DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myh6 and ck

DIOPT Version :9

Sequence 1:XP_006518740.1 Gene:Myh6 / 17888 MGIID:97255 Length:1939 Species:Mus musculus
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2082 Identity:540/2082 - (25%)
Similarity:890/2082 - (42%) Gaps:400/2082 - (19%)


- Green bases have known domain annotations that are detailed below.


Mouse    26 AQTRPFDIRTECFVPDDKEEYVKAKVVSREGGKVTAETENGKTVTI-KEDQVMQQNPPKFDKIED 89
            |..|.||:.            :.|:|||.||.::....::|..|.: .|.::...:......:||
  Fly    15 ASGREFDVA------------IGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVED 67

Mouse    90 MAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHI 154
            |..|..|||..:|.||..||...:||||:|...|.||||:.||:|..:.:..|:.:|..|.||||
  Fly    68 MISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHI 132

Mouse   155 FSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRSKKENPNANKGTLED 219
            |:|.||||.:|...|::|.|:|:||||||||.:||.::||.|:|:  |..|          .:|.
  Fly   133 FAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAIS--GKHS----------WIEQ 185

Mouse   220 QIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERNY 284
            ||::|||.|||||||||:||||||||||:|.|||.|.|.:..|.||.|||||||::.|..:||||
  Fly   186 QILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNY 250

Mouse   285 HIFYQI---LSNKKPELLDMLLVTNNPYDYAFVSQG-EVSVASIDDSEELLATDSAFDVLSFTAE 345
            |:||.|   ||..:...||:.:..    ||.:::.| .::....||:.|.....||..||.|:.:
  Fly   251 HVFYCILAGLSADEKSRLDLGMAA----DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQ 311

Mouse   346 EKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTE-----DADKSAYLMGLNSADLLKGLCHPRV 405
            |...:.||..|::|.||:|:|....:..   |.||     :.::.|.|:||....|:..|....:
  Fly   312 EIWEIIKLLAALLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTL 373

Mouse   406 KVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRIN-ATLETKQPRQYFIGVLDIAGFEIF 469
            ....|.|....|..|......|..|.:|.:||..:|.:|| |..:.:...:..||||||.|||.|
  Fly   374 FAHGETVVSTLSRDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENF 438

Mouse   470 DFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIE-KPMGIMS 533
            |.|||||.|||:.||.|||||..|:|.||||||..|.|.|:.|:| :|.|..:|||. |.:.||:
  Fly   439 DQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMA 502

Mouse   534 ILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHFSLVHYAGTVDYNIMGWLEKN 598
            :::||..|||.:|.|..|||:..| |...|:.||   |......|.|.|:||.|.|:..|:|:||
  Fly   503 LIDEEARFPKGTDQTMLAKLHKTH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRGFLDKN 563

Mouse   599 KDPLNETVVGLYQKSSLKLMATLFSTYASADTGDSGKGKGGKKKGSSFQTVSALHRENLNKLMTN 663
            :|..:..::.|..:|:.|.:..:|:.       |...|...:|:   ..|:|...|::|:.||..
  Fly   564 RDTFSPDLLHLVSQSTNKFLRQIFAQ-------DIEMGAETRKR---TPTLSTQFRKSLDALMKT 618

Mouse   664 LKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILN 728
            |.:..|.|:|||.|||.|.|.:.|..|...|||.:|::|.|||.|.|:|.|..:.:|.:|||.|.
  Fly   619 LSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLI 683

Mouse   729 PAAIPEGQFIDSRKGAEKL----LGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITR 789
            | .:|.....|.:....::    ||..|     |:.||||||.|......||:.||..|:|.|..
  Fly   684 P-GVPPAHRTDCQAATSRICAVVLGKSD-----YQLGHTKVFLKDAHDLFLEQERDRVLTRKILI 742

Mouse   790 IQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKL-YFKIKPLLKSAETEKEMAN 853
            :|...||.:.|..|.::   |.|.:.:|...:.:...|.:..|:: |.:::.|::|........:
  Fly   743 LQRSIRGWVYRRRFLRL---RAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRH 804

Mouse   854 MKEEFGRVKDALEKSEAR----RKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNK 914
            ::   |.:...  ::.||    |:|...||.::::.::.::..:...:              ..|
  Fly   805 LR---GHIVGL--QAHARGYLVRREYGHKMWAVIKIQSHVRRMIAMRR--------------YRK 850

Mouse   915 IQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 979
            ::||.  |:..|.|:            .||||::  ||..            ...|||.|...::
  Fly   851 LRLEH--KQFAEVLQ------------LRKLEEQ--ELLH------------RGNKHAREIAEQH 887

Mouse   980 LTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKSKVKLEQQVDD---LEGSLE 1041
            ..:.:..|         |::.:||    .|::.:..|..:|.:..:..|.|:.|||   :|...:
  Fly   888 YRDRLHEL---------ERREIQE----QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFD 939

Mouse  1042 ---------------QEKKVRMDLERAKRKLEGDLKLTQESI---MDLENDKLQLEEKLKKKEFD 1088
                           :|..|..||..|:       .:.|:.|   :.:..|:..|.| .|.::|.
  Fly   940 FLPDSSSDAPTPHGGRETSVFNDLPHAQ-------NVNQDDIIAPIHISEDEEDLSE-FKFQKFA 996

Mouse  1089 ISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE 1153
            .:.....:..:.|     :|.||.....:....::|.|: .....:.:...|:........:|::
  Fly   997 ATYFQGNVNHQYA-----KKALKHPLLPLHTQGDQLAAQ-ALWITILRFTGDMPEPKYHTMDRMD 1055

Mouse  1154 EAGGATSVQIEMNKK--REAEFQK---MRRD------LEEATLQHEATAAALRKKHADSVAELGE 1207
            .....:.|...:.:.  |..|||:   |..|      .:..:::|:..:..|::|:     :|||
  Fly  1056 TTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKN-----KLGE 1115

Mouse  1208 QIDNLQRVKQKLEKEKSEFKLELDD-VTSNMEQ--------IIKAKANLE---KVSRTL------ 1254
            .:   :|..|..|.....::..|.. .|||:|:        |::|:...|   ::.:.|      
  Fly  1116 DV---RRRLQDDEYTADSYQSWLQSRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLK 1177

Mouse  1255 --------------------EDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEAL 1299
                                |...|..|..:.|.......:..:|.|....||   .:.:....|
  Fly  1178 SSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNG---TRNQPPSWL 1239

Mouse  1300 ISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSSRHDCD------LLREQY--------- 1349
            ..|.|:.|......:..:      :|..|..||.:..::|..|:      .|::|:         
  Fly  1240 ELQATKSKKPIMLPITFM------DGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALF 1298

Mouse  1350 ----------EEEMEAKAELQRVLSK--ANSEVAQWRTKYETDAIQRTEE-----------LEEA 1391
                      :..|:|.::.::...:  |....|.||..:..:......|           .::.
  Fly  1299 DKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTHDQVATNLIYQQV 1363

Mouse  1392 KK--KLAQRLQDAEEAVEAVNAK--------CSSLEKTKHRLQNEIEDLM---VDVERSNAAAAA 1443
            .:  |..:...|.||.:..:.|:        ..|:|:....|.|.|.|..   ||......||..
  Fly  1364 VRGVKFGEYRCDKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERWAALV 1428

Mouse  1444 LDKKQRNF---DKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENK 1505
            |...::::   ||| |..|.|     .::.|..|....|....|            .|.::....
  Fly  1429 LQAYKKSYYVKDKI-APLKIK-----EDIVSYAKYKWPLLFSRF------------YEAYRNSGP 1475

Mouse  1506 NLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQI 1570
            ||.:  :|:...:...|..|.:        :.|::.|:.:..|..|....:..|:.......:.:
  Fly  1476 NLPK--NDVIIAVNWTGVYVVD--------DQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTV 1530

Mouse  1571 KAE---IERKLAEKDEEME----QAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 1628
            :.|   .:...||...::.    ...:...:.|.:||     :.|:.::........:|||..:|
  Fly  1531 RGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQ-----DYRAPSDGTSFLSFFKGDLIILE 1590

Mouse  1629 IQLSQANRIASEAQKHLKNSQAHLKDTQLQLDDAVHANDDLKENIAIVERRNNLLQAELEELRAV 1693
            .:        |..:..|.|.....:     .|.:....|...|.:.::.    .|....:::.|:
  Fly  1591 DE--------SCGESVLNNGWCIGR-----CDRSQERGDFPAETVYVLP----TLSKPPQDILAL 1638

Mouse  1694 --VEQTERSRKLAEQE---LIETSERVQLL--HSQNTSLINQKKKMESDLTQLQTEVEE------ 1745
              :|:....|:|:...   .:|..:|...|  ::.:...:..|:.|...||......||      
  Fly  1639 FNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSR 1703

Mouse  1746 ------AVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKD--LQHRLDEA 1802
                  .:::.::.||.|::|   ....|..||...|..:...||...:...|.|  |:|.:...
  Fly  1704 DPIKAPLLRKLQSKEEFAEEA---CFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRD 1765

Mouse  1803 EQIALKGGKKQLQKLEARVRELENELEAEQKRNAESV---KGM-RKSERRIKEL-----TYQTEE 1858
            |...      ||.|     :..:|.....::|..|.:   .|: ..|:..:|||     |.:...
  Fly  1766 EIYC------QLMK-----QLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLRTRRHPI 1819

Mouse  1859 DKKNLMRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLR 1923
            .:.::.|||..:...|.|...::.:. ||.:...|.:  |.||... |:.:|..::..|    .|
  Fly  1820 SQDSMHRLQKTIRHGQRKYPPHQVEV-EAIQHKTTQI--FHKVYFP-DDTDEAFEVDSS----TR 1876

Mouse  1924 AK 1925
            ||
  Fly  1877 AK 1878

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh6XP_006518740.1 Myosin_N 34..72 CDD:367160 8/38 (21%)
MYSc_class_II 99..768 CDD:276951 279/683 (41%)
Myosin_tail_1 848..1925 CDD:366712 218/1241 (18%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 289/708 (41%)
MYSc_Myo7 77..721 CDD:276832 279/683 (41%)
MyTH4 <1138..1245 CDD:214535 18/109 (17%)
B41 1251..1467 CDD:214604 41/239 (17%)
FERM_B-lobe 1355..1439 CDD:271216 16/83 (19%)
FERM_C1_MyoVII 1461..1559 CDD:270019 16/119 (13%)
SH3 1560..1624 CDD:302595 14/81 (17%)
MyTH4 1701..1849 CDD:214535 34/162 (21%)
B41 1856..2068 CDD:214604 9/28 (32%)
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.