DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myh9 and didum

DIOPT Version :9

Sequence 1:NP_071855.2 Gene:Myh9 / 17886 MGIID:107717 Length:1960 Species:Mus musculus
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:1936 Identity:522/1936 - (26%)
Similarity:884/1936 - (45%) Gaps:353/1936 - (18%)


- Green bases have known domain annotations that are detailed below.


Mouse    32 VWVPSSKNGFEPASLKEEV--GEEAIVELVENGK----KVKVNKDDIQKM-NPPKFSKVEDMAEL 89
            :|||.:...:|.|:|:|..  |...:....::||    |:|.:..|:..: ||.......|:..|
  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTL 78

Mouse    90 TCLNEASVLHNLKERYYS-GLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAI 153
            :.|:|..|||||:.|:.. .:||||.|:..|.||||..:|:|...|:..|:|....::.|||:|:
  Fly    79 SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFAL 143

Mouse   154 TDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKSKKDQGELERQLLQANPIL 218
            .:.||..:.::..:.||:.:||||||||.:.|..::|.|.|..|    :.:.::||::|.::||:
  Fly   144 AEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS----ESETQVERKVLASSPIM 204

Mouse   219 EAFGNAKTVKNDNSSRFGKFIRINF-DVNG--YIVGANIETYLLEKSRAIRQAKEERTFHIFYYL 280
            ||||||||.:||||||||||.::.| :..|  ::.||.:.||||||||.:.||:.||.:||||.|
  Fly   205 EAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQL 269

Mouse   281 LSGAGEHLKTDLLLEPYNKYRFLS-NGHVTIPGQQDKDMFQETMEAMRIMGIPEDEQMGLLRVIS 344
            .:...::  .:|:|:..:|::||: .|...|....|.:.|.||::||.::|....:...::::::
  Fly   270 CAARSKY--PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQQIADIVKILA 332

Mouse   345 GVLQLGNIAFKK-------ERNTDQASMPDNTA-AQKVSHLLGINVTDFTRGILTPRIKVGRDYV 401
            |:|.||||...|       |.::|...:..|.. .|..:.||.::..|..|.:|..:|:...:||
  Fly   333 GILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEYV 397

Mouse   402 QKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQ 466
            ....:.|.|..|.:||||..|.::|:::|..:||:|:...:| .||||:|||.|||.|::|||||
  Fly   398 LIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CSFIGVLDIYGFETFEVNSFEQ 461

Mouse   467 LCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEE 531
            .||||.||||||.||..:|.||||||.:|||.|..||| .|.||||||||...   |:|.|||||
  Fly   462 FCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRL---GVLDLLDEE 522

Mouse   532 CWFPKATDKSFVEKVVQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNI 596
            |..||.:|:|:..|::.:....|.|:||:  .....|.|.|::..|:|..:.:|.||.|.::..:
  Fly   523 CRMPKGSDESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSDTVEYDVNGFLEKNRDTVSKEL 585

Mouse   597 ATLLHQSSDKFVSELW--KDVDRIIGLDQVAGMSETALPGAF-----------KTRKGMF----- 643
            ..:|.:|:.....::.  :::|.:.    |.....:.|.|..           .||:.:.     
  Fly   586 TQVLSESNMSLAKQVMTLEEIDTLC----VDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH 646

Mouse   644 -RTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQG 707
             :|||..::|.||.|::||..|.|::||||.||.:|.|.|.:...::.|||..||||.:||...|
  Fly   647 RKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAG 711

Mouse   708 FPNRVVFQEFRQRYEILTPNS-IPKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHL 771
            ||:|.::.:|..||::|...| :.|.  |.|.:|..::.....|.:.||.|.:::|||||.:|.|
  Fly   712 FPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAFL 774

Mouse   772 EEERD-----------------------LKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQ 813
            |:.|.                       |:|..||.|.|...||||||:. .::.::..|..:|.
  Fly   775 EQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARER-TQKMREARAGLILS 838

Mouse   814 RNCAAYLRLRNWQWWRLFTKVKPLLNSIR-HEDELLAKEAELTKVREKHLAAENRLTEMETMQSQ 877
            :..      |.|...|.:.:::..::.|: :...:||        |.|..|..:....::..:..
  Fly   839 KYA------RGWLCRRRYLRLRHSISGIQTYARGMLA--------RNKFHAMRDHYRAVQIQRFV 889

Mouse   878 LMAEKLQLQEQLQAETELCAEAEE---LRARLTAKKQELEEICHDLEARVEEEEERCQYLQAEKK 939
            ..|...:..::.:....:|..|..   .|.:....|.|.:.|.|     :|.     :|:..|.|
  Fly   890 RGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISH-----MEN-----KYMGLENK 944

Mouse   940 --KMQQNIQE-------LEEQLEEEESARQKLQLEKVTTEAKLKKLEEDQIIMEDQNCKLAKEKK 995
              .|||.|.|       |:.:..|....:.||:|:| |.||:.|            |.|.|.:.|
  Fly   945 IISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKK-TLEAEFK------------NVKAACQDK 996

Mouse   996 LLEDRVAEFTTNLMEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDL 1060
               |::.|.....:|.|...|.....:|.|..     ||.:.:::..|||.|:.||::       
  Fly   997 ---DKLIEALNKQLEAERDEKMQLLEENGHAQ-----EEWISQKQTWRQENEELRRQI------- 1046

Mouse  1061 SDQIAELQAQIAELKMQLAKKEEELQAALARVE-EEAAQKNMALKKIRE-----LETQISELQE- 1118
             |:|.:: |:.||:..:  .:|:.:.|.:...| .||.|:.:..|::.|     |:.::|.|.. 
  Fly  1047 -DEIIDM-AKNAEVNQR--NQEDRMLAEIDNRELNEAYQRAIKDKEVIENENFMLKEELSRLTAG 1107

Mouse  1119 --DLESERASRNKAEKQKRDLGEELEALKTELE-----DTL-------DSTAAQQELRSKREQE- 1168
              .|.:.:|| |.:.:.:.|:|  ..:.|..|:     |.|       |||:...:|||..|:| 
  Fly  1108 SFSLHARKAS-NASSQNEDDVG--YASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEK 1169

Mouse  1169 ------------VSILKKTLEDEAKT----------------------HEAQIQEMRQKHSQAVE 1199
                        :|...|..||..:.                      |..:|.|:..:|:...|
  Fly  1170 QKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQE 1234

Mouse  1200 ELADQLEQTKRVKATL---EKAKQTLENERGEL-ANEVKALLQGKGDSEHKRKKVEAQLQ-ELQV 1259
            |:..:.|:..::||.|   .::.::||.|..:: .|:|..|:    ::.|.:|.:..||: ||:.
  Fly  1235 EVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELM----EAFHSQKLINRQLESELKA 1295

Mouse  1260 KFSEGERVRTELADKVTKLQVELDSVTGLLSQS-----DSKSSKLTKDFSALESQLQDTQE---L 1316
            ...|......|:..::.:|..|.|.:..::.:|     ||....|.::...|..:||....   |
  Fly  1296 ITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLL 1360

Mouse  1317 LQEENRQKLSLSTKLKQMEDEKNSFREQLEEEEEAKRNLEKQIATLHAQVTDMKKKMEDGVGCLE 1381
            :|||  .||: :.|||....:......:: |||..:.......|.:.|.||..|.:...|:....
  Fly  1361 VQEE--LKLA-NAKLKAYRQDGGQLEHKI-EEEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFH 1421

Mouse  1382 TAEEAKRRLQKDLEGLSQRLEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSVSNLEKKQKKF 1446
            ::         ||:.:.|||...:.     .:|...|.......|:.:..:...::|.:.     
  Fly  1422 SS---------DLDKILQRLLSALT-----PRTVVGLLPGFPAYLIFMCIRYTDLTNADD----- 1467

Mouse  1447 DQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA--LEEAMEQKAELERLNKQFRTEMEDL 1509
                 :.:.:.:|:..:..:........|.:.:.|..:  |...|:|..:::...| |.||.::.
  Fly  1468 -----DVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVK-FNTEKQNQ 1526

Mouse  1510 MSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQ 1574
            ...|:      ..|.:.:|.:...:..:   .:.|..::|...|.|:   |.......:.:|..|
  Fly  1527 QQLKN------FNLFEYRRVILDLIVNL---YQALIMQIQGLLDPKI---VPAILNNDEIQRGRQ 1579

Mouse  1575 GRDEQSEEKK---------------KQLVRQVREMEAELEDERKQRSMAMAARKKLEMDLKDLEA 1624
            ....:|....               |||:.|:.....:.:                         
  Fly  1580 AHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQ------------------------- 1619

Mouse  1625 HIDTANKNREEAIKQ---------LRKLQAQMKDCMRE-----------LDD----TRASREEIL 1665
            |....|...|:...|         |..|..:...||.|           ::|    .:.|.:.:.
  Fly  1620 HFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMIIRYNIGCIEDWVRSKKMSNDVLT 1684

Mouse  1666 AQAKENE--KKLKSMEAE-----MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEE 1723
            |.|..|:  :.|:|.::|     :..|...|:.|:..|.....:.|:...||.|      :.||:
  Fly  1685 ALAPLNQVSQLLQSRKSEQDVQTICDLCTSLSTAQVLKVMKSYKLDDYESEITN------VFLEK 1743

Mouse  1724 -KRRLEARIAQL--EEELEEEQGNTELINDRLKKANLQIDQIN--TDLNLE 1769
             ..:|.||..|.  .:|...:|...:......:.::::::.|.  :.|||:
  Fly  1744 LTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDIKLEDIELPSHLNLD 1794

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh9NP_071855.2 Mediates interaction with LIMCH1. /evidence=ECO:0000250|UniProtKB:P35579 2..838 309/868 (36%)
Myosin_N 30..68 CDD:280832 12/41 (29%)
Myosin_head 83..764 CDD:278492 269/713 (38%)
Motor_domain 95..764 CDD:277568 265/701 (38%)
Actin-binding 654..676 12/21 (57%)
Myosin_tail_1 842..1921 CDD:279860 212/1063 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1035..1057 6/21 (29%)
UBAN 1038..1149 CDD:301588 29/119 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1117..1167 16/64 (25%)
RRF <1206..1261 CDD:294170 16/59 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1327..1352 6/24 (25%)
RILP-like <1480..1587 CDD:304877 20/123 (16%)
DUF2390 <1610..1678 CDD:295281 15/93 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1768..1788 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1877..1908
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1939..1960
didumNP_724569.1 MYSc 65..778 CDD:214580 278/731 (38%)
MYSc_Myo5 84..767 CDD:276831 265/701 (38%)
IQ 900..922 CDD:197470 3/21 (14%)
GBP_C <971..1086 CDD:303769 38/146 (26%)
coiled coil 1049..1068 CDD:293879 5/21 (24%)
coiled coil 1077..1086 CDD:293879 3/8 (38%)
JAKMIP_CC3 <1190..1299 CDD:292653 24/112 (21%)
Myo5_CBD 1424..1792 CDD:271254 68/426 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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