DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myh11 and didum

DIOPT Version :9

Sequence 1:XP_006521906.1 Gene:Myh11 / 17880 MGIID:102643 Length:1979 Species:Mus musculus
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:2006 Identity:548/2006 - (27%)
Similarity:907/2006 - (45%) Gaps:410/2006 - (20%)


- Green bases have known domain annotations that are detailed below.


Mouse    36 VWVPSEKQGFEAASIKE--EKGDEVVVELVENGK----KVTVGKDDIQKM-NPPKFSKVEDMAEL 93
            :|||.....:|:|:::|  .||...:....::||    |:.....|:..: ||.......|:..|
  Fly    14 IWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTL 78

Mouse    94 TCLNEASVLHNLRERYFS-GLIYTYSGLFCVVVNPYKYLPIYSEKIVDMYKGKKRHEMPPHIYAI 157
            :.|:|..||||||.|:.. .:||||.|:..|.:|||..:|:|...|:..|:|....::.|||:|:
  Fly    79 SYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFAL 143

Mouse   158 ADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDSSITQGPSFAYGELE 222
            |:.||..:.::..:.||:.:||||||||.:.|..::|.|.|..|      .|.||        :|
  Fly   144 AEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGGS------ESETQ--------VE 194

Mouse   223 KQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF-DVTG--YIVGANIETYLLEKSRAIRQARD 284
            :::|.::||:||||||||.:||||||||||.::.| :..|  ::.||.:.||||||||.:.||:.
  Fly   195 RKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQG 259

Mouse   285 ERTFHIFYYLLAGAKEKMKSDLLLESFNSYTFLSNGFVP-IPAAQDDEMFQETLEAMSIMGFNEE 348
            ||.:||||.|.| |:.|. .:|:|:..:.:.||:.|..| |....|.|.|.||::||:::||:.:
  Fly   260 ERNYHIFYQLCA-ARSKY-PELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQ 322

Mouse   349 EQLAILKVVSSVLQLGNI-VFKK------ERNTDQASMPDNTA-AQKVCHLVGINVTDFTRAILT 405
            :...|:|:::.:|.|||| |.||      |.::|...:..|.. .|....|:.::..|..|.:|.
  Fly   323 QIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLM 387

Mouse   406 PRIKVGRDVVQKAQTKEQADFAIEALAKATYERLFRWILSRVNKALDKTHRQGASFLGILDIAGF 470
            .:|:...:.|....:.|.|..|.:||||..|.:||::|:..:||:|:...:| .||:|:|||.||
  Fly   388 RKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQ-CSFIGVLDIYGF 451

Mouse   471 EIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNP 535
            |.||||||||.||||.||||||.||..:|.||||||.:|||.|..||| .|.||||:|||   :.
  Fly   452 ETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIE---SR 512

Mouse   536 PGVLALLDEECWFPKATDKSFVEKLCSEQGNHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLT 600
            .|||.||||||..||.:|:|:..||..:....|.|:||:  ...|.|.|.|::..|:|:.:.:|.
  Fly   513 LGVLDLLDEECRMPKGSDESWAGKLIGKCNKFPHFEKPR--FGTTSFFIKHFSDTVEYDVNGFLE 575

Mouse   601 KNMDPLNDNVTSLL---NASSDKFVADLWKDVD--------------RIV---GLDQMAKMTESS 645
            ||.|.::..:|.:|   |.|..|.|..| :::|              |:|   |..|....|...
  Fly   576 KNRDTVSKELTQVLSESNMSLAKQVMTL-EEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRR 639

Mouse   646 LPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNG 710
            :..:.:.:|    |||..::|.|..|::||..|||::||||.||.:|.:.|.:...:::|||..|
  Fly   640 VVPSKQHRK----TVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACG 700

Mouse   711 VLEGIRICRQGFPNRIVFQEFRQRYEILA-ANAIPKGFMDGKQACILMIKALELDPNLYRIGQSK 774
            |||.:||...|||:|.::.:|..||::|. .:.:.|.  |.|.:|..::.....|.:.||.|.::
  Fly   701 VLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN--DMKLSCRNIVMKWIQDEDKYRFGNTQ 763

Mouse   775 IFFRTGVLAHLEEERD-----------------------LKITDVIMAFQAMCRGYLARKAFTKR 816
            ||||.|.:|.||:.|.                       |:|..||...|...||||||:. |::
  Fly   764 IFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARER-TQK 827

Mouse   817 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTR---QEEEMQAKEEEMQKIKERQQKA 878
            .::..|..::.:....:|..|  ::.||...:..:....|   ...:..|..:..:.::.::...
  Fly   828 MREARAGLILSKYARGWLCRR--RYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVR 890

Mouse   879 ETELKELEQKH------TQLAEEKTLLQ---EQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934
            ....:...||.      .|.|..:.|.:   ::::||.:..:..|.       |...||..:..|
  Fly   891 GALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMEN-------KYMGLENKIISM 948

Mouse   935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDDILVMDD 999
            :.|::|              :.:...:|:.:..|....:.||:|:| |.||:.|.::   ....|
  Fly   949 QQRIDE--------------LNRDNSNLKHKTSEISVLKMKLELKK-TLEAEFKNVK---AACQD 995

Mouse  1000 QNSKLSKERKLLEERVSDLTTNLAEEEEKAKNLTKLKSKHESMISELEVRLKKEEKSRQELEKLK 1064
            ::..:....|.||          ||.:||.:.|.:.....|..||:       ::..|||.|:|:
  Fly   996 KDKLIEALNKQLE----------AERDEKMQLLEENGHAQEEWISQ-------KQTWRQENEELR 1043

Mouse  1065 RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD----EEIAQKNNALKKIRELEG 1125
            |::        ::|.|: |:.||:..:  .:|:.:   ||.:|    .|..|:  |:|....:|.
  Fly  1044 RQI--------DEIIDM-AKNAEVNQR--NQEDRM---LAEIDNRELNEAYQR--AIKDKEVIEN 1092

Mouse  1126 HISDLQEDLD---------SERAARNKAEKQKRDLGEELEALKTELE-----DTL-------DST 1169
            ....|:|:|.         ..|.|.|.:.:.:.|:|  ..:.|..|:     |.|       |||
  Fly  1093 ENFMLKEELSRLTAGSFSLHARKASNASSQNEDDVG--YASAKNTLDINRPPDLLSKNYSYNDST 1155

Mouse  1170 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHTQAVEELTEQLEQFKRAKANLDKSKQ 1234
            :...:||:..|:|                      :|||....|:..:...:.|..:.:...|: 
  Fly  1156 SLVVKLRSILEEE----------------------KQKHKVLQEQYIKLSSRHKPTEDSFRVSE- 1197

Mouse  1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEVQLQDLQSKCSDGERARAELSDKVHKLQNEVESV 1299
             ||.||..|..|   ..|.:..::|     .|::.:|.::       .|.|.::|.:.:.|...:
  Fly  1198 -LEVENEKLRSE---YDQLRTSIKH-----GVEINELNAQ-------HAALQEEVRRRREECIQL 1246

Mouse  1300 TGMLNEAEGKAIKLAKDVASLGSQLQDTQELLQEETRQKL---NVSTKLRQLEDERNSLQDQLDE 1361
            ..:|.:.......|..:  ||..:..|..||::....|||   .:.::|:.:.:|.||...::.:
  Fly  1247 KAVLLQQSQSMRSLEPE--SLQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNSKLVEMTQ 1309

Mouse  1362 EMEAKQNLERHVSTLNIQLSDSKKKLQDFASTIEVMEEGKKRLQKEMEGLSQQYEEKAAAYDKLE 1426
            |:|   .|......|...:.:|..:.:|  |.::.:.:..:.|::|:        :||.|...| 
  Fly  1310 EIE---RLNNEKDELQKVMFESIDEFED--SNVDTLRQNDRYLRREL--------QKAVAQFLL- 1360

Mouse  1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQKKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491
                 :|:||......|...||....||.|        .||:.|.:|    .:...|:.....||
  Fly  1361 -----VQEELKLANAKLKAYRQDGGQLEHK--------IEEEMIRNK----SNGTSADVGANVTK 1408

Mouse  1492 ALS-------------LARALEEALEAKEELERTNKM---------LKAEMEDLVSSKDDVGKNV 1534
            ..|             |.:.|:..|.|.........:         :.....||.::.||    |
  Fly  1409 QKSQNPQGLMKFHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDD----V 1469

Mouse  1535 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL--EVNMQALKGQFERDLQARDEQNEEK 1597
            .||          :.:...|::::.......|:..:.|  .:.:..|..|: .|:....:.|.||
  Fly  1470 REL----------LSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQY-GDVDEYVKFNTEK 1523

Mouse  1598 RRQLQRQ---LHEYETELED--ERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE--------- 1648
            :.|.|.:   |.||...:.|  ....:||....:..|:..:....|..|...:||:         
  Fly  1524 QNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRAT 1588

Mouse  1649 -------------EAIKQL-RKLQAQMKDFQR-ELDDARASRDEIF--------ATSKENEKKAK 1690
                         .|.||| .:|:...|.||. .||:..|  ::||        |.:    ....
  Fly  1589 SIGASSSPEHGGGPAWKQLIGQLEHFYKQFQHFGLDNCYA--EQIFHQLLYFICAVA----LNCL 1647

Mouse  1691 SLEADL------MQLQEDLAAAE---RARKQADLEKEELAEELASSLSGRNTLQDEKRRLEARIA 1746
            .|..|:      |.::.::...|   |::|        ::.::.::|:..|           :::
  Fly  1648 MLRGDICMWETGMIIRYNIGCIEDWVRSKK--------MSNDVLTALAPLN-----------QVS 1693

Mouse  1747 QLEEELEEEQGNMEAMSDRVRKATLQAEQLSNELATERSTAQKNESARQQLERQNKELRS-KLQE 1810
            ||.:..:.|| :::.:.|               |.|..||||           ..|.::| ||.:
  Fly  1694 QLLQSRKSEQ-DVQTICD---------------LCTSLSTAQ-----------VLKVMKSYKLDD 1731

Mouse  1811 VEGAV-KAKLKSTVAALEAKIAQLEEQVEQEAREK--QAATKSLKQKDKKLKEVLL 1863
            .|..: ...|:.....|.|:..|.....|....:|  |......:..|.||:::.|
  Fly  1732 YESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDIKLEDIEL 1787

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh11XP_006521906.1 Myosin_N 33..71 CDD:367160 11/40 (28%)
MYSc_class_II 99..778 CDD:276951 283/712 (40%)
Myosin_tail_1 855..1935 CDD:366712 223/1123 (20%)
didumNP_724569.1 MYSc 65..778 CDD:214580 295/742 (40%)
MYSc_Myo5 84..767 CDD:276831 283/712 (40%)
IQ 900..922 CDD:197470 4/21 (19%)
GBP_C <971..1086 CDD:303769 38/151 (25%)
coiled coil 1049..1068 CDD:293879 6/24 (25%)
coiled coil 1077..1086 CDD:293879 3/10 (30%)
JAKMIP_CC3 <1190..1299 CDD:292653 26/127 (20%)
Myo5_CBD 1424..1792 CDD:271254 82/431 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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