DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mybpc3 and hbs

DIOPT Version :9

Sequence 1:	NP_032679.2	Gene:	Mybpc3 / 17868	MGIID:	102844	Length:	1278	Species:	Mus musculus
Sequence 2:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	1356	Identity:	258/1356 - (19%)
Similarity:	429/1356 - (31%)	Gaps:	415/1356 - (30%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MPGVTVLKMPEPGKK----PVSAFNKKPRSAEVTAGSAAVFEAETERSGVKVRWQRDG------S 55
            |..||.   |.|..:    ||..|:..|...::..|:..:...|......||:|.:||      :
  Fly    21 MAAVTA---PTPAAQVAAPPVQKFHLTPHDLQILEGTDTLLRCEVSNRAGKVQWTKDGFALGFSA 82

Mouse    56 DITANDKYGLAAEGKR--HTLTVRDASPDDQGSY----AVIAGSSKVKFDLKVTEPAPPEKAESE 114
            .|....:|.:..:.|:  :.|.:::|:.:|...|    ...||:..::.:.|::..|.|.....|
  Fly    83 VIPGFPRYSVLVDAKQNAYNLQIKNATLEDDAEYQCQVGPAAGNPAIRANAKLSIVAAPSSIVIE 147

Mouse   115 -VAPGAPKEVPA--------------PATEL-----EESVSS----------------------- 136
             .|..|..||..              ||.|:     |..||:
  Fly   148 GYARNARVEVEERQNLTLHCIAENANPAAEIVWFQGEVPVSTAPIVTVNQTAPKRFTTSSTLHLQ 212

Mouse   137 PEGSVSVTQDGSAAEHQGAPDDPIGLFLMRPQDGEVTVGGSIVFSARVAGASLLKPPVVKWFKGK 201
            |.......:....|.|:..|.|.       |...:|.:             |:|.||...:|:|.
  Fly   213 PRAEDDYKEFSCEARHKALPPDV-------PMRAQVQL-------------SVLYPPGAPFFEGY 257

Mouse   202 WVDLSSKVGQHLQLH---------------------DSYDRAS-----KVYLFELHITDAQTTSA 240
            ....:...||.:|:.                     .|..|.|     .||.|    |.|...:.
  Fly   258 SQGETLHRGQEVQIACRSRGGNPPAQLTWYRNGVAISSPQRTSGRLSENVYKF----TAAAEDNG 318

Mouse   241 GGYRCEV-------------------STKDKF----------D----SC-----NFNLTVHEAIG 267
            ....||.                   :.||.:          |    ||     |....:..:|.
  Fly   319 ANLVCEAKNLLATTPLRAELNLTVLYAPKDVYLSGANQAKVGDSVQLSCVTAPSNPQARISWSIN 383

Mouse   268 SGDLDLRSAFRRTSLAGAG-------RRTSDS--------------------------------- 292
            ...|| .|.::.||.:..|       ..|.||
  Fly   384 GRPLD-NSTYKTTSSSDGGWVSSSNISLTIDSQSRTFIAVCHALNTELTQNVVGSHTVNVLYPPS 447

Mouse   293 ------HEDAGTLDFSSLLKKRDS------------FRRDSKLEAPAE-------EDVWEILRQA 332
                  :.|...|...|:||.:.|            ::.|..:.||::       .::..::..:
  Fly   448 PPLLTGYNDGDILISGSILKLQCSSAGGNPPPTLQWYKNDKIINAPSKLVDSKITSELSLLVNAS 512

Mouse   333 PPSEYERIAFQHGVTDLRGMLKRLKGM--KQDEKKSTAFQKKLEPAYQVNKGHKIRLTVELADPD 395
            ..:...:...|:...|:.....:..|:  ..:..|.:...|.|.|..:.    |:......::|.
  Fly   513 DNNAIYKCKVQNAAIDIPLFATKTLGVHFPPETVKISVVPKNLVPGIRA----KLICDSSSSNPP 573

Mouse   396 AEVKWLKNGQEIQ----------MSGSKYIFESVGAKRTLTISQCSLADDAAYQCVVGGEKC--- 447
            |::.|.|:|..::          ..||....|..     :.|:|.  .|...|.|....|..
  Fly   574 AKISWWKDGIPVEGLNLANRPGLWGGSVSTLEMY-----VNITQD--LDGIVYTCQSHNEVLQRS 631

Mouse   448 ---STELFVKEPPVLITRSLEDQLVMVG-QRVEFECEVSEEGAQV----KWLKDGVELTREETFK 504
               :..|.:..||...|   ......|| :...|..|:...|..:    .|.|||:.::......
  Fly   632 VHETISLDILYPPKFET---PQSTTFVGVEGAPFHVELLASGNPMVITYTWTKDGLPISSNSLSG 693

Mouse   505 YRFKKDGRKHHLIINEATLEDAGHYAVRTSGGQSLAELIVQEKKLEVYQSIADLAVG----AKDQ 565
            .|...||.:  |.|:..:..|||.|.......|..|.|.:| ..:|...:|..::.|    |.:.
  Fly   694 QRLISDGPR--LNISRLSRNDAGVYICEALNSQGTALLEIQ-VAVEYAPTITAVSEGRSFVAGEP 755

Mouse   566 AVFKCEVSDENVRGV---WLKNGKELVPDNRIKVSHIGRVHKLTIDDVTPADEADYSFVPEGFAC 627
            ||..|.:....:...   |.::|.:|.  .|...|.......|.|..|..:|..:::.:.:....
  Fly   756 AVLACHIQARPLEAAHVRWSRDGYDLA--TRTISSFENGTALLQIASVERSDIGNFTCIVDNQRG 818

Mouse   628 NLSAKLHFMEVKIDFVPRQEPPKIHLDCPGSTPDTIVVVAGNKLRLDVPISGDPAPTVVWQKTVT 692
            ..:|:...:.|       |..|:|. ..||.|  ......|.:.:|.......|.|:.:|::
  Fly   819 APAAQNVLLVV-------QTAPEID-HSPGFT--RYAARLGVRAQLICRSLASPQPSFIWRR--- 870

Mouse   693 QGKKASTGPHPDAPEDAGADEEWVFDKKLLCETEGRV---RVETTKDRSVFTVEGAEKEDEGVYT 754
            .||                      |.|:....:.:.   :|:.....|...:|....:|.|.|.
  Fly   871 HGK----------------------DLKMQRRNKFKSVERQVDALNFESALLIENTSPDDYGQYE 913

Mouse   755 VTVKNPVGEDQVNLTVKVIDVPDAPAAPKISNVGEDSCTVQWEPPAYDGG-QPVLGYILERKKKK 818
            ..|:|.:|:....|.......||||...::.||.:....:.| .|.:||| |......|::..:.
  Fly   914 CVVRNSLGQASTTLEFSKPSRPDAPLQLRVGNVSDTGVDLNW-TPGFDGGMQTYFRLRLKQHGED 977

Mouse   819 SYRWM-------RLNFDLLRELSHEARRMIEGVAYEMRVYAVNAVGMSRPSPASQPFMPIGPPGE 876
            .|:::       .::.|.|:          .|..|...|.|.|..|.|:       |||
  Fly   978 KYKYVDAKPGHQNISLDGLK----------PGATYYFSVMAANEAGGSK-------FMP------ 1019

Mouse   877 PTHLAVEDVSDTTVSLKWRPPERVGAGGLDGYSVEYCQEGCSEWTPALQ--GLTERTSMLVKDLP 939
                      |..::|         :.|...:|.||.::   :..|.:.  |:|....:|   |.
  Fly  1020 ----------DIKLTL---------SKGSQPHSAEYTEK---DELPNVMIIGITSAAMVL---LV 1059

Mouse   940 TGARLL--FRVRAHN----VAGPG---------GPIVTKEPVTVQEILQRPRLQLPRHLRQTIQK 989
            ..|.|:  |.:|..|    .|.|.         ...|.|.|:|.              |:..:||
  Fly  1060 LNAALVAWFVIRRQNKSQSEAEPSNDDVYSKDDSQSVYKLPITA--------------LQADVQK 1110

Mouse   990 KVG------EPVNLLIPFQGKPRPQ-VTWTKEGQPLAGEEVSIRNSPTDTILFIRAARRTHSGTY 1047
            |..      |.|:::......|:.| .:......||...:.: |..|..         :.||...
  Fly  1111 KAAASTYLVENVDIIQSTAYPPKYQESSMCTPPYPLCNPDFT-RTLPNP---------KRHSQRN 1165

Mouse  1048 QVTVRIENME----DKATLILQIVDKPSP-PQDIRIVETWGFNVALEWKPPQDDGN 1098
            ..|..||.|:    |...||...:..||| |....:::  |..::.....|..||:
  Fly  1166 SATGMIEGMQMRSKDDHMLISNGLYIPSPSPASSLVIK--GSYISSPSPAPPADGS 1219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mybpc3	NP_032679.2	Ig	20..102	CDD:386229	18/93 (19%)
		Ig	163..262	CDD:386229	27/162 (17%)
		THB	324..357	CDD:375788	2/32 (6%)
		Ig	369..453	CDD:386229	19/99 (19%)
		Ig	460..544	CDD:386229	22/88 (25%)
		Ig	557..621	CDD:386229	14/70 (20%)
		Ig_C5_MyBP-C	660..772	CDD:143302	19/114 (17%)
		FN3	776..866	CDD:238020	23/97 (24%)
		FN3	874..967	CDD:238020	21/109 (19%)
		Ig_Titin_like	994..1066	CDD:319305	16/76 (21%)
		FN3	1070..1153	CDD:238020	8/30 (27%)
		I-set	1185..1274	CDD:369462
hbs	NP_001286439.1	Ig	44..122	CDD:299845	15/77 (19%)
		IG_like	45..137	CDD:214653	18/91 (20%)
		Ig	153..231	CDD:299845	12/77 (16%)
		IG_like	258..342	CDD:214653	13/87 (15%)
		Ig	266..327	CDD:299845	13/64 (20%)
		IG_like	357..>414	CDD:214653	12/57 (21%)
		Ig	360..427	CDD:299845	14/67 (21%)
		Ig	<468..526	CDD:299845	5/57 (9%)
		I-set	547..633	CDD:254352	19/96 (20%)
		Ig	556..631	CDD:299845	16/85 (19%)
		I-set	644..735	CDD:254352	24/96 (25%)
		IGc2	668..725	CDD:197706	14/58 (24%)
		IG_like	751..829	CDD:214653	14/79 (18%)
		IGc2	753..815	CDD:197706	12/63 (19%)
		Ig	852..928	CDD:143165	17/100 (17%)
		FN3	935..1017	CDD:238020	23/99 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000