DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myh2 and didum

DIOPT Version :9

Sequence 1:NP_001034634.2 Gene:Myh2 / 17882 MGIID:1339710 Length:1942 Species:Mus musculus
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:2070 Identity:520/2070 - (25%)
Similarity:906/2070 - (43%) Gaps:461/2070 - (22%)


- Green bases have known domain annotations that are detailed below.


Mouse    20 SEKERIEAQNRPFDAKTSVFVAEP---KESFVKGTIQSKDAGKVTVKTEAGATLTVK----EDQI 77
            |.:|.:.||........:..|.|.   :||:.||      ||.:.:.|::|....||    ...:
  Fly     2 SSEEMLYAQGAKIWVPHADLVWESATLEESYRKG------AGFLKICTDSGKLKEVKLKADGSDL 60

Mouse    78 FPM-NPPKYDKIEDMAMMTHLHEPAVLYNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYNPEVV 140
            .|: ||.......|:..:::||||.||:||:.|:. ..:||||.|:..|.:|||..:|:|.|.::
  Fly    61 PPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125

Mouse   141 AAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDK 205
            .||||....:..||||::::.||..:..:..|.||:::|||||||||:.|..::|||  ||.|.:
  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFA--AVGGSE 188

Mouse   206 KKEEATSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIE 267
            .:.:         :|.::::::|::||||||||.|||||||||||.::.| ...|.  |..|.:.
  Fly   189 SETQ---------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMH 244

Mouse   268 TYLLEKSRVTFQLKAERSYHIFYQITS--NKKPELIEMLLITTNPYDYPFVSQGEI-SVASIDDQ 329
            |||||||||.:|.:.||:||||||:.:  :|.||     |:..:...:.|::.|.. .:..:.|.
  Fly   245 TYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDA 304

Mouse   330 EELMATDSAIDILGFTNDEKVSIYKLTGAVMHYGNMKFKQKQRE--EQAEPDGTEVADKAAYLQG 392
            |:...|..|:.:|||:..:...|.|:...::|.||::..:|..|  |:.:.|..::.....:|| 
  Fly   305 EQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQ- 368

Mouse   393 LNSADLLKA--------LCYPRVKVGNEYVTKGQTVEQVTNAVGALAKAMYEKMFLWMVTRINQQ 449
             .:||||:.        |...:::..||||....::|....|..||||.:|.|:|.::|..:|:.
  Fly   369 -ITADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKS 432

Mouse   450 LDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFI 514
            |:....:..|||||||.|||.|:.||.||.|||:.||||||.||.|:|.||||||.||||.||.|
  Fly   433 LNNGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMI 497

Mouse   515 DFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVKGKAEAH 579
            || .|...||:|||..:|:..:|:|||..||.:|.|:..||..: ..|..:|:||:.    ....
  Fly   498 DF-YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKLIGK-CNKFPHFEKPRF----GTTS 556

Mouse   580 FSLIHYAGTVDYNITGWLDKNKDPLNETVVGLYQKSS------VKTLAYLFSGAQTAEAEASSGG 638
            |.:.|::.||:|::.|:|:||:|.:::.:..:..:|:      |.||..:.:....:...::.||
  Fly   557 FFIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGG 621

Mouse   639 --AAKKGAKKKGSSF-----------QTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGA 690
              ....|.|::|:..           :||.:.|:|:|..|::.|.:|.||:||||.||:.|....
  Fly   622 RVVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFK 686

Mouse   691 MEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVL-NASAIPEGQYIDSKKASEKLLG 754
            .|...::.|||..||||.:||...|||||.||.||..||::| ..|.:.:.   |.|.:...::.
  Fly   687 WETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVM 748

Mouse   755 SIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDD-----------------------KLAQLITRTQ 796
            ....|..:|:||:|::||:||.:..||::|.:                       ::.::|...|
  Fly   749 KWIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQ 813

Mouse   797 AMCRGFLARVEYQKMVERRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKE 861
            ...||:|||...|||.|.|..:...:|       .:.|...:.:.:::..:...:|.......:.
  Fly   814 KHARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQTYARGMLARN 871

Mouse   862 EFQKTKDD--------LAKSEAKRKELEEKMVSLL-------------KEKNDLQLQVQAEAEGL 905
            :|...:|.        ..:....|:..:::..:::             |.|     :::|||:.:
  Fly   872 KFHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFK-----RMKAEAKTI 931

Mouse   906 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 970
            :..|.:...|....|.::.:|.|:.....:.:...:|::..|.||     ||||.::      |:
  Fly   932 SHMENKYMGLENKIISMQQRIDELNRDNSNLKHKTSEISVLKMKL-----ELKKTLE------AE 985

Mouse   971 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLE 1035
            .:..|.|.::|           |:.|..|.|:              |:||.|:...|      ||
  Fly   986 FKNVKAACQDK-----------DKLIEALNKQ--------------LEAERDEKMQL------LE 1019

Mouse  1036 QQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDERLKKKEFEMSNLQSK 1100
            :.....|..:.|::..|.:.|..:|:::..:.:|:.:.::..|::.::...:..:|...: .|..
  Fly  1020 ENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAEIDNRELNEA-YQRA 1083

Mouse  1101 IEDEQAIGIQLQKKIKELQARIEELEEEIEAERASRAKAE----------KQRSDLSRELEEISE 1155
            |:|::.|..: ...:||..:|:......:.|.:||.|.::          |...|::|..:.:|:
  Fly  1084 IKDKEVIENE-NFMLKEELSRLTAGSFSLHARKASNASSQNEDDVGYASAKNTLDINRPPDLLSK 1147

Mouse  1156 RLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV 1220
            .. ....:||..:::....|.|.||.:      .||.:....:.|.|..:....:.|        
  Fly  1148 NY-SYNDSTSLVVKLRSILEEEKQKHK------VLQEQYIKLSSRHKPTEDSFRVSE-------- 1197

Mouse  1221 KQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQVSELKSKEEEQQRLINDLTTQRG 1285
               ||.|..:::.|.|.|.:::      |..:|                       ||:|..|..
  Fly  1198 ---LEVENEKLRSEYDQLRTSI------KHGVE-----------------------INELNAQHA 1230

Mouse  1286 RLQTESGEFSRQLDEKEALVSQLS-------------RGK------QAFTQQIEELKRQLEEEVK 1331
            .||.|......:..:.:|::.|.|             ||.      :||..| :.:.||||.|:|
  Fly  1231 ALQEEVRRRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEAFHSQ-KLINRQLESELK 1294

Mouse  1332 AKNALAHALQSSRHDCDL--LREQYEEEQESKAELQRALSKANSEVAQWRTKYETDAIQRTEEL- 1393
            |        .:..|:..|  :.::.|.....|.|||:.:.::..|...    ...|.:::.:.. 
  Fly  1295 A--------ITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFED----SNVDTLRQNDRYL 1347

Mouse  1394 -EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFD 1457
             .|.:|.:||.|...|| ::..|||..:..:...:|::::|:.|:                    
  Fly  1348 RRELQKAVAQFLLVQEE-LKLANAKLKAYRQDGGQLEHKIEEEMI-------------------- 1391

Mouse  1458 KILAEWKQKYEETHAELEASQKEARSLGTE-LFKMKNAYEESLDQLETLKRENKNLQQEISDLTE 1521
                  :.|...|.|::.|:..:.:|...: |.|.   :...||::         ||:.:|.||.
  Fly  1392 ------RNKSNGTSADVGANVTKQKSQNPQGLMKF---HSSDLDKI---------LQRLLSALTP 1438

Mouse  1522 QIAEG------------GKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRI-----Q 1569
            :...|            ..|..:|......|.:...:....:::...:....|.:::.:     .
  Fly  1439 RTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITL 1503

Mouse  1570 LELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRIKKKMEGDLNEMEI 1634
            |.|.:...::|..:....|:.:|.:..:..:.|..:..||                      :.:
  Fly  1504 LNLMKQYGDVDEYVKFNTEKQNQQQLKNFNLFEYRRVILD----------------------LIV 1546

Mouse  1635 QLNHSNRMAAEALRNYRNTQGILKDTQLHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRAT- 1698
            .|..:..|..:.|.:.:....||.:     |:..||            |:|:.:::....:.|: 
  Fly  1547 NLYQALIMQIQGLLDPKIVPAILNN-----DEIQRG------------RQAHGMRSRATSIGASS 1594

Mouse  1699 -------------LEQTERSRKIAEQELLD--ASERV--QLLHTQNTSLINTKKKLETDISQIQ- 1745
                         :.|.|...|..:...||  .:|::  |||:......:|. ..|..||...: 
  Fly  1595 SPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNC-LMLRGDICMWET 1658

Mouse  1746 --------GEMEDIVQEARNAEE--KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDL 1800
                    |.:||.|:..:.:.:  .|...:...:.:.:..|.|||.            ||:.||
  Fly  1659 GMIIRYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDV------------QTICDL 1711

Mouse  1801 QLRLDEAEQL-ALKGGK--------------KQIQKLEARVRELEGEVESEQKRNAEAVKGLRKH 1850
            ...|..|:.| .:|..|              |..:||.||         ..||.|::        
  Fly  1712 CTSLSTAQVLKVMKSYKLDDYESEITNVFLEKLTEKLNAR---------QMQKSNSD-------- 1759

Mouse  1851 ERRVKELTYQTE--EDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLSKF 1903
                 |.|...:  :..|.:.|..|:             :.|:.|..|:.||.:|
  Fly  1760 -----EFTIDQKFIQPFKVVFRYSDI-------------KLEDIELPSHLNLDEF 1796

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh2NP_001034634.2 Myosin_N 36..73 CDD:280832 10/39 (26%)
Myosin_head 88..773 CDD:278492 270/721 (37%)
Motor_domain 100..773 CDD:277568 266/709 (38%)
Myosin_tail_1 853..1930 CDD:279860 210/1169 (18%)
RILP-like 968..1101 CDD:304877 24/132 (18%)
MIT_CorA-like <1302..>1414 CDD:294313 31/134 (23%)
DUF342 <1673..1770 CDD:302792 21/125 (17%)
didumNP_724569.1 MYSc 65..778 CDD:214580 277/739 (37%)
MYSc_Myo5 84..767 CDD:276831 266/709 (38%)
IQ 900..922 CDD:197470 1/21 (5%)
GBP_C <971..1086 CDD:303769 32/157 (20%)
coiled coil 1049..1068 CDD:293879 2/18 (11%)
coiled coil 1077..1086 CDD:293879 2/9 (22%)
JAKMIP_CC3 <1190..1299 CDD:292653 31/157 (20%)
Myo5_CBD 1424..1792 CDD:271254 78/463 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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