DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myb and Myb

DIOPT Version :9

Sequence 1:	NP_001185843.1	Gene:	Myb / 17863	MGIID:	97249	Length:	755	Species:	Mus musculus
Sequence 2:	NP_511170.1	Gene:	Myb / 32543	FlyBaseID:	FBgn0002914	Length:	657	Species:	Drosophila melanogaster

Alignment Length:	812	Identity:	238/812 - (29%)
Similarity:	328/812 - (40%)	Gaps:	293/812 - (36%)

- Green bases have known domain annotations that are detailed below.

Mouse    10 YSSDED--------DEDIEMCDHD------YDGLLP------------------KSGKRHLGKT- 41
            |.|:.|        :||.::||.|      .|...|                  ||||..:|..
  Fly    15 YGSNSDSEESEYSENEDTQVCDKDSQQNSNADSGYPLDSPELQDSKTTGQKGQNKSGKTSIGAVH 79

Mouse    42 -------RWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEE 99
                   ||::.||..||:|||.:| ::|::|..:..:|.:.|.|.||.|||||||||||||::|
  Fly    80 PNYGFGKRWSKSEDVLLKQLVETHG-ENWEIIGPHFKDRLEQQVQQRWAKVLNPELIKGPWTRDE 143

Mouse   100 DQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGN 164
            |..||:||:.:|||:|::||::|.|||||||||||||||||.:|||:|||:||.||||||..|||
  Fly   144 DDMVIKLVRNFGPKKWTLIARYLNGRIGKQCRERWHNHLNPNIKKTAWTEKEDEIIYQAHLELGN 208

Mouse   165 RWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQEPSKASQTPVATSFQKNNHLMGFGHASPP 229
            :||:|||.||||||||||||||||||||.:.|   :....||.:.:.:|   ..||:
  Fly   209 QWAKIAKRLPGRTDNAIKNHWNSTMRRKYDVE---RRSVNASGSDLKSS---RTHLI-------- 259

Mouse   230 SQLSPSGQSSVNSEYPYYHIAEAQNISSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKR 294
             .|..||           .|::..|             |:.:..:....|:.:..| .|......
  Fly   260 -TLIKSG-----------GISKCMN-------------NMQHNKESGGEAVNKSEN-ADGASVTA 298

Mouse   295 IKELELLLMSTENELKGQQ-ALPTQNHTCSYPGWHSTSIV-DQTRPHGDSAPVSCLGEHHATPSL 357
            :|..:|...|.::..||.. |..:..|.........|.|: .:||.|
  Fly   299 VKGGDLAQESQDDHQKGSNLAHLSMQHLIKLTMPRQTPIILKRTRKH------------------ 345

Mouse   358 PADPGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSDSSWCDLSSFEFSEEAAAFSP 422
                  :||..         ||                        :.|. ||..|::|.||.:.
  Fly   346 ------IPETH---------HQ------------------------AGCS-SSETFNQEEAAGNA 370

Mouse   423 SQQPTGKAFQLQQREGHGTRSAGEPSLRVTRRVLSEASLGPDSPQARHSKVPLVVLRKRRGQASP 487
            ..:|                                    |.||
  Fly   371 RSRP------------------------------------PSSP--------------------- 378

Mouse   488 LAAGEPSPSLFADVISSTLKRSPVKSLPFSPSQFLNTS--SNHESSGLDAPTLPSTPLIGHKLTP 550
                         ||      ||:||||||||.||.:.  :..|...|.|    |||:.  |:..
  Fly   379 -------------VI------SPIKSLPFSPSHFLKSPCLTTFEDMDLRA----STPVT--KVYN 418

Mouse   551 CRDQTVKTQKENSIFRTPAIKRSILESSPRTPTPFKHALAAQEIKYGPLKMLPQTPSHAVEDLQD 615
            .....:|.:.|.|...||  .:|.|  .||||||||.||||...|....:..|.:||..||||.:
  Fly   419 RVGMEIKKEMETSSIETP--HKSQL--GPRTPTPFKKALAAIGKKRDGRRYEPSSPSSLVEDLAE 479

Mouse   616 VIKQE-----------------SDESGIVAEFQESGPPLLKKIKQEVESPTEKSGNFFCSNH--W 661
            :|.:|                 ...|.:..|:....||.:|:.::.:.|.       :.|||  .
  Fly   480 IIHEEHLSNSLTANNSKMMGAADQNSTLSTEYNAQSPPHMKRARKSLLST-------WSSNHPYN 537

Mouse   662 AENSLSTQLFSQASPVADAPNILTSSVLMTPVSEDEDNVLKAFTVP------KNRP--------- 711
            |.::...|.|...:|         |..|.:|....:|.:.....:|      :|||
  Fly   538 AGSAKRIQPFETETP---------SKFLTSPGDILKDTLCSEQDLPFDEGRKENRPFHNRRINKY 593

Mouse   712 --------LVGPLQPCSGAWEPASCGKTEDQM 735
                    ::.|      .|...:|||:.|||
  Fly   594 RGGLTYDHVIDP------KWARVACGKSRDQM 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myb	NP_001185843.1	SANT	40..88	CDD:197842	20/55 (36%)
		Myb_DNA-binding	40..86	CDD:278669	18/53 (34%)
		Interaction with HIPK2 and NLK. /evidence=ECO:0000269\|PubMed:15082531	90..193		78/102 (76%)
		SANT	92..140	CDD:197842	33/47 (70%)
		Myb_DNA-binding	92..138	CDD:278669	31/45 (69%)
		SANT	144..191	CDD:197842	38/46 (83%)
		Myb_DNA-binding	144..189	CDD:278669	36/44 (82%)
		LMSTEN	269..313	CDD:285262	8/43 (19%)
		Transcriptional activation domain. /evidence=ECO:0000250	275..327		10/52 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..368		4/30 (13%)
		Leucine-zipper	375..396		2/20 (10%)
		Cmyb_C	516..677	CDD:286408	54/181 (30%)
Myb	NP_511170.1	SANT	85..132	CDD:197842	30/46 (65%)
		Myb_DNA-bind_6	88..147	CDD:290632	43/58 (74%)
		SANT	136..184	CDD:197842	37/47 (79%)
		Myb_DNA-bind_6	139..197	CDD:290632	47/57 (82%)
		SANT	188..235	CDD:197842	16/46 (35%)
		Myb_DNA-binding	188..233	CDD:278669	16/44 (36%)
		Cmyb_C	388..530	CDD:286408	25/141 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I8733
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	299	1.000	Inparanoid score	I2683
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119160at33208
OrthoFinder	1	1.000	-	-		FOG0000329
OrthoInspector	1	1.000	-	-		otm43530
orthoMCL	1	0.900	-	-		OOG6_100129
Panther	1	1.100	-	-	LDO	PTHR45614
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2047
SonicParanoid	1	1.000	-	-		X1086
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.860