Protein Alignment DNM2 and VPS1

DIOPT Version :10

• Sequence 1: NP_001005360.1
• Gene: DNM2 / 1785
• HGNCID: 2974
• Length: 870
• Species: Homo sapiens
• Sequence 2: NP_012926.1
• Gene: VPS1 / 853870
• SGDID: S000001709
• Length: 704
• Species: Saccharomyces cerevisiae
• Alignment Length: 796
• Identity: 311/796 - (39%)
• Similarity: 426/796 - (53%)
• Gaps: 157/796 - (19%)

Human     7 EELIPLVNKLQDAFSSI--GQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPL 69
            |.||..:||||||.:.:  |....:|||||.|||.||:||||||||.|||||||||:||||||||
Yeast     3 EHLISTINKLQDALAPLGGGSQSPIDLPQITVVGSQSSGKSSVLENIVGRDFLPRGTGIVTRRPL 67

Human    70 ILQLIF---SKTEHA-----------------------------------------EFLHCKSKK 90
            :||||.   .|:|||                                         ||||...||
Yeast    68 VLQLINRRPKKSEHAKVNQTANELIDLNINDDDKKKDESGKHQNEGQSEDNKEEWGEFLHLPGKK 132

Human    91 FTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQ 155
            |.:|||:|:||..|||:|||.|.|||.||||||:||||||.|||:||||:|||||||||||||.|
Yeast   133 FYNFDEIRKEIVKETDKVTGANSGISSVPINLRIYSPHVLTLTLVDLPGLTKVPVGDQPPDIERQ 197

Human   156 IKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVL 220
            ||||:|::||:.:::||:|..||.||||||.||||:||||:|.|||||:||:||||:|||..|:|
Yeast   198 IKDMLLKYISKPNAIILSVNAANTDLANSDGLKLAREVDPEGTRTIGVLTKVDLMDQGTDVIDIL 262

Human   221 ENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQL 285
            ..:::|||.|||.|:||.|||||.||.||.||..|||||.:||:|...|...|||:|.|.||..|
Yeast   263 AGRVIPLRYGYIPVINRGQKDIEHKKTIREALENERKFFENHPSYSSKAHYCGTPYLAKKLNSIL 327

Human   286 TNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQ 350
            .:|||::||.:::|:::   :|:|...|..|..|:.....:..:|.|:..|..::...::|...:
Yeast   328 LHHIRQTLPEIKAKIEA---TLKKYQNELINLGPETMDSASSVVLSMITDFSNEYAGILDGEAKE 389

Human   351 VDTLELSGGARINRIFHERF--------PFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDL 407
            :.:.||||||||:.:|||.|        ||:.:|    :.|: |.|.|   |..|....||....
Yeast   390 LSSQELSGGARISYVFHETFKNGVDSLDPFDQIK----DSDI-RTIMY---NSSGSAPSLFVGTE 446

Human   408 AFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTS--KLSSYPRLREETERIVTTYIREREGR 470
            |||.:||:|:.:.:||.|:.|.||..||:..::|..|  |.|.||.|||........::::....
Yeast   447 AFEVLVKQQIRRFEEPSLRLVTLVFDELVRMLKQIISQPKYSRYPALREAISNQFIQFLKDATIP 511

Human   471 TKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMK 535
            |.:.::.:|..||:||||.|.|                                        |:|
Yeast   512 TNEFVVDIIKAEQTYINTAHPD----------------------------------------LLK 536

Human   536 GGSKEYWFVLTAESLSWYKDEEEKEKKYMLPL------DNLKIRDVEKGFMSNKHVFAIFNTEQR 594
            |...   .|:..|.|  :..:...:.|...||      ....:.:.:.||..     ..|:|:.:
Yeast   537 GSQA---MVMVEEKL--HPRQVAVDPKTGKPLPTQPSSSKAPVMEEKSGFFG-----GFFSTKNK 591

Human   595 NVYKDLRQIELACDSQEDVDSWKASFLRA-GVYPEKDQAENEDGAQENTFSMDPQLERQVETIRN 658
               |.|..:|    |...|       |:| |...|::..|                   .|.|:.
Yeast   592 ---KKLAALE----SPPPV-------LKATGQMTERETME-------------------TEVIKL 623

Human   659 LVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDML 723
            |:.||.:|:.::|.|::||.:|..:|..:|..|...||..||...|...|.:|:....|||.:..
Yeast   624 LISSYFSIVKRTIADIIPKALMLKLIVKSKTDIQKVLLEKLYGKQDIEELTKENDITIQRRKECK 688

Human   724 RMYHALKEALNIIGDI 739
            :|...|:.|..|:..:
Yeast   689 KMVEILRNASQIVSSV 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNM2	NP_001005360.1	DYNc	6..245	CDD:197491	166/283 (59%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	38..45		4/6 (67%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	64..66		1/1 (100%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	136..139		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	205..208		2/2 (100%)
		Dynamin_M	215..502	CDD:460033	111/296 (38%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	235..238		1/2 (50%)
		PH_dynamin	520..629	CDD:269958	21/115 (18%)
		GED	649..739	CDD:460495	28/89 (31%)
		PHA03247	<737..868	CDD:223021	0/3 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	741..870
VPS1	NP_012926.1	DLP_1	27..336	CDD:206738	182/308 (59%)
		Dynamin_M	257..541	CDD:460033	114/337 (34%)
		GED	614..704	CDD:460495	29/108 (27%)