DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppp1r15a and PPP1R15

DIOPT Version :9

Sequence 1:NP_032680.1 Gene:Ppp1r15a / 17872 MGIID:1927072 Length:657 Species:Mus musculus
Sequence 2:NP_611863.1 Gene:PPP1R15 / 37820 FlyBaseID:FBgn0034948 Length:317 Species:Drosophila melanogaster


Alignment Length:244 Identity:58/244 - (23%)
Similarity:79/244 - (32%) Gaps:87/244 - (35%)


- Green bases have known domain annotations that are detailed below.


Mouse   372 EDTEEENSDLDSAEEDTAQTGATPHTSAFLKAWVYRPGEDTEEENSDLDSAE------EDTAQTG 430
            :||.|: .....|..|..........||...:|        :.:.|..:.:|      ||.|   
  Fly   147 KDTAED-CPTSQASSDRNNNAGCSQGSAAKSSW--------QRQRSISECSEDSFICFEDDA--- 199

Mouse   431 ATPHTSPFLKAWVYRPGEDTEDDTEEEEDSENVAPGDSETADSSQSPCLQPQRCLPGEKTKGRGE 495
                             |..::|.||:||.::        .|||    :|...|...|.|    |
  Fly   200 -----------------EQADEDVEEDEDDDD--------DDSS----VQFTACGEDENT----E 231

Mouse   496 EPPLFQVAFYLPGEKPESPWAAPKLPLRLQRRLRLFKAPTRDQDPEIPLKARKVHFAEKVTVHFL 560
            |                                  .||.....|...|:|  ||.|..|..||.:
  Fly   232 E----------------------------------LKACQCSDDSSTPVK--KVRFNMKPEVHVM 260

Mouse   561 AVWAGPAQAARRGPWEQFARDRSRFARRIAQAEEKLGPYLTPDSRARAW 609
            ..|....:|||:..|:..||||.||.:||.:....|...|||..|.|.:
  Fly   261 LAWDYAYRAARKSEWQVMARDRDRFQQRIRRISPILNAVLTPVHRDRVY 309

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ppp1r15aNP_032680.1 Required for localization in the endoplasmic reticulum. /evidence=ECO:0000250|UniProtKB:O75807 1..60
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 65..89
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 101..123
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 156..278
4.5 X approximate repeats 283..451 14/84 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 291..496 26/129 (20%)
Interaction with SMAD7. /evidence=ECO:0000250 323..503 28/136 (21%)
Interaction with KMT2A/MLL1. /evidence=ECO:0000250 443..548 20/104 (19%)
Interaction with SMARCB1. /evidence=ECO:0000250 529..576 15/46 (33%)
PP1c_bdg <545..612 CDD:287462 26/65 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..657 58/244 (24%)
PPP1R15NP_611863.1 PP1c_bdg <243..309 CDD:287462 27/67 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167839517
Domainoid 1 1.000 49 1.000 Domainoid score I11789
eggNOG 1 0.900 - - E1_2DZKW
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006935
OrthoInspector 1 1.000 - - oto93084
orthoMCL 1 0.900 - - OOG6_113613
Panther 1 1.100 - - LDO PTHR16489
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5794
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.860

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