DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myb and Cdc5

DIOPT Version :9

Sequence 1:	NP_001185843.1	Gene:	Myb / 17863	MGIID:	97249	Length:	755	Species:	Mus musculus
Sequence 2:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	742	Identity:	149/742 - (20%)
Similarity:	253/742 - (34%)	Gaps:	211/742 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse    43 WTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELV 107
            |...|||.||..|.:.|.:.|..||:.|..::..||:.||.:.|:|.:.|..|::|||::::.|.
  Fly    11 WRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEDEKLLHLA 75

Mouse   108 QKYGPKRWSVIAKHLKGRIGKQCRERWHNHL--------------------------NPEVKKT- 145
             |..|.:|..||. :.||...||.||:...|                          |||.|..
  Fly    76 -KLMPTQWRTIAP-IIGRTAAQCLERYEYLLDQAQRKEDGEDTMDDPRKLKPGEIDPNPETKPAR 138

Mouse   146 ----SWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQEPSKAS 206
                ...|:|..::.:|..||.|...:.||                   ||. :|..|:|..:.:
  Fly   139 PDPKDMDEDELEMLSEARARLANTQGKKAK-------------------RKA-REKQLEEARRLA 183

Mouse   207 QTPVATSFQKNNHLMGFG--------------HASPPSQLSP------SGQSSVNSEYPYYHIAE 251
                  :.||...|...|              :|..|.:..|      :.:..:....|.::...
  Fly   184 ------TLQKRRELRAAGIGSGNRKRIKGIDYNAEIPFEKRPAHGFYDTSEEHLQKNEPDFNKMR 242

Mouse   252 AQNISSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELEL---LLMSTENELK-GQ 312
            .|::...:                 .:..:......|.:|.|:.||.|:   :|.:.|.|.| .:
  Fly   243 QQDLDGEL-----------------RSEKEERERKRDKQKLKQRKENEVPTAMLQNMEPERKRSK 290

Mouse   313 QALPTQNHTCSYPGWHSTSIVDQTRPHGDSAPVS--CLGEH--HATPSLPADPGSLPEESASPAR 373
            ..|||..        .|...:.|....|.::.::  ..||.  ..|.:|.||....|:.:|:| |
  Fly   291 LVLPTPQ--------ISDMELQQVVKLGRASEMAKEIAGESGIETTDALLADYSITPQVAATP-R 346

Mouse   374 CMIVHQGTILDNVKNLLEFAET---------LQFIDSDSS-------------WCDLSSFEFSEE 416
            ....:...|:...:|::....|         ....:||.|             ....:.|....|
  Fly   347 TPAPYTDRIMQEAQNMMALTHTETPLKGGLNTPLHESDFSGVLPKAASIATPNTVIATPFRTQRE 411

Mouse   417 AAAFSPS--QQPTGKAFQLQQREGHGTRSAGEPS-LRVTRRVLSEASLGPDSPQARHSKVPLVVL 478
            ..|.:|.  |.|:..|....:..|..|.....|: :|....:..|.|:|.....|.:..
  Fly   412 GGAATPGGFQTPSSGALVPVKGAGGATGVVNTPAYVRDKLSINPEESMGVTETPAHYKN------ 470

Mouse   479 RKRRGQASPLAAGEPSPSLFADVISSTLKRSPVKSLPFSP-------------SQFLNTSSN--- 527
                               :...:.||| |..:.:|| :|             |:.:.|:|.
  Fly   471 -------------------YQKQLKSTL-RDGLSTLP-APRNDYEIVVPEQEESERIETNSEPAV 514

Mouse   528 HESSGLDAPTLPSTPLIGHKLTPCRDQTVK------TQKENSIFRTPAIKRSILESSPRTPTPFK 586
            .:.:.:||..|........:....|.|.::      |:....|.|..:.|:::.|.. :.....|
  Fly   515 EDQADVDARLLAEQEARRKRELEKRSQVIQRSLPRPTEVNTKILRPQSEKQNLTEQQ-QAEELIK 578

Mouse   587 HALAAQEIKYGPLK-MLPQTPSHAVEDLQDVIKQESDESGIVAEFQESGPPLLKKIKQ----EVE 646
            |.:...:: |..:| .:|....|.:|.||...|..        .:::.....|.|.||    |:|
  Fly   579 HEMITMQL-YDSVKDPVPGQSQHKLEQLQSYFKAN--------PYEDISQQELAKAKQMLTEEME 634

Mouse   647 SPTEKSGNFFCSNHWAENSLSTQLFSQ 673
            ...|:         .|...|...:::|
  Fly   635 VVKER---------MAHGELPLDVYAQ 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myb	NP_001185843.1	SANT	40..88	CDD:197842	17/44 (39%)
		Myb_DNA-binding	40..86	CDD:278669	16/42 (38%)
		Interaction with HIPK2 and NLK. /evidence=ECO:0000269\|PubMed:15082531	90..193		31/133 (23%)
		SANT	92..140	CDD:197842	18/73 (25%)
		Myb_DNA-binding	92..138	CDD:278669	17/45 (38%)
		SANT	144..191	CDD:197842	8/51 (16%)
		Myb_DNA-binding	144..189	CDD:278669	8/49 (16%)
		LMSTEN	269..313	CDD:285262	10/47 (21%)
		Transcriptional activation domain. /evidence=ECO:0000250	275..327		13/55 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..368		8/34 (24%)
		Leucine-zipper	375..396		3/29 (10%)
		Cmyb_C	516..677	CDD:286408	34/185 (18%)
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842	17/44 (39%)
		Myb_DNA-bind_6	11..71	CDD:290632	23/59 (39%)
		SANT_CDC5_II	56..108	CDD:212557	19/53 (36%)
		SANT	60..104	CDD:197842	17/45 (38%)
		Myb_Cef	397..648	CDD:288664	54/296 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810