DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myh1 and didum

DIOPT Version :9

Sequence 1:NP_109604.1 Gene:Myh1 / 17879 MGIID:1339711 Length:1942 Species:Mus musculus
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:2100 Identity:527/2100 - (25%)
Similarity:909/2100 - (43%) Gaps:521/2100 - (24%)


- Green bases have known domain annotations that are detailed below.


Mouse    20 SEKERIEAQNKPFDAKSSVFVVDAKESFVKATVQS--REG-GKVTAKTEGGTTVTVK---DDQVY 78
            |.:|.:.||.      :.::|..|...:..||::.  |:| |.:...|:.|....||   |....
  Fly     2 SSEEMLYAQG------AKIWVPHADLVWESATLEESYRKGAGFLKICTDSGKLKEVKLKADGSDL 60

Mouse    79 P--MNPPKYDKIEDMAMMTHLHEPAVLYNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYNAEVV 140
            |  .||.......|:..:::||||.||:||:.|:. ..:||||.|:..|.:|||..:|:|...::
  Fly    61 PPLRNPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSII 125

Mouse   141 AAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEK 205
            .||||....:..||||::::.||..:..:..|.||:::|||||||||:.|..::|||  ||.|.:
  Fly   126 RAYRGHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFA--AVGGSE 188

Mouse   206 KKEEATSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIE 267
            .:.:         :|.::::::|::||||||||.|||||||||||.::.| ...|.  |..|.:.
  Fly   189 SETQ---------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMH 244

Mouse   268 TYLLEKSRVTFQLKAERSYHIFYQIMS--NKKPDLIEMLLITTNPYDYAFVSQGEI-TVPSIDDQ 329
            |||||||||.:|.:.||:||||||:.:  :|.|:     |:..:...:.|::.|.. .:..:.|.
  Fly   245 TYLLEKSRVVYQAQGERNYHIFYQLCAARSKYPE-----LVLDHQDKFQFLNMGGAPEIERVSDA 304

Mouse   330 EELMATDSAIDILGFTSDERVSIYKLTGAVMHYGNMKFKQKQRE--EQAEPDGTEVADKAAYLQ- 391
            |:...|..|:.:|||:..:...|.|:...::|.||::..:|..|  |:.:.|..::.....:|| 
  Fly   305 EQFNETVQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQI 369

Mouse   392 -----NLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNSVGALAKAVYEKMFLWMVTRINQQLD 451
                 .:::.||.:.|...:::..||||....:::....:..||||.:|.|:|.::|..:|:.|:
  Fly   370 TADLLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLN 434

Mouse   452 TKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDF 516
            ....:..|||||||.|||.|:.||.||.|||:.||||||.||.|:|.||||||.||||.|..|||
  Fly   435 NGSKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF 499

Mouse   517 GMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQK-PKPAKGKVEAHF 580
             .|...||:|||..:|:..:|:|||..||.:|.|:..||    :||.|.|.. .||..|...  |
  Fly   500 -YDNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPRFGTTS--F 557

Mouse   581 SLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSMK------TLAYLFSGAAAAAEAESGGGG 639
            .:.|::.||:|::.|:|:||:|.:::.:..:..:|:|.      ||..:.:....:|::.:.||.
  Fly   558 FIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGR 622

Mouse   640 G--KKGAKKKGSSF-----------QTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAM 691
            .  ..|.|::|:..           :||.:.|:|:|..|::.|.:|.||:||||.||:.|.....
  Fly   623 VVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKW 687

Mouse   692 EHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVL-NASAIPEGQFIDSKKASEKLLGS 755
            |...::.|||..||||.:||...|||||.||.||..||::| ..|.:.:.   |.|.:...::..
  Fly   688 ETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVMK 749

Mouse   756 IDIDHTQYKFGHTKVFFKAGLLGLLEEMRDD-----------------------KLAQLITRTQA 797
            ...|..:|:||:|::||:||.:..||::|.:                       ::.::|...|.
  Fly   750 WIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQK 814

Mouse   798 MCRGYLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAET-------EKE 855
            ..||||||...|||.|.|..:...:|       .:.|...:.|.:::..:...:|       ..:
  Fly   815 HARGYLARERTQKMREARAGLILSKY-------ARGWLCRRRYLRLRHSISGIQTYARGMLARNK 872

Mouse   856 MANMKEE------------------FEKAKEN-----------LAKAEAKRKELEEKMVALMQEK 891
            ...|::.                  ::|.:.|           ||:.:.||.:.|.|.::.|:.|
  Fly   873 FHAMRDHYRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENK 937

Mouse   892 NDLQLQVQSEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 956
               .:.::::..|:   ::|.|:|.:....|:.|              .:|::..|.||     |
  Fly   938 ---YMGLENKIISM---QQRIDELNRDNSNLKHK--------------TSEISVLKMKL-----E 977

Mouse   957 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEE 1021
            |||.::      |:.:..|.|.::|           |:.|..|.|:              |:||.
  Fly   978 LKKTLE------AEFKNVKAACQDK-----------DKLIEALNKQ--------------LEAER 1011

Mouse  1022 DKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLA---------QESTMDVE 1077
            |:...|      ||:.....|..:.|::..|.:.|..:|:::..:.:|         ||..|..|
  Fly  1012 DEKMQL------LEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLAE 1070

Mouse  1078 NDKQQLDE----KLKKKEFEMSNLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAK 1138
            .|.::|:|    .:|.||.        ||:|..:       :||..:|:......:.|.:||.|.
  Fly  1071 IDNRELNEAYQRAIKDKEV--------IENENFM-------LKEELSRLTAGSFSLHARKASNAS 1120

Mouse  1139 AE----------KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHE 1193
            ::          |...|::|..:.:|:.. ....:||..:::....|.|.||.:      .||.:
  Fly  1121 SQNEDDVGYASAKNTLDINRPPDLLSKNY-SYNDSTSLVVKLRSILEEEKQKHK------VLQEQ 1178

Mouse  1194 ATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMEVISKSKGNLEKMCRT 1258
            ....:.|.|..:....:.|           ||.|..:::.|.|.|.:::      |..:|     
  Fly  1179 YIKLSSRHKPTEDSFRVSE-----------LEVENEKLRSEYDQLRTSI------KHGVE----- 1221

Mouse  1259 LEDQVSELKTKEEEQQRLINELTAQRGRLQTESGEYSRQLDEKDSLVSQLSRGKQAFTQQIEELK 1323
                              ||||.||...||                               ||::
  Fly  1222 ------------------INELNAQHAALQ-------------------------------EEVR 1237

Mouse  1324 RQLEEEIKAKSALAHALQSSR-----------HDCDLLREQYEEE----QEAKAELQRAMSKANS 1373
            |:.||.|:.|:.|....||.|           :|.:.|.|.:..:    ::.::||:....:.||
  Fly  1238 RRREECIQLKAVLLQQSQSMRSLEPESLQMRGNDVNELMEAFHSQKLINRQLESELKAITEEHNS 1302

Mouse  1374 EVAQW-----RTKYETDAIQRT-----EELEEAK--------KKLAQRLQDA-------EEHVEA 1413
            ::.:.     |...|.|.:|:.     :|.|::.        :.|.:.||.|       :|.::.
  Fly  1303 KLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQNDRYLRRELQKAVAQFLLVQEELKL 1367

Mouse  1414 VNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKYEETHAELEASQ 1478
            .|||..:..:...:|::::|:.||                          :.|...|.|::.|:.
  Fly  1368 ANAKLKAYRQDGGQLEHKIEEEMI--------------------------RNKSNGTSADVGANV 1406

Mouse  1479 KESRSLSTE-LFKIKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEG------------GKRI 1530
            .:.:|.:.: |.|.   :...||         |.||:.:|.||.:...|            ..|.
  Fly  1407 TKQKSQNPQGLMKF---HSSDLD---------KILQRLLSALTPRTVVGLLPGFPAYLIFMCIRY 1459

Mouse  1531 HELEKIKKQIEQEKSELQAALEEAEASLEHEEGKILRI-----QLELNQVKSEIDRKIAEKDEEI 1590
            .:|......:.:..|:....:::...:....|.:::.:     .|.|.:...::|..:....|:.
  Fly  1460 TDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVDEYVKFNTEKQ 1524

Mouse  1591 DQLKRNHIRVVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHSNRMAAEALRNYRNTQG 1655
            :|.:..:..:.|..:..||                      :.:.|..:..|..:.|.:.:....
  Fly  1525 NQQQLKNFNLFEYRRVILD----------------------LIVNLYQALIMQIQGLLDPKIVPA 1567

Mouse  1656 ILKDTQLHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRAT--------------LEQTERSR 1706
            ||.:     |:..||            |:|:.:::....:.|:              :.|.|...
  Fly  1568 ILNN-----DEIQRG------------RQAHGMRSRATSIGASSSPEHGGGPAWKQLIGQLEHFY 1615

Mouse  1707 KIAEQELLD--ASERV--QLLHTQNTSLINTKKKLETDISQIQ---------GEMEDIVQEARNA 1758
            |..:...||  .:|::  |||:......:|. ..|..||...:         |.:||.|:..:.:
  Fly  1616 KQFQHFGLDNCYAEQIFHQLLYFICAVALNC-LMLRGDICMWETGMIIRYNIGCIEDWVRSKKMS 1679

Mouse  1759 EE--KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1821
            .:  .|...:...:.:.:..|.|||.            ||:.||...|..|:.|.:....|    
  Fly  1680 NDVLTALAPLNQVSQLLQSRKSEQDV------------QTICDLCTSLSTAQVLKVMKSYK---- 1728

Mouse  1822 LEARVRELEGEVENE-QKRNVEAIKGLRKHERRVKELTYQTE--EDRKNVLRLQDLVDKLQSKVK 1883
                :.:.|.|:.|. .::..|.:...:..:....|.|...:  :..|.|.|..|:         
  Fly  1729 ----LDDYESEITNVFLEKLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYSDI--------- 1780

Mouse  1884 AYKRQAEEAEEQSNVNLAKF 1903
                :.|:.|..|::||.:|
  Fly  1781 ----KLEDIELPSHLNLDEF 1796

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh1NP_109604.1 Myosin_N 35..73 CDD:367160 9/40 (23%)
MYSc_Myh1_mammals 100..773 CDD:276875 263/708 (37%)
Actin-binding. /evidence=ECO:0000250 662..684 11/21 (52%)
Actin-binding. /evidence=ECO:0000250 764..778 7/13 (54%)
Myosin_tail_1 853..1930 CDD:366712 217/1192 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1156..1175 2/18 (11%)
didumNP_724569.1 MYSc 65..778 CDD:214580 274/738 (37%)
MYSc_Myo5 84..767 CDD:276831 263/708 (37%)
IQ 900..922 CDD:197470 4/21 (19%)
GBP_C <971..1086 CDD:303769 35/156 (22%)
coiled coil 1049..1068 CDD:293879 3/18 (17%)
coiled coil 1077..1086 CDD:293879 1/8 (13%)
JAKMIP_CC3 <1190..1299 CDD:292653 33/179 (18%)
Myo5_CBD 1424..1792 CDD:271254 75/449 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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