DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myh8 and ck

DIOPT Version :9

Sequence 1:XP_036012291.1 Gene:Myh8 / 17885 MGIID:1339712 Length:1966 Species:Mus musculus
Sequence 2:NP_001285949.1 Gene:ck / 34882 FlyBaseID:FBgn0000317 Length:2167 Species:Drosophila melanogaster


Alignment Length:2089 Identity:534/2089 - (25%)
Similarity:878/2089 - (42%) Gaps:437/2089 - (20%)


- Green bases have known domain annotations that are detailed below.


Mouse    54 IQSKDGGKVTVKTESGATL-TVKEDQVFPMNPPKYDKIEDMAMMTHLHEPGVLYNLKERYAAWMI 117
            :.|.:|.::.|:.:.|..: ...|.::..|:......:|||..:..|||.|:|.||..||...:|
  Fly    28 VVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVEDMISLGDLHEAGILRNLLIRYKENLI 92

Mouse   118 YTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 182
            |||:|...|.||||:.||:|..:.:..|:.:|..|.|||||:|.||||..|...|::|.|:|:||
  Fly    93 YTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGE 157

Mouse   183 SGAGKTVNTKRVIQYFATIAVTGDKKKEESGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRF 247
            ||||||.:||.::||.|.|          ||| ...:|.||:.|||:|||||||||:||||||||
  Fly   158 SGAGKTESTKLILQYLAAI----------SGK-HSWIEQQILEANPILEAFGNAKTIRNDNSSRF 211

Mouse   248 GKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQI----TSNKKPEL-IEMLLIT 307
            ||:|.|||...|.:..|.||.|||||||:..|..:||:||:||.|    ::::|..| :.|..  
  Fly   212 GKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAA-- 274

Mouse   308 TNPYDYAFVSQG-EITVPSIDDQEELMATDSAIDILGFSPEEKVSIYKLTGAVMHYGNMKFKQKQ 371
                ||.:::.| .||....||..|.....||:.:|.||.:|...|.||..|::|.||:|:|...
  Fly   275 ----DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATV 335

Mouse   372 REEQAEPDGTEV-----ADKAAYLQCLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVGALA 431
            .:..   |.||:     .::.|.|..|....|:.||....:....|.|....:..|..:...|..
  Fly   336 VDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFV 397

Mouse   432 KAVYEKMFLWMVTRINQQLDTKQPR---QYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFN 493
            |.:|.:||:.:|.:||..:  .:||   :..||||||.|||.||.||.||.|||:.||.|||||.
  Fly   398 KGIYGRMFVHIVRKINTAI--FKPRGTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQFFV 460

Mouse   494 HHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIE-KPLGIFSILEEECMFPKATDTSFKNKLYD 557
            .|:|.||||||..|.|.|..|:| :|....::||. |.|.|.::::||..|||.||.:...||:.
  Fly   461 QHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHK 524

Mouse   558 QHLGKSNNFQKPKPTKGKAEAHFSLVHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLAS 622
            .| |...|:.||   |......|.|.|:||.|.|:..|:||||:|..:..::.|..:|..|.|..
  Fly   525 TH-GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQ 585

Mouse   623 LFSTYASAEADGGAKKGAKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAM 687
            :|    :.:.:.||:  .:|:   ..|:|..||::|:.||..|.|..|.|:|||.|||.|.|...
  Fly   586 IF----AQDIEMGAE--TRKR---TPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPMMF 641

Mouse   688 EHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFIDSKKASEKLLGSI 752
            :..|...|||.:|::|.|||.|.|:|.|..:.:|.:||:.| ...:|.....|.:.|:.::. ::
  Fly   642 DRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFL-IPGVPPAHRTDCQAATSRIC-AV 704

Mouse   753 DIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAVCRGYLMRVEYQKMLLR-RESIFC 816
            .:..:.|:.||||||.|......||:.||..|.:.|...|...||::    |::..|| |.:...
  Fly   705 VLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWV----YRRRFLRLRAAAIT 765

Mouse   817 IQYNVRAFMNVKHWPWMKL-FFKIKPLLKSAETEKEMATMKEEFQKTKDEL------AKSEAKRK 874
            :|...:.:...|.:..|:: :.:::.|::|       ..:...|:..:..:      |:....|:
  Fly   766 VQRFWKGYAQRKRYRNMRVGYMRLQALIRS-------RVLSHRFRHLRGHIVGLQAHARGYLVRR 823

Mouse   875 ELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEDEEEINAEL 939
            |...||..::|.::.::..:         |..|     ..|::||.|     :.||         
  Fly   824 EYGHKMWAVIKIQSHVRRMI---------AMRR-----YRKLRLEHK-----QFAE--------- 860

Mouse   940 TAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDENIAKLTKEKKALQE 1004
            ..:.||||::  ||..            ...|||.|...::..:.:..|         |::.:||
  Fly   861 VLQLRKLEEQ--ELLH------------RGNKHAREIAEQHYRDRLHEL---------ERREIQE 902

Mouse  1005 AHQQTLDDLQAEEDKVNTLTKAKTKLEQQVDD---LEGSLE---------------QEKKLRMDL 1051
                .|::.:..|..:|.:..|..|.|:.|||   :|...:               :|..:..||
  Fly   903 ----QLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDL 963

Mouse  1052 ERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEISNLISKIEDEQAVEIQLQKKIKELQA 1116
            ..|:...:.|:    .:.:.|..|::.|.| .|.::|..:.....:..:.|.: .|:..:..|..
  Fly   964 PHAQNVNQDDI----IAPIHISEDEEDLSE-FKFQKFAATYFQGNVNHQYAKK-ALKHPLLPLHT 1022

Mouse  1117 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG--GATSAQVEMNKKRETEFQK--- 1176
            :.::|     |.:|......:...|:........:|::...  ...:|.:..|..|..|||:   
  Fly  1023 QGDQL-----AAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIRSKEFQEAQL 1082

Mouse  1177 --------LRRDLEEATLQHEATAAALRKKHADSVAELGEQI-----------DNLQ-----RVK 1217
                    |::  :..:::|:..:..|::|:     :|||.:           |:.|     |..
  Fly  1083 MGLDPDAFLKQ--KPRSIRHKLVSLTLKRKN-----KLGEDVRRRLQDDEYTADSYQSWLQSRPT 1140

Mouse  1218 QKLEK---------EKSELKMEI-----DDLSSNAEAIAKAKGNL------------EKMCRTLE 1256
            ..|||         .::||:.||     ..|::|....:.|:|.:            ||....|.
  Fly  1141 SNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNYLR 1205

Mouse  1257 DQVSE-----LKSKEEEQQRLINELTAQR--ARLQTEAGEYSRQL---------DEKDALVSQLS 1305
            ..:.|     ....||..:|..|..|..:  :.|:.:|.:..:.:         :.|..|....:
  Fly  1206 AFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSAT 1270

Mouse  1306 RSKQASTQQIEELKRQLEEETKAKNALAHAL------------QSSRHDCDLLR--EQYEEEQEG 1356
            .::        ||..||.::...|:....:|            ....|..|.:.  |||.:||  
  Fly  1271 TAR--------ELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQ-- 1325

Mouse  1357 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL--QAAEEHVEAVNAKCASLEK 1419
                     .|....|.||..:..:......  |....::|..|  |.....|:....:|     
  Fly  1326 ---------GAQERNAPWRLFFRKEIFAPWH--EPTHDQVATNLIYQQVVRGVKFGEYRC----- 1374

Mouse  1420 TKQRLQNEVEDL-MIDVER------TNAACAALDKKQRNF---------DKVLSEWRQKYEETQA 1468
                  ::.||| ||..::      |:.:...|.....||         ||.:..|       .|
  Fly  1375 ------DKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIERW-------AA 1426

Mouse  1469 ELESCQKESRTLSTEL--FKVKNAYEESLDH------------LETLRRENKNLQQEISDLTEQI 1519
            .:....|:|..:..::  .|:|   |:.:.:            .|..|....||.:  :|:...:
  Fly  1427 LVLQAYKKSYYVKDKIAPLKIK---EDIVSYAKYKWPLLFSRFYEAYRNSGPNLPK--NDVIIAV 1486

Mouse  1520 AEGGKHIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDE 1584
            ...|.::.:        :||:..::.:..|..|....:..|:......|:.|:.|.....:...|
  Fly  1487 NWTGVYVVD--------DQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEFTFQSPNAE 1543

Mouse  1585 EI--------DQLKRNHVRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAE 1641
            :|        |.||:....|:...      :.|:.:|........:|||..:|      :....|
  Fly  1544 DIRDLVVYFLDGLKKRSKYVIALQ------DYRAPSDGTSFLSFFKGDLIILE------DESCGE 1596

Mouse  1642 SLRNYRNTQGILKDTQLHLDDALRGQE--DLKEQLAIVERRANLLQAEIEELRA--TLEQTERSR 1702
            |:.|.....|       ..|   |.||  |...:...|   ...|....:::.|  .:|:....|
  Fly  1597 SVLNNGWCIG-------RCD---RSQERGDFPAETVYV---LPTLSKPPQDILALFNIEEAHHGR 1648

Mouse  1703 KIAEQELLDASERVQLLHTQNTSLIN-----TKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAI 1762
            :::......|.|.....||.....::     .|:.:...::......||:.:.||:         
  Fly  1649 RLSMASNGGAVEPRDRPHTLMEYALDHFRLPPKRTMSKTLTLSSKRSEELWRYSRD--------- 1704

Mouse  1763 TDVSTTHITLPTPVLPATTRAYFCLDLFASQAAM-MAEELKKEQDTSAHLERMKKNMEQTVKD-- 1824
                        |:.....|.....:.||.:|.. .|..||...|..:...||...:...:.|  
  Fly  1705 ------------PIKAPLLRKLQSKEEFAEEACFAFAAILKYMGDLPSKRPRMGNEITDHIFDGP 1757

Mouse  1825 LQHRLDEAE---QLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAV----------KGLRKHE 1876
            |:|.:...|   ||     .||:.....|:.|         :|..|.:          :||    
  Fly  1758 LKHEILRDEIYCQL-----MKQLTDNRNRMSE---------ERGWELMWLATGLFACSQGL---- 1804

Mouse  1877 RRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLAKFRKLQHEL---EEA 1938
              :|||.......|..:  .||.:.:||..::..:|:....:.:..|...|..::.|::   ::.
  Fly  1805 --LKELLLFLRTRRHPI--SQDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDT 1865

Mouse  1939 EERADIAES 1947
            :|..::..|
  Fly  1866 DEAFEVDSS 1874

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh8XP_036012291.1 Myosin_N 37..75 CDD:397036 4/21 (19%)
Motor_domain 102..769 CDD:419868 276/681 (41%)
Myosin_tail_1 849..1955 CDD:396244 227/1276 (18%)
ckNP_001285949.1 MYSc 64..733 CDD:214580 285/706 (40%)
MYSc_Myo7 77..721 CDD:276832 276/681 (41%)
MyTH4 <1138..1245 CDD:214535 23/106 (22%)
B41 1251..1467 CDD:214604 43/257 (17%)
FERM_B-lobe 1355..1439 CDD:271216 20/101 (20%)
FERM_C1_MyoVII 1461..1559 CDD:270019 19/107 (18%)
SH3 1560..1624 CDD:302595 16/85 (19%)
MyTH4 1701..1849 CDD:214535 37/190 (19%)
B41 1856..2068 CDD:214604 3/19 (16%)
FERM_M 1966..2068 CDD:278785
FERM_C2_MyoVII 2064..2159 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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