DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myh8 and didum

DIOPT Version :9

Sequence 1:XP_036012291.1 Gene:Myh8 / 17885 MGIID:1339712 Length:1966 Species:Mus musculus
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:2099 Identity:546/2099 - (26%)
Similarity:905/2099 - (43%) Gaps:496/2099 - (23%)


- Green bases have known domain annotations that are detailed below.


Mouse    22 SEKERIEAQNKPFDAKTSVFVAEP---KESYVKSVIQSKDGGKVTVKTESGATLTVK---EDQVF 80
            |.:|.:.||........:..|.|.   :|||      .|..|.:.:.|:||....||   :....
  Fly     2 SSEEMLYAQGAKIWVPHADLVWESATLEESY------RKGAGFLKICTDSGKLKEVKLKADGSDL 60

Mouse    81 P--MNPPKYDKIEDMAMMTHLHEPGVLYNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYNPEVV 142
            |  .||.......|:..:::|||||||:||:.|:. ..:||||.|:..|.:|||..:|:|.|.::
  Fly    61 PPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125

Mouse   143 AAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDK 207
            .||||....:..||||::::.||..:..:..|.||:::|||||||||:.|..::|||  ||.|.:
  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFA--AVGGSE 188

Mouse   208 KKEESGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIETY 269
            .:.:       :|.::::::|::||||||||.|||||||||||.::.| ...|.  |..|.:.||
  Fly   189 SETQ-------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTY 246

Mouse   270 LLEKSRVTFQLKAERSYHIFYQITS--NKKPELIEMLLITTNPYDYAFVSQGEI-TVPSIDDQEE 331
            |||||||.:|.:.||:||||||:.:  :|.||     |:..:...:.|::.|.. .:..:.|.|:
  Fly   247 LLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDAEQ 306

Mouse   332 LMATDSAIDILGFSPEEKVSIYKLTGAVMHYGNMKFKQKQRE--EQAEPDGTEVADKAAYLQCLN 394
            ...|..|:.:||||.::...|.|:...::|.||::..:|..|  |:.:.|..::.....:||.  
  Fly   307 FNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQI-- 369

Mouse   395 SADLLKA--------LCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQLD 451
            :||||:.        |...:::..||||....:::....|..||||.:|.|:|.::|..:|:.|:
  Fly   370 TADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLN 434

Mouse   452 TKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDF 516
            ....:..|||||||.|||.|:.||.||.|||:.||||||.||.|:|.||||||.||||.||.|||
  Fly   435 NGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF 499

Mouse   517 GMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSN---NFQKPKPTKGKAEA 578
             .|...||:|||..||:..:|:|||..||.:|.|:..||    :||.|   :|:||:    ....
  Fly   500 -YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPR----FGTT 555

Mouse   579 HFSLVHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLFSTY----------ASAEAD 633
            .|.:.|::.||:|::.|:|:||:|.::..:..:..:|.| :||....|.          |.:...
  Fly   556 SFFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNM-SLAKQVMTLEEIDTLCVDSAKSSTL 619

Mouse   634 GG---AKKGAKKKGSSF-----------QTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTP 684
            ||   ...|.|::|:..           :||.:.|:|:|..|::.|.:|.||:||||.||:.|..
  Fly   620 GGRVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVA 684

Mouse   685 GAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVL-NASAIPEGQFIDSKKASEKL 748
            ...|...::.|||..||||.:||...|||||.||.||..||::| ..|.:.:.   |.|.:...:
  Fly   685 FKWETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNI 746

Mouse   749 LGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAV------------------- 794
            :.....|..:|:||:|::||:||.:..||::|.....:.||..|:|                   
  Fly   747 VMKWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVING 811

Mouse   795 ----CRGYLMRVEYQKMLLRRESIFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATM 855
                .||||.|...|||...|..:...:|       .:.|...:.:.:::..:...:|.......
  Fly   812 IQKHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQTYARGMLA 869

Mouse   856 KEEFQKTKDELAKSEAKR-------KELEEKMVTLLKEKNDLQLQ--------------VQSEAD 899
            :.:|...:|.....:.:|       :...:|     :.:|.:..|              :::||.
  Fly   870 RNKFHAMRDHYRAVQIQRFVRGALARRAYQK-----RRRNIIICQAAIRRFLARRKFKRMKAEAK 929

Mouse   900 SLADAEERCEQLIKNKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 964
            :::..|.:...|....|.::.:|.|:.....:.:...:|::..|.||     ||||.::      
  Fly   930 TISHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKL-----ELKKTLE------ 983

Mouse   965 AKVEKEKHATENKVKNLTEEMAGLDENIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKTK 1029
            |:.:..|.|.::|           |:.|..|.|:              |:||.|:...|      
  Fly   984 AEFKNVKAACQDK-----------DKLIEALNKQ--------------LEAERDEKMQL------ 1017

Mouse  1030 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA---------QESTMDIENDKQQLDEKLKK 1085
            ||:.....|..:.|::..|.:.|..:|:::..:.:|         ||..|..|.|.::|:|..::
  Fly  1018 LEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEAYQR 1082

Mouse  1086 KEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELEEEIEAERASRAKAE----------KQRS 1140
                      .|:|::.:|.: ...:||..:|:......:.|.:||.|.::          |...
  Fly  1083 ----------AIKDKEVIENE-NFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTL 1136

Mouse  1141 DLSRELEEISERLEEAGGATSAQVEMNKKRETEFQKLRRDLEEATLQHEATAAALRKKHADSVAE 1205
            |::|..:.:|:.. ....:||..|::....|.|.||      ...||.:....:.|.|..:....
  Fly  1137 DINRPPDLLSKNY-SYNDSTSLVVKLRSILEEEKQK------HKVLQEQYIKLSSRHKPTEDSFR 1194

Mouse  1206 LGEQIDNLQRVKQKLEKEKSELKMEIDDLSSNAEAIAKAKGNLEKMCRTLEDQVSELKSKEEEQQ 1270
            :.|           ||.|..:|:.|.|.|.::      .|..:|                     
  Fly  1195 VSE-----------LEVENEKLRSEYDQLRTS------IKHGVE--------------------- 1221

Mouse  1271 RLINELTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKRQLEEETKAKNALAHA 1335
              ||||.||.|.||.|......:..:..|::.|.|:|           .|.||.|         :
  Fly  1222 --INELNAQHAALQEEVRRRREECIQLKAVLLQQSQS-----------MRSLEPE---------S 1264

Mouse  1336 LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1400
            ||...:|.:.|.|.:..::                           .|.|  :||...|.:    
  Fly  1265 LQMRGNDVNELMEAFHSQK---------------------------LINR--QLESELKAI---- 1296

Mouse  1401 QAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKVLSEWRQKYEE 1465
              .|||    |:|...:.:..:||.||.::|                     .||:.|...::|:
  Fly  1297 --TEEH----NSKLVEMTQEIERLNNEKDEL---------------------QKVMFESIDEFED 1334

Mouse  1466 TQAELESCQKESRTLSTELFKVKNAYEESLDHLETLRRENKNLQQEISDLTEQIAEGGKHIHELE 1530
              :.:::.::..|.|..||.|   |..:.|...|.|:..|..|:....|       ||:..|::|
  Fly  1335 --SNVDTLRQNDRYLRRELQK---AVAQFLLVQEELKLANAKLKAYRQD-------GGQLEHKIE 1387

Mouse  1531 K-------------IKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEID------ 1576
            :             :...|.::|.:....|.:..:|   :..|||:..|.....::.:.      
  Fly  1388 EEMIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSS---DLDKILQRLLSALTPRTVVGLLPGFP 1449

Mouse  1577 ----------RKIAEKDEEIDQLKRNHVRVVETMQSTLDAEIRSR------NDALRVKKKMEGDL 1625
                      ..:...|:::.:|....|..::.|..| ...|.:|      :..|....|..||:
  Fly  1450 AYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRT-PHPIENRVIWLVNSITLLNLMKQYGDV 1513

Mouse  1626 NE---MEIQLNHANRLAAESLRNYRNTQGILKDTQLHLDDAL----RGQEDLKEQLAIVE----- 1678
            :|   ...:..:..:|...:|..||.   ::.|..::|..||    :|..|.|...||:.     
  Fly  1514 DEYVKFNTEKQNQQQLKNFNLFEYRR---VILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQ 1575

Mouse  1679 --RRANLLQAEIEELRAT--------------LEQTERSRKIAEQELLD--ASERV--QLLHTQN 1723
              |:|:.:::....:.|:              :.|.|...|..:...||  .:|::  |||:...
  Fly  1576 RGRQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFIC 1640

Mouse  1724 TSLINTKKKLENDVSQLQSEVEEVIQESRNAEE---KAKKAITDVSTTHITLPTPVLPATTRAYF 1785
            ...:|. ..|..|:...::.:  :|:.:....|   ::||...||.|....|             
  Fly  1641 AVALNC-LMLRGDICMWETGM--IIRYNIGCIEDWVRSKKMSNDVLTALAPL------------- 1689

Mouse  1786 CLDLFASQAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQHRLDEAEQLALKGGKKQIQKLEAR 1850
                  :|.:.:.:..|.|||.            ||:.||...|..|:.|.:....|        
  Fly  1690 ------NQVSQLLQSRKSEQDV------------QTICDLCTSLSTAQVLKVMKSYK-------- 1728

Mouse  1851 VRELEGEVEN------EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKS 1909
            :.:.|.|:.|      .:|.||..::.....|..:.:...|   ..|.|.|..|:          
  Fly  1729 LDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQ---PFKVVFRYSDI---------- 1780

Mouse  1910 YKRQAEEAEEQSNANLAKF 1928
               :.|:.|..|:.||.:|
  Fly  1781 ---KLEDIELPSHLNLDEF 1796

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh8XP_036012291.1 Myosin_N 37..75 CDD:397036 10/40 (25%)
Motor_domain 102..769 CDD:419868 272/711 (38%)
Myosin_tail_1 849..1955 CDD:396244 229/1196 (19%)
didumNP_724569.1 MYSc 65..778 CDD:214580 283/741 (38%)
MYSc_Myo5 84..767 CDD:276831 272/711 (38%)
IQ 900..922 CDD:197470 3/26 (12%)
GBP_C <971..1086 CDD:303769 36/166 (22%)
coiled coil 1049..1068 CDD:293879 3/18 (17%)
coiled coil 1077..1086 CDD:293879 2/18 (11%)
JAKMIP_CC3 <1190..1299 CDD:292653 38/203 (19%)
Myo5_CBD 1424..1792 CDD:271254 80/429 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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