISLMLTNMNKNRTI 2164

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo15NP_034992.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..690
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 712..1030
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1105..1135
MYSc 1201..1883 CDD:214580 289/690 (42%)
MYSc_Myo15 1220..1871 CDD:276838 275/657 (42%)
Actin-binding. /evidence=ECO:0000255 1776..1783 4/6 (67%)
FliJ 1870..1960 CDD:280262 38/135 (28%)
Neck or regulatory domain 1872..2013 56/239 (23%)
Tail 2014..3511 315/1660 (19%)
MyTH4 2049..2195 CDD:214535 52/240 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2330..2359 5/30 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2392..2425 4/32 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2460..2509 4/48 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2565..2584 1/18 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2629..2648 0/18 (0%)
SH3 2852..2931 CDD:302595 23/84 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2964..2984 3/19 (16%)
MyTH4 3031..3185 CDD:214535 51/160 (32%)
B41 3195..3400 CDD:214604 46/238 (19%)
FERM_B-lobe 3290..3390 CDD:271216 22/106 (21%)
FERM_C_MyoXV 3396..3497 CDD:270022 20/100 (20%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 288/682 (42%)
MYSc_Myo7 77..721 CDD:276832 275/657 (42%)
MyTH4 <1138..1245 CDD:214535 35/108 (32%)
B41 1251..1467 CDD:214604 62/558 (11%)
FERM_B-lobe 1355..1439 CDD:271216 24/294 (8%)
FERM_C1_MyoVII 1461..1559 CDD:270019 30/106 (28%)
SH3 1560..1624 CDD:302595 24/84 (29%)
MyTH4 1701..1849 CDD:214535 51/163 (31%)
B41 1856..2068 CDD:214604 46/238 (19%)
FERM_M 1966..2068 CDD:278785 26/113 (23%)
FERM_C2_MyoVII 2064..2159 CDD:270020 20/101 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.710

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