DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myh9 and ck

DIOPT Version :9

Sequence 1:NP_071855.2 Gene:Myh9 / 17886 MGIID:107717 Length:1960 Species:Mus musculus
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2180 Identity:550/2180 - (25%)
Similarity:901/2180 - (41%) Gaps:530/2180 - (24%)


- Green bases have known domain annotations that are detailed below.


Mouse    32 VWVPSSKNGFEPASLKE-EVGEEAIVELVENGKKVKVNKDD-----------IQKMNPPKFSKVE 84
            :|:       ||||.:| :|...|.|...| |::::|..||           |:.|:......||
  Fly    10 IWI-------EPASGREFDVAIGARVVSAE-GRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVE 66

Mouse    85 DMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPH 149
            ||..|..|:||.:|.||..||...|||||:|...|.:|||:.||||:.:.:::||.:|..|:|||
  Fly    67 DMISLGDLHEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPH 131

Mouse   150 IYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKSKKDQGELERQLLQA 214
            |:||.|.||..|.:.|:||.|:.:|||||||||:||.::||||.::..|      ..:|:|:|:|
  Fly   132 IFAIGDNAYAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISGKH------SWIEQQILEA 190

Mouse   215 NPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYY 279
            ||||||||||||::|||||||||:|.|:|..||.|.||.||.|||||||.:.|...||.:|:||.
  Fly   191 NPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYC 255

Mouse   280 LLSGAGEHLKTDLLLEPYNKYRFLSNGH-VTIPGQQDKDMFQETMEAMRIMGIPEDEQMGLLRVI 343
            :|:|.....|:.|.|.....|::|:.|: :|..|:.|...|.:...||:::...:.|...:::::
  Fly   256 ILAGLSADEKSRLDLGMAADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLL 320

Mouse   344 SGVLQLGNIAFKKE--RNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQT 406
            :.:|..|||.:|..  .|.|...:|::...::|:.|||:.:......:....:....:.|....:
  Fly   321 AALLHCGNIKYKATVVDNLDATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLS 385

Mouse   407 KEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINY 471
            ::|:....:|..|..|.|||..:|.:||.|:.|.:....:.||:|||.|||.||.|||||.||||
  Fly   386 RDQSVDVRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSRNAIGVLDIFGFENFDQNSFEQFCINY 450

Mouse   472 TNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPK 536
            .||.|||.|...:|.||||||..|.|.|..|:| :|.|..:|||  ......|:||:|||..|||
  Fly   451 ANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLI--AIKQLNIMALIDEEARFPK 512

Mouse   537 ATDKSFVEKVVQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLH 601
            .||::.:.|:.:..|:|..:.|||. .....|.:.|:||.|.|....:|.||.|..:.::..|:.
  Fly   513 GTDQTMLAKLHKTHGSHKNYLKPKS-DINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVS 576

Mouse   602 QSSDKFVSELW-KDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTN 665
            ||::||:.::: :|::.                || :||| ...|:...:::.|..||.||.:..
  Fly   577 QSTNKFLRQIFAQDIEM----------------GA-ETRK-RTPTLSTQFRKSLDALMKTLSSCQ 623

Mouse   666 PNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIP 730
            |.|:|||.||..||....|..|...|||.:|::|.|||.|.|:|.|..|:||.:||..|.| .:|
  Fly   624 PFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFLIP-GVP 687

Mouse   731 KGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLA 795
            .......||....|.|:.|..:.|::|.:|||.:......||:|||..:|..|:..|...||::.
  Fly   688 PAHRTDCQAATSRICAVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVY 752

Mouse   796 RKAFAKRQQQLTAMKVLQRNCAAYLRLRNWQWWRL-FTKVKPLLNS------IRH-EDELLAKEA 852
            |:.|.:.:   .|...:||....|.:.:.::..|: :.:::.|:.|      .|| ...::..:|
  Fly   753 RRRFLRLR---AAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIRSRVLSHRFRHLRGHIVGLQA 814

Mouse   853 ELT--KVREKH-------LAAENRLTEMETMQSQLMAEKLQLQEQLQAETELCAEAEELRARLTA 908
            ...  .||.::       :..::.:..|..|:..   .||:|:.:..||.            |..
  Fly   815 HARGYLVRREYGHKMWAVIKIQSHVRRMIAMRRY---RKLRLEHKQFAEV------------LQL 864

Mouse   909 KKQELEEICH--DLEAR-VEEEEERCQYLQAEKKKMQQNIQELEEQLEE-----------EESAR 959
            :|.|.:|:.|  :..|| :.|:..|.:..:.|::       |::||||.           .::||
  Fly   865 RKLEEQELLHRGNKHAREIAEQHYRDRLHELERR-------EIQEQLENRRRVEVNMNIINDAAR 922

Mouse   960 QKLQLEKVTTEAKL---------------------------------KKLEEDQI-----IMEDQ 986
            ::   |:...:.||                                 :.:.:|.|     |.|| 
  Fly   923 KQ---EEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISED- 983

Mouse   987 NCKLAKEKKLLEDRVAEFTTNLMEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051
                  |:.|.|.:..:|..... :...:...||...||..    |....:.::...|.|..|..
  Fly   984 ------EEDLSEFKFQKFAATYF-QGNVNHQYAKKALKHPL----LPLHTQGDQLAAQALWITIL 1037

Mouse  1052 KLEGD-------STDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIREL 1109
            :..||       :.|..|..:.:....|.|.....:.:|..:|.|..::.:|..|    :|.|.:
  Fly  1038 RFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQLMGLDPDAFLK----QKPRSI 1098

Mouse  1110 ETQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEV----- 1169
            ..::..|             ..|:|..|||::.....:.|.|.||  .|..|:|:....:     
  Fly  1099 RHKLVSL-------------TLKRKNKLGEDVRRRLQDDEYTADS--YQSWLQSRPTSNLEKLHF 1148

Mouse  1170 ----SILKKTLEDEAKTHEAQI------QEMRQKH-------SQAVEELADQLEQTKRVKATL-- 1215
                .||:..|.||.   ..||      ..::..|       |..|...|...:....::|.:  
  Fly  1149 IIGHGILRAELRDEI---YCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIRE 1210

Mouse  1216 ----------EKAKQTLENERGELANEVKALLQGKGDSEHKRKKVEAQLQE------LQVKFSEG 1264
                      |:.|:|..|                |........:|.|..:      |.:.|.:|
  Fly  1211 GPPGYAPYCEERLKRTFNN----------------GTRNQPPSWLELQATKSKKPIMLPITFMDG 1259

Mouse  1265 ERVRTELADKVTKLQVELDSVTGLLSQSD-----------SKSSKLTKDFSALESQLQDTQELLQ 1318
             ..:|.|||..|..:...:.::..:|..|           .|.|.|......:...:...::..:
  Fly  1260 -NTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAK 1323

Mouse  1319 EENRQKLSLSTKLKQMEDEKNSFREQL------EEEEEAKRNL------------------EKQI 1359
            |:..|:.:...:|        .||:::      ...::...||                  |:.:
  Fly  1324 EQGAQERNAPWRL--------FFRKEIFAPWHEPTHDQVATNLIYQQVVRGVKFGEYRCDKEEDL 1380

Mouse  1360 ATLHAQ------VTDMKKK---------MEDGVGCLETAEEAKRR-----LQ--------KDLEG 1396
            |.:.||      .|||..:         :.|  .||...::|..|     ||        || :.
  Fly  1381 AMIAAQQYFIEYSTDMSMERLFTLLPNFIPD--FCLSGVDKAIERWAALVLQAYKKSYYVKD-KI 1442

Mouse  1397 LSQRLEEKVAAYDK--------------------LEK---------TKTRLQQELDDLLVDLDHQ 1432
            ...:::|.:.:|.|                    |.|         |...:..:.:.:|::|...
  Fly  1443 APLKIKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFP 1507

Mouse  1433 RQSVSNLEKKQKKFDQLLA------EEKTISAKYAEE-RDRA-----EAEAREKETKALSLARAL 1485
            ..:..:.:|..|.|.|..:      ||.|..:..||: ||..     ..:.|.|...||...||.
  Fly  1508 EITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLDGLKKRSKYVIALQDYRAP 1572

Mouse  1486 EEAMEQKAELERLNKQFRTEME-DLMSSKDD-VGKSVHE----LEKSKRALE------QQVEEMK 1538
            .:           ...|.:..: ||:..:|: .|:||..    :.:..|:.|      :.|..:.
  Fly  1573 SD-----------GTSFLSFFKGDLIILEDESCGESVLNNGWCIGRCDRSQERGDFPAETVYVLP 1626

Mouse  1539 TQLEELEDEL------QATEDAKLRLEVNLQAM---------------------KAQFERDLQGR 1576
            |..:..:|.|      :|....:|.:..|..|:                     |....:.|...
  Fly  1627 TLSKPPQDILALFNIEEAHHGRRLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKRTMSKTLTLS 1691

Mouse  1577 DEQSEEK--------KKQLVRQVREMEAELEDERKQRSMAMAARKKLEMDL--------KDLEAH 1625
            .::|||.        |..|:|:::..|...|    :...|.||..|...||        .::..|
  Fly  1692 SKRSEELWRYSRDPIKAPLLRKLQSKEEFAE----EACFAFAAILKYMGDLPSKRPRMGNEITDH 1752

Mouse  1626 I-----------------------DTANKNREEAIKQLRKLQAQMKDC----MRELDDTRASREE 1663
            |                       |..|:..||...:|..|...:..|    ::||.....:|..
  Fly  1753 IFDGPLKHEILRDEIYCQLMKQLTDNRNRMSEERGWELMWLATGLFACSQGLLKELLLFLRTRRH 1817

Mouse  1664 ILAQ---------AKENEKKLKSMEAEMIQLQE-------------------ELAAAERAKRQAQ 1700
            .::|         .:..::|....:.|:..:|.                   |:.::.|||    
  Fly  1818 PISQDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFEVDSSTRAK---- 1878

Mouse  1701 QERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN-----TELINDRLKKANLQID 1760
                   |...|.|.:.:|...|...|..:||  ::.:...:|:     ...:.|.:|||....|
  Fly  1879 -------DFCNNISQRLSLRTSEGFSLFVKIA--DKVISVPEGDFFFDFVRHLTDWIKKARPIRD 1934

Mouse  1761 QINTDLNLE---------RSHAQKNENA------RQQL-------ERQNKELKAKLQEMESAVKS 1803
            ..|.....:         .:...|:.||      .|:|       .:.::|..|||..:  ..:.
  Fly  1935 GANPQFTYQVFFMKKLWTNTVPGKDRNADLIFHYHQELPKLLRGYHKCSREEAAKLAAL--VFRV 1997

Mouse  1804 KYKASIAALEAKIAQLEEQLDNETKERQAASKQVR 1838
            ::..:...|:|....|.|.:.::..:.|:.|:..|
  Fly  1998 RFGENKQELQAIPQMLRELIPSDIMKIQSTSEWKR 2032

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh9NP_071855.2 Mediates interaction with LIMCH1. /evidence=ECO:0000250|UniProtKB:P35579 2..838 309/822 (38%)
Myosin_N 30..68 CDD:280832 11/36 (31%)
Myosin_head 83..764 CDD:278492 276/684 (40%)
Motor_domain 95..764 CDD:277568 269/672 (40%)
Actin-binding 654..676 11/21 (52%)
Myosin_tail_1 842..1921 CDD:279860 239/1347 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1035..1057 5/28 (18%)
UBAN 1038..1149 CDD:301588 22/117 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1117..1167 12/49 (24%)
RRF <1206..1261 CDD:294170 9/72 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1327..1352 3/30 (10%)
RILP-like <1480..1587 CDD:304877 25/153 (16%)
DUF2390 <1610..1678 CDD:295281 19/111 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1768..1788 5/41 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1877..1908
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1939..1960
ckNP_001285949.1 MYSc 64..733 CDD:214580 279/697 (40%)
MYSc_Myo7 77..721 CDD:276832 269/672 (40%)
MyTH4 <1138..1245 CDD:214535 19/125 (15%)
B41 1251..1467 CDD:214604 39/227 (17%)
FERM_B-lobe 1355..1439 CDD:271216 16/85 (19%)
FERM_C1_MyoVII 1461..1559 CDD:270019 16/97 (16%)
SH3 1560..1624 CDD:302595 15/74 (20%)
MyTH4 1701..1849 CDD:214535 26/151 (17%)
B41 1856..2068 CDD:214604 35/192 (18%)
FERM_M 1966..2068 CDD:278785 13/69 (19%)
FERM_C2_MyoVII 2064..2159 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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