DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hir-1 and btl

DIOPT Version :9

Sequence 1:	NP_504458.1	Gene:	hir-1 / 178936	WormBaseID:	WBGene00016059	Length:	903	Species:	Caenorhabditis elegans
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	1071	Identity:	232/1071 - (21%)
Similarity:	397/1071 - (37%)	Gaps:	330/1071 - (30%)

- Green bases have known domain annotations that are detailed below.

Worm    70 CWSTCNGELVP-EKTLPAPTNLTLKGVRGLSWSPVPGAVMYYI---------------------G 112
            |:.....|..| ::.|.:..::||:.||       |.|..:|.                     .
  Fly    30 CYIDVTVENSPRQRHLLSDMDITLQCVR-------PMAKWFYEDKFQLRATLLRLERAQSGNSGN 87

Worm   113 YRTLNSKT-FTSDDFVITEKQTV--DLSTLTNIDPCSELEVAVAAFSEDGIGNESKELKISSPKP 174
            |..|:|:. :.:...|:..|:.|  |:::...::....|..:...|..   .|||:.||:..|.|
  Fly    88 YGCLDSQNRWYNISLVVGHKEPVGNDIASFVKLEDAPALPESDLFFQP---LNESRSLKLLQPLP 149

Worm   175 TANPKLDLLELQYLNTTLVSDFYQANAT--------VHVEF------------RYKTDPWFLGPD 219
            ....:            .....:|.|.:        |::.:            |.|...|.|...
  Fly   150 KTVQR------------TAGGLFQLNCSPMDPDAKGVNISWLHNDTQILGGRGRIKLKRWSLTVG 202

Worm   220 DLDVQP----LFHLISCVDPDLSQGIPVPDFDVHVKNSTI-----------STSIGSDM------ 263
            .|  ||    .:|...||:.|..:..|. ..:|..:..|:           |.::|.::
  Fly   203 QL--QPEDAGSYHCELCVEQDCQRSNPT-QLEVISRKHTVPMLKPGYPRNTSIALGDNVSIECLL 264

Worm   264 ----MDRKCRYVY---------YLQSVMSKK------CNTMTEMPSPPSSALQTIQVE------C 303
                ::.|..:::         .||.:..:.      ...:|.|..|....|..:.:|      |
  Fly   265 EDSALEPKITWLHKGNADNIDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYIC 329

Worm   304 ----DIVKNAPCVKVPSYQPPLCGMVENVAFSVLSR----------DRENLNDPASNLTVNVTFI 354
                .:.:......|..|.|.....|.....:.::.          :.:::.:||:..:..|.
  Fly   330 IAENQVGRTVAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVG-- 392

Worm   355 PVTRNNEMPTLYY----------IGIFGTASEYHTKEEETF---LGVNI--------THVIGKES 398
            |.....|:..|.:          ..::|.|:...||:::..   |||.:        .....::|
  Fly   393 PPVFRKELKRLQHSLSGNTVNLACPVYGKANITWTKDKKPLNRELGVYVQKNWTLRFVEATSEDS 457

Worm   399 -----------SCTGFDSSGN-----------CLAEN----LNRSIVLQ-----GIHPKT----- 427
                       .|..||.|..           .:.:|    :|.|:|::     .:||..
  Fly   458 GLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVVPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRV 522

Worm   428 --------------LYGLTICAVKDIRNLTLPDVTLDSKSF----------RAKAD---RI---- 461
                          :..|......|...|||.:||.|.:.:          |:.:.   |:
  Fly   523 VLKNASLDGLKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPL 587

Worm   462 -------MLVAHTSNNPVGMIIGIVIGSLVVILVAIVVIWFYFRKKSENMKFKFQMEQVGK---- 515
                   :|.||    |:|..:. .|..:.:.|:....|.|..|:.......|.::|.|.:
  Fly   588 PPLEIYALLHAH----PLGFTLA-AITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKK 647

Worm   516 --------------------------------------------NNMNRYIDFPIMAAKNDIWEI 536
                                                        ...|.| :||:    :..|||
  Fly   648 VIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEY-EFPL----DSNWEI 707

Worm   537 ERRNLIIHNDKKLGSGAFGAVYLGKLIGKSLAHKDANSPLGINLMRAENCQVAVKMLPEYADEMS 601
            .|:.|.:  ...||.||||.|.:.:..|.      ..||     ..||.. |||||:.|...:..
  Fly   708 PRQQLSL--GSILGEGAFGRVVMAEAEGL------PRSP-----QLAETI-VAVKMVKEEHTDTD 758

Worm   602 KHEFLREIALMKTLGYHERLVNMLACVTESEPLCLVVEYCDNGDLLKFLRERCKYMMKLDDLGIN 666
            ....:||:.:||.:|.|..::|:|.|.::..||.::|||..:|:|..||::             |
  Fly   759 MASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQ-------------N 810

Worm   667 YHDPP----ENENY--DTNMIVTL----KQLLQFAVQISYGLEYLSQKGFVHRDVAARNVLVHEG 721
            ....|    :::.|  |..:|.|.    |:|.:||.||:.|:|||:.:..:|||:|||||||.:|
  Fly   811 RPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDG 875

Worm   722 TACKIGDFGLCRYIYADQSQYKSKGGKLPLKWMSPEAIRHYEFSIKSDIWSFGILLFEVITLGGS 786
            ...||.||||.|.|...:...|:..|:||:|||:||:::..::..:||:||:|:||:|::|.|..
  Fly   876 YVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQ 940

Worm   787 PYPG-MPPEDVLPFLEGGGRIEKPDNCPENFYDVMMQCWNADPDDRIEFSD-------VRMQLAT 843
            |||. :..|::..:|..|.|:|||..|..|.|.||.|||:.:...|..|::       :..|.::
  Fly   941 PYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASS 1005

Worm   844 QLEDITEDYSYLKLDAAKDYYNVQYGDEKKT 874
            ...|...|.|...|:......:...|.:.:|
  Fly  1006 NPNDAYLDLSMPMLETPPSSGDEDDGSDTET 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hir-1	NP_504458.1	fn3	85..163	CDD:365830	16/101 (16%)
hir-1	NP_504458.1	PTKc	547..842	CDD:270623	111/312 (36%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653	16/97 (16%)
		IGc2	157..215	CDD:197706	11/59 (19%)
		IG	247..336	CDD:214652	11/88 (13%)
		Ig	258..340	CDD:143165	9/81 (11%)
		I-set	394..479	CDD:254352	14/84 (17%)
		IGc2	408..469	CDD:197706	8/60 (13%)
		IG_like	492..583	CDD:214653	15/90 (17%)
		Ig	507..583	CDD:299845	11/75 (15%)
		PKc_like	700..1000	CDD:304357	116/330 (35%)
		TyrKc	712..996	CDD:197581	111/310 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910