DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myh3 and didum

DIOPT Version :9

Sequence 1:NP_001093105.1 Gene:Myh3 / 17883 MGIID:1339709 Length:1940 Species:Mus musculus
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:2037 Identity:523/2037 - (25%)
Similarity:912/2037 - (44%) Gaps:469/2037 - (23%)


- Green bases have known domain annotations that are detailed below.


Mouse    44 KEEYVKGKIKSSQDGKVTVETEDSRTLVVK----PEDVYAM-NPPKFDKIEDMAMLTHLNEPAVL 103
            :|.|.||.      |.:.:.|:..:...||    ..|:..: ||.......|:..|::|:||.||
  Fly    29 EESYRKGA------GFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVL 87

Mouse   104 YNLKDRYTS-WMIYTYSGLFCVTVNPYKWLPVYNPEVVDGYRGKKRQEAPPHIFSISDNAYQFML 167
            :||:.|:.. .:||||.|:..|.:|||..:|:|.|.::..|||....:..||||::::.||..:.
  Fly    88 HNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLE 152

Mouse   168 TDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFG 232
            .:..|.||:::|||||||||:.|..::|||.:..         |:.:..:|.::::::|::||||
  Fly   153 RENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGG---------SESETQVERKVLASSPIMEAFG 208

Mouse   233 NAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIETYLLEKSRVTFQLKAERSYHIFYQILS-- 292
            ||||.|||||||||||.::.| ...|.  |..|.:.|||||||||.:|.:.||:||||||:.:  
  Fly   209 NAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAAR 273

Mouse   293 NKKPELIELLLITTNPYDYPFISQG---EILVASIDDAEELLATDSAIDILGFTPEEKSGLYKLT 354
            :|.||     |:..:...:.|::.|   ||  ..:.|||:...|..|:.:|||:.::.:.:.|:.
  Fly   274 SKYPE-----LVLDHQDKFQFLNMGGAPEI--ERVSDAEQFNETVQAMTVLGFSIQQIADIVKIL 331

Mouse   355 GAVMHYGNMKFKQKQRE--EQAEPDGTEVADK------TAYLMGLNSSDLLKALCFPRVKVGNEY 411
            ..::|.||::..:|..|  |:.:.|..::...      ||.|:.:::.||.:.|...:::..|||
  Fly   332 AGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEY 396

Mouse   412 VTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQ 476
            |....:::....|.:||:|.:|.|||.::|..:|:.|:....:..|||||||.|||.||.||.||
  Fly   397 VLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQ 461

Mouse   477 LCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMF 541
            .|||:.||||||.||.|:|.||||||.||||.||.||| .|...||:|||..:|:..:|:|||..
  Fly   462 FCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECRM 525

Mouse   542 PKATDTSFKNKLYDQHLGKSN---NFQKPKVVKGKAEAHFSLVHYAGTVDYSVSGWLEKNKDPLN 603
            ||.:|.|:..||    :||.|   :|:||:.    ....|.:.|::.||:|.|:|:||||:|.::
  Fly   526 PKGSDESWAGKL----IGKCNKFPHFEKPRF----GTTSFFIKHFSDTVEYDVNGFLEKNRDTVS 582

Mouse   604 ETVVGLYQKSSNRLLAHLYATF----------ATTDADGGKKKVA---KKKGSSF---------- 645
            :.:..:..: ||..||....|.          |.:...||:..::   |::|:..          
  Fly   583 KELTQVLSE-SNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH 646

Mouse   646 -QTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKG 709
             :||.:.|:|:|..|:|.|..|.||:||||.||:.|.....|.:.::.|||..||||.:||...|
  Fly   647 RKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAG 711

Mouse   710 FPNRILYGDFKQRYRVL-NASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGT 773
            ||:|.||.||..||::| ..|.:.:.   |.|.:|..::.....|..:|:||:|::||:||.:..
  Fly   712 FPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAF 773

Mouse   774 LEEMRDERLAKLITRTQAV-----------------------CRGFLMRVEFQKMMQRRESIFCI 815
            ||::|.....|.||..|:|                       .||:|.|...|||.:.|..:...
  Fly   774 LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILS 838

Mouse   816 QYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDE----------------- 863
            :|       .:.|...:.:.:::..:...:|.......:.:|...:|.                 
  Fly   839 KY-------ARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARR 896

Mouse   864 -------------------LAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQL 909
                               ||:.:.||.:.|.|.::.::.|      .......::..::|.|:|
  Fly   897 AYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENK------YMGLENKIISMQQRIDEL 955

Mouse   910 IKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 974
            .:....|:.|              .:|::..|.||     ||||.::      |:.:..|.|.::
  Fly   956 NRDNSNLKHK--------------TSEISVLKMKL-----ELKKTLE------AEFKNVKAACQD 995

Mouse   975 KVKNLTEELAGLDETIAKLTREKKALQEAHQQTLDDL-QAEEDKVNSLSKLKSKLEQQVDDLESS 1038
            |           |:.|..|.::.:|.::...|.|::. .|:|:.::.    |....|:.::|...
  Fly   996 K-----------DKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQ----KQTWRQENEELRRQ 1045

Mouse  1039 LEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKK--KDFEYSQLQSKVEDEQTL 1101
            :::...:..:.|.|:|..| |..||       |.|.::|:|..::  ||.|.      :|:|..:
  Fly  1046 IDEIIDMAKNAEVNQRNQE-DRMLA-------EIDNRELNEAYQRAIKDKEV------IENENFM 1096

Mouse  1102 SLQLQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK 1166
                   :||..:|:                |....|.:||:....|.:.|:..|..|.:..|:.
  Fly  1097 -------LKEELSRL----------------TAGSFSLHARKASNASSQNEDDVGYASAKNTLDI 1138

Mouse  1167 KREAEFL--------------KLRRDLEE-----ATLQHEATVATLRKKHADSAAELAEQIDNLQ 1212
            .|..:.|              |||..|||     ..||.:....:.|.|..:.:..::|      
  Fly  1139 NRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSE------ 1197

Mouse  1213 RVKQKLEKEKSEFKLEIDDLSSSVESVSKSKANLEKICRTLEDQLSEARGKNEEMQRSLSELTTQ 1277
                 ||.|..:.:.|.|.|.:|:      |..:|                       ::||..|
  Fly  1198 -----LEVENEKLRSEYDQLRTSI------KHGVE-----------------------INELNAQ 1228

Mouse  1278 KSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQIEELKRQLEEENKAKNALAHALQSSRHDCD 1342
            .:.||.|......:..:.::::.|.|:|           .|.||.|         :||...:|.:
  Fly  1229 HAALQEEVRRRREECIQLKAVLLQQSQS-----------MRSLEPE---------SLQMRGNDVN 1273

Mouse  1343 LLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEA 1407
            .|.|.:..::....:|:..| ||.:|      ::.:..::.|:|:|        ||.:.:::::.
  Fly  1274 ELMEAFHSQKLINRQLESEL-KAITE------EHNSKLVEMTQEIE--------RLNNEKDELQK 1323

Mouse  1408 VNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK-KQRNFDKVLAEWKTKCEESQAELEAA 1471
            |..:  |::        |.||..||..|.|      |: .:|...|.:|::..    .|.||:.|
  Fly  1324 VMFE--SID--------EFEDSNVDTLRQN------DRYLRRELQKAVAQFLL----VQEELKLA 1368

Mouse  1472 LKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEI-ADLTEQIAENGKSIHELEKSRKQME 1535
            ..:.::...:..:|::..||     |.::.::.....:: |::|:|.::|.:.:         |:
  Fly  1369 NAKLKAYRQDGGQLEHKIEE-----EMIRNKSNGTSADVGANVTKQKSQNPQGL---------MK 1419

Mouse  1536 LEKADIQMALEEAEAALEHE---------EAKILRIQLELTQVKSEID--RKIAEKDEEIEQLKR 1589
            ...:|:...|:...:||...         .|.::.:.:..|.:.:..|  |::..|  .:.|:|:
  Fly  1420 FHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSK--FVIQIKK 1482

Mouse  1590 NYQRTVETMQGALDAEVRSRNEAIRLKKKME--GDLNE-IEIQLSHANRQAAETIKHLRSVQGQL 1651
            .: ||...::..:...|.|    |.|...|:  ||::| ::......|:|..:.. :|...:..:
  Fly  1483 MH-RTPHPIENRVIWLVNS----ITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNF-NLFEYRRVI 1541

Mouse  1652 KDTQLHLDDAL----RGQEDLKEQLAIVE-------RRANLLQAEVEELRAT------------- 1692
            .|..::|..||    :|..|.|...||:.       |:|:.:::....:.|:             
  Fly  1542 LDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQ 1606

Mouse  1693 -LEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLTQLQSE--------------- 1741
             :.|.|...|..:...||:....|:.|    .|::....:..:...|:.:               
  Fly  1607 LIGQLEHFYKQFQHFGLDNCYAEQIFH----QLLYFICAVALNCLMLRGDICMWETGMIIRYNIG 1667

Mouse  1742 -VEDACRDARNAEE--KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 1803
             :||..|..:.:.:  .|...:...:.:.:..|.|||.            ||:.||...|..|:.
  Fly  1668 CIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDV------------QTICDLCTSLSTAQV 1720

Mouse  1804 LALKGGKKQIQKLETRIRELEFELEGE-------QKRNTESVKGLRKYERRVKELTYQSEEDRKN 1861
            |.:....| :...|:.|..:..|...|       ||.|::.....:|:.:..|.:...|:     
  Fly  1721 LKVMKSYK-LDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSD----- 1779

Mouse  1862 VLRLQDL-------VDKLQVKV 1876
             ::|:|:       :|:...|:
  Fly  1780 -IKLEDIELPSHLNLDEFLTKI 1800

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh3NP_001093105.1 Myosin_N 35..73 CDD:367160 6/28 (21%)
MYSc_Myh3 100..767 CDD:276878 270/711 (38%)
Actin-binding. /evidence=ECO:0000250 656..678 12/21 (57%)
Actin-binding. /evidence=ECO:0000250 758..772 7/13 (54%)
Myosin_tail_1 847..1924 CDD:366712 216/1161 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1260..1289 6/28 (21%)
didumNP_724569.1 MYSc 65..778 CDD:214580 281/741 (38%)
MYSc_Myo5 84..767 CDD:276831 270/711 (38%)
IQ 900..922 CDD:197470 2/21 (10%)
GBP_C <971..1086 CDD:303769 33/148 (22%)
coiled coil 1049..1068 CDD:293879 5/19 (26%)
coiled coil 1077..1086 CDD:293879 1/8 (13%)
JAKMIP_CC3 <1190..1299 CDD:292653 33/175 (19%)
Myo5_CBD 1424..1792 CDD:271254 73/398 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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